AutismKB 2.0

Annotation Detail for CAD


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Basic Information Top
Gene Symbol:CAD ( - )
Gene Full Name: carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
Band: 2p23.3
Quick LinksEntrez ID:790; OMIM: 114010; Uniprot ID:PYR1_HUMAN; ENSEMBL ID: ENSG00000084774; HGNC ID: 1424
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
PWY-5686uridine-5'-phosphate biosynthesis
PWY0-162pyrimidine ribonucleotides de novo biosynthesis
Pathway IDPathway Name
hsa00240Pyrimidine metabolism
hsa00250Alanine, aspartate and glutamate metabolism
hsa01100Metabolic pathways
Pathway IDPathway Name
Metabolism of nucleotides
Pathway IDPathway Name
200045Validated targets of C-MYC transcriptional activation
Pathway IDPathway Name
P02728Arginine biosynthesis
P02740De novo pyrimidine ribonucleotides biosythesis
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of CAD mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of CAD mRNAaffects expression 21346803
C472791 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in increased expression of CAD mRNAincreases expression 16788091
C035207 4-amino-2,6-dinitrotoluene 4-amino-2,6-dinitrotoluene affects the expression of CAD mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of CAD mRNAaffects expression 17562736
C006632 arsenic trioxide arsenic trioxide results in decreased expression of CAD mRNAdecreases expression 20458559
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of CAD mRNAaffects expression 17484886
D002995 Clofibric Acid [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of CAD mRNAaffects cotreatment|affects expression 17602206
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of CAD mRNAaffects cotreatment|affects expression 17602206
D004121 Dimethyl Sulfoxide Dimethyl Sulfoxide promotes the reaction [AHR protein binds to CAD promoter]affects binding|increases reaction 16675542
D004121 Dimethyl Sulfoxide Dimethyl Sulfoxide promotes the reaction [ARNT protein binds to CAD promoter]affects binding|increases reaction 16675542
D004121 Dimethyl Sulfoxide Dimethyl Sulfoxide promotes the reaction [ESR1 protein binds to CAD promoter]affects binding|increases reaction 16675542
D004121 Dimethyl Sulfoxide Dimethyl Sulfoxide promotes the reaction [SP1 protein binds to CAD promoter]affects binding|increases reaction 16675542
D004958 Estradiol Estradiol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [ESR1 protein binds to CAD promoter]]affects binding|decreases reaction|increases reaction 16675542
D004958 Estradiol Estradiol promotes the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to CAD promoter]]affects binding|increases reaction 16675542
D004958 Estradiol Estradiol results in increased expression of CAD mRNAincreases expression 16675542
D004958 Estradiol fulvestrant inhibits the reaction [Estradiol results in increased expression of CAD mRNA]decreases reaction|increases expression 16675542
D004958 Estradiol Tetrachlorodibenzodioxin inhibits the reaction [Estradiol results in increased expression of CAD mRNA]decreases reaction|increases expression 16675542
D005472 Fluorouracil TP53 protein affects the reaction [Fluorouracil results in decreased expression of CAD mRNA]affects reaction|decreases expression 15016801
C070081 fulvestrant fulvestrant inhibits the reaction [Estradiol results in increased expression of CAD mRNA]decreases reaction|increases expression 16675542
C487081 PXD101 PXD101 results in decreased expression of CAD mRNAdecreases expression 19606018
D013749 Tetrachlorodibenzodioxin Estradiol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [ESR1 protein binds to CAD promoter]]affects binding|decreases reaction|increases reaction 16675542
D013749 Tetrachlorodibenzodioxin Estradiol promotes the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to CAD promoter]]affects binding|increases reaction 16675542
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin inhibits the reaction [AHR protein binds to CAD promoter]affects binding|decreases reaction 16675542
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin inhibits the reaction [Estradiol results in increased expression of CAD mRNA]decreases reaction|increases expression 16675542
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin promotes the reaction [ESR1 protein binds to CAD promoter]affects binding|increases reaction 16675542
C012589 trichostatin A trichostatin A results in decreased expression of CAD mRNAdecreases expression 19606018
D014415 Tunicamycin Tunicamycin results in increased expression of CAD mRNAincreases expression 17127020
C025643 vinclozolin vinclozolin results in decreased expression of CAD mRNAdecreases expression 18042343
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced 4-amino-2,6-dinitrotoluene 8.367525203
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 8.3615322242 11752688 14514962
