AutismKB 2.0

Annotation Detail for TRPM8


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Basic Information Top
Gene Symbol:TRPM8 ( LTRPC6,MGC2849,TRPP8 )
Gene Full Name: transient receptor potential cation channel, subfamily M, member 8
Band: 2q37.1
Quick LinksEntrez ID:79054; OMIM: 606678; Uniprot ID:TRPM8_HUMAN; ENSEMBL ID: ENSG00000144481; HGNC ID: 17961
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1752Neuroendocrine tumor
1758Common cold
1831Prostate cancer
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C060229 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Menthol results in increased activity of TRPM8]decreases reaction|increases activity 15046718
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of TRPM8 mRNAincreases expression 18648102
C068314 6-(bromomethylene)tetrahydro-3-(1-naphthaleneyl)-2H-pyran-2-one 6-(bromomethylene)tetrahydro-3-(1-naphthaleneyl)-2H-pyran-2-one inhibits the reaction [icilin inhibits the reaction [Menthol results in increased activity of TRPM8 protein]]decreases reaction|increases activity 19363131
C068314 6-(bromomethylene)tetrahydro-3-(1-naphthaleneyl)-2H-pyran-2-one 6-(bromomethylene)tetrahydro-3-(1-naphthaleneyl)-2H-pyran-2-one inhibits the reaction [icilin inhibits the reaction [Phenylephrine results in increased activity of TRPM8 protein]]decreases reaction|increases activity 19363131
C068314 6-(bromomethylene)tetrahydro-3-(1-naphthaleneyl)-2H-pyran-2-one 6-(bromomethylene)tetrahydro-3-(1-naphthaleneyl)-2H-pyran-2-one inhibits the reaction [Menthol inhibits the reaction [Menthol results in increased activity of TRPM8 protein]]decreases reaction|increases activity 19363131
C068314 6-(bromomethylene)tetrahydro-3-(1-naphthaleneyl)-2H-pyran-2-one 6-(bromomethylene)tetrahydro-3-(1-naphthaleneyl)-2H-pyran-2-one inhibits the reaction [Menthol inhibits the reaction [Phenylephrine results in increased activity of TRPM8 protein]]decreases reaction|increases activity 19363131
D000096 Acetone TRPM8 protein results in increased susceptibility to Acetoneincreases response to substance 17481392
D000643 Ammonium Chloride Ammonium Chloride affects the expression of TRPM8 mRNAaffects expression 16483693
D002118 Calcium [icilin results in increased activity of TRPM8 protein] which results in increased transport of Calciumincreases activity|increases transport 16386244
D002118 Calcium [Menthol results in increased activity of TRPM8 protein] which results in increased transport of Calciumincreases activity|increases transport 16386244
D002118 Calcium [mustard oil results in increased activity of TRPM8 protein] which results in increased transport of Calciumincreases activity|increases transport 16386244
D002118 Calcium N-(4-tert-butylphenyl)-4-(3-chloropyridin-2-yl)tetrahydropyrazine-1(2H)-carboxamide inhibits the reaction [[icilin results in increased activity of TRPM8 protein] which results in increased transport of Calcium]decreases reaction|increases activity|increases transport 16386244
D002118 Calcium N-(4-tert-butylphenyl)-4-(3-chloropyridin-2-yl)tetrahydropyrazine-1(2H)-carboxamide inhibits the reaction [[Menthol results in increased activity of TRPM8 protein] which results in increased transport of Calcium]decreases reaction|increases activity|increases transport 16386244
D002118 Calcium N-(4-tert-butylphenyl)-4-(3-chloropyridin-2-yl)tetrahydropyrazine-1(2H)-carboxamide inhibits the reaction [[mustard oil results in increased activity of TRPM8 protein] which results in increased transport of Calcium]decreases reaction|increases activity|increases transport 16386244
D002118 Calcium icilin promotes the reaction [TRPM8 protein results in increased transport of Calcium]increases reaction|increases transport 17517434
D002118 Calcium [icilin results in increased activity of TRPM8 protein] which results in increased transport of Calciumincreases activity|increases transport 16174775
D002118 Calcium [Menthol analog binds to and results in increased activity of TRPM8 protein] which results in increased transport of Calciumaffects binding|increases activity|increases transport 17517434
D002118 Calcium Menthol promotes the reaction [TRPM8 protein results in increased transport of Calcium]increases reaction|increases transport 18485891
