AutismKB 2.0

Annotation Detail for VKORC1


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:VKORC1 ( EDTP308,FLJ00289,IMAGE3455200,MGC2694,MST134,MST576,VKCFD2,VKOR )
Gene Full Name: vitamin K epoxide reductase complex, subunit 1
Band: 16p11.2
Quick LinksEntrez ID:79001; OMIM: 608547; Uniprot ID:VKOR1_HUMAN; ENSEMBL ID: ENSG00000167397; HGNC ID: 23663
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
Pathway IDPathway Name
Metabolism of proteins
No data
No data
Pathway IDPathway Name
500540Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1724Vascular disease
1918Atherosclerosis
2120Rabies
Desease Name
HEMATOLOGICAL
Thrombosis
Atherosclerosis
CARDIOVASCULAR
warfarin response
aortic dissection atherosclerosis, coronary stroke
Coronary Disease
PHARMACOGENOMIC
warfarin sensitivity
over anticoagulation
METABOLIC
anticoagulant complications
warfarin therapy, response to
phenprocoumon requirements
warfarin maintenance dose
Postoperative Complications
Desease Name
Warfarin maintenance dose
Desease Name
Warfarin resistance
Vitamin K-dependent clotting factors, combined deficiency of, 2
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of VKORC1 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of VKORC1 mRNAaffects expression 21346803
C472791 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in increased expression of VKORC1 mRNAincreases expression 16788091
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of VKORC1 mRNAdecreases expression 18648102
D000074 Acenocoumarol VKORC1 gene polymorphism affects the susceptibility to Acenocoumarolaffects response to substance 16611310
19578179
18698879
D000074 Acenocoumarol VKORC1 intron SNP affects the susceptibility to Acenocoumarolaffects response to substance 16201835
D000074 Acenocoumarol VKORC1 promoter polymorphism results in decreased susceptibility to Acenocoumaroldecreases response to substance 19875892
D000074 Acenocoumarol VKORC1 protein polymorphism results in decreased susceptibility to Acenocoumaroldecreases response to substance 17036862
D000082 Acetaminophen Acetaminophen affects the expression of VKORC1 mRNAaffects expression 17562736
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of VKORC1 mRNAdecreases expression 20106945
D003374 Coumarins Coumarins affects the activity of VKORC1 proteinaffects activity 18278162
C021636 bromadiolone VKORC1 gene mutant form results in decreased susceptibility to bromadiolonedecreases response to substance 19752778
C004662 chlorophacinone VKORC1 gene mutant form results in decreased susceptibility to chlorophacinonedecreases response to substance 19752778
D002995 Clofibric Acid [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of VKORC1 mRNAaffects cotreatment|affects expression 17602206
C030123 coumarin VKORC1 gene mutant form results in decreased susceptibility to coumarindecreases response to substance 18278162
C030123 coumarin VKORC1 gene mutant form results in increased susceptibility to coumarinincreases response to substance 18278162
C030123 coumarin VKORC1 promoter SNP results in increased susceptibility to coumarinincreases response to substance 17849045
D016572 Cyclosporine Cyclosporine results in decreased expression of VKORC1 mRNAdecreases expression 20106945
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of VKORC1 mRNAaffects cotreatment|affects expression 17602206
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of VKORC1 mRNAaffects cotreatment|increases expression 17942748
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of VKORC1 mRNAdecreases expression 17557909
D010644 Phenprocoumon VKORC1 gene polymorphism affects the susceptibility to Phenprocoumonaffects response to substance 15536456
18698879
D010644 Phenprocoumon VKORC1 intron SNP affects the susceptibility to Phenprocoumonaffects response to substance 16201835
D010644 Phenprocoumon VKORC1 protein polymorphism results in decreased susceptibility to Phenprocoumondecreases response to substance 17036862
D012643 Selenium [Selenium co-treated with Vitamin E] results in increased expression of VKORC1 mRNAaffects cotreatment|increases expression 19244175
D012643 Selenium Selenium results in increased expression of VKORC1 mRNAincreases expression 19244175
D018038 Sodium Selenite Sodium Selenite results in decreased expression of VKORC1 mRNAdecreases expression 18175754
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of VKORC1 mRNAaffects cotreatment|increases expression 17942748
D014810 Vitamin E [Selenium co-treated with Vitamin E] results in increased expression of VKORC1 mRNAaffects cotreatment|increases expression 19244175
D014810 Vitamin E Vitamin E results in increased expression of VKORC1 mRNAincreases expression 19244175
D014859 Warfarin VKORC1 3' UTR results in decreased susceptibility to Warfarindecreases response to substance 16676068
D014859 Warfarin VKORC1 gene affects the susceptibility to Warfarinaffects response to substance 19207028
15630486
D014859 Warfarin VKORC1 gene mutant form affects the susceptibility to Warfarinaffects response to substance 16879214
D014859 Warfarin VKORC1 gene mutant form results in decreased susceptibility to Warfarindecreases response to substance 18266023
14765194
D014859 Warfarin VKORC1 gene polymorphism affects the susceptibility to Warfarinaffects response to substance 19998810
19018718
18805772
18776969
18698879
16960144
16270629