MESH:D000230 Adenocarcinoma arsenic trioxide 7.0619825857 11798837
MESH:D000230 Adenocarcinoma Estradiol 7.0611473722
MESH:D000230 Adenocarcinoma Fluorouracil 7.0617638652
MESH:D000236 Adenoma Diethylnitrosamine 2.826695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 9.9419061943 18056438 17620307 19052882 17162532 16434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 9.9416835633
MESH:D000740 Anemia Fluorouracil 8.5517963324 15504547 16511603
MESH:D000740 Anemia Tetrachlorodibenzodioxin 8.5511748828
MESH:D000799 Angioedema Acetaminophen 3.8110982225
MESH:D001008 Anxiety Disorders vinclozolin 3.6019015723
MESH:D001284 Atrophy fulvestrant 4.8111514358
MESH:D001321 Autistic Disorder Acetaminophen 1.4218445737
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 8.8216206674
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.8212125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.7615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.7315746008
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.3317474063
MESH:D001943 Breast Neoplasms Estradiol 2.3316675129 17018787 17289903 19861407 12948864 18497071 17261762 14630087
MESH:D001943 Breast Neoplasms Fluorouracil 2.3319217205 16110121 15136595 16595493 18608205 18357371 16557594
MESH:D001943 Breast Neoplasms fulvestrant 2.3318984771
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.3320435547
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.2911589617
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.4316111702
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.7418705752 16227642 16011737 16050911 16192424 15700767 16097048 15673190 3786805 15721981 10355542 16124888
MESH:D002276 Carcinoid Tumor Fluorouracil 4.6416051944
MESH:D002277 Carcinoma Fluorouracil 8.0617121937
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 8.0616835633
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 16.8416705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 16.8416705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 16.843084413
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 16.8416217749 11135700 15553829 15073043 14691202
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 16.8418788625
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 16.8416288022 16502159 17138121 16569478 17978847 19052882 19822196 20727157 17173139 19539802 20524982 20214788 18785209 16935385 18506893 3084413 16807293 19701751 16779866 19208518 17761372 18393292 11831363 18210153 19171122 16328049 21159647 18665156 20007298 16878318 10737359 18691550 17055752 17162532 20084675 10672840 20512989 16540662 20935162 19919837 20514400 18056438 16681979 19335982 18971187 19383236 19418558 19107877 17428255 19519916 3581430 20432363 20101231 16698587 18788625 19394651 16830150 18978308 18494052
MESH:D006528 Carcinoma, Hepatocellular Estradiol 16.8416924424
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 16.8418930000 16799960 17088986 17045692 17971768 16332177
MESH:D002291 Carcinoma, Papillary arsenic trioxide 4.8519014326
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 3.0018695887
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.0812490120
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 2.4818986760 16757204 17066447 16280240
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3418670907 16120746 18850075
MESH:D002386 Cataract 4-amino-2,6-dinitrotoluene 7.3414694615
MESH:D002386 Cataract Acetaminophen 7.3410977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 11.016135515
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 11.017505956 17174075 21159647 2727394
MESH:D002471 Cell Transformation, Neoplastic Estradiol 11.0118566989
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 9.2019052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 9.2016835633
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.0812621046 8697196 15668235 15340226 16354765
MESH:D003110 Colonic Neoplasms Fluorouracil 2.2316510598 17725105 18772588 15001691 17172411 17169374 16340194 17018589 17287894 17016597
MESH:D015179 Colorectal Neoplasms arsenic trioxide 2.5420501625
MESH:D015179 Colorectal Neoplasms Fluorouracil 2.5416524972 17016601 18383874 17594712 16331619 18949393 18802399 18288408 17695437 18448328 20501625 15289873 17094418 16391804 17454858 16282729 17255274 17401013 14970324 18509181 16303861 15148649
MESH:D000013 Congenital Abnormalities 4-amino-2,6-dinitrotoluene 9.0615095906
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 9.0614669216 17141729
MESH:D023903 Coronary Restenosis arsenic trioxide 4.1412609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 2.4610525206
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.4615322242 10048152 20055451
MESH:D003456 Cryptorchidism vinclozolin 4.3014966744
MESH:D003490 Cyanosis 2,4-dinitrotoluene 10.7618551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 10.7618551238
