AutismKB 2.0

Annotation Detail for DDX50


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Basic Information Top
Gene Symbol:DDX50 ( GU2,GUB,MGC3199,RH-II/GuB )
Gene Full Name: DEAD (Asp-Glu-Ala-Asp) box polypeptide 50
Band: 10q22.1
Quick LinksEntrez ID:79009; OMIM: 610373; Uniprot ID:DDX50_HUMAN; ENSEMBL ID: ENSG00000107625; HGNC ID: 17906
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of DDX50 mRNAdecreases expression 15003993
D016572 Cyclosporine Cyclosporine results in increased expression of DDX50 mRNAincreases expression 20106945
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of DDX50 mRNAaffects expression 17555576
D020849 Raloxifene Raloxifene affects the expression of DDX50 mRNAaffects expression 16079270
D013629 Tamoxifen Tamoxifen affects the expression of DDX50 mRNAaffects expression 17555576
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 5.1614745880
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.5517505938
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8814692618
MESH:D000419 Albuminuria Raloxifene 5.0417308373 17451421
MESH:D000544 Alzheimer Disease Raloxifene 2.6015800139
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.9511256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.8615885639
MESH:D001930 Brain Injuries Raloxifene 4.9616580743
MESH:D001943 Breast Neoplasms Raloxifene 2.2816912660 17049068 17595753 15758505 16837676 15775269 15572757 17242785 17952589 17440819 17893378 17261762
MESH:D001943 Breast Neoplasms Tamoxifen 2.2816873071 18351453 19487384 18855134 17049068 20859285 16818667 19084267 17440819 15668708 19244106 19011961 20390343 15565566 16273361 19200415 18821012 19189212 18997820 20544844 20065188 21152245 19410462 18629630 19059307 19288272 21138602 11161223 19103187 20135344 19289846 19221464 20005174 18815881 19066611 19189210 18425577 19115204 19142967 19155303 16202921 17893378 18984771 17261762 17242785
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.9919066611
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 1.8516924424
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 10.6817572228
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 10.6817572228
MESH:D002318 Cardiovascular Diseases Raloxifene 3.6815775269
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 2.7612371664
MESH:D002779 Cholestasis Cyclosporine 8.6519486331
MESH:D002779 Cholestasis Ethinyl Estradiol 8.6511677210 16919318 17333356 16105132 15861022 17681005 17110522
MESH:D003072 Cognition Disorders Raloxifene 5.1015800139
MESH:D003711 Demyelinating Diseases Tamoxifen 4.8519031437
MESH:D003865 Depressive Disorder, Major Raloxifene 4.4917474826
MESH:D003928 Diabetic Nephropathies Raloxifene 10.1317451421 17308373 15920148
MESH:D003928 Diabetic Nephropathies Tamoxifen 10.1319279558
MESH:D004487 Edema Raloxifene 3.7015860553
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 18.0712538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 18.0715845917
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 18.0719031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 3.2620544844 16202921 17893378 19155303
MESH:D005234 Fatty Liver Cyclosporine 22.0819224547
MESH:D005234 Fatty Liver Ethinyl Estradiol 22.0815345470
MESH:D005234 Fatty Liver Raloxifene 22.0817473493
MESH:D005234 Fatty Liver Tamoxifen 22.0814986274 19224547
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.4316709447
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 5.0714745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.7219069698
MESH:D005355 Fibrosis Cyclosporine 3.6212639820 12168785
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.768708960
MESH:D006331 Heart Diseases Raloxifene 3.7711110106
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.9615720958
MESH:D006973 Hypertension Cyclosporine 5.6710903974
MESH:D006973 Hypertension Raloxifene 5.6717577099 15787275
MESH:D007021 Hypospadias Ethinyl Estradiol 4.2916569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.8712013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.7117937319
MESH:D007249 Inflammation Tamoxifen 2.5119457130
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 5.0515604871
MESH:D007674 Kidney Diseases Cyclosporine 2.5218776723 10903974 8314463
MESH:D007680 Kidney Neoplasms Cyclosporine 8.3312371664
MESH:D007680 Kidney Neoplasms Tamoxifen 8.3318625569
MESH:D007889 Leiomyoma Raloxifene 4.9016973256
MESH:D008064 Lipidoses Tamoxifen 3.4017567588 15342952
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 1.7518564211
MESH:D008113 Liver Neoplasms Tamoxifen 2.3216684651
MESH:D008175 Lung Neoplasms Tamoxifen 1.7418625569
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 4.3019428831
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 2.8311731420 19196723 14580682 19196722 16827153
MESH:D020149 Manganese Poisoning Tamoxifen 5.1619453300
MESH:D008545 Melanoma Tamoxifen 1.9219393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.7215990972
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.4016801185
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 6.1715863610
MESH:D009101 Multiple Myeloma Raloxifene 3.6816497877
MESH:D009232 Myxoma Raloxifene 6.1716343187
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.6619393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.6019410462
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.6119196722 19189210 19200415
MESH:D009402 Nephrosis, Lipoid Cyclosporine 5.0517954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.6118481113 19348381
MESH:D010024 Osteoporosis Raloxifene 3.5917882678 15775268 19059307
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 4.6317823083 15758505 17893378 15579764
MESH:D016584 Panic Disorder Ethinyl Estradiol 4.0911578682
MESH:D011230 Precancerous Conditions Cyclosporine 3.5512371664
MESH:D011471 Prostatic Neoplasms Raloxifene 3.2915731164 16536755 16220300
MESH:D011471 Prostatic Neoplasms Tamoxifen 3.2915067354
MESH:D011537 Pruritus Ethinyl Estradiol 3.8516919318 15861022
MESH:D011565 Psoriasis Cyclosporine 2.3216882103
MESH:D011693 Purpura Raloxifene 6.1715770314
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 2.838532709
MESH:D013088 Spermatocele Ethinyl Estradiol 13.6916709447
MESH:D013088 Spermatocele Tamoxifen 13.6916709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.5819457130
MESH:D020521 Stroke Raloxifene 4.1116837676
MESH:D019851 Thrombophilia Ethinyl Estradiol 4.0211994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.4815669648
MESH:D013978 Tibial Fractures Raloxifene 5.8219048282
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 5.6117572228
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 5.6116712894 8653321 17572228
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.7414692618
MESH:D014605 Uveitis Cyclosporine 4.591336536
MESH:D054556 Venous Thromboembolism Raloxifene 5.8216837676
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.9114671159 15869587
MESH:D014846 Vulvar Neoplasms Raloxifene 6.1716343187
MESH:D014985 Xerophthalmia Cyclosporine 5.0517120751
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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