AutismKB 2.0

Annotation Detail for KCNAB1


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Basic Information Top
Gene Symbol:KCNAB1 ( AKR6A3,KCNA1B,KV-BETA-1,Kvb1.3,hKvBeta3,hKvb3 )
Gene Full Name: potassium voltage-gated channel, shaker-related subfamily, beta member 1
Band: 3q25.31
Quick LinksEntrez ID:7881; OMIM: 601141; Uniprot ID:KCAB1_HUMAN; ENSEMBL ID: ENSG00000169282; HGNC ID: 6228
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
No data
Desease Name
AGING
Aging traits
Desease Name
Aging traits
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000638 Amiodarone Amiodarone results in increased expression of KCNAB1 mRNAincreases expression 15520326
D000643 Ammonium Chloride Ammonium Chloride affects the expression of KCNAB1 mRNAaffects expression 16483693
C002791 bismuth tripotassium dicitrate bismuth tripotassium dicitrate results in decreased expression of KCNAB1 mRNAdecreases expression 15912405
D004041 Dietary Fats Dietary Fats results in decreased expression of KCNAB1 mRNAdecreases expression 18042831
D004052 Diethylnitrosamine Diethylnitrosamine results in increased expression of KCNAB1 mRNAincreases expression 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of KCNAB1 mRNA]decreases reaction|increases expression 17942915
D019833 Genistein Genistein results in increased expression of KCNAB1 mRNAincreases expression 16169203
D006220 Haloperidol Haloperidol results in decreased expression of KCNAB1 mRNAdecreases expression 18797397
C008493 methylselenic acid methylselenic acid results in increased expression of KCNAB1 mRNAincreases expression 18548127
D009151 Mustard Gas Mustard Gas results in increased expression of KCNAB1 mRNAincreases expression 15674843
C076029 olanzapine olanzapine results in decreased expression of KCNAB1 mRNAdecreases expression 18797397
C041786 palm oil palm oil results in decreased expression of KCNAB1 mRNAdecreases expression 18042831
C025299 polyphenols polyphenols results in decreased expression of KCNAB1 mRNAdecreases expression 16293270
D018038 Sodium Selenite Sodium Selenite results in decreased expression of KCNAB1 mRNAdecreases expression 18175754
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.6818287403
MESH:D000230 Adenocarcinoma Genistein 2.5011473722
MESH:D000236 Adenoma Diethylnitrosamine 2.896695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 4.0217162532 17620307 16434500 19061943 18056438 19052882
MESH:D001145 Arrhythmias, Cardiac Amiodarone 3.8818218290 20041841 18057881
MESH:D001161 Arteriosclerosis Dietary Fats 3.9915238619
MESH:D001249 Asthma Mustard Gas 2.7310378619
MESH:D001281 Atrial Fibrillation Amiodarone 3.9618651412 19698954
MESH:D001321 Autistic Disorder Haloperidol 2.8419368416 18080171
MESH:D001321 Autistic Disorder olanzapine 2.8417069543 18685284
MESH:D001768 Blister Mustard Gas 5.2819167455
MESH:D001778 Blood Coagulation Disorders Amiodarone 3.9819483382
MESH:D001943 Breast Neoplasms Dietary Fats 1.9420435547
MESH:D001943 Breast Neoplasms Diethylnitrosamine 1.9417474063
MESH:D001943 Breast Neoplasms Genistein 1.9416873071 17200150 16541309
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 5.2815286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 5.1117687719 10378619
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 3.1716698587 11831363 19519916 20727157 16681979 19171122 21159647 19919837 10737359 18210153 3581430 16878318 19394651 19539802 19335982 16569478 20101231 19052882 20084675 17055752 18978308 20514400 18665156 19701751 16779866 18393292 19107877 16288022 18785209 16935385 17162532 16502159 18056438 17761372 20432363 3084413 18691550 18788625 16807293 16328049 16540662 17138121 20007298 10672840 18971187 17173139 16830150 20214788 19822196 18506893 18494052 17978847 19418558 19208518 19383236 17428255 20512989 20935162 20524982
MESH:D006528 Carcinoma, Hepatocellular Genistein 3.1716924424
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 2.9215710769 19225199
MESH:D002318 Cardiovascular Diseases Genistein 3.3616332659
MESH:D002341 Carotid Artery Thrombosis Amiodarone 5.2018974383
MESH:D002375 Catalepsy Haloperidol 5.0315215559 1977408
MESH:D002389 Catatonia olanzapine 6.3818071103 16772815
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 2.9121159647 7505956 2727394 17174075
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 3.7619052882
MESH:D019457 Chromosome Breakage Sodium Selenite 4.8615894690
MESH:D003110 Colonic Neoplasms Genistein 4.0617182828
MESH:D003110 Colonic Neoplasms polyphenols 4.0616293270
MESH:D016757 Death, Sudden, Cardiac Haloperidol 4.9320210726
MESH:D003704 Dementia Haloperidol 4.6611575062
MESH:D002658 Developmental Disabilities olanzapine 4.7417069543
MESH:D003920 Diabetes Mellitus Sodium Selenite 3.8516285004
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 4.5820387270
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 4.5816647724
MESH:D056486 Drug-Induced Liver Injury Amiodarone 9.2518218290 15265979
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 9.2519107877
MESH:D056486 Drug-Induced Liver Injury polyphenols 9.2519370779
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 9.2515131321
MESH:D050171 Dyslipidemias Dietary Fats 3.5118367378
MESH:D004487 Edema Mustard Gas 3.3911428631 9260866 11402378 11428647
MESH:D004714 Endometrial Hyperplasia Genistein 4.7116402032
MESH:D016889 Endometrial Neoplasms Genistein 3.4111473722
MESH:D004890 Erythema Mustard Gas 5.289357497
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.2516302075
MESH:D005234 Fatty Liver Amiodarone 13.6914986274
MESH:D005234 Fatty Liver Dietary Fats 13.6917967931 18296743 19551842 19004024
MESH:D005234 Fatty Liver Diethylnitrosamine 13.6920387270 21071580
MESH:D005355 Fibrosis Dietary Fats 3.6318296743
MESH:D005909 Glioblastoma Genistein 3.3116598420
MESH:D006529 Hepatomegaly Amiodarone 3.8515265979
MESH:D006937 Hypercholesterolemia Amiodarone 9.448137927 9751232
MESH:D006937 Hypercholesterolemia Dietary Fats 9.4421332399
MESH:D006949 Hyperlipidemias Dietary Fats 3.7021332399
MESH:D006963 Hyperphagia olanzapine 6.3517933447
MESH:D007037 Hypothyroidism Amiodarone 4.6217991464 18020914
MESH:D007249 Inflammation Dietary Fats 12.3720412841
MESH:D007249 Inflammation Diethylnitrosamine 12.3718785209
MESH:D007249 Inflammation Mustard Gas 12.3716001271 9357497 17524151 11428631 9260866 11402378 11428647 11428620 8975870
MESH:D007249 Inflammation polyphenols 12.3716366677
MESH:D007333 Insulin Resistance Dietary Fats 7.6611836018 18457598
MESH:D007333 Insulin Resistance Sodium Selenite 7.6614714311
MESH:D007938 Leukemia Genistein 3.0618980019 17468513
MESH:D008064 Lipidoses Amiodarone 3.5715342952 17567588
MESH:D008103 Liver Cirrhosis Dietary Fats 6.7818296743
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 6.7820032147 18407596 18522880 19638242 18665156
MESH:D008106 Liver Cirrhosis, Experimental Genistein 2.0617823541
MESH:D008107 Liver Diseases Diethylnitrosamine 4.3917034775
MESH:D008107 Liver Diseases polyphenols 4.3916698588
MESH:D008113 Liver Neoplasms Diethylnitrosamine 2.2620492335 19812893 9163691 19690152 10737359 12771043 19256749 19294768 20405173 18648771 19551842 18977376 19427195 19254457 2862719 15175105 21071580 20101389 20434301 20452335 21167192 19499222 19642983 19426721 19090486 12112319 15885732 19638242 19833225 21278145 19073162 20137499 16942905 18754104 18978307 18644402 20118626 20501860 19255062 19996281 21047994 20583210 19850985 2422723
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 2.6818775883 17854601 19009564 17174075 16267830 17942915 18079962 9362446 19539802 21159647 18544905 16842330 18164116 18308698 18253720 19004024 3124819 19519916 18093689 18282651 19126423 2563599
MESH:D008133 Long QT Syndrome Amiodarone 8.9117391786 11989578 15350150
MESH:D008133 Long QT Syndrome olanzapine 8.9120210726
MESH:D008171 Lung Diseases Amiodarone 7.8012587719
MESH:D008171 Lung Diseases Mustard Gas 7.8018702808 18161513
MESH:D017563 Lung Diseases, Interstitial Amiodarone 4.6118516814
MESH:D008175 Lung Neoplasms Diethylnitrosamine 2.6220970405 6695378 20512841 21163286
MESH:D008175 Lung Neoplasms Mustard Gas 2.628781369 3148597
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 4.1514737004
MESH:D008325 Mammary Neoplasms, Experimental Genistein 2.9912929590 14578162
MESH:D001523 Mental Disorders Haloperidol 9.0116856516
MESH:D001523 Mental Disorders olanzapine 9.0116856516
MESH:D008659 Metabolic Diseases olanzapine 5.4719142110
MESH:D009181 Mycoses Amiodarone 5.0417974566 12754197
MESH:D009203 Myocardial Infarction Genistein 2.8917141266
MESH:D015428 Myocardial Reperfusion Injury Genistein 3.7217141266
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.599029167 3581430
MESH:D009421 Nervous System Malformations Genistein 4.1316427766
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 3.4120387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.2520387270
MESH:D009503 Neutropenia Mustard Gas 4.0616761898 7688884
MESH:D009765 Obesity Dietary Fats 5.1920132043 21332399 18457598 19632207 20518802 17217161 18674790 11836018 16723640
MESH:D009765 Obesity olanzapine 5.1918515891
MESH:D010024 Osteoporosis Genistein 3.3019401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 4.1716169203
MESH:D010051 Ovarian Neoplasms Genistein 2.6219005980
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 2.4516540662
MESH:D011041 Poisoning Mustard Gas 3.8815727166
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.622563599
MESH:D011471 Prostatic Neoplasms Genistein 2.7015378649 15256057 16925846
MESH:D011471 Prostatic Neoplasms methylselenic acid 2.7016205645
MESH:D011471 Prostatic Neoplasms Sodium Selenite 2.7018760546
MESH:D011537 Pruritus Mustard Gas 4.2118058305
MESH:D011595 Psychomotor Agitation Haloperidol 12.1711575062
MESH:D011595 Psychomotor Agitation olanzapine 12.1718685284
MESH:D011618 Psychotic Disorders Haloperidol 4.3111575062
MESH:D011658 Pulmonary Fibrosis Amiodarone 5.9411597910 12490602 12832656
MESH:D011658 Pulmonary Fibrosis Mustard Gas 5.9417620002 17266442 10334151 17894541 17720292
MESH:D012559 Schizophrenia Haloperidol 4.3919369910 18513383 20107430 1830565
MESH:D012559 Schizophrenia olanzapine 4.3920107430 20521326 17726453
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 5.2018724381
MESH:D012871 Skin Diseases Mustard Gas 2.7312880345 15451306 16961503
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 1.7618456281
MESH:D013276 Stomach Ulcer Amiodarone 3.4018087811
MESH:D013610 Tachycardia Amiodarone 4.3811238279
MESH:D017180 Tachycardia, Ventricular Amiodarone 18.0819225199
MESH:D017180 Tachycardia, Ventricular Haloperidol 18.0820210726
MESH:D017180 Tachycardia, Ventricular olanzapine 18.0820210726
MESH:D013705 Temporomandibular Joint Disorders polyphenols 5.3917997062
MESH:D013959 Thyroid Diseases Amiodarone 4.8919731979
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 3.047505956
MESH:D013971 Thyrotoxicosis Amiodarone 4.9618020914 19584973
MESH:D016171 Torsades de Pointes Amiodarone 4.3117467628 11989578
MESH:D015430 Weight Gain Dietary Fats 10.3216723640
MESH:D015430 Weight Gain olanzapine 10.3220107430 17933447 19434072
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA370
    • No data
    No data
    Releated drug ID Related drug Name
    PA452249antiarrhythmics, class i and iii
    Drug Bank Top

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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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