MESH:D007644 Darier Disease Fluorouracil 4.7616733453
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.0515213294
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 4.1820387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.1817107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.3719279558
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 18.5118551238 21346803
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 18.5121346803 18551238
MESH:D056486 Drug-Induced Liver Injury 4-amino-2,6-dinitrotoluene 18.5121346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 18.5112594235 12705907 14550746 16177239 19164858 11743745 12540782 14725611 12153990 19416960 16393943 11287661 16485898 18071297 11529661 19085960 17562736 16781746 19370779 17906064 2444490 10915739 19923254 19739265 10663392 11739529 11834606 16081117 16109766 15968718 16227642 18713872 12958197 11461765 11421492 17522070 10774834 12392966 15619225 14986274 19420014
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 18.5111566570 10915739 19336974 21278145 9327722 10092053 16177239 2869522 15968718 15027814 4309450 6623471 7440962 7120509 16227642 15998439 17522070 3786805 19085960 7179309 6884620 3732212
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 18.5119107877
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 18.5120420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.0719426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.7311462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.3412711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.8716714409 18230668 15322242
MESH:D004701 Endocrine Gland Neoplasms trichostatin A 5.6119294695
MESH:D018159 Endolymphatic Hydrops Dimethyl Sulfoxide 6.5320641076
MESH:D016889 Endometrial Neoplasms Estradiol 2.9519148513 18566989 11473722
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.9810568697 9294722
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.0916302075
MESH:D004938 Esophageal Neoplasms arsenic trioxide 4.5612903497
MESH:D004938 Esophageal Neoplasms Fluorouracil 4.5616337965 15173087 16481741 17638652 16785472
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.9811564622
MESH:D005234 Fatty Liver arsenic trioxide 12.9315073043
MESH:D005234 Fatty Liver Carbon Tetrachloride 12.9361145 15959796 12795759 12631006 19224547 16239168 17595544 16045604
MESH:D005234 Fatty Liver Diethylnitrosamine 12.9320387270 21071580
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.4211858732
MESH:D005355 Fibrosis Carbon Tetrachloride 8.4718705752
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 8.4720067830
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.2216904648
MESH:D005756 Gastritis Acetaminophen 3.6516983495
MESH:D030342 Genetic Diseases, Inborn vinclozolin 4.9016973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.2716417039
MESH:D005909 Glioblastoma trichostatin A 3.8018801729
MESH:D005910 Glioma Fluorouracil 2.8516145905
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.5710696789
MESH:D006258 Head and Neck Neoplasms Fluorouracil 3.3618337622 15162350 15102660
MESH:D034381 Hearing Loss Dimethyl Sulfoxide 5.1320641076
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.3111294989 10048152
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.2911000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.5519900420 19110552
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.8515340226 16120746 12621046
MESH:D006558 Herpes Genitalis Estradiol 5.0015709030
MESH:D019584 Hot Flashes Estradiol 3.7217088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.0215340226 18606429 8697196 16354765 16959395
MESH:D006930 Hyperalgesia Acetaminophen 2.6616870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.5016899240
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.8918670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.0515338365
MESH:D007248 Infertility, Male fulvestrant 7.0311514358
MESH:D007248 Infertility, Male vinclozolin 7.0316467254
MESH:D007249 Inflammation Diethylnitrosamine 4.8218785209
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 4.8212878042 12200463
MESH:D007333 Insulin Resistance Estradiol 2.9416627594 16393666
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.2916580747
MESH:D007674 Kidney Diseases Acetaminophen 5.8015629191 12587719
MESH:D007674 Kidney Diseases Estradiol 5.8015618244
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 17.4716705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 17.4716705839
MESH:D007680 Kidney Neoplasms Estradiol 17.4715610895
MESH:D007680 Kidney Neoplasms Fluorouracil 17.4716985049
MESH:D007938 Leukemia arsenic trioxide 2.8115070760
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.7517077332 12560223
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.2716972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.3914633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 3.7219077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 4.1617050201 16968895 19850784 16467208 20471514
