Annotation Detail for FTO
Basic Information Top
| Gene Symbol: | FTO ( KIAA1752,MGC5149 ) |
|---|---|
| Gene Full Name: | fat mass and obesity associated |
| Band: | 16q12.2 |
| Quick Links | Entrez ID:79068; OMIM: 610966; Uniprot ID:FTO_HUMAN; ENSEMBL ID: ENSG00000140718; HGNC ID: 24678 |
| Relate to Another Database: | SFARIGene; denovo-db |
Related Pathway Information| Desease ID | Desease Name |
|---|---|
| Metabolic diseases | |
| Diabetes | |
| H00409 | Type II diabetes mellitus |
| Desease ID | Desease Name |
|---|---|
| 1712 | Yersinia infection |
| 1856 | Obesity |
| 1879 | Glucose intolerance |
| 1904 | Diabetes mellitus |
| 2102 | Polycystic ovary syndrome |
| 2237 | Neoplasm metastasis |
| Desease Name |
|---|
| obesity (early onset extreme) |
| Birth Weight |
| Body mass index |
| Biomedical quantitative traits |
| C-reactive protein blood levels |
| obesity (extreme) |
| obesity-related traits |
| adiposity and blood pressure |
| weight |
| BMI |
| METABOLIC |
| obesity |
| type 2 diabetes |
| waist circumference |
| Cardiovascular Diseases |
| diabetes, type 2 |
| Diabetes Mellitus, Type 2 |
| Desease Name |
|---|
| Waist circumference |
| Type 2 diabetes |
| Biomedical quantitative traits |
| Body mass index |
| Obesity (early onset extreme) |
| Obesity |
| Obesity (extreme) |
| Weight |
| Obesity-related traits |
| Desease Name |
|---|
| Growth retardation, developmental delay, coarse facies, and early death |
| Chemical ID | Chemical Name | Interaction | Interaction Action | Publication |
|---|---|---|---|---|
| D016604 | Aflatoxin B1 | Aflatoxin B1 affects the expression of FTO protein | affects expression | 20106945 |
| D001564 | Benzo(a)pyrene | Benzo(a)pyrene results in decreased expression of FTO mRNA | decreases expression | 20106945 |
| D004041 | Dietary Fats | Dietary Fats results in decreased expression of FTO mRNA | decreases expression | 18042831 |
| C051890 | irinotecan | irinotecan analog results in decreased expression of FTO mRNA | decreases expression | 18927307 |
| C041786 | palm oil | palm oil results in decreased expression of FTO mRNA | decreases expression | 18042831 |
| Disease ID | Disease Name | Direct Evidence | Inference Chemical Name | Inference Score | Publication |
|---|---|---|---|---|---|
| MESH:D000230 | Adenocarcinoma | Benzo(a)pyrene | 2.05 | 20127859 20464547 | |
| MESH:D000236 | Adenoma | Benzo(a)pyrene | 2.84 | 6695378 | |
| MESH:D017544 | Aortic Aneurysm, Abdominal | Benzo(a)pyrene | 4.56 | 19183758 | |
| MESH:D001161 | Arteriosclerosis | Dietary Fats | 4.37 | 15238619 | |
| MESH:D001943 | Breast Neoplasms | Benzo(a)pyrene | 2.07 | 17474063 20146248 | |
| MESH:D001943 | Breast Neoplasms | Dietary Fats | 2.07 | 20435547 | |
| MESH:D006528 | Carcinoma, Hepatocellular | Aflatoxin B1 | 1.98 | 21507988 12907637 12619106 | |
| MESH:D002294 | Carcinoma, Squamous Cell | Benzo(a)pyrene | 2.13 | 20419170 | |
| MESH:D003110 | Colonic Neoplasms | irinotecan | 2.64 | 17725105 17287894 | |
| MESH:D015179 | Colorectal Neoplasms | irinotecan | 2.36 | 17454858 18259882 16303861 17159606 15273666 16391804 18509181 | |
| MESH:D050171 | Dyslipidemias | Dietary Fats | 3.70 | 18367378 | |
| MESH:D004938 | Esophageal Neoplasms | Benzo(a)pyrene | 2.07 | 16530937 | |
| MESH:D005234 | Fatty Liver | Dietary Fats | 3.61 | 19004024 17967931 18296743 19551842 | |
| MESH:D005355 | Fibrosis | Dietary Fats | 4.01 | 18296743 | |
| OMIM:612938 | GROWTH RETARDATION, DEVELOPMENTAL DELAY, COARSE FACIES, AND EARLY DEATH | marker/mechanism | |||
| MESH:D006330 | Heart Defects, Congenital | Benzo(a)pyrene | 2.82 | 20471113 | |
| MESH:D006937 | Hypercholesterolemia | Dietary Fats | 3.97 | 21332399 | |
| MESH:D006949 | Hyperlipidemias | Dietary Fats | 4.02 | 21332399 | |
| MESH:D007249 | Inflammation | Dietary Fats | 2.59 | 20412841 | |
| MESH:D007333 | Insulin Resistance | Dietary Fats | 3.32 | 11836018 18457598 | |
| MESH:D008103 | Liver Cirrhosis | Dietary Fats | 3.05 | 18296743 | |
| MESH:D008113 | Liver Neoplasms | Aflatoxin B1 | 4.93 | 2125692 18177683 9163691 15890375 | |
| MESH:D008113 | Liver Neoplasms | Benzo(a)pyrene | 4.93 | 21137059 20195826 | |
| MESH:D008114 | Liver Neoplasms, Experimental | Aflatoxin B1 | 2.94 | 8603461 | |
| MESH:D008175 | Lung Neoplasms | Aflatoxin B1 | 2.50 | 14755239 | |
| MESH:D008175 | Lung Neoplasms | Benzo(a)pyrene | 2.50 | 20464547 18520028 18569708 17053015 18816296 20064080 6695378 20869020 20135361 | |
| MESH:D009062 | Mouth Neoplasms | Benzo(a)pyrene | 3.46 | 16381670 | |
| MESH:D052016 | Mucositis | irinotecan | 5.55 | 17159606 | |
| MESH:D009362 | Neoplasm Metastasis | irinotecan | 3.28 | 18259882 | |
| MESH:D009369 | Neoplasms | Benzo(a)pyrene | 2.31 | 11141357 | |
| MESH:D009447 | Neuroblastoma | irinotecan | 3.64 | 8761367 | |
| MESH:D017599 | Neuroectodermal Tumors | irinotecan | 5.27 | 8761367 | |
| MESH:D009765 | Obesity | marker/mechanism | 21076408 19151714 19079260 19079261 17496892 | ||
| MESH:D009765 | Obesity | Dietary Fats | 2.35 | 17217161 11836018 21332399 20518802 18457598 20132043 16723640 18674790 19632207 | |
| MESH:D011471 | Prostatic Neoplasms | Benzo(a)pyrene | 2.91 | 17292933 | |
| MESH:D012878 | Skin Neoplasms | Benzo(a)pyrene | 2.51 | 19755658 10029692 | |
| MESH:D013274 | Stomach Neoplasms | Benzo(a)pyrene | 2.62 | 2093021 20155912 | |
| MESH:D013274 | Stomach Neoplasms | irinotecan | 2.62 | 15723263 | |
| MESH:D001749 | Urinary Bladder Neoplasms | Benzo(a)pyrene | 2.29 | 17053015 | |
| MESH:D015430 | Weight Gain | Dietary Fats | 4.06 | 16723640 |
| No data |