15578879
15930419
16432637
16611750
16847429
16890578
17048007
17329985
17391071
17764537
18370846
18535201
18574025
19135231
19300499
19567378
20386359
20579077
D014859 Warfarin VKORC1 gene polymorphism results in decreased metabolism of Warfarindecreases metabolic processing 20073138
D014859 Warfarin VKORC1 gene polymorphism results in decreased susceptibility to Warfarindecreases response to substance 18030307
19942260
17961434
18034619
D014859 Warfarin VKORC1 intron polymorphism affects the susceptibility to Warfarinaffects response to substance 18523153
15358623
D014859 Warfarin VKORC1 intron polymorphism results in increased susceptibility to Warfarinincreases response to substance 16676068
D014859 Warfarin VKORC1 intron SNP affects the susceptibility to Warfarinaffects response to substance 18240904
D014859 Warfarin VKORC1 promoter polymorphism affects the susceptibility to Warfarinaffects response to substance 18523153
D014859 Warfarin VKORC1 protein affects the metabolism of Warfarinaffects metabolic processing 20073138
D014859 Warfarin VKORC1 protein affects the susceptibility to Warfarinaffects response to substance 19752777
D014859 Warfarin Warfarin results in decreased activity of VKORC1 proteindecreases activity 19300499
18240904
14765194
18805772
D014859 Warfarin VKORC1 gene mutant form results in decreased susceptibility to Warfarindecreases response to substance 19200363
D014859 Warfarin VKORC1 gene mutant form results in decreased susceptibility to Warfarindecreases response to substance 15879509
D014859 Warfarin VKORC1 gene SNP affects the susceptibility to Warfarinaffects response to substance 17009238
D014859 Warfarin VKORC1 protein SNP affects the metabolism of Warfarinaffects metabolic processing 17009238
D014859 Warfarin VKORC1 gene mutant form results in decreased susceptibility to Warfarindecreases response to substance 14765194
16421894
15879509
19200363
D014859 Warfarin VKORC1 gene mutant form results in decreased susceptibility to Warfarindecreases response to substance 20497562
D014859 Warfarin VKORC1 gene polymorphism results in decreased susceptibility to Warfarindecreases response to substance 19884975
D014859 Warfarin VKORC1 protein affects the susceptibility to Warfarinaffects response to substance 20497562
19884975
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.7415322242 14514962 11752688
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.8417505938
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.0820464547 20127859
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.0814692618
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 10.763712494
MESH:D000236 Adenoma Benzo(a)pyrene 10.766695378
MESH:D000236 Adenoma Diethylnitrosamine 10.766695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 9.6918056438 19052882 17162532 16434500 19061943 17620307
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 9.6916835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.8511748828
MESH:D000799 Angioedema Acetaminophen 3.7410982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.9619183758
MESH:D001019 Aortic Rupture marker/mechanism 16549638
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.3611256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.6015885639
MESH:D001321 Autistic Disorder Acetaminophen 1.4318445737
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 4.9111289319 1440618
MESH:D001778 Blood Coagulation Disorders marker/mechanism 19141161
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 2.9412125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.6915340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.6915746008
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.8020146248 17474063
MESH:D001943 Breast Neoplasms Diethylnitrosamine 1.8017474063
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.8020435547
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 3.8216050911
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.7116835633
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 8.6716705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 8.6716705839
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 8.673581430 7296757
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 8.673084413
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 8.6720084675 17055752 19335982 19208518 20007298 16935385 19539802 20512989 3581430 20214788 19519916 18788625 11831363 10672840 21159647 17173139 20524982 16288022 19822196 3084413 16807293 16569478 19701751 20514400 19394651 16698587 18393292 19052882 17428255 20727157 20935162 18494052 18785209 19919837 16779866 18210153 16878318 18506893 18978308 16328049 19418558 20432363 16830150 10737359 17761372 17978847 16502159 18971187 19383236 19107877 18056438 19171122 16681979 16540662 17162532 17138121 18665156 20101231 18691550
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.627296757
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.0220419170
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3118850075 16120746 18670907
MESH:D002386 Cataract Acetaminophen 2.5210977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 15.386135515
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 15.387505956
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 15.3812371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 15.3817174075 2727394 21159647 7505956
MESH:D002543 Cerebral Hemorrhage Warfarin 5.7411061249
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 9.0119052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 9.0116835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 12.919022650 19486331
MESH:D002779 Cholestasis Cyclosporine 12.9119486331
MESH:D002779 Cholestasis Ethinyl Estradiol 12.9117333356 16919318 16105132 17110522 11677210 15861022 17681005
MESH:D019457 Chromosome Breakage Sodium Selenite 4.6415894690
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.0612621046 15340226 15668235 8697196 16354765
MESH:D003092 Colitis Selenium 3.6717936198
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.9614669216 17141729
MESH:D003327 Coronary Disease marker/mechanism 16549638
MESH:D023903 Coronary Restenosis Warfarin 5.5712872399
OMIM:122700 COUMARIN RESISTANCE marker/mechanism 20210733 20386359 20497562 20579077 14765194
OMIM:122700 COUMARIN RESISTANCE Warfarin 5.7220579077 20497562
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.4520055451 15322242 10048152
MESH:D019465 Craniofacial Abnormalities Vitamin E 2.4519769572
MESH:D003490 Cyanosis 2,4-dinitrotoluene 10.5318551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 10.5318551238
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.708156756 11906362 8970840 12868966 18759878 14531868 2524372 11298694
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.393621924 2952479
MESH:D003920 Diabetes Mellitus Sodium Selenite 3.6816285004
MESH:D003922 Diabetes Mellitus, Type 1 Warfarin 4.0218772604
MESH:D003924 Diabetes Mellitus, Type 2 coumarin 7.0419647726
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 7.0420387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 7.0417107852
MESH:D003928 Diabetic Nephropathies Warfarin 5.0012644472
MESH:D003875 Drug Eruptions Warfarin 5.8714723717
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 21.7018551238 21346803
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 21.7018551238 21346803
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 21.709022650 18289764 6482804 18692083 18648102 7440962 8291058 16192314 11289319 1440618 6679447 9328219 9653073
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 21.7016485898 12153990 16109766 17906064 11421492 10915739 19370779 16177239 12594235 19416960 11834606 12540782 16081117 19420014 14986274 11739529 2444490 16781746 12958197 14550746 16227642 10774834 17522070 11743745 17562736 18713872 16393943 10663392 19164858 11461765 19923254 12392966 15968718 19085960 11287661 12705907 19739265 11529661 15619225 14725611 18071297
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 21.7019107877
MESH:D056486 Drug-Induced Liver Injury Selenium 21.7015131321
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 21.7015131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 21.7020420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.9919426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.6811462148
MESH:C538011 Eales disease Vitamin E 4.609068938
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.2812711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.8016714409 15322242 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.0812538720
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.929294722 10568697
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.0116302075
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 4.273581430
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.2716530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.9311564622
MESH:D005234 Fatty Liver Cyclosporine 12.4719224547
MESH:D005234 Fatty Liver Diethylnitrosamine 12.4720387270 21071580
MESH:D005234 Fatty Liver Ethinyl Estradiol 12.4715345470
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.3511858732
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 4.916705139
MESH:D005355 Fibrosis Cyclosporine 8.1212168785 12639820
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 8.1220067830
MESH:D005756 Gastritis Acetaminophen 3.5716983495
MESH:D006471 Gastrointestinal Hemorrhage Warfarin 6.6111794436
MESH:D005776 Gaucher Disease Warfarin 5.8512359135
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.118708960
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 3.937505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.4910696789
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 10.7720471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 10.7710048152 11294989
MESH:D006330 Heart Defects, Congenital Vitamin E 10.7716080930
MESH:D006333 Heart Failure Selenium 3.0117162251
MESH:D006406 Hematoma Warfarin 6.6117493413
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.3115720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 10.1711000095
MESH:D006470 Hemorrhage Warfarin 10.1718429757
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.416705139
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.7812621046 16120746 15340226
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.6616490937 16863852
MESH:D019584 Hot Flashes Vitamin E 3.8714716179
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.9416354765 18606429 8697196 16959395 15340226
MESH:D006930 Hyperalgesia Acetaminophen 2.6116870215
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 3.8315034207
MESH:D006973 Hypertension Cyclosporine 4.8110903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.8118850075 18670907
MESH:D006976 Hypertension, Pulmonary Warfarin 4.7312359135
MESH:D007021 Hypospadias Ethinyl Estradiol 3.7016569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.3612013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.4117937319
MESH:D007249 Inflammation Diethylnitrosamine 4.7118785209
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 4.7112878042 12200463
MESH:D007251 Influenza, Human Selenium 10.6116624496
MESH:D007251 Influenza, Human Vitamin E 10.6116624496
MESH:D007333 Insulin Resistance Sodium Selenite 3.2014714311
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 4.919022650 8074119
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.2316580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.3415604871
MESH:D007674 Kidney Diseases Acetaminophen 9.6412587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 9.648314463 18776723 10903974
MESH:D007674 Kidney Diseases Vitamin E 9.6412488133
MESH:D007676 Kidney Failure, Chronic Selenium 3.7816518626
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 16.9916705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 16.9916705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 16.996582329
MESH:D007680 Kidney Neoplasms Cyclosporine 16.9912371664
MESH:D054068 Livedo Reticularis Warfarin 6.6118280355
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.7618665156 20032147 19638242 18407596 18522880
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.139327722 15034207
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.3112878042
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 2.3116169303
MESH:D008107 Liver Diseases Acetaminophen 3.8111587558 12969438 12587719 16611625 19460945 19014921 19784758 16610002
MESH:D008107 Liver Diseases Diethylnitrosamine 3.8117034775
MESH:D017114 Liver Failure, Acute Acetaminophen 3.1416871587 17185352
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 13.807678174
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 13.8021137059 20195826
MESH:D008113 Liver Neoplasms Clofibric Acid 13.8017602206
MESH:D008113 Liver Neoplasms Diethylnitrosamine 13.8019254457 19427195 18644402 16942905 21167192 19073162 19294768 21047994 12771043 19256749 19090486 19833225 20137499 9163691 20583210 10737359 18977376 19690152 20434301 20405173 2862719 20492335 2422723 19426721 19996281 19642983 12112319 20452335 20501860 20101389 20118626 19638242 15885732 19499222 19812893 18754104 18648771 21278145 21071580 19850985 19551842 15175105 18978307 19255062
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 13.8016984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 13.532876784 2876786 6135515
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 13.533712494 1399818 6587162 598648
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 13.533124819 18093689 18253720 2563599 18164116 17854601 17942915 17174075 19126423 19009564 18308698 19539802 18079962 18544905 21159647 19519916 19004024 16842330 9362446 18775883 16267830 18282651
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 13.5312151625
MESH:D008171 Lung Diseases Vitamin E 3.1016863852
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 4.7220464547 20135361 17053015 20869020 18520028 20064080 6695378 18569708 18816296
MESH:D008175 Lung Neoplasms Diethylnitrosamine 4.7220970405 6695378 21163286 20512841
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 4.7219555203 11884234
MESH:D008175 Lung Neoplasms Vitamin E 4.7211062179
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 3.9514737004
MESH:D008325 Mammary Neoplasms, Experimental Selenium 2.6915318939
MESH:D008546 Melanoma, Experimental Acetaminophen 3.4619513568
MESH:D008654 Mesothelioma Selenium 2.7515107826
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.6816801185
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.1016381670
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.9312213967
MESH:D009336 Necrosis 2,4-dinitrotoluene 17.2718551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 17.2718551238 7678174
MESH:D009336 Necrosis Warfarin 17.2714723717
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 5.563581430
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 5.563581430 9029167
MESH:D009369 Neoplasms Benzo(a)pyrene 2.1211141357
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.3417954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.1919348381 18481113
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.1114600291
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 2.846679447
MESH:D019636 Neurodegenerative Diseases Acetaminophen 7.8818514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 7.8820387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.0120387270
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 14.5016049721 12819281
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 14.5016049721
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 14.506482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 4.913988306
MESH:D010146 Pain Acetaminophen 2.3016870215
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 2.3816540662
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.5811578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.387296757
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.1412520081
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.366228378
