AutismKB 2.0

Annotation Detail for ELOVL6


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:ELOVL6 ( FACE,FAE,FLJ23378,LCE,MGC5487 )
Gene Full Name: ELOVL family member 6, elongation of long chain fatty acids (FEN1/Elo2, SUR4/Elo3-like, yeast)
Band: 4q25
Quick LinksEntrez ID:79071; OMIM: 611546; Uniprot ID:ELOV6_HUMAN; ENSEMBL ID: ENSG00000170522; HGNC ID: 15829
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
PWY-5972stearate biosynthesis I (animals)
Pathway IDPathway Name
hsa01040Biosynthesis of unsaturated fatty acids
Pathway IDPathway Name
Metabolism of lipids and lipoproteins
No data
No data
Pathway IDPathway Name
500802Synthesis of very long-chain fatty acyl-CoAs
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C014024 2,4,5,2',4',5'-hexachlorobiphenyl 2,4,5,2',4',5'-hexachlorobiphenyl results in decreased expression of ELOVL6 mRNAdecreases expression 20005886
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of ELOVL6 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of ELOVL6 mRNAaffects expression 21346803
C026114 2-xylene 2-xylene results in increased expression of ELOVL6 mRNAincreases expression 20359517
C544762 3-(3-cyclohexyl-1-(2-(dimethylamino)-2-oxoethyl)-6-(4-methyl-5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)-1H-indol-2-yl)-N,N-dimethylbenzamide 3-(3-cyclohexyl-1-(2-(dimethylamino)-2-oxoethyl)-6-(4-methyl-5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)-1H-indol-2-yl)-N,N-dimethylbenzamide binds to and results in decreased activity of ELOVL6 proteinaffects binding|decreases activity 19505953
C544762 3-(3-cyclohexyl-1-(2-(dimethylamino)-2-oxoethyl)-6-(4-methyl-5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)-1H-indol-2-yl)-N,N-dimethylbenzamide 3-(3-cyclohexyl-1-(2-(dimethylamino)-2-oxoethyl)-6-(4-methyl-5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)-1H-indol-2-yl)-N,N-dimethylbenzamide binds to and results in decreased activity of ELOVL6 proteinaffects binding|decreases activity 19505953
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of ELOVL6 mRNAincreases expression 18648102
D000082 Acetaminophen Acetaminophen affects the expression of ELOVL6 mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of ELOVL6 mRNAaffects expression 16483693
D001554 Benzene Benzene results in increased expression of ELOVL6 mRNAincreases expression 20359517
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of ELOVL6 mRNAdecreases expression 20064835
20106945
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of ELOVL6 mRNAdecreases expression 20382639
19150397
D002251 Carbon Tetrachloride PLG gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of ELOVL6 mRNA]increases expression|increases reaction 16006527
D002251 Carbon Tetrachloride Carbon Tetrachloride results in decreased expression of ELOVL6 mRNAdecreases expression 19224547
D016572 Cyclosporine Cyclosporine results in decreased expression of ELOVL6 mRNAdecreases expression 20106945
D016572 Cyclosporine Cyclosporine results in decreased expression of ELOVL6 mRNAdecreases expression 19224547
D003907 Dexamethasone [Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of ELOVL6 mRNAaffects cotreatment|increases expression 16054899
D004041 Dietary Fats Dietary Fats results in decreased expression of ELOVL6 mRNAdecreases expression 18042831
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of ELOVL6 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ELOVL6 mRNAaffects cotreatment|increases expression 17942748
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of ELOVL6 mRNAaffects expression 17351261
C004912 ethylbenzene ethylbenzene results in increased expression of ELOVL6 mRNAincreases expression 20359517
D005395 Fish Oils Fish Oils results in decreased activity of ELOVL6 proteindecreases activity 15654130
D005395 Fish Oils Fish Oils results in decreased expression of ELOVL6 mRNAdecreases expression 15654130
D005419 Flavonoids Flavonoids results in increased expression of ELOVL6 mRNAincreases expression 18035473
D005632 Fructose Fructose results in increased expression of ELOVL6 mRNAincreases expression 15066988
D005947 Glucose Glucose results in increased expression of ELOVL6 mRNAincreases expression 15066988
D005947 Glucose Glucose results in increased expression of ELOVL6 mRNAincreases expression 16790840
D006830 Hydralazine [Hydralazine co-treated with Valproic Acid] results in increased expression of ELOVL6 mRNAaffects cotreatment|increases expression 17183730
D015056 1-Methyl-3-isobutylxanthine [Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of ELOVL6 mRNAaffects cotreatment|increases expression 16054899
D008752 Methylene Chloride Methylene Chloride results in increased expression of ELOVL6 mRNAincreases expression 20359517
D008770 Methylnitrosourea Methylnitrosourea results in increased expression of ELOVL6 mRNAincreases expression 16525678
C041786 palm oil palm oil results in decreased expression of ELOVL6 mRNAdecreases expression 18042831
C023036 perfluorooctanoic acid perfluorooctanoic acid results in increased expression of ELOVL6 mRNAincreases expression 18467677
C023036 perfluorooctanoic acid perfluorooctanoic acid results in increased expression of ELOVL6 mRNAincreases expression 16221955
D010795 Phthalic Acids Phthalic Acids results in decreased expression of ELOVL6 mRNAdecreases expression 15728792
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of ELOVL6 mRNAaffects binding|increases activity|increases expression 19710929
C006253 pirinixic acid pirinixic acid results in decreased expression of ELOVL6 mRNAdecreases expression 18445702
C006253 pirinixic acid pirinixic acid results in increased expression of ELOVL6 mRNAincreases expression 16790840
18467677
C006253 pirinixic acid PPARA protein affects the reaction [pirinixic acid results in increased expression of ELOVL6 mRNA]affects reaction|increases expression 16790840
C006253 pirinixic acid PPARA protein promotes the reaction [pirinixic acid results in increased expression of ELOVL6 mRNA]increases expression|increases reaction 18467677
C006253 pirinixic acid pirinixic acid results in increased activity of ELOVL6 proteinincreases activity 15654130
C006253 pirinixic acid pirinixic acid results in increased expression of ELOVL6 mRNAincreases expression 15654130
D011374 Progesterone Progesterone results in increased expression of ELOVL6 mRNAincreases expression 18070364
C089730 rosiglitazone [Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of ELOVL6 mRNAaffects cotreatment|increases expression 16054899
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of ELOVL6 mRNAdecreases expression 20106945
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ELOVL6 mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of ELOVL6 mRNAdecreases expression 20005886
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of ELOVL6 mRNAincreases expression 18796159
D013752 Tetracycline Tetracycline results in increased expression of ELOVL6 mRNAincreases expression 16917069
D013752 Tetracycline Tetracycline results in decreased expression of ELOVL6 mRNAdecreases expression 19224547
D014050 Toluene Toluene results in increased expression of ELOVL6 mRNAincreases expression 20359517
D014241 Trichloroethylene Trichloroethylene results in increased expression of ELOVL6 mRNAincreases expression 20359517
D014635 Valproic Acid [Hydralazine co-treated with Valproic Acid] results in increased expression of ELOVL6 mRNAaffects cotreatment|increases expression 17183730
C025643 vinclozolin vinclozolin affects the expression of ELOVL6 mRNAaffects expression 19015723
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 7.0515322242 14514962 11752688
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 7.058875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 3.5919490988
MESH:D000138 Acidosis Ammonium Chloride 3.1818287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.5517505938
MESH:D055371 Acute Lung Injury pirinixic acid 2.7718653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 6.5020127859 20464547
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 6.5014692618
MESH:D000230 Adenocarcinoma Methylnitrosourea 6.5015688392 15113128
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 5.843712494
MESH:D000236 Adenoma Benzo(a)pyrene 5.846695378
MESH:D018248 Adenoma, Liver Cell pirinixic acid 8.6316434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 8.6316835633
MESH:D000544 Alzheimer Disease rosiglitazone 2.7719621015
MESH:D000550 Amblyopia Valproic Acid 4.8417688650
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.6211748828
MESH:D000741 Anemia, Aplastic Benzene 4.0817661222 11369114 14761424
MESH:D000799 Angioedema Acetaminophen 3.4610982225
MESH:D001008 Anxiety Disorders Valproic Acid 7.8617497229
MESH:D001008 Anxiety Disorders vinclozolin 7.8619015723
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.7019183758
MESH:D001161 Arteriosclerosis Dietary Fats 8.6715238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 8.6711256880
MESH:D001169 Arthritis, Experimental Dexamethasone 6.5817659584
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 6.5815885639
MESH:D001289 Attention Deficit Disorder with Hyperactivity Phthalic Acids 4.1020106747
MESH:D001321 Autistic Disorder Acetaminophen 1.8518445737
MESH:D001321 Autistic Disorder Valproic Acid 1.8518985861 18177632 18316065 17688650 18558336 19232924 17507914 19460635 20603192 16609825 17157402 18775368 15238991 18940202 18396377
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 4.631440618 11289319
MESH:D001714 Bipolar Disorder Valproic Acid 2.8820046352 17594078
MESH:D001778 Blood Coagulation Disorders pirinixic acid 7.6419483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 7.6412125929
MESH:D001836 Body Weight Changes 2-xylene 10.817457028
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 10.8115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 7.2015746008
MESH:D001848 Bone Diseases, Developmental Valproic Acid 7.208888407
MESH:D001855 Bone Marrow Diseases Benzene 4.8416183116
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 4.9517868700
MESH:D001930 Brain Injuries Progesterone 3.8915665606 15380490 15845082
MESH:D001943 Breast Neoplasms Benzene 4.3811921183 17162533
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 4.3820146248 17474063
MESH:D001943 Breast Neoplasms Dietary Fats 4.3820435547
MESH:D001943 Breast Neoplasms Methylene Chloride 4.3815986119
MESH:D001943 Breast Neoplasms Methylnitrosourea 4.3814633655 16253758 11306469
MESH:D001943 Breast Neoplasms Progesterone 4.3817614352 16175315 15562024
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 4.3820435547
MESH:D001943 Breast Neoplasms Trichloroethylene 4.3815986119
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.413786805 15673190 16050911 16011737 16097048 10355542 16192424 15721981 16124888 16227642 18705752 15700767
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.5016835633
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 8.0916705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 8.0916705839
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 8.097296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 8.093084413
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 8.0918788625
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.497296757
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 1.9420419170
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.1516120746 18670907 18850075
MESH:D002386 Cataract Acetaminophen 6.8010977129
MESH:D002386 Cataract Methylnitrosourea 6.8012484553
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 18.306135515
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 18.307505956
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 18.3020889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 18.3012371664
MESH:D002471 Cell Transformation, Neoplastic Methylnitrosourea 18.302727394 7505956
MESH:D002547 Cerebral Palsy Toluene 5.479294310
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.5620734317
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 2.8416835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 16.909022650 19486331
MESH:D002779 Cholestasis Cyclosporine 16.9019486331
MESH:D002779 Cholestasis Ethinyl Estradiol 16.9017681005 17333356 17110522 15861022 16105132 11677210 16919318
MESH:D002779 Cholestasis pirinixic acid 16.9019176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 1.948697196 12621046 16354765 15340226 15668235
MESH:D003110 Colonic Neoplasms Dexamethasone 2.4315824018
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.7414669216 17141729
MESH:D003327 Coronary Disease Fructose 4.2318504504
MESH:D019465 Craniofacial Abnormalities Benzene 6.8215643154
MESH:D019465 Craniofacial Abnormalities Dexamethasone 6.8217728286
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 6.8215322242 20055451 10048152
MESH:D019465 Craniofacial Abnormalities Toluene 6.829294310
MESH:D019465 Craniofacial Abnormalities Valproic Acid 6.8216575769 17688650 8888407
MESH:D003456 Cryptorchidism vinclozolin 3.9814966744
MESH:D003490 Cyanosis 2,4-dinitrotoluene 9.6518551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 9.6518551238
MESH:D003643 Death Toluene 5.286431079
MESH:D003872 Dermatitis Benzene 4.3915902427
