AutismKB 2.0

Annotation Detail for METRN


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:METRN ( C16orf23,MGC2601,c380A1.2 )
Gene Full Name: meteorin, glial cell differentiation regulator
Band: 16p13.3
Quick LinksEntrez ID:79006; OMIM: 610998; Uniprot ID:METRN_HUMAN; ENSEMBL ID: ENSG00000103260; HGNC ID: 14151
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C068073 Am 580 Am 580 results in decreased expression of METRN mRNAdecreases expression 16982809
D003520 Cyclophosphamide METRN mRNA affects the susceptibility to [Paclitaxel co-treated with Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide]affects cotreatment|affects response to substance 16896004
D016572 Cyclosporine Cyclosporine results in decreased expression of METRN mRNAdecreases expression 20106945
D004317 Doxorubicin METRN mRNA affects the susceptibility to [Paclitaxel co-treated with Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide]affects cotreatment|affects response to substance 16896004
C056516 exemestane exemestane results in increased expression of METRN mRNAincreases expression 17254854
D005472 Fluorouracil METRN mRNA affects the susceptibility to [Paclitaxel co-treated with Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide]affects cotreatment|affects response to substance 16896004
D017239 Paclitaxel METRN mRNA affects the susceptibility to [Paclitaxel co-treated with Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide]affects cotreatment|affects response to substance 16896004
C089730 rosiglitazone rosiglitazone results in decreased expression of METRN mRNAdecreases expression 16982809
D014635 Valproic Acid Valproic Acid results in increased expression of METRN mRNAincreases expression 19101580
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 3.778875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 4.1319490988
MESH:D000230 Adenocarcinoma Doxorubicin 4.7617418594
MESH:D000230 Adenocarcinoma Fluorouracil 4.7617638652
MESH:D000419 Albuminuria Doxorubicin 4.7821441931
MESH:D000544 Alzheimer Disease rosiglitazone 2.8919621015
MESH:D000550 Amblyopia Valproic Acid 5.5517688650
MESH:D000740 Anemia Fluorouracil 3.9017963324 15504547 16511603
MESH:D001008 Anxiety Disorders Valproic Acid 3.7417497229
MESH:D001161 Arteriosclerosis Cyclophosphamide 4.8615014928
MESH:D001321 Autistic Disorder Valproic Acid 1.9918985861 17507914 17157402 18316065 19460635 20603192 18396377 15238991 18558336 17688650 18940202 16609825 19232924 18775368 18177632
MESH:D001714 Bipolar Disorder Valproic Acid 3.1717594078 20046352
MESH:D001848 Bone Diseases, Developmental Valproic Acid 3.528888407
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 5.0214601052
MESH:D001859 Bone Neoplasms Paclitaxel 4.7915867366
MESH:D001932 Brain Neoplasms Doxorubicin 4.0017150277
MESH:D001943 Breast Neoplasms Cyclophosphamide 2.4617020986 17388661 15136595 18234424 15093573 11325840 18323546 12006526 16978400
MESH:D001943 Breast Neoplasms Doxorubicin 2.4617426702 19526202 17369602 18695136 15136595 16264153 15994142 18628466 16595493 15939500 15634643 16096432 16935488 11325840 16826403 16115903 18234424 15692762 17983394 15668708 15567936 15993339 18382427 16322301
MESH:D001943 Breast Neoplasms exemestane 2.4617892469 16002280 17952589
MESH:D001943 Breast Neoplasms Fluorouracil 2.4616595493 19217205 16557594 16110121 18608205 15136595 18357371
MESH:D001943 Breast Neoplasms Paclitaxel 2.4616244791 18223236 16273361 18234424 15136595 16115903 18323546 11325840
MESH:D002276 Carcinoid Tumor Doxorubicin 13.4416051944
MESH:D002276 Carcinoid Tumor Fluorouracil 13.4416051944
MESH:D002277 Carcinoma Fluorouracil 3.7317121937
MESH:D006528 Carcinoma, Hepatocellular Cyclophosphamide 6.9119701751
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 6.9118059187 16023760 17876044 16234567
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 6.9116799960 17045692 16332177 17971768 17088986 18930000
MESH:D006528 Carcinoma, Hepatocellular Paclitaxel 6.9116313753
MESH:D018827 Carcinoma, Lewis Lung Cyclophosphamide 5.1716152834
MESH:D002292 Carcinoma, Renal Cell Cyclophosphamide 11.4016201981
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 11.4016201981 1485588
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 11.4018695887
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 5.036189445
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 5.0316280240 16757204 18986760 17066447
MESH:D009202 Cardiomyopathies Doxorubicin 3.6617007740 17329180 17924179 16364871 15792986 16612575 16242529 17519947 17928571 15476868 15505089 18627295 16269455 17131338 16455267 17308081 16952015 17351982 16109756 16651473 16278810 16731534 15811867 17974986 17382496
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 3.0016243910 17334414
MESH:D002386 Cataract Am 580 4.4617460283
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 2.6612371664
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.7720734317
MESH:D002779 Cholestasis Cyclosporine 3.0619486331
MESH:D003092 Colitis Am 580 5.2217035595
MESH:D003110 Colonic Neoplasms Fluorouracil 2.2615001691 17172411 17725105 18772588 16510598 17287894 17016597 17018589 16340194 17169374
MESH:D015179 Colorectal Neoplasms Doxorubicin 3.6418259882 18802399
MESH:D015179 Colorectal Neoplasms Fluorouracil 3.6418448328 20501625 18288408 16524972 18949393 17454858 14970324 16303861 17594712 18509181 15289873 18383874 16391804 17401013 17094418 16331619 15148649 17695437 17255274 16282729 17016601 18802399
MESH:D015179 Colorectal Neoplasms Paclitaxel 3.6418802399
MESH:D019465 Craniofacial Abnormalities Valproic Acid 1.9017688650 16575769 8888407
MESH:D003556 Cystitis Cyclophosphamide 5.3015276878 17010015 12161096 12388444 18093676 18483878 15643279 11948286 12913760 16651033 18433785 17979934 16413132 10700343 16614059 18710439 10498854 18372110 16989017 18295254
MESH:D007644 Darier Disease Fluorouracil 5.0816733453
MESH:D003920 Diabetes Mellitus rosiglitazone 4.4817446233
MESH:D003921 Diabetes Mellitus, Experimental Cyclophosphamide 4.2410990075 15331540 11751995
MESH:D003922 Diabetes Mellitus, Type 1 Cyclophosphamide 3.2718772604
MESH:D003924 Diabetes Mellitus, Type 2 rosiglitazone 2.9812642470
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 4.2817416283
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 4.2819641884 1733752
MESH:D004362 Drug Toxicity Doxorubicin 3.8218602426
MESH:D004421 Dystonia Valproic Acid 4.271851702
MESH:D004487 Edema rosiglitazone 3.8512083418
MESH:D016889 Endometrial Neoplasms Doxorubicin 3.5817359293
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 5.4718037988
MESH:D004802 Eosinophilia Cyclophosphamide 4.4711006010
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.4117275665 3659116
MESH:D004828 Epilepsies, Partial Valproic Acid 4.233922381 16628512
MESH:D004827 Epilepsy Valproic Acid 3.0320417680 18234410
MESH:D004832 Epilepsy, Absence Valproic Acid 3.776254150 7562514 6426943
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.567750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.353659116
MESH:D004938 Esophageal Neoplasms Fluorouracil 4.9616785472 16337965 16481741 15173087 17638652
MESH:D004938 Esophageal Neoplasms Paclitaxel 4.9616481741
MESH:D005234 Fatty Liver Cyclosporine 14.4619224547
MESH:D005234 Fatty Liver rosiglitazone 14.4619196556
MESH:D005234 Fatty Liver Valproic Acid 14.4614986274 19224547
MESH:D005315 Fetal Diseases Valproic Acid 5.2016575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.378888407 18558336
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 4.8719069698
MESH:D005355 Fibrosis Cyclosporine 3.4012168785 12639820
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.508708960
MESH:D005909 Glioblastoma Doxorubicin 3.4717150277
MESH:D005910 Glioma Fluorouracil 2.9416145905
MESH:D018316 Gliosarcoma Cyclophosphamide 5.8011389073
MESH:D006086 Graft vs Host Disease Cyclophosphamide 5.2916376943 15172196 11014644
MESH:D006258 Head and Neck Neoplasms Doxorubicin 8.3615692506
MESH:D006258 Head and Neck Neoplasms Fluorouracil 8.3615162350 18337622 15102660
MESH:D006331 Heart Diseases Doxorubicin 3.6216879835 16330681 17875725 16244371 16244372 16144979 14766674 17888722 16495754 12587719 18006777 18674790 16707910
MESH:D006333 Heart Failure Doxorubicin 3.4617481944
MESH:D006394 Hemangiosarcoma Doxorubicin 4.1115692506
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.7115720958
MESH:D006467 Hemophilia A Cyclophosphamide 5.5511918545
MESH:D006504 Hepatic Veno-Occlusive Disease Cyclophosphamide 5.8514986274
MESH:D006689 Hodgkin Disease Cyclophosphamide 8.3216135485 17606976
MESH:D006689 Hodgkin Disease Doxorubicin 8.3217606976 18501091 15147373
MESH:D006849 Hydrocephalus Valproic Acid 5.1517688650
MESH:D006930 Hyperalgesia rosiglitazone 4.0812083418
MESH:D006973 Hypertension Cyclosporine 2.1610903974
MESH:D007154 Immune System Diseases Cyclophosphamide 5.6516076520
MESH:D007248 Infertility, Male Cyclophosphamide 3.7516517039 7193160
MESH:D007249 Inflammation rosiglitazone 3.2212083418
MESH:D007333 Insulin Resistance rosiglitazone 3.9316306350
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.7615604871
MESH:D007674 Kidney Diseases Cyclosporine 6.478314463 18776723 10903974
MESH:D007674 Kidney Diseases Doxorubicin 6.4715369732 15699352 16775033
MESH:D007676 Kidney Failure, Chronic Doxorubicin 4.3616707910
MESH:D007680 Kidney Neoplasms Cyclosporine 7.9712371664
MESH:D007680 Kidney Neoplasms Fluorouracil 7.9716985049
MESH:D007938 Leukemia Cyclophosphamide 3.5810602166
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 5.4716085563
MESH:D015451 Leukemia, Lymphocytic, Chronic, B-Cell Cyclophosphamide 3.5718587576 18172266 17008537 17802794 17296974 17658394
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Cyclophosphamide 4.2410373061
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 2.1816294345 17596541
MESH:D007970 Leukopenia Cyclophosphamide 5.2511830472 10052129
MESH:D008080 Liposarcoma Paclitaxel 5.0417353645
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 2.9516595196 16439617
MESH:D008106 Liver Cirrhosis, Experimental rosiglitazone 2.9515980055 17347453
MESH:D008113 Liver Neoplasms Fluorouracil 2.5416603448 18383874 15113037 17045692
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 3.1317085340 16842330
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.5817228818
MESH:D008175 Lung Neoplasms Doxorubicin 2.7317418594 6189445
MESH:D008175 Lung Neoplasms Fluorouracil 2.7315246190
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 5.0815086387
MESH:D008223 Lymphoma Cyclophosphamide 8.3612854902
MESH:D008223 Lymphoma Doxorubicin 8.3616098063
MESH:D016393 Lymphoma, B-Cell Cyclophosphamide 4.8216675587
MESH:D008228 Lymphoma, Non-Hodgkin Cyclophosphamide 15.7111911406
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 15.7117654614
MESH:D008228 Lymphoma, Non-Hodgkin Paclitaxel 15.7114749477
MESH:D016399 Lymphoma, T-Cell Doxorubicin 4.8315621674
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 6.8415458769
MESH:D008325 Mammary Neoplasms, Experimental rosiglitazone 6.8416827153
MESH:D008545 Melanoma Doxorubicin 3.7716827129
MESH:D008545 Melanoma Paclitaxel 3.7716342250 12025231 12040289
MESH:D008546 Melanoma, Experimental Cyclophosphamide 5.0616388313
MESH:D008654 Mesothelioma Doxorubicin 3.1317638057
MESH:D024821 Metabolic Syndrome X rosiglitazone 4.5517261469
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.1116801185
MESH:D008881 Migraine Disorders Valproic Acid 3.3318765137 18803445
MESH:D028361 Mitochondrial Diseases Doxorubicin 4.7015792986
MESH:D009062 Mouth Neoplasms Fluorouracil 3.7916757204 18986760
MESH:D052016 Mucositis Doxorubicin 5.0817415656
MESH:D009101 Multiple Myeloma Paclitaxel 3.8314749477
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.238888407
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 3.2617596541
MESH:D009203 Myocardial Infarction Doxorubicin 3.0219429709 15857846
MESH:D009362 Neoplasm Metastasis Doxorubicin 6.3718259882
MESH:D009362 Neoplasm Metastasis Paclitaxel 6.3715867366
MESH:D009369 Neoplasms Cyclophosphamide 5.7218854779