MESH:D010954 Plasmacytoma Selenium 4.7815087411
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.4518163543
MESH:D011230 Precancerous Conditions Cyclosporine 8.6312371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 8.632563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.0811222880 11118676 11399792 11896295
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.6017292933
MESH:D011471 Prostatic Neoplasms Sodium Selenite 2.6018760546
MESH:D011471 Prostatic Neoplasms Vitamin E 2.6015084515
MESH:D020151 Protein C Deficiency Warfarin 6.2418376272
MESH:D011537 Pruritus Ethinyl Estradiol 3.2016919318 15861022
MESH:D011565 Psoriasis Cyclosporine 2.1916882103
MESH:D011655 Pulmonary Embolism Warfarin 6.2419300499
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.7318990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.293692021
MESH:D012640 Seizures 2,4-dinitrotoluene 5.6218551238
MESH:D012640 Seizures 2,6-dinitrotoluene 5.6218551238
MESH:D012851 Sinus Thrombosis, Intracranial Warfarin 5.7612269725
MESH:D012871 Skin Diseases Vitamin E 2.4118709164
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 5.3010029692 19755658
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.3016192470
MESH:D013088 Spermatocele Ethinyl Estradiol 3.8416709447
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.302093021 20155912
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 2.3018456281
MESH:D020521 Stroke marker/mechanism 16549638
MESH:D020521 Stroke Vitamin E 8.8416517955
MESH:D020521 Stroke Warfarin 8.8419300499
MESH:D013923 Thromboembolism Acenocoumarol 22.6018698879
MESH:D013923 Thromboembolism Phenprocoumon 22.6018698879
MESH:D013923 Thromboembolism Warfarin 22.6016960144 18698879
MESH:D019851 Thrombophilia Ethinyl Estradiol 10.6711994571
MESH:D019851 Thrombophilia Warfarin 10.6717493413
MESH:D013927 Thrombosis Ethinyl Estradiol 9.1015669648
MESH:D013927 Thrombosis Warfarin 9.1017245631 11518727 11307788 17672075 19300499 15720958
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.8012697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 6.843712494 1399818 6587162 6582329 7505956
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 6.847505956
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 11.5516049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 11.5516049721
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 11.558074119
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 11.5517053015
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 11.6310091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 11.6310091137
MESH:D014581 Urticaria Acetaminophen 2.8710982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.1914692618
MESH:D014605 Uveitis Cyclosporine 3.881336536
MESH:D014652 Vascular Diseases marker/mechanism 16549638
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.4912125929
MESH:D014657 Vasculitis Warfarin 5.7620337814
MESH:D014689 Venous Insufficiency coumarin 5.6712708602
MESH:D054556 Venous Thromboembolism Warfarin 6.2618776969
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 10.4014671159 15869587
MESH:D020246 Venous Thrombosis Warfarin 10.4015733061 14723717
OMIM:607473 VITAMIN K-DEPENDENT CLOTTING FACTORS, COMBINED DEFICIENCY OF, 2 marker/mechanism 14765194
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.1415886252
MESH:D014985 Xerophthalmia Cyclosporine 4.3417120751
Pathway ID Pathway Name
REACT:17015 Metabolism of proteins
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA133787052
    • Releated gene ID Related gene Name
    PA26047CALU
    PA133787052VKORC1
    Releated disease ID Related disease Name
    PA445850Thrombosis
    PA443421Arrhythmias, Cardiac
    PA159018367Brugada syndrome
    PA443633Cardiomyopathy, Hypertrophic
    PA443796Coronary Artery Disease
    PA443797Coronary Disease
    PA446379Death, Sudden, Cardiac
    PA444807Long QT Syndrome
    PA445769Sudden Infant Death
    PA446294Torsades de Pointes
    PA446028Ventricular Fibrillation
    PA444368Heart Diseases
    PA445465Pulmonary Embolism
    PA447298venous thromboembolism
    PA446969Venous Thrombosis
    PA444417Hemorrhage
    PA446900Coagulation Protein Disorders
    PA446021Vascular Diseases
    PA443459Atrial Fibrillation
    PA443842Death
    PA443425Arteriosclerosis
    PA446997Intracranial Hemorrhages
    PA445019Myocardial Infarction
    PA153619833Peripheral Vascular Diseases
    PA447054Stroke
    PA445848Thromboembolism
    Releated drug ID Related drug Name
    PA448383amiodarone
    PA451363simvastatin
    PA164712547Beta blocking agents, selective
    PA451906warfarin
    PA134521193coumarin
    PA450921phenprocoumon
    PA452632acenocoumarol
    PA451906warfarin
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00170 cofactor Menadione Dietary supplement;Micronutrient;Antifibrinolytic Agents;Vitamins/minerals;Vitamins
    DB00266 antagonist Dicumarol Anticoagulants;Enzyme Inhibitors;Uncoupling Agents
    DB00498 inhibitor Phenindione Anticoagulants
    DB00682 antagonist Warfarin Anticoagulants;Rodenticides;Coumarin and Indandione Derivatives
    DB00946 antagonist Phenprocoumon Anticoagulants
    DB01418 antagonist Acenocoumarol Anticoagulants;Coumarin and Indandione Derivatives
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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