18524940
17517434
D002118 Calcium [Menthol results in increased activity of TRPM8 protein] which results in increased transport of Calciumincreases activity|increases transport 16174775
D002118 Calcium TRPM8 protein results in increased transport of Calciumincreases transport 17517434
18485891
18524940
D002118 Calcium TRPM8 protein affects the transport of Calciumaffects transport 19363131
D002211 Capsaicin Capsaicin results in decreased expression of TRPM8 mRNAdecreases expression 18079164
C071423 capsazepine capsazepine binds to and results in decreased activity of TRPM8 proteinaffects binding|decreases activity 19363131
C071423 capsazepine capsazepine inhibits the reaction [Phenylephrine results in increased activity of TRPM8 protein]decreases reaction|increases activity 19363131
C071423 capsazepine capsazepine inhibits the reaction [Potassium Chloride results in increased activity of TRPM8 protein]decreases reaction|increases activity 19363131
C500528 cyclohexyl carbamic acid 3'-carbamoylbiphenyl-3-yl ester cyclohexyl carbamic acid 3'-carbamoylbiphenyl-3-yl ester results in decreased activity of TRPM8 proteindecreases activity 17314320
D005419 Flavonoids Flavonoids results in increased expression of TRPM8 mRNAincreases expression 18035473
C490483 icilin icilin results in increased activity of TRPM8 proteinincreases activity 16386244
C490483 icilin [icilin results in increased activity of TRPM8 protein] which results in increased transport of Calciumincreases activity|increases transport 16386244
C490483 icilin N-(4-tert-butylphenyl)-4-(3-chloropyridin-2-yl)tetrahydropyrazine-1(2H)-carboxamide inhibits the reaction [[icilin results in increased activity of TRPM8 protein] which results in increased transport of Calcium]decreases reaction|increases activity|increases transport 16386244
C490483 icilin icilin promotes the reaction [TRPM8 protein results in increased transport of Calcium]increases reaction|increases transport 17517434
C490483 icilin icilin results in increased activity of TRPM8 proteinincreases activity 16174775
C490483 icilin [icilin results in increased activity of TRPM8 protein] which results in increased transport of Calciumincreases activity|increases transport 16174775
C490483 icilin icilin binds to and results in increased activity of TRPM8 proteinaffects binding|increases activity 17825279
C490483 icilin TRPM8 protein results in increased susceptibility to icilinincreases response to substance 17481392
C490483 icilin 6-(bromomethylene)tetrahydro-3-(1-naphthaleneyl)-2H-pyran-2-one inhibits the reaction [icilin inhibits the reaction [Menthol results in increased activity of TRPM8 protein]]decreases reaction|increases activity 19363131
C490483 icilin 6-(bromomethylene)tetrahydro-3-(1-naphthaleneyl)-2H-pyran-2-one inhibits the reaction [icilin inhibits the reaction [Phenylephrine results in increased activity of TRPM8 protein]]decreases reaction|increases activity 19363131
C490483 icilin icilin binds to and results in increased activity of TRPM8 proteinaffects binding|increases activity 19363131
C490483 icilin icilin inhibits the reaction [Phenylephrine results in increased activity of TRPM8 protein]decreases reaction|increases activity 19363131
C490483 icilin icilin inhibits the reaction [Potassium Chloride results in increased activity of TRPM8 protein]decreases reaction|increases activity 19363131
C490483 icilin icilin binds to and results in increased activity of TRPM8 proteinaffects binding|increases activity 18930858
D008610 Menthol Menthol results in increased activity of TRPM8 proteinincreases activity 16386244
D008610 Menthol [Menthol results in increased activity of TRPM8 protein] which results in increased transport of Calciumincreases activity|increases transport 16386244
D008610 Menthol N-(4-tert-butylphenyl)-4-(3-chloropyridin-2-yl)tetrahydropyrazine-1(2H)-carboxamide inhibits the reaction [[Menthol results in increased activity of TRPM8 protein] which results in increased transport of Calcium]decreases reaction|increases activity|increases transport 16386244
D008610 Menthol Menthol analog binds to and results in increased activity of TRPM8 proteinaffects binding|increases activity 17517434
D008610 Menthol [Menthol analog binds to and results in increased activity of TRPM8 protein] which results in increased transport of Calciumaffects binding|increases activity|increases transport 17517434
D008610 Menthol Menthol analog results in increased activity of TRPM8 proteinincreases activity 18930858
D008610 Menthol Menthol promotes the reaction [TRPM8 protein results in increased transport of Calcium]increases reaction|increases transport 18485891
18524940
17517434
D008610 Menthol Menthol results in increased activity of TRPM8 proteinincreases activity 16174775
D008610 Menthol [Menthol results in increased activity of TRPM8 protein] which results in increased transport of Calciumincreases activity|increases transport 16174775
D008610 Menthol 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Menthol results in increased activity of TRPM8]decreases reaction|increases activity 15046718
D008610 Menthol Menthol results in increased activity of TRPM8increases activity 15046718
D008610 Menthol Menthol results in increased activity of TRPM8 proteinincreases activity 16520735
D008610 Menthol TRPM8 protein affects the susceptibility to Mentholaffects response to substance 18199758
D008610 Menthol TRPM8 protein results in increased susceptibility to Mentholincreases response to substance 17481392
D008610 Menthol 6-(bromomethylene)tetrahydro-3-(1-naphthaleneyl)-2H-pyran-2-one inhibits the reaction [icilin inhibits the reaction [Menthol results in increased activity of TRPM8 protein]]decreases reaction|increases activity 19363131
D008610 Menthol 6-(bromomethylene)tetrahydro-3-(1-naphthaleneyl)-2H-pyran-2-one inhibits the reaction [Menthol inhibits the reaction [Menthol results in increased activity of TRPM8 protein]]decreases reaction|increases activity 19363131
D008610 Menthol 6-(bromomethylene)tetrahydro-3-(1-naphthaleneyl)-2H-pyran-2-one inhibits the reaction [Menthol inhibits the reaction [Phenylephrine results in increased activity of TRPM8 protein]]decreases reaction|increases activity 19363131
D008610 Menthol Menthol binds to and results in increased activity of TRPM8 proteinaffects binding|increases activity 19363131
D008610 Menthol Menthol inhibits the reaction [Phenylephrine results in increased activity of TRPM8 protein]decreases reaction|increases activity 19363131
D008610 Menthol Menthol inhibits the reaction [Potassium Chloride results in increased activity of TRPM8 protein]decreases reaction|increases activity 19363131
D008610 Menthol Menthol binds to and results in increased activity of TRPM8 proteinaffects binding|increases activity 18930858
C027793 mustard oil mustard oil results in increased activity of TRPM8 proteinincreases activity 16386244
C027793 mustard oil [mustard oil results in increased activity of TRPM8 protein] which results in increased transport of Calciumincreases activity|increases transport 16386244
C027793 mustard oil N-(4-tert-butylphenyl)-4-(3-chloropyridin-2-yl)tetrahydropyrazine-1(2H)-carboxamide inhibits the reaction [[mustard oil results in increased activity of TRPM8 protein] which results in increased transport of Calcium]decreases reaction|increases activity|increases transport 16386244
C475772 N-(4-tert-butylphenyl)-4-(3-chloropyridin-2-yl)tetrahydropyrazine-1(2H)-carboxamide N-(4-tert-butylphenyl)-4-(3-chloropyridin-2-yl)tetrahydropyrazine-1(2H)-carboxamide inhibits the reaction [[icilin results in increased activity of TRPM8 protein] which results in increased transport of Calcium]decreases reaction|increases activity|increases transport 16386244
C475772 N-(4-tert-butylphenyl)-4-(3-chloropyridin-2-yl)tetrahydropyrazine-1(2H)-carboxamide N-(4-tert-butylphenyl)-4-(3-chloropyridin-2-yl)tetrahydropyrazine-1(2H)-carboxamide inhibits the reaction [[Menthol results in increased activity of TRPM8 protein] which results in increased transport of Calcium]decreases reaction|increases activity|increases transport 16386244
C475772 N-(4-tert-butylphenyl)-4-(3-chloropyridin-2-yl)tetrahydropyrazine-1(2H)-carboxamide N-(4-tert-butylphenyl)-4-(3-chloropyridin-2-yl)tetrahydropyrazine-1(2H)-carboxamide inhibits the reaction [[mustard oil results in increased activity of TRPM8 protein] which results in increased transport of Calcium]decreases reaction|increases activity|increases transport 16386244
C475772 N-(4-tert-butylphenyl)-4-(3-chloropyridin-2-yl)tetrahydropyrazine-1(2H)-carboxamide N-(4-tert-butylphenyl)-4-(3-chloropyridin-2-yl)tetrahydropyrazine-1(2H)-carboxamide binds to and results in decreased activity of TRPM8 proteinaffects binding|decreases activity 19363131
C475772 N-(4-tert-butylphenyl)-4-(3-chloropyridin-2-yl)tetrahydropyrazine-1(2H)-carboxamide N-(4-tert-butylphenyl)-4-(3-chloropyridin-2-yl)tetrahydropyrazine-1(2H)-carboxamide inhibits the reaction [Phenylephrine results in increased activity of TRPM8 protein]decreases reaction|increases activity 19363131
C475772 N-(4-tert-butylphenyl)-4-(3-chloropyridin-2-yl)tetrahydropyrazine-1(2H)-carboxamide N-(4-tert-butylphenyl)-4-(3-chloropyridin-2-yl)tetrahydropyrazine-1(2H)-carboxamide inhibits the reaction [Potassium Chloride results in increased activity of TRPM8 protein]decreases reaction|increases activity 19363131
D010618 Phenanthrolines Phenanthrolines binds to and results in decreased activity of TRPM8 proteinaffects binding|decreases activity 19363131
D010618 Phenanthrolines Phenanthrolines inhibits the reaction [Phenylephrine results in increased activity of TRPM8 protein]decreases reaction|increases activity 19363131
D010618 Phenanthrolines Phenanthrolines inhibits the reaction [Potassium Chloride results in increased activity of TRPM8 protein]decreases reaction|increases activity 19363131
D010656 Phenylephrine 6-(bromomethylene)tetrahydro-3-(1-naphthaleneyl)-2H-pyran-2-one inhibits the reaction [icilin inhibits the reaction [Phenylephrine results in increased activity of TRPM8 protein]]decreases reaction|increases activity 19363131
D010656 Phenylephrine 6-(bromomethylene)tetrahydro-3-(1-naphthaleneyl)-2H-pyran-2-one inhibits the reaction [Menthol inhibits the reaction [Phenylephrine results in increased activity of TRPM8 protein]]decreases reaction|increases activity 19363131
D010656 Phenylephrine capsazepine inhibits the reaction [Phenylephrine results in increased activity of TRPM8 protein]decreases reaction|increases activity 19363131
D010656 Phenylephrine icilin inhibits the reaction [Phenylephrine results in increased activity of TRPM8 protein]decreases reaction|increases activity 19363131
D010656 Phenylephrine Menthol inhibits the reaction [Phenylephrine results in increased activity of TRPM8 protein]decreases reaction|increases activity 19363131
D010656 Phenylephrine N-(4-tert-butylphenyl)-4-(3-chloropyridin-2-yl)tetrahydropyrazine-1(2H)-carboxamide inhibits the reaction [Phenylephrine results in increased activity of TRPM8 protein]decreases reaction|increases activity 19363131
D010656 Phenylephrine Phenanthrolines inhibits the reaction [Phenylephrine results in increased activity of TRPM8 protein]decreases reaction|increases activity 19363131
D010656 Phenylephrine Phenylephrine binds to and results in increased activity of TRPM8 proteinaffects binding|increases activity 19363131
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of TRPM8 mRNAaffects binding|decreases expression|increases activity 19710929
D011189 Potassium Chloride capsazepine inhibits the reaction [Potassium Chloride results in increased activity of TRPM8 protein]decreases reaction|increases activity 19363131
D011189 Potassium Chloride icilin inhibits the reaction [Potassium Chloride results in increased activity of TRPM8 protein]decreases reaction|increases activity 19363131
D011189 Potassium Chloride Menthol inhibits the reaction [Potassium Chloride results in increased activity of TRPM8 protein]decreases reaction|increases activity 19363131
D011189 Potassium Chloride N-(4-tert-butylphenyl)-4-(3-chloropyridin-2-yl)tetrahydropyrazine-1(2H)-carboxamide inhibits the reaction [Potassium Chloride results in increased activity of TRPM8 protein]decreases reaction|increases activity 19363131
D011189 Potassium Chloride Phenanthrolines inhibits the reaction [Potassium Chloride results in increased activity of TRPM8 protein]decreases reaction|increases activity 19363131
D011189 Potassium Chloride Potassium Chloride results in increased activity of TRPM8 proteinincreases activity 19363131
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of TRPM8 mRNAincreases expression 18372398
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Capsaicin 8.4918926900
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 8.4915322242 14514962 11752688
MESH:D000138 Acidosis Ammonium Chloride 3.5018287403
MESH:D058186 Acute Kidney Injury Capsaicin 4.4818460982
MESH:D055371 Acute Lung Injury pirinixic acid 3.0518653653
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.713712494
MESH:D018248 Adenoma, Liver Cell pirinixic acid 9.7016434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 9.7016835633
MESH:D000505 Alopecia Capsaicin 4.6717569567
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.8911748828
MESH:D001145 Arrhythmias, Cardiac Phenylephrine 4.0517460149
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 4.9611289319 1440618
MESH:D001778 Blood Coagulation Disorders pirinixic acid 8.5619483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.5612125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.7315340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.7215746008
MESH:D001919 Bradycardia Capsaicin 10.7118207255
MESH:D001919 Bradycardia Phenylephrine 10.7115306635
MESH:D002545 Brain Ischemia Capsaicin 4.9119211983
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.7220435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.7416835633
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 1.747296757 3581430
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.647296757
MESH:D006332 Cardiomegaly Phenylephrine 6.7615728586 11179087 11754973 17124262 16170337 17287366
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 6.7616120746 18670907 18850075
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 2.717505956
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.1016835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 7.689022650 19486331
MESH:D002779 Cholestasis pirinixic acid 7.6819176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.0815340226 15668235 12621046 8697196 16354765
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.0014669216 17141729
MESH:D003371 Cough Capsaicin 5.1210350223
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2510048152 20055451 15322242
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.7412868966 14531868 8156756 18759878 2524372 8970840 11298694 11906362
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3918249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.433621924 2952479
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6517107852
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 3.639653073 6679447 6482804 9328219 11289319 1440618 9022650 18289764 8291058 16192314 18648102 7440962 18692083
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.6320420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.7111462148
MESH:D004381 Duodenal Ulcer Capsaicin 4.6311535926 10671773
MESH:D004487 Edema cyclohexyl carbamic acid 3'-carbamoylbiphenyl-3-yl ester 11.3816100529
MESH:D004487 Edema pirinixic acid 11.3812083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 11.3811000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.8518230668 15322242 16714409
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.969294722 10568697
MESH:D004935 Esophageal Diseases Capsaicin 5.6419566590
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 2.093581430
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.9611564622
MESH:D005234 Fatty Liver pirinixic acid 2.7019236843 20131406
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.3911858732
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 4.966705139
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 2.8920067830
MESH:D005909 Glioblastoma Capsaicin 4.0718405923
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 3.977505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.5410696789
MESH:D006356 Heartburn Capsaicin 5.6419566590
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.3011294989 10048152
MESH:D006333 Heart Failure pirinixic acid 2.5020558911
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.2711000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.456705139
MESH:D006529 Hepatomegaly pirinixic acid 8.0518467677 19772884 16221962 19176532
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 8.0512621046 15340226 16120746
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.998697196 16959395 18606429 16354765 15340226
MESH:D006930 Hyperalgesia Capsaicin 4.2717043245 17434803
MESH:D006943 Hyperglycemia pirinixic acid 3.1220558911
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 3.8815034207
MESH:D006973 Hypertension Phenylephrine 5.228949925 12717712
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.2218850075 18670907
MESH:D006984 Hypertrophy Phenylephrine 4.4918502941 12791704
MESH:D007249 Inflammation Capsaicin 11.8616956363
MESH:D007249 Inflammation Flavonoids 11.8617296493
MESH:D007249 Inflammation mustard oil 11.8616793879
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 11.8612878042 12200463
MESH:D007333 Insulin Resistance pirinixic acid 2.5916306350
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 4.968074119 9022650
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.2716580747
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 2.916582329
MESH:D007683 Kidney Tubular Necrosis, Acute Calcium 4.9916316344
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.1515034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.1115474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.1112878042
MESH:D008107 Liver Diseases Capsaicin 3.2416956363
MESH:D008113 Liver Neoplasms pirinixic acid 4.1620007298 16377806 15890375
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 4.1616984957
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 5.596587162 1399818 3712494 598648
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 5.5912151625
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 1.2319555203 11884234
MESH:D009101 Multiple Myeloma Capsaicin 4.1117505005
MESH:D009135 Muscular Diseases pirinixic acid 3.4416239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.1119151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.9612213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.8916411023
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.443581430
MESH:D009369 Neoplasms pirinixic acid 1.9217405874
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.1514600291
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 2.876679447
MESH:D020078 Neurogenic Inflammation Capsaicin 5.0317961222
MESH:D009765 Obesity Capsaicin 4.7819056576
MESH:D009765 Obesity pirinixic acid 4.7820558911
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.364026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 4.963988306
MESH:D010024 Osteoporosis Calcium 3.7417882678
MESH:D010146 Pain 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione 11.7218987195
MESH:D010146 Pain Capsaicin 11.7217434803 18987195 16996476 17043245 19081190 17084039
MESH:D010146 Pain N-(4-tert-butylphenyl)-4-(3-chloropyridin-2-yl)tetrahydropyrazine-1(2H)-carboxamide 11.7216996476
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.427296757
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.1912520081
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.416228378
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.4918163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.1311118676 11222880 11896295 11399792
MESH:D015427 Reperfusion Injury Capsaicin 6.7218460982 19211983
MESH:D015427 Reperfusion Injury pirinixic acid 6.7219058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.7718990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.323692021
MESH:D012852 Sinusitis Phenylephrine 4.647327846
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.0116192470
MESH:D013705 Temporomandibular Joint Disorders Capsaicin 5.6717997062
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.8512697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 2.833712494 6582329 7505956 1399818 6587162
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 2.258074119
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.5412125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.1915886252
No data
Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB00825 agonist Zilactin-lip Antipruritics
No data
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Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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