AutismKB 2.0

Annotation Detail for DCTPP1


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:DCTPP1 ( MGC5627,RS21C6,XTP3TPA )
Gene Full Name: dCTP pyrophosphatase 1
Band: 16p11.2
Quick LinksEntrez ID:79077; OMIM: NA; Uniprot ID:DCTP1_HUMAN; ENSEMBL ID: ENSG00000179958; HGNC ID: 28777
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of DCTPP1 mRNAaffects expression 21346803
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of DCTPP1 mRNAdecreases expression 18648102
D000643 Ammonium Chloride Ammonium Chloride affects the expression of DCTPP1 mRNAaffects expression 16483693
C006780 bisphenol A bisphenol A results in increased expression of DCTPP1 mRNAincreases expression 18180321
D002995 Clofibric Acid [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of DCTPP1 mRNAaffects cotreatment|affects expression 17602206
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of DCTPP1 mRNAaffects cotreatment|affects expression 17602206
C014707 nitrosobenzylmethylamine nitrosobenzylmethylamine results in increased expression of DCTPP1 mRNAincreases expression 17616710
D018038 Sodium Selenite Sodium Selenite results in increased expression of DCTPP1 mRNAincreases expression 18175754
D014303 Trinitrotoluene Trinitrotoluene affects the expression of DCTPP1 mRNAaffects expression 21346803
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Trinitrotoluene 4.477525203
MESH:D000138 Acidosis Ammonium Chloride 3.8418287403
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 7.043712494
MESH:D000236 Adenoma Diethylnitrosamine 7.046695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 4.1819052882 19061943 17162532 17620307 18056438 16434500
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.3411289319 1440618
MESH:D001862 Bone Resorption bisphenol A 4.0711985600
MESH:D001943 Breast Neoplasms bisphenol A 2.2317123778
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.2317474063
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 4.7316705839
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 4.737296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 4.7319418558 3581430 16878318 16779866 18788625 17173139 20101231 16288022 20432363 16807293 20514400 19822196 18056438 18785209 16502159 19519916 18691550 18978308 19107877 17138121 19383236 16830150 18494052 17428255 17162532 11831363 10737359 16698587 18665156 18971187 16328049 19539802 16681979 19335982 20512989 20935162 17055752 19394651 20727157 20524982 18210153 21159647 19052882 16540662 16569478 17978847 3084413 20084675 19701751 19171122 19208518 20007298 20214788 16935385 10672840 19919837 17761372 18393292 18506893
MESH:D002278 Carcinoma in Situ bisphenol A 5.2717123778
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.767296757
MESH:D002386 Cataract Trinitrotoluene 3.9815817613 14694615
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 12.006135515
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 12.007505956
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 12.0017174075 2727394 21159647 7505956
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 3.8719052882
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 3.309022650 19486331
MESH:D019457 Chromosome Breakage Sodium Selenite 5.0115894690
MESH:D000013 Congenital Abnormalities Trinitrotoluene 4.5815095906
MESH:D003490 Cyanosis 2,6-dinitrotoluene 12.1118551238
MESH:D003490 Cyanosis Trinitrotoluene 12.1118551238
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.0612868966 11906362 14531868 8970840 18759878 11298694 2524372 8156756
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.712952479 3621924
MESH:D003920 Diabetes Mellitus Sodium Selenite 3.9616285004
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 2.2320387270
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 12.6221346803 18551238
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 12.6218648102 16192314 9653073 1440618 6679447 7440962 9022650 18289764 8291058 11289319 18692083 9328219 6482804
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 12.6219107877
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 12.6215131321
MESH:D056486 Drug-Induced Liver Injury Trinitrotoluene 12.6221346803 18551238
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.4416302075
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 4.793581430
MESH:D004938 Esophageal Neoplasms nitrosobenzylmethylamine 4.7915547721 15547733 16510608 15623463 15264214 16805852 15878914 16704527 15150132
MESH:D005234 Fatty Liver Diethylnitrosamine 3.3921071580 20387270
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.346705139
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.267505956
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.756705139
MESH:D006529 Hepatomegaly Trinitrotoluene 4.4915817613
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.2015034207
MESH:D007248 Infertility, Male Trinitrotoluene 3.8012150543
MESH:D007249 Inflammation Diethylnitrosamine 2.4718785209
MESH:D007333 Insulin Resistance bisphenol A 7.9816393666
MESH:D007333 Insulin Resistance Sodium Selenite 7.9814714311
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.349022650 8074119
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 7.9416705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 7.946582329
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.9320032147 18407596 18522880 19638242 18665156
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.319327722 15034207
MESH:D008107 Liver Diseases Diethylnitrosamine 2.1417034775
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 7.917678174
MESH:D008113 Liver Neoplasms Clofibric Acid 7.9117602206
MESH:D008113 Liver Neoplasms Diethylnitrosamine 7.9115885732 19833225 19551842 19090486 20118626 20137499 18978307 20583210 20501860 19256749 20434301 19850985 18977376 20492335 19499222 9163691 18754104 20405173 18644402 21047994 19254457 19690152 21278145 16942905 19294768 19996281 15175105 12771043 18648771 2422723 19426721 19255062 19812893 21167192 20101389 19638242 20452335 19073162 21071580 10737359 19427195 19642983 2862719 12112319
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 10.562876786 2876784 6135515
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 10.561399818 3712494 6587162 598648
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 10.5618775883 17854601 18544905 2563599 18079962 21159647 18164116 19539802 17942915 16267830 18308698 19009564 16842330 19004024 3124819 17174075 9362446 18282651 19126423 19519916 18093689 18253720
MESH:D008175 Lung Neoplasms Diethylnitrosamine 1.7621163286 20970405 20512841 6695378
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 4.2814737004
MESH:D009336 Necrosis 2,6-dinitrotoluene 11.657678174 18551238
MESH:D009336 Necrosis Trinitrotoluene 11.6518551238
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 5.943581430
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 5.943581430 9029167
MESH:D009421 Nervous System Malformations bisphenol A 4.2116427766 11399458
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 3.046679447
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 3.5120387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.4420387270
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 16.3516049721
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 16.354026338 6482804
MESH:D009784 Occupational Diseases Trinitrotoluene 16.3512819281 17852074 14694615
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.343988306
MESH:D010049 Ovarian Diseases bisphenol A 5.2711985600
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 2.4816540662
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.747296757
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.796228378
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.732563599
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 4.2410548101
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 4.4120887781
MESH:D011471 Prostatic Neoplasms bisphenol A 3.3316740699
MESH:D011471 Prostatic Neoplasms Sodium Selenite 3.3318760546
MESH:D011629 Puberty, Precocious bisphenol A 5.0710548101
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.523692021
MESH:D012640 Seizures 2,6-dinitrotoluene 6.6518551238
MESH:D012640 Seizures Trinitrotoluene 6.6518551238
MESH:D013163 Splenomegaly Trinitrotoluene 5.4615817613
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 2.6518456281
MESH:D013274 Stomach Neoplasms nitrosobenzylmethylamine 2.6512958204 17575124
MESH:D019966 Substance-Related Disorders bisphenol A 4.2716684133 16045194
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 7.641399818 6582329 6587162 7505956 3712494
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 7.647505956
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 5.2416049721
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 5.248074119
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.6010091137
MESH:D014591 Uterine Diseases bisphenol A 5.3314652134
No data
Pharmacogenomics Knowledge Base Top
Drug Bank Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved