AutismKB 2.0

Annotation Detail for ALDH5A1


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Basic Information Top
Gene Symbol:ALDH5A1 ( SSADH,SSDH )
Gene Full Name: aldehyde dehydrogenase 5 family, member A1
Band: 6p22.3
Quick LinksEntrez ID:7915; OMIM: 610045; Uniprot ID:SSDH_HUMAN; ENSEMBL ID: ENSG00000112294; HGNC ID: 408
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
PWY-65354-aminobutyrate degradation I
GLUDEG-I-PWYglutamate degradation III (via 4-aminobutyrate)
Pathway IDPathway Name
hsa00250Alanine, aspartate and glutamate metabolism
hsa01100Metabolic pathways
hsa00650Butanoate metabolism
Pathway IDPathway Name
Synaptic Transmission
No data
Pathway IDPathway Name
P02726Aminobutyrate degradation
P04384Gamma-aminobutyric acid synthesis
No data
Related Diseases/Disorders Top
No data
No data
Desease Name
memory disturbance
NEUROLOGICAL
No data
Desease Name
Succinic semialdehyde dehydrogenase deficiency
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of ALDH5A1 mRNAaffects expression 17562736
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of ALDH5A1 proteinaffects expression 20106945
D000643 Ammonium Chloride Ammonium Chloride affects the expression of ALDH5A1 mRNAaffects expression 16483693
D001542 Benomyl Benomyl results in decreased activity of ALDH5A1 proteindecreases activity 17010440
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of ALDH5A1 mRNAdecreases expression 20064835
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of ALDH5A1 mRNAincreases expression 20127859
C006780 bisphenol A bisphenol A results in increased expression of ALDH5A1 mRNAincreases expression 17010207
D016572 Cyclosporine Cyclosporine results in decreased expression of ALDH5A1 mRNAdecreases expression 20106945
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of ALDH5A1 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ALDH5A1 mRNAaffects cotreatment|increases expression 17942748
D019833 Genistein Genistein results in increased expression of ALDH5A1 mRNAincreases expression 17010207
C013099 mancozeb mancozeb results in decreased activity of ALDH5A1 proteindecreases activity 17010440
D008344 Maneb Maneb results in decreased activity of ALDH5A1 proteindecreases activity 17010440
C025256 nonylphenol nonylphenol results in increased expression of ALDH5A1 mRNAincreases expression 17010207
C009338 succinic semialdehyde ALDH5A1 protein results in increased metabolism of succinic semialdehydeincreases metabolic processing 17010440
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ALDH5A1 mRNAaffects cotreatment|increases expression 17942748
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced mancozeb 15.19982313
MESH:D000014 Abnormalities, Drug-Induced Maneb 15.19982313
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 15.1914514962 15322242 11752688
MESH:D000138 Acidosis Ammonium Chloride 3.6418287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.0417505938
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 7.1320127859 20464547
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 7.1314692618
MESH:D000230 Adenocarcinoma Genistein 7.1311473722
MESH:D000236 Adenoma Benzo(a)pyrene 2.686695378
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.4616835633
MESH:D000382 Agricultural Workers' Diseases mancozeb 10.1415864902 16132792 8807224
MESH:D000382 Agricultural Workers' Diseases Maneb 10.148807224
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0011748828
MESH:D000799 Angioedema Acetaminophen 3.9410982225
MESH:D000853 Anophthalmos Benomyl 6.1315907663
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.1519183758
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.5411256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.6915885639
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.1012125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.8915340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8015746008
MESH:D001862 Bone Resorption bisphenol A 3.9211985600
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.9520146248 17474063
MESH:D001943 Breast Neoplasms bisphenol A 1.9517123778
MESH:D001943 Breast Neoplasms Genistein 1.9516541309 16873071 17200150
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9520435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8416835633
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.633084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 4.6321507988 12619106 12907637
MESH:D006528 Carcinoma, Hepatocellular Genistein 4.6316924424
MESH:D002278 Carcinoma in Situ bisphenol A 5.0717123778
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.0620419170
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3918850075 18670907 16120746
MESH:D002318 Cardiovascular Diseases Genistein 3.3416332659
MESH:D002386 Cataract Acetaminophen 2.6110977129
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 2.5612371664
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2116835633
MESH:D002779 Cholestasis Cyclosporine 7.9119486331
MESH:D002779 Cholestasis Ethinyl Estradiol 7.9115861022 17681005 16105132 16919318 17110522 11677210 17333356
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.128697196 12621046 16354765 15668235 15340226
MESH:D003110 Colonic Neoplasms Genistein 2.2917182828
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1114669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2610048152 15322242 20055451
MESH:D017449 Dermatitis, Allergic Contact mancozeb 8.548807224
MESH:D017449 Dermatitis, Allergic Contact Maneb 8.548807224
MESH:D009783 Dermatitis, Occupational mancozeb 12.218807224
MESH:D009783 Dermatitis, Occupational Maneb 12.218807224
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 4.3716647724
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.3717107852
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 3.6011287661 14550746 19416960 10774834 11461765 12153990 19739265 11529661 14725611 11739529 18071297 11743745 16781746 12540782 18713872 12392966 10915739 16393943 10663392 17562736 12705907 19370779 16227642 16485898 11834606 17906064 14986274 19085960 12594235 12958197 19420014 16109766 19164858 16081117 17522070 15619225 15968718 16177239 2444490 11421492 19923254
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.6020420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.1919426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8011462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.4311000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.0018230668 16714409 15322242
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.2512538720
MESH:D004714 Endometrial Hyperplasia Genistein 4.6716402032
MESH:D016889 Endometrial Neoplasms Genistein 3.3911473722
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.0710568697 9294722
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 2.0216530937
MESH:D005124 Eye Abnormalities Benomyl 9.611914497
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 9.6111564622
MESH:D005234 Fatty Liver Cyclosporine 7.7619224547
MESH:D005234 Fatty Liver Ethinyl Estradiol 7.7615345470
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5311858732
MESH:D005355 Fibrosis Cyclosporine 8.7212168785 12639820
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 8.7220067830
MESH:D005756 Gastritis Acetaminophen 3.7716983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.308708960
MESH:D005909 Glioblastoma Genistein 3.2916598420
MESH:D005911 Gliosis Maneb 6.7811124998
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.6910696789
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.5420471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.5411294989 10048152
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.5015720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.3911000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.9615340226 16120746 12621046
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.1416354765 16959395 8697196 18606429 15340226
MESH:D006930 Hyperalgesia Acetaminophen 2.7416870215
MESH:D006973 Hypertension Cyclosporine 5.0110903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.0118850075 18670907
MESH:D007021 Hypospadias Ethinyl Estradiol 3.8816569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.5212013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.5217937319
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.8812878042 12200463
MESH:D007333 Insulin Resistance bisphenol A 3.3216393666
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.3916580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.5415604871
MESH:D007674 Kidney Diseases Acetaminophen 5.8912587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 5.898314463 10903974 18776723
MESH:D007680 Kidney Neoplasms Cyclosporine 2.7812371664
MESH:D007938 Leukemia Genistein 3.0517468513 18980019
MESH:D007945 Leukemia, Lymphoid mancozeb 6.4016132792
MESH:D008106 Liver Cirrhosis, Experimental Genistein 2.4117823541
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.4112878042
MESH:D008107 Liver Diseases Acetaminophen 1.6419460945 19784758 19014921 16611625 12587719 12969438 16610002 11587558
MESH:D017114 Liver Failure, Acute Acetaminophen 3.2917185352 16871587
MESH:D008113 Liver Neoplasms Aflatoxin B1 7.492125692 15890375 18177683 9163691
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 7.4920195826 21137059
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.4916984957
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 5.918603461
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 5.9112151625
MESH:D008175 Lung Neoplasms Aflatoxin B1 3.3914755239
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 3.396695378 17053015 18816296 20464547 20135361 18520028 18569708 20064080 20869020
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.3911884234 19555203
MESH:D008325 Mammary Neoplasms, Experimental Genistein 2.9714578162 12929590
MESH:D008546 Melanoma, Experimental Acetaminophen 3.6419513568
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.8816801185
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.2316381670
MESH:D009203 Myocardial Infarction Genistein 2.8817141266
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0612213967
MESH:D015428 Myocardial Reperfusion Injury Genistein 3.7017141266
MESH:D009369 Neoplasms Benzo(a)pyrene 2.1911141357
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.5417954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.3319348381 18481113
MESH:D009410 Nerve Degeneration mancozeb 9.8315350641
MESH:D009410 Nerve Degeneration Maneb 9.8315350641 16893418
MESH:D009421 Nervous System Malformations Benomyl 24.1214502586
MESH:D009421 Nervous System Malformations bisphenol A 24.1216427766 11399458
MESH:D009421 Nervous System Malformations Genistein 24.1216427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 24.1214600291
MESH:D009436 Neural Tube Defects mancozeb 4.9515864902
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.9118514411
MESH:D010024 Osteoporosis Genistein 3.2819401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 4.1416169203
MESH:D010049 Ovarian Diseases bisphenol A 5.0711985600
MESH:D010051 Ovarian Neoplasms Genistein 2.6119005980
MESH:D010146 Pain Acetaminophen 2.4316870215
MESH:D010190 Pancreatic Neoplasms mancozeb 4.358603375 16965848
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.7511578682
MESH:D010300 Parkinson Disease Maneb 4.3516510128 11124998 16140633 12911755 15824117
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.3512520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.6218163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.2712371664
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 9.7910548101
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 9.7911222880 11118676 11896295 11399792
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 4.2620887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.5817292933
MESH:D011471 Prostatic Neoplasms bisphenol A 2.5816740699
MESH:D011471 Prostatic Neoplasms Genistein 2.5815378649 15256057 16925846
MESH:D011537 Pruritus Ethinyl Estradiol 3.3916919318 15861022
MESH:D011565 Psoriasis Cyclosporine 2.2416882103
MESH:D011629 Puberty, Precocious bisphenol A 4.8710548101
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.9018990726
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 9.7810029692 19755658
MESH:D012878 Skin Neoplasms mancozeb 9.781733566
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 9.7816192470
MESH:D013088 Spermatocele Ethinyl Estradiol 4.0416709447
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.562093021 20155912
MESH:D019966 Substance-Related Disorders bisphenol A 4.0716684133 16045194
MESH:C535803 succinic semialdehyde dehydrogenase deficiency marker/mechanism
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.6811994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.2015669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.0012697716
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 2.2017053015
MESH:D014581 Urticaria Acetaminophen 3.0310982225
MESH:D014591 Uterine Diseases bisphenol A 5.1114652134
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.3614692618
MESH:D014605 Uveitis Cyclosporine 4.081336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.6912125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.5914671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.3515886252
MESH:D014985 Xerophthalmia Cyclosporine 4.5417120751
Pathway ID Pathway Name
KEGG:00250 Alanine, aspartate and glutamate metabolism
KEGG:00650 Butanoate metabolism
KEGG:01100 Metabolic pathways
REACT:13685 Synaptic Transmission
Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB00139 inhibitor Ubicoenzyme Anti-Ulcer Agents;Dietary supplement;Micronutrient;Radiation-Protective Agents
DB00157 - NADH Dietary supplement;Micronutrient
DB00534 inhibitor Chlormerodrin Diagnostic aids;Mercurial Diuretics
No data
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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