MESH:D015470 Leukemia, Myeloid, Acute trichostatin A 4.1618206229
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.1811161223 17107899 16331271 11468182 15748426 19642359 16966277 12712474 19225113 19035177 17217047 16330433 12018890 16112521 15336539 15213294 17869043 15622746 9834237 16823087 17649720 17712046 19075265 12679006 16891316
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.3116882451
MESH:D007984 Leydig Cell Tumor vinclozolin 4.7016417039
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 6.5316943688 17157831 17174718 16221502 17334410 11903743 21278145 16239168 11408273
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 6.5318665156 18522880 18407596 20032147 19638242
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 4.9712741479 18472094 16116963 17976157 15123356 18481824 18205269 15959796 17525996 17900296 12958196 18420326 13678700 18263696 12445421 14716833 15673190 15931870 15730626 16638106 18412020 17922224 18418968 12389079 18156304 16011737 15057751 12609069 17557913 17481882 18395914 17698563 18339082 16136751 12667390 16097048 15650968 18395095 15996030 18166357 15362042 12649538 18317297 18006644 18210741 15052691 10355542 17869086 17721639 15370692 15893842 16033810 14724832 15925388 16248980 14512876 12632512 14620537 18279442 18054572 17631135 14748882 12586293 17805973 18429990 18376398 16192424 18251166 11481614 12445418 12546737 16015684 17640975 17714472 12898905 14716496 15876570 12666154 18187930 17823541 12632514 18277467 17565644 17708605 20821823 17761835 18705752 15818738 17944888 18472332 15338365 16027843 17766677
MESH:D008106 Liver Cirrhosis, Experimental Dimethyl Sulfoxide 4.9711682029
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 4.9714659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 4.9712878042
MESH:D008107 Liver Diseases Acetaminophen 6.4116611625 12969438 11587558 19460945 19014921 12587719 19784758 16610002
MESH:D008107 Liver Diseases Carbon Tetrachloride 6.4116964402 17285989 15720792 15830285 16246199
MESH:D008107 Liver Diseases Diethylnitrosamine 6.4117034775
MESH:D017093 Liver Failure Carbon Tetrachloride 4.1215123358
MESH:D017114 Liver Failure, Acute Acetaminophen 9.2816871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 9.2814706259 16899240
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 21.677678174
MESH:D008113 Liver Neoplasms arsenic trioxide 21.6714682389
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 21.6719294768
MESH:D008113 Liver Neoplasms Clofibric Acid 21.6717602206
MESH:D008113 Liver Neoplasms Diethylnitrosamine 21.6718977376 21167192 19690152 9163691 18754104 10737359 19426721 19551842 19294768 19255062 18644402 15885732 19254457 2862719 15175105 20118626 18648771 20583210 20101389 21071580 19812893 19642983 19427195 19090486 19499222 20492335 20137499 20501860 21047994 18978307 16942905 19833225 21278145 19850985 20452335 19996281 19073162 19256749 19638242 20434301 12112319 20405173 12771043 2422723
MESH:D008113 Liver Neoplasms Fluorouracil 21.6717045692 16603448 18383874 15113037
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 21.6716984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 18.356135515 2876784 2876786
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 18.3520377131
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 18.3515583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 18.3518775883 18308698 18079962 17174075 3124819 19009564 19126423 21159647 18164116 16267830 18253720 17942915 18544905 16842330 9362446 19519916 19004024 2563599 17854601 18282651 19539802 18093689
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 18.3512151625
MESH:D008133 Long QT Syndrome arsenic trioxide 3.3115213294
MESH:D008175 Lung Neoplasms arsenic trioxide 4.8019825857 11798837
MESH:D008175 Lung Neoplasms Diethylnitrosamine 4.8021163286 20512841 6695378 20970405
MESH:D008175 Lung Neoplasms Fluorouracil 4.8015246190
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 4.8019555203 11884234
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.7615086387
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 2.5316891317 11807958 11408345 17203775
MESH:D020149 Manganese Poisoning Estradiol 4.4519453300
MESH:D008545 Melanoma trichostatin A 2.7616505122
MESH:D008546 Melanoma, Experimental Acetaminophen 3.5319513568
MESH:D009062 Mouth Neoplasms Fluorouracil 3.6016757204 18986760
MESH:D009101 Multiple Myeloma arsenic trioxide 7.4615949261 14977855 19417148 11468182 19549372
MESH:D009101 Multiple Myeloma trichostatin A 7.4618172295
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.6418349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 3.1216882451 16105982
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.9812213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.2416810080
MESH:D009336 Necrosis 2,4-dinitrotoluene 10.2318551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 10.237678174 18551238
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 3.9216624393
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.553581430 9029167
MESH:D009369 Neoplasms Fluorouracil 2.5918600527 18239605 16928823
MESH:D009389 Neovascularization, Pathologic Estradiol 3.7017289903
MESH:D009421 Nervous System Malformations Estradiol 9.3311399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 9.3314600291
MESH:D009436 Neural Tube Defects arsenic trioxide 3.0910525206
MESH:D019636 Neurodegenerative Diseases Acetaminophen 8.0618514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 8.0620387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.0920387270
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.4116436463
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 14.9312819281 16049721
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 14.9316049721
MESH:D009784 Occupational Diseases 4-amino-2,6-dinitrotoluene 14.9314694615
MESH:D010051 Ovarian Neoplasms arsenic trioxide 7.9019769630 16624393 12452020
MESH:D010051 Ovarian Neoplasms Estradiol 7.9019401270
MESH:D010051 Ovarian Neoplasms trichostatin A 7.9019331143
MESH:D010146 Pain Acetaminophen 2.3516870215
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 12.2515580305
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 12.2516540662
MESH:D010190 Pancreatic Neoplasms Fluorouracil 12.2519003803 16500647 15113037 16929163
MESH:D010190 Pancreatic Neoplasms trichostatin A 12.2519294695
MESH:D010235 Paraganglioma arsenic trioxide 4.1219927285
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.2212520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.5218163543
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.512563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 9.3711222880 11118676 11399792 11896295
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 9.3718042343 18220299 19015723
MESH:D055728 Primary Myelofibrosis trichostatin A 5.2117616702
MESH:D011469 Prostatic Diseases vinclozolin 4.9018220299
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.8420887781
MESH:D011471 Prostatic Neoplasms arsenic trioxide 2.1219131511
MESH:D011471 Prostatic Neoplasms Estradiol 2.1216740699
MESH:D011471 Prostatic Neoplasms Fluorouracil 2.1218626508 19082440
MESH:D011471 Prostatic Neoplasms trichostatin A 2.1219789329 18798265
MESH:D011472 Prostatitis vinclozolin 4.9018629315
MESH:D012004 Rectal Neoplasms Fluorouracil 3.9715538739 18286688 18722050 16160472
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.8018990726
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 3.9216646077
MESH:D012640 Seizures 2,4-dinitrotoluene 5.7718551238
MESH:D012640 Seizures 2,6-dinitrotoluene 5.7718551238
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.0216192470
MESH:D013274 Stomach Neoplasms arsenic trioxide 3.3717007042
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 3.3718456281
MESH:D013274 Stomach Neoplasms Fluorouracil 3.3716424979 15786421 17172411 18567086 17498489 19015929 17522103 16951190 18396642 19084572
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.8712697716
MESH:D013964 Thyroid Neoplasms arsenic trioxide 7.0819014326
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 7.087505956
MESH:D013978 Tibial Fractures Estradiol 4.6619048282
MESH:D014062 Tongue Neoplasms Fluorouracil 3.9516280240
MESH:D016171 Torsades de Pointes arsenic trioxide 3.9315213294
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 8.2116049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 8.2116049721
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 8.2112973940 12845720 20435036 11780464
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 11.8710091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 11.8710091137
MESH:D014581 Urticaria Acetaminophen 2.9410982225
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 3.8416803524
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.5712125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.2215886252
Pathway ID Pathway Name
KEGG:00250 Alanine, aspartate and glutamate metabolism
KEGG:01100 Metabolic pathways
REACT:1698 Metabolism of nucleotides
KEGG:00240 Pyrimidine metabolism
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA26023
    • No data
    No data
    Releated drug ID Related drug Name
    PA10090l-glutamine
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00128 - L-Aspartic Acid Dietary supplement;Micronutrient;Non-Essential Amino Acids
    DB00130 - L-Glutamine Dietary supplement;Micronutrient;Non-Essential Amino Acids
    DB03459 - N-(Phosphonacetyl)-L-Aspartic Acid Antiviral Agents;Enzyme Inhibitors;Antimetabolites, Antineoplastic
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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