MESH:D009369 Neoplasms Fluorouracil 5.7218239605 18600527 16928823
MESH:D009401 Nephrosis Doxorubicin 5.0316899518 16636307
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.7617954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 9.9119348381 18481113
MESH:D009404 Nephrotic Syndrome Doxorubicin 9.9116889571 15640375
MESH:D009436 Neural Tube Defects Valproic Acid 3.2516359493 8888407
MESH:D009447 Neuroblastoma Cyclophosphamide 7.538761367 15176712 16115947
MESH:D009447 Neuroblastoma Doxorubicin 7.5315555623
MESH:D017599 Neuroectodermal Tumors Cyclophosphamide 5.1712837982 8761367
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.5716436463
MESH:D009503 Neutropenia Cyclophosphamide 4.548291058
MESH:D009845 Oligospermia Cyclophosphamide 5.0016517039
MESH:D010014 Osteolysis Paclitaxel 5.2615867366
MESH:D012516 Osteosarcoma Doxorubicin 4.2815930896
MESH:D010051 Ovarian Neoplasms Paclitaxel 3.0411161223
MESH:D010146 Pain Cyclophosphamide 3.7912161096 18093676
MESH:D010190 Pancreatic Neoplasms Cyclophosphamide 5.8211332152
MESH:D010190 Pancreatic Neoplasms Fluorouracil 5.8215113037 16929163 19003803 16500647
MESH:D003557 Phyllodes Tumor Doxorubicin 5.4717983394
MESH:D010997 Pleural Neoplasms Doxorubicin 5.4717638057
MESH:D011230 Precancerous Conditions Cyclosporine 3.4012371664
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Cyclophosphamide 3.9121297632
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 4.1120603192
MESH:D011471 Prostatic Neoplasms Cyclophosphamide 2.1417136230
MESH:D011471 Prostatic Neoplasms Doxorubicin 2.1415897917 16729912 18437689 16888761 16868541 15749863
MESH:D011471 Prostatic Neoplasms Fluorouracil 2.1419082440 18626508
MESH:D011471 Prostatic Neoplasms Paclitaxel 2.1417172428 17136230 16356831 16729912
MESH:D019310 Pseudolymphoma Valproic Acid 4.8612752131 11422049
MESH:D011565 Psoriasis Cyclosporine 2.2916882103
MESH:D011658 Pulmonary Fibrosis Cyclophosphamide 3.3516636934
MESH:D012004 Rectal Neoplasms Fluorouracil 4.1916160472 15538739 18286688 18722050
MESH:D051437 Renal Insufficiency Doxorubicin 4.4817922066
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.4019155313
MESH:D012509 Sarcoma Doxorubicin 4.1818313854 16767912 15675481 15625365 17203757 17710206
MESH:D012512 Sarcoma, Ewing's Doxorubicin 4.4816326096 14601052
MESH:D012514 Sarcoma, Kaposi Doxorubicin 5.0817846226
MESH:D012559 Schizophrenia Valproic Acid 2.0915737665 19110320
MESH:D012595 Scleroderma, Systemic Cyclophosphamide 5.0416636934
MESH:D012640 Seizures Valproic Acid 2.873137016 11738929 15475178 16876388 1511512 17978042 14763951 11044598
MESH:D012878 Skin Neoplasms Doxorubicin 3.0315692506
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 4.8317203757 15625365 16767912
OMIM:102530 SPERMATOGENIC FAILURE 6 Cyclophosphamide 5.8016517039
MESH:D016135 Spinal Dysraphism Valproic Acid 3.9419490988
MESH:D013226 Status Epilepticus Valproic Acid 4.8612833885
MESH:D013274 Stomach Neoplasms Fluorouracil 2.7918567086 19084572 17522103 19015929 16424979 17498489 18396642 17172411 16951190 15786421
MESH:D013274 Stomach Neoplasms Paclitaxel 2.7918396642 18506536
MESH:D015173 Supratentorial Neoplasms Cyclophosphamide 5.3412837982
MESH:D024801 Tauopathies Paclitaxel 5.1016930453
MESH:D013964 Thyroid Neoplasms Doxorubicin 3.5217909728 16010429
MESH:D014062 Tongue Neoplasms Fluorouracil 4.1816280240
MESH:D014178 Translocation, Genetic Valproic Acid 5.5517262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.813119515
MESH:D001749 Urinary Bladder Neoplasms Cyclophosphamide 5.7314692829
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 5.7317653716
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.908888407
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 4.0716803524
MESH:D014605 Uveitis Cyclosporine 4.301336536
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 4.4817638931 17678736 16364871 17334414
MESH:D014985 Xerophthalmia Cyclosporine 4.7617120751
No data
Pharmacogenomics Knowledge Base Top
Drug Bank Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved