AutismKB 2.0

Annotation Detail for SCG2


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Basic Information Top
Gene Symbol:SCG2 ( CHGC,SN,SgII )
Gene Full Name: secretogranin II
Band: 2q36.1
Quick LinksEntrez ID:7857; OMIM: 118930; Uniprot ID:SCG2_HUMAN; ENSEMBL ID: ENSG00000171951; HGNC ID: 10575
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
No data
Desease Name
osteoporosis-related phenotypes
METABOLIC
Desease Name
Osteoporosis-related phenotypes
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000643 Ammonium Chloride Ammonium Chloride affects the expression of SCG2 mRNAaffects expression 16483693
D003913 Dextroamphetamine Dextroamphetamine results in decreased expression of SCG2 mRNAdecreases expression 12558987
D000661 Amphetamine Amphetamine results in increased expression of SCG2 mRNAincreases expression 15033416
12638131
15592348
D000661 Amphetamine Baclofen inhibits the reaction [Amphetamine results in increased expression of SCG2 mRNA]decreases reaction|increases expression 15033416
15592348
D001418 Baclofen Baclofen inhibits the reaction [Amphetamine results in increased expression of SCG2 mRNA]decreases reaction|increases expression 15033416
15592348
D005419 Flavonoids Flavonoids results in decreased expression of SCG2 mRNAdecreases expression 18035473
D005472 Fluorouracil Fluorouracil results in decreased expression of SCG2 proteindecreases expression 15352031
D005472 Fluorouracil SCG2 protein affects the susceptibility to Fluorouracilaffects response to substance 15352031
D008770 Methylnitrosourea Methylnitrosourea results in increased expression of SCG2 mRNAincreases expression 17412507
D009151 Mustard Gas Mustard Gas results in increased expression of SCG2 mRNAincreases expression 15674843
D011189 Potassium Chloride Potassium Chloride results in increased expression of SCG2 mRNAincreases expression 16412482
D011374 Progesterone Progesterone results in increased expression of SCG2 mRNAincreases expression 16376865
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.8018287403
MESH:D000230 Adenocarcinoma Fluorouracil 4.9517638652
MESH:D000230 Adenocarcinoma Methylnitrosourea 4.9515113128 15688392
MESH:D019969 Amphetamine-Related Disorders Amphetamine 6.2918475255 16916582 15010207 16459022
MESH:D000740 Anemia Fluorouracil 3.8716511603 17963324 15504547
MESH:D000855 Anorexia Amphetamine 5.1712005258 16101753 16084549 12183048
MESH:D001249 Asthma Mustard Gas 2.7510378619
MESH:D001768 Blister Mustard Gas 5.4019167455
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.6017868700
MESH:D001930 Brain Injuries Progesterone 4.4715845082 15380490 15665606
MESH:D001943 Breast Neoplasms Fluorouracil 2.0816110121 15136595 18357371 19217205 16595493 16557594 18608205
MESH:D001943 Breast Neoplasms Methylnitrosourea 2.0811306469 14633655 16253758
MESH:D001943 Breast Neoplasms Progesterone 2.0815562024 17614352 16175315
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 5.4015286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 5.2417687719 10378619
MESH:D002276 Carcinoid Tumor Fluorouracil 4.9316051944
MESH:D002277 Carcinoma Fluorouracil 3.7017121937
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 2.1017045692 17971768 16799960 18930000 16332177 17088986
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 3.0918695887
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 2.5316280240 18986760 16757204 17066447
MESH:D002386 Cataract Methylnitrosourea 4.0812484553
MESH:D002471 Cell Transformation, Neoplastic Methylnitrosourea 3.917505956 2727394
MESH:D003110 Colonic Neoplasms Fluorouracil 2.2616340194 17018589 15001691 17172411 17725105 16510598 17016597 17287894 17169374 18772588
MESH:D015179 Colorectal Neoplasms Fluorouracil 2.0016391804 15148649 15289873 17094418 18802399 18288408 17016601 18509181 18448328 17454858 17594712 16282729 17255274 16331619 16303861 16524972 18383874 17695437 17401013 14970324 20501625 18949393
MESH:D007644 Darier Disease Fluorouracil 5.0316733453
MESH:D003929 Diabetic Neuropathies Progesterone 4.7117187935
MESH:D004487 Edema Mustard Gas 3.4811402378 11428631 9260866 11428647
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 3.9817692515
MESH:D004715 Endometriosis Progesterone 3.9316134523
MESH:D004890 Erythema Mustard Gas 5.409357497
MESH:D004938 Esophageal Neoplasms Fluorouracil 2.4816481741 17638652 15173087 16337965 16785472
MESH:D005221 Fatigue Amphetamine 5.8419890266
MESH:D005354 Fibrosarcoma Methylnitrosourea 5.4711555667
MESH:D005910 Glioma Fluorouracil 6.5716145905
MESH:D005910 Glioma Methylnitrosourea 6.579825942
MESH:D006258 Head and Neck Neoplasms Fluorouracil 3.5018337622 15162350 15102660
MESH:D006948 Hyperkinesis Amphetamine 5.6714960337 1977408
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.6215869954
MESH:D007248 Infertility, Male Methylnitrosourea 3.907193160
MESH:D007249 Inflammation Flavonoids 8.9517296493
MESH:D007249 Inflammation Mustard Gas 8.959357497 17524151 8975870 11428631 11402378 11428620 9260866 16001271 11428647
MESH:D007249 Inflammation Progesterone 8.9515869954
MESH:D007680 Kidney Neoplasms Fluorouracil 3.4516985049
MESH:D017880 Limb Deformities, Congenital Methylnitrosourea 4.3215526292
MESH:D008113 Liver Neoplasms Fluorouracil 2.5317045692 18383874 15113037 16603448
MESH:D038061 Lower Extremity Deformities, Congenital Methylnitrosourea 5.6816080182
MESH:D008171 Lung Diseases Mustard Gas 3.5618702808 18161513
MESH:D008175 Lung Neoplasms Fluorouracil 3.7515246190
MESH:D008175 Lung Neoplasms Methylnitrosourea 3.7518062963
MESH:D008175 Lung Neoplasms Mustard Gas 3.753148597 8781369
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 5.0315086387
MESH:D008223 Lymphoma Methylnitrosourea 4.1316257854 11418001
MESH:D016393 Lymphoma, B-Cell Methylnitrosourea 4.9514633661
MESH:D008325 Mammary Neoplasms, Experimental Methylnitrosourea 6.7919196723 10767621 14999141 11751437 16051031 10838139 15688392 12931682 16944150 17020996 16827153 15113128 14633655 15313902 16619500 11807958 17131329
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 6.7911408345 17203775
MESH:D009041 Motion Sickness Dextroamphetamine 5.791613127
MESH:D009062 Mouth Neoplasms Fluorouracil 3.7618986760 16757204
MESH:D009369 Neoplasms Fluorouracil 5.7416928823 18600527 18239605
MESH:D009369 Neoplasms Methylnitrosourea 5.7415533788
MESH:D009374 Neoplasms, Experimental Methylnitrosourea 4.6912696579
MESH:D009442 Neurilemmoma Methylnitrosourea 5.7211555667
MESH:D019636 Neurodegenerative Diseases Amphetamine 4.7915183010
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.5516436463
MESH:D009503 Neutropenia Mustard Gas 4.1516761898 7688884
MESH:D010051 Ovarian Neoplasms Progesterone 2.5717393432 16525653
MESH:D010190 Pancreatic Neoplasms Fluorouracil 5.8516500647 16929163 15113037 19003803
MESH:D010190 Pancreatic Neoplasms Methylnitrosourea 5.8516965848
MESH:D011041 Poisoning Mustard Gas 3.9815727166
MESH:D011471 Prostatic Neoplasms Fluorouracil 3.6119082440 18626508
MESH:D011471 Prostatic Neoplasms Methylnitrosourea 3.6115682402 12376480
MESH:D011537 Pruritus Mustard Gas 4.3318058305
MESH:D011658 Pulmonary Fibrosis Mustard Gas 2.9817266442 10334151 17720292 17894541 17620002
MESH:D012004 Rectal Neoplasms Fluorouracil 4.1615538739 18286688 18722050 16160472
MESH:D012162 Retinal Degeneration Methylnitrosourea 4.5418172121 18155124
MESH:D012175 Retinoblastoma Methylnitrosourea 5.7211555667
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.9118045962
MESH:D012871 Skin Diseases Mustard Gas 2.7515451306 12880345 16961503
MESH:D013119 Spinal Cord Injuries Progesterone 4.5216503802 15862959
MESH:D019956 Stereotypic Movement Disorder Amphetamine 6.691977408
MESH:D013274 Stomach Neoplasms Fluorouracil 2.8718396642 19084572 16424979 18567086 17172411 19015929 17498489 16951190 17522103 15786421
MESH:D013274 Stomach Neoplasms Methylnitrosourea 2.8716257854 18593901 15930296
MESH:D013953 Thymus Neoplasms Methylnitrosourea 5.4711418001
MESH:D013964 Thyroid Neoplasms Methylnitrosourea 4.053078959 7505956
MESH:D014062 Tongue Neoplasms Fluorouracil 4.1516280240
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 4.0416803524
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA34987
    • No data
    Releated disease ID Related disease Name
    PA447199Bipolar Disorder
    PA447216Schizophrenia
    No data
    Drug Bank Top

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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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