AutismKB 2.0

Annotation Detail for CENPM


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Basic Information Top
Gene Symbol:CENPM ( C22orf18,CENP-M,MGC861,PANE1,bK250D10.2 )
Gene Full Name: centromere protein M
Band: 22q13.2
Quick LinksEntrez ID:79019; OMIM: 610152; Uniprot ID:CENPM_HUMAN; ENSEMBL ID: ENSG00000100162; HGNC ID: 18352
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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No data
Pathway IDPathway Name
Cell Cycle, Mitotic
DNA Replication
No data
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of CENPM mRNAaffects expression 17562736
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of CENPM proteinaffects expression 20106945
C015001 arsenite arsenite results in decreased expression of CENPM mRNAdecreases expression 18929588
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of CENPM mRNAdecreases expression 20064835
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of CENPM mRNAdecreases expression 15336504
D016572 Cyclosporine Cyclosporine results in decreased expression of CENPM mRNAdecreases expression 20106945
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of CENPM mRNAaffects expression 17351261
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of CENPM mRNAaffects binding|decreases expression|increases activity 19710929
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.3217505938
MESH:D055371 Acute Lung Injury pirinixic acid 3.3818653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.3520127859 20464547
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.3514692618
MESH:D000236 Adenoma Benzo(a)pyrene 2.786695378
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.8216434500
MESH:D000799 Angioedema Acetaminophen 4.2210982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.3819183758
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.7711256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.8015885639
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.3919483382
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.0117474063 20146248
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 2.983084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 2.9812907637 21507988 12619106
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.1020419170
MESH:D002386 Cataract Acetaminophen 2.7110977129
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 2.6812371664
MESH:D002779 Cholestasis Cyclosporine 14.3819486331
MESH:D002779 Cholestasis Ethinyl Estradiol 14.3816105132 17110522 16919318 15861022 17681005 11677210 17333356
MESH:D002779 Cholestasis pirinixic acid 14.3819176532
MESH:D003110 Colonic Neoplasms arsenite 2.6215037631
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5218249437
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 1.6414550746 11739529 12540782 11287661 12153990 19416960 15619225 16109766 12392966 16781746 19420014 14725611 11529661 16081117 10774834 18713872 10663392 11743745 16227642 19739265 2444490 18071297 19164858 17906064 12958197 10915739 16485898 16177239 17562736 15968718 16393943 19085960 19370779 12705907 12594235 11461765 11421492 19923254 14986274 11834606 17522070
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.4719426721
MESH:D004487 Edema pirinixic acid 2.7212083418
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.4712538720
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 2.0616530937
MESH:D005234 Fatty Liver arsenite 20.8818296743
MESH:D005234 Fatty Liver Cyclosporine 20.8819224547
MESH:D005234 Fatty Liver Ethinyl Estradiol 20.8815345470
MESH:D005234 Fatty Liver pirinixic acid 20.8819236843 20131406
MESH:D005355 Fibrosis arsenite 9.9318296743
MESH:D005355 Fibrosis Cyclosporine 9.9312639820 12168785
MESH:D005756 Gastritis Acetaminophen 4.0516983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.568708960
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.7720471113
MESH:D006333 Heart Failure pirinixic acid 2.6720558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.7615720958
MESH:D006529 Hepatomegaly pirinixic acid 3.3016221962 19772884 18467677 19176532
MESH:D006930 Hyperalgesia Acetaminophen 2.8916870215
MESH:D006943 Hyperglycemia pirinixic acid 3.4120558911
MESH:D006973 Hypertension Cyclosporine 2.1710903974
MESH:D007021 Hypospadias Ethinyl Estradiol 4.1216945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.7212013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.6417937319
MESH:D007333 Insulin Resistance pirinixic acid 2.7816306350
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.8215604871
MESH:D007674 Kidney Diseases Acetaminophen 6.2215629191 12587719
MESH:D007674 Kidney Diseases Cyclosporine 6.228314463 10903974 18776723
MESH:D007680 Kidney Neoplasms Cyclosporine 2.9312371664
MESH:D008103 Liver Cirrhosis arsenite 3.5418296743
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 1.3515474484
MESH:D008107 Liver Diseases Acetaminophen 1.6716611625 19784758 12969438 12587719 11587558 16610002 19014921 19460945
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4616871587 17185352
MESH:D008113 Liver Neoplasms Aflatoxin B1 7.8615890375 2125692 9163691 18177683
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 7.8621137059 20195826
MESH:D008113 Liver Neoplasms pirinixic acid 7.8620007298 16377806 15890375
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 2.888603461
MESH:D008175 Lung Neoplasms Aflatoxin B1 3.6314755239
MESH:D008175 Lung Neoplasms arsenite 3.6316809336
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 3.6317053015 20064080 18520028 20869020 18569708 20464547 18816296 20135361 6695378
MESH:D008546 Melanoma, Experimental Acetaminophen 3.8719513568
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.1616801185
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.3716381670
MESH:D009135 Muscular Diseases pirinixic acid 3.8116239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2219151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1316411023
MESH:D009369 Neoplasms Benzo(a)pyrene 5.1711141357
MESH:D009369 Neoplasms pirinixic acid 5.1717405874
MESH:D009389 Neovascularization, Pathologic arsenite 4.7515738583
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.8217954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.5018481113 19348381
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.0718514411
MESH:D009765 Obesity pirinixic acid 1.8620558911
MESH:D010146 Pain Acetaminophen 2.5916870215
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.9511578682
MESH:D011230 Precancerous Conditions Cyclosporine 3.4412371664
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.9317292933
MESH:D011537 Pruritus Ethinyl Estradiol 3.6516919318 15861022
MESH:D011565 Psoriasis Cyclosporine 2.3016882103
MESH:D015427 Reperfusion Injury pirinixic acid 2.4919058328
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 6.0419755658 10029692
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 6.048532709
MESH:D013088 Spermatocele Ethinyl Estradiol 4.3216709447
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.5620155912 2093021
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.8811994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.3715669648
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 2.2517053015
MESH:D014581 Urticaria Acetaminophen 3.2410982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.5814692618
MESH:D014605 Uveitis Cyclosporine 4.361336536
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.7815869587 14671159
MESH:D014985 Xerophthalmia Cyclosporine 4.8217120751
Pathway ID Pathway Name
REACT:152 Cell Cycle, Mitotic
REACT:383 DNA Replication
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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