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 5.8318759878 14531868 8156756 2524372 12868966 11906362 11298694 8970840
MESH:D017449 Dermatitis, Allergic Contact Dexamethasone 5.8312438553
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.2418249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.142952479 3621924
MESH:D003920 Diabetes Mellitus rosiglitazone 3.9817446233
MESH:D003921 Diabetes Mellitus, Experimental Fructose 4.1918603373
MESH:D003924 Diabetes Mellitus, Type 2 Fructose 6.7018603373
MESH:D003924 Diabetes Mellitus, Type 2 rosiglitazone 6.7012642470
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 6.7017107852
MESH:D003929 Diabetic Neuropathies Progesterone 4.1217187935
MESH:D003967 Diarrhea Dexamethasone 3.347237001
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 23.4421346803 18551238
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 23.4421346803 18551238
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 23.449328219 6679447 18692083 9022650 7440962 1440618 18648102 6482804 9653073 11289319 8291058 16192314 18289764
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 23.4412392966 16781746 16485898 16109766 19164858 14725611 12594235 19085960 11743745 12705907 11739529 15968718 10663392 11461765 19370779 16081117 19420014 19416960 16393943 18071297 18713872 10774834 17562736 16177239 12153990 17906064 2444490 17522070 19923254 12958197 15619225 11421492 11529661 16227642 14550746 11834606 19739265 14986274 10915739 12540782 11287661
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 23.442869522 4309450 16177239 7120509 19085960 9327722 15968718 16227642 17522070 3786805 21278145 3732212 7440962 19336974 10915739 6623471 11566570 7179309 15027814 15998439 10092053 6884620
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 23.4420420201
MESH:D056486 Drug-Induced Liver Injury Tetracycline 23.4417522070
MESH:D056486 Drug-Induced Liver Injury Trichloroethylene 23.447120509
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 23.4419641884 1733752
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.7119426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.4811462148
MESH:D050171 Dyslipidemias Dietary Fats 3.1818367378
MESH:D004421 Dystonia Valproic Acid 3.701851702
MESH:D004485 Eczema Dexamethasone 4.1012438553
MESH:D004487 Edema Dexamethasone 18.0819703484
MESH:D004487 Edema perfluorooctanoic acid 18.0812083418 17259670
MESH:D004487 Edema pirinixic acid 18.0812083418
MESH:D004487 Edema rosiglitazone 18.0812083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 18.0811000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.5116714409 18230668 15322242
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 7.8412538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 7.8417692515
MESH:D004715 Endometriosis Progesterone 7.8416134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 7.849294722 10568697
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 3.783659116 17275665
MESH:D004828 Epilepsies, Partial Valproic Acid 3.533922381 16628512
MESH:D004827 Epilepsy Valproic Acid 2.7420417680 18234410
MESH:D004832 Epilepsy, Absence Valproic Acid 3.276426943 7562514 6254150
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 3.927750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 3.683659116
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 6.533581430
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 6.5320426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 6.5316530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.7311564622
MESH:D005234 Fatty Liver Carbon Tetrachloride 49.1412631006 19224547 15959796 61145 12795759 16045604 17595544 16239168
MESH:D005234 Fatty Liver Cyclosporine 49.1419224547
MESH:D005234 Fatty Liver Dietary Fats 49.1417967931 18296743 19004024 19551842
MESH:D005234 Fatty Liver Ethinyl Estradiol 49.1415345470
MESH:D005234 Fatty Liver Fish Oils 49.1418620774
MESH:D005234 Fatty Liver Fructose 49.1418395287 19196556 18641190
MESH:D005234 Fatty Liver pirinixic acid 49.1419236843 20131406
MESH:D005234 Fatty Liver rosiglitazone 49.1419196556
MESH:D005234 Fatty Liver Tetracycline 49.1419224547 16917069
MESH:D005234 Fatty Liver Valproic Acid 49.1414986274 19224547
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.0811858732
MESH:D005315 Fetal Diseases Valproic Acid 4.5016575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 3.778888407 18558336
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 4.636705139
MESH:D005354 Fibrosarcoma Methylnitrosourea 4.8511555667
MESH:D005355 Fibrosis Carbon Tetrachloride 23.7918705752
MESH:D005355 Fibrosis Cyclosporine 23.7912639820 12168785
MESH:D005355 Fibrosis Dietary Fats 23.7918296743
MESH:D005355 Fibrosis Fructose 23.7918504504
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 23.7920067830
MESH:D005756 Gastritis Acetaminophen 3.2916983495
MESH:D030342 Genetic Diseases, Inborn vinclozolin 4.5516973722
MESH:D005832 Genital Diseases, Male vinclozolin 4.9116417039
MESH:D005885 Gingival Hyperplasia Cyclosporine 3.848708960
MESH:D005910 Glioma Methylnitrosourea 3.419825942
MESH:D018149 Glucose Intolerance Fructose 4.9719165636
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 3.697505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.2110696789
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 5.7620471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 5.7611294989 10048152
MESH:D006333 Heart Failure pirinixic acid 2.3020558911
MESH:D006402 Hematologic Diseases Benzene 4.3016183116
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.0415720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.0011000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 8.026705139
MESH:D006505 Hepatitis Carbon Tetrachloride 8.0219900420 19110552
MESH:D006529 Hepatomegaly 2-xylene 17.717457013 7457028
MESH:D006529 Hepatomegaly perfluorooctanoic acid 17.713609246
MESH:D006529 Hepatomegaly pirinixic acid 17.7116221962 19176532 19772884 18467677
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 17.7115340226 12621046 16120746
MESH:D006548 Hernia, Diaphragmatic Dexamethasone 2.937520565
MESH:D006849 Hydrocephalus Valproic Acid 4.4817688650
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.6618606429 15340226 16354765 8697196 16959395
MESH:D006930 Hyperalgesia Acetaminophen 11.4516870215
MESH:D006930 Hyperalgesia perfluorooctanoic acid 11.4512083418
MESH:D006930 Hyperalgesia rosiglitazone 11.4512083418
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.1516899240
MESH:D006937 Hypercholesterolemia Dietary Fats 3.2621332399
MESH:D006943 Hyperglycemia pirinixic acid 2.8520558911
MESH:D006946 Hyperinsulinism Fructose 4.5818563319 14757778 15752949 19008412 18360027
MESH:D006949 Hyperlipidemias Dietary Fats 13.6621332399
MESH:D006949 Hyperlipidemias Fish Oils 13.6615752949
MESH:D006949 Hyperlipidemias Fructose 13.6615752949
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 3.5715034207
MESH:D006968 Hypersensitivity, Delayed Fish Oils 5.1211484837
MESH:D006973 Hypertension Benzene 14.7617940673
MESH:D006973 Hypertension Cyclosporine 14.7610903974
MESH:D006973 Hypertension Dexamethasone 14.7617042910
MESH:D006973 Hypertension Fructose 14.7614568997 14573337 19008412 16843071 14633139
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 14.7618850075 18670907
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.7215338365
MESH:D046110 Hypertension, Pregnancy-Induced Hydralazine 4.2516612254
MESH:D015228 Hypertriglyceridemia Fructose 4.7519799862 19342510
MESH:D007021 Hypospadias Ethinyl Estradiol 3.4416945680 16569931
MESH:D007077 Ileal Diseases 1-Methyl-3-isobutylxanthine 5.0518306037
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.0315869954
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.1112013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 9.8317937319
MESH:D007248 Infertility, Male Methylnitrosourea 9.837193160
MESH:D007248 Infertility, Male vinclozolin 9.8316467254
MESH:D007249 Inflammation Dexamethasone 21.098960868 11099482
MESH:D007249 Inflammation Dietary Fats 21.0920412841
MESH:D007249 Inflammation Flavonoids 21.0917296493
MESH:D007249 Inflammation perfluorooctanoic acid 21.0912083418
MESH:D007249 Inflammation Progesterone 21.0915869954
MESH:D007249 Inflammation rosiglitazone 21.0912083418
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 21.0912878042 12200463
MESH:D007333 Insulin Resistance Dietary Fats 15.6611836018 18457598
MESH:D007333 Insulin Resistance Fructose 15.6618057795 19008412 14573337 19799862 18563319 19342510 14633139 14757778 19586609 17133782 18981581
MESH:D007333 Insulin Resistance pirinixic acid 15.6616306350
MESH:D007333 Insulin Resistance rosiglitazone 15.6616306350
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 4.638074119 9022650
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.0016580747
MESH:D007579 Jejunal Diseases 1-Methyl-3-isobutylxanthine 5.0518306037
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.0515604871
MESH:D007674 Kidney Diseases Acetaminophen 5.0512587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 5.0518776723 10903974 8314463
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 15.2116705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 15.2116705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 15.216582329
MESH:D007680 Kidney Neoplasms Cyclosporine 15.2112371664
MESH:D007938 Leukemia Benzene 3.2018335105 15935818 14694614 17119257
MESH:D007951 Leukemia, Myeloid Benzene 3.9817506065
MESH:D015470 Leukemia, Myeloid, Acute Benzene 3.8519478238
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 3.8516294345 17596541
MESH:D007984 Leydig Cell Tumor perfluorooctanoic acid 11.678812269
MESH:D007984 Leydig Cell Tumor vinclozolin 11.6716417039
MESH:D017880 Limb Deformities, Congenital Methylnitrosourea 3.9315526292
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 5.9121278145 17174718 11903743 11408273 17334410 16221502 16239168 17157831 16943688
MESH:D008103 Liver Cirrhosis Dietary Fats 5.9118296743
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 2.9615034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 6.1618166357 12632514 18054572 12898905 18156304 17557913 12445418 17698563 18263696 14748882 18205269 16136751 18705752 15370692 18317297 17869086 16015684 18472332 14724832 14620537 15959796 17481882 18418968 12649538 17525996 15925388 15650968 15673190 18429990 17823541 15996030 18277467 16116963 14716496 17944888 18472094 12958196 18006644 14716833 12666154 12741479 15730626 12609069 12546737 18481824 16248980 17721639 18210741 16033810 14512876 18395095 15931870 15876570 17708605 15893842 12389079 17565644 17761835 13678700 17805973 12667390 15338365 15052691 17922224 11481614 16638106 16011737 15362042 10355542 18376398 18420326 18395914 17900296 18251166 15057751 18412020 20821823 18187930 18279442 17714472 16097048 15123356 17640975 17766677 17976157 18339082 12445421 12632512 16027843 17631135 12586293 15818738 16192424
MESH:D008106 Liver Cirrhosis, Experimental Dexamethasone 6.1616718785
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 6.1615474484
MESH:D008106 Liver Cirrhosis, Experimental rosiglitazone 6.1617347453 15980055
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 6.1612878042
MESH:D008107 Liver Diseases Acetaminophen 3.5412969438 16611625 19784758 12587719 19014921 16610002 19460945 11587558
MESH:D008107 Liver Diseases Carbon Tetrachloride 3.5415720792 17285989 16246199 15830285 16964402
MESH:D017093 Liver Failure Carbon Tetrachloride 3.7915123358
MESH:D017114 Liver Failure, Acute Acetaminophen 8.3116871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 8.3116899240 14706259
MESH:D008113 Liver Neoplasms 2,4,5,2',4',5'-hexachlorobiphenyl 19.5118644402 16835634
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 19.517678174
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 19.5121137059 20195826
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 19.5119294768
MESH:D008113 Liver Neoplasms perfluorooctanoic acid 19.5118709148 14757943
MESH:D008113 Liver Neoplasms pirinixic acid 19.5115890375 20007298 16377806
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 19.5116984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 20.242876784 2876786 6135515
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 20.24598648 6587162 1399818 3712494
MESH:D008114 Liver Neoplasms, Experimental Benzene 20.2412562636
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 20.2412014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 20.2412151625
MESH:D008114 Liver Neoplasms, Experimental Trichloroethylene 20.247955063
MESH:D038061 Lower Extremity Deformities, Congenital Methylnitrosourea 5.0916080182
MESH:D017563 Lung Diseases, Interstitial Benzene 10.0914698565
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 10.0917228818
MESH:D008175 Lung Neoplasms Benzene 7.8612562636
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 7.8620064080 18569708 18520028 20464547 6695378 18816296 17053015 20869020 20135361
MESH:D008175 Lung Neoplasms Dexamethasone 7.8611195469 15824018
MESH:D008175 Lung Neoplasms Methylene Chloride 7.8615172992
MESH:D008175 Lung Neoplasms Methylnitrosourea 7.8618062963
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 7.8619555203 11884234
MESH:D008223 Lymphoma Benzene 7.1417119257 17584886
MESH:D008223 Lymphoma Methylnitrosourea 7.1416257854 11418001
MESH:D016393 Lymphoma, B-Cell Methylnitrosourea 4.4214633661
MESH:D015674 Mammary Neoplasms, Animal Benzene 4.0612562636
MESH:D008325 Mammary Neoplasms, Experimental Benzene 12.3511921183
MESH:D008325 Mammary Neoplasms, Experimental Methylnitrosourea 12.3516619500 11807958 11751437 17020996 10767621 14633655 15313902 16051031 15688392 12931682 10838139 15113128 16944150 16827153 17131329 19196723 14999141
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 12.3517203775 11408345
MESH:D008325 Mammary Neoplasms, Experimental rosiglitazone 12.3516827153
MESH:D008545 Melanoma Glucose 3.0214993021
MESH:D008546 Melanoma, Experimental Acetaminophen 3.2019513568
MESH:D008607 Mental Retardation Toluene 3.529294310
MESH:D024821 Metabolic Syndrome X Fructose 9.0119165636 17098227 16815490 17261469 18497449
MESH:D024821 Metabolic Syndrome X rosiglitazone 9.0117261469
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.4016801185
MESH:D008881 Migraine Disorders Valproic Acid 2.9218803445 18765137
MESH:D019957 Motor Skills Disorders Toluene 4.889294310
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 2.9016381670
MESH:D009101 Multiple Myeloma Benzene 6.7417119195
MESH:D009101 Multiple Myeloma Dexamethasone 6.7415867202 16118317 15744524
MESH:D009135 Muscular Diseases pirinixic acid 3.1416239165
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 3.698888407
MESH:D009190 Myelodysplastic Syndromes Dexamethasone 6.829809623
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 6.8217596541
MESH:D009203 Myocardial Infarction pirinixic acid 1.9819151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.7212213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.6616411023
MESH:D009336 Necrosis 2,4-dinitrotoluene 9.0818551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 9.0818551238 7678174
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.313581430
MESH:D009369 Neoplasms 2,4,5,2',4',5'-hexachlorobiphenyl 13.688820588
MESH:D009369 Neoplasms Benzo(a)pyrene 13.6811141357
MESH:D009369 Neoplasms Methylnitrosourea 13.6815533788
MESH:D009369 Neoplasms pirinixic acid 13.6817405874
MESH:D009369 Neoplasms Trichloroethylene 13.6811911487
MESH:D009374 Neoplasms, Experimental Methylnitrosourea 4.1012696579
MESH:D009395 Nephritis, Interstitial Tetracycline 4.409884423
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.0517954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 2.9719348381 18481113
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 2.8514600291
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 10.756679447
MESH:D009436 Neural Tube Defects Benzene 10.7515643154
MESH:D009436 Neural Tube Defects Valproic Acid 10.7516359493 8888407
MESH:D009442 Neurilemmoma Methylnitrosourea 5.1011555667
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.5618514411
MESH:D052556 Niemann-Pick Disease, Type C perfluorooctanoic acid 4.589802331
MESH:D009765 Obesity Dietary Fats 6.9011836018 21332399 20132043 17217161 18457598 20518802 18674790 16723640 19632207
MESH:D009765 Obesity Fructose 6.9018585860 17707055
MESH:D009765 Obesity pirinixic acid 6.9020558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 18.8912819281 16049721
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 18.8916049721
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 18.896482804 4026338
MESH:D009784 Occupational Diseases Benzene 18.8917479406 15612468 15935809 15727169 15576619 16737584 17178637 15913788 17119257
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 4.633988306
MESH:D010051 Ovarian Neoplasms Benzene 4.7112562636
MESH:D010051 Ovarian Neoplasms Progesterone 4.7117393432 16525653
MESH:D010146 Pain Acetaminophen 2.1016870215
MESH:D010190 Pancreatic Neoplasms Methylnitrosourea 3.2216965848
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.3411578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.117296757
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.8612520081
MESH:D010391 Pemphigoid, Bullous Tetracycline 5.0411026799
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.086228378
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.2018163543
MESH:D011230 Precancerous Conditions Cyclosporine 2.9012371664
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Dexamethasone 3.3321297632
MESH:D011297 Prenatal Exposure Delayed Effects perfluorooctanoic acid 20.1217132714
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 20.1211896295 11399792 11222880 11118676
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 20.1220603192
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 20.1218220299 18042343 19015723
MESH:D017096 Prion Diseases Tetracycline 5.0310903871
MESH:D011469 Prostatic Diseases vinclozolin 4.5518220299
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.6417292933
MESH:D011471 Prostatic Neoplasms Methylnitrosourea 3.6415682402 12376480
MESH:D011472 Prostatitis vinclozolin 4.5518629315
MESH:D011537 Pruritus Ethinyl Estradiol 2.9316919318 15861022
MESH:D019310 Pseudolymphoma Valproic Acid 4.1511422049 12752131
MESH:D011565 Psoriasis Cyclosporine 2.0916882103
MESH:D015427 Reperfusion Injury pirinixic acid 2.2019058328
MESH:D012128 Respiratory Distress Syndrome, Adult Dexamethasone 3.6718379247 11700416
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.4718990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 8.173692021
MESH:D012162 Retinal Degeneration Methylnitrosourea 8.1718155124 18172121
MESH:D012175 Retinoblastoma Methylnitrosourea 5.1011555667
MESH:D012208 Rhabdomyosarcoma Valproic Acid 3.8219155313
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.7218045962
MESH:D012559 Schizophrenia Valproic Acid 2.0215737665 19110320
MESH:D012640 Seizures 2,4-dinitrotoluene 11.9818551238
MESH:D012640 Seizures 2,6-dinitrotoluene 11.9818551238
MESH:D012640 Seizures Toluene 11.986431079 9294310
MESH:D012640 Seizures Valproic Acid 11.9817978042 3137016 15475178 11044598 16876388 14763951 11738929 1511512
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 8.4510029692 19755658
MESH:D012878 Skin Neoplasms Glucose 8.4514993021
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 8.4516192470
MESH:D013088 Spermatocele Ethinyl Estradiol 3.5516709447
MESH:D013119 Spinal Cord Injuries Progesterone 3.9016503802 15862959
MESH:D016135 Spinal Dysraphism Valproic Acid 3.4919490988
MESH:D013226 Status Epilepticus Valproic Acid 4.1512833885
MESH:D013272 Stomach Diseases Dexamethasone 3.9415472012
MESH:D013274 Stomach Neoplasms Benzene 3.3012562636
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 3.302093021 20155912
MESH:D013274 Stomach Neoplasms Methylnitrosourea 3.3016257854 18593901 15930296
MESH:D013276 Stomach Ulcer Dexamethasone 3.1615138204
MESH:D013733 Testicular Diseases Toluene 4.5810048760 10514026
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.2711994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.8315669648
MESH:D013953 Thymus Neoplasms Benzene 10.9510850423
MESH:D013953 Thymus Neoplasms Methylnitrosourea 10.9511418001
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.5112697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 6.516582329 7505956 6587162 3712494 1399818
MESH:D013964 Thyroid Neoplasms Methylnitrosourea 6.513078959 7505956
MESH:D014178 Translocation, Genetic Valproic Acid 4.8417262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.143119515
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 10.5816049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 10.5816049721
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 10.588074119
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 10.5817053015
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.278888407
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 10.7210091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 10.7210091137
MESH:D014581 Urticaria Acetaminophen 2.6310982225
MESH:D014594 Uterine Neoplasms Benzene 8.3712562636
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 8.3714692618
MESH:D014605 Uveitis Cyclosporine 10.471336536
MESH:D014605 Uveitis Dexamethasone 10.471336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.2112125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.2014671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.8615886252
MESH:D015430 Weight Gain Dietary Fats 3.4216723640
MESH:D014985 Xerophthalmia Cyclosporine 4.0517120751
Pathway ID Pathway Name
KEGG:01040 Biosynthesis of unsaturated fatty acids
REACT:22258 Metabolism of lipids and lipoproteins
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA134939058
    • No data
    Releated disease ID Related disease Name
    PA445451Psoriasis
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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