AutismKB 2.0

Annotation Detail for GDPD3


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Basic Information Top
Gene Symbol:GDPD3 ( FLJ22603,MGC4171 )
Gene Full Name: glycerophosphodiester phosphodiesterase domain containing 3
Band: 16p11.2
Quick LinksEntrez ID:79153; OMIM: NA; Uniprot ID:GDPD3_HUMAN; ENSEMBL ID: ENSG00000102886; HGNC ID: 28638
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000638 Amiodarone Amiodarone results in increased expression of GDPD3 mRNAincreases expression 17567588
D000639 Amitriptyline Amitriptyline results in increased expression of GDPD3 mRNAincreases expression 17567588
15342952
C084597 chlorcyclizine chlorcyclizine results in increased expression of GDPD3 mRNAincreases expression 15342952
D002746 Chlorpromazine Chlorpromazine results in increased expression of GDPD3 mRNAincreases expression 15342952
D015283 Citalopram Citalopram results in increased expression of GDPD3 mRNAincreases expression 17567588
D003024 Clozapine Clozapine results in increased expression of GDPD3 mRNAincreases expression 15342952
D004316 Doxepin Doxepin results in increased expression of GDPD3 mRNAincreases expression 17567588
D005424 Flecainide Flecainide results in increased expression of GDPD3 mRNAincreases expression 15342952
D005473 Fluoxetine Fluoxetine results in increased expression of GDPD3 mRNAincreases expression 17567588
D005492 Folic Acid Folic Acid affects the expression of GDPD3 mRNAaffects expression 17320366
D007099 Imipramine Imipramine results in increased expression of GDPD3 mRNAincreases expression 15342952
17567588
D007654 Ketoconazole Ketoconazole results in increased expression of GDPD3 mRNAincreases expression 15342952
D017336 Loratadine Loratadine results in increased expression of GDPD3 mRNAincreases expression 15342952
D010480 Perhexiline Perhexiline results in increased expression of GDPD3 mRNAincreases expression 15342952
D020280 Sertraline Sertraline results in increased expression of GDPD3 mRNAincreases expression 17567588
15342952
D013629 Tamoxifen Tamoxifen results in increased expression of GDPD3 mRNAincreases expression 17567588
15342952
D001371 trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride results in increased expression of GDPD3 mRNAincreases expression 15342952
D014302 Trinitrobenzenesulfonic Acid Trinitrobenzenesulfonic Acid results in decreased expression of GDPD3 mRNAdecreases expression 17982090
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.5214745880
MESH:D058186 Acute Kidney Injury Folic Acid 4.2917003819 16316344 16595132
MESH:D000236 Adenoma Folic Acid 3.7716963246
MESH:D000380 Agranulocytosis Clozapine 5.0212649775 14617031 16160616
OMIM:607154 ALLERGIC RHINITIS Loratadine 5.7216527031
MESH:D000544 Alzheimer Disease Folic Acid 3.0417116317
MESH:D001008 Anxiety Disorders Citalopram 15.2218083778
MESH:D001008 Anxiety Disorders Fluoxetine 15.2218083778
MESH:D001008 Anxiety Disorders Sertraline 15.2218822694
MESH:D001145 Arrhythmias, Cardiac Amiodarone 3.7618218290 20041841 18057881
MESH:D001249 Asthma Loratadine 4.219196086
MESH:D001281 Atrial Fibrillation Amiodarone 3.8718651412 19698954
MESH:D001321 Autistic Disorder Citalopram 2.9619232924 18775368
MESH:D001321 Autistic Disorder Fluoxetine 2.9618775368 19232924
MESH:D001321 Autistic Disorder Folic Acid 2.9621388746
MESH:D001321 Autistic Disorder Sertraline 2.9618775368
MESH:D001778 Blood Coagulation Disorders Amiodarone 3.8619483382
MESH:D001943 Breast Neoplasms Folic Acid 2.5116777985
MESH:D001943 Breast Neoplasms Tamoxifen 2.5119189212 18351453 20390343 19084267 19189210 17893378 21138602 19221464 17261762 19011961 19288272 20135344 19410462 20544844 17440819 15668708 19059307 19115204 19487384 11161223 16818667 18425577 19244106 16202921 18984771 18855134 19066611 15565566 17049068 19142967 20065188 18629630 18821012 19155303 20005174 18815881 19200415 16873071 16273361 19103187 21152245 18997820 19289846 20859285 17242785
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.4719066611
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 1.8216924424
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.5717572228
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 2.8819225199 15710769
MESH:D002318 Cardiovascular Diseases Folic Acid 3.9216755160
MESH:D002341 Carotid Artery Thrombosis Amiodarone 5.0518974383
MESH:D002659 Child Development Disorders, Pervasive Citalopram 4.5415782081
MESH:D002971 Cleft Lip Folic Acid 3.9621254359
MESH:D002972 Cleft Palate Folic Acid 3.558946559 21254359
MESH:D003072 Cognition Disorders Clozapine 4.9217123785
MESH:D003092 Colitis Trinitrobenzenesulfonic Acid 4.5116804969 17991707 16782535 17936198 18200517 16867261 16474422 18023891 11698051
MESH:D003093 Colitis, Ulcerative Trinitrobenzenesulfonic Acid 3.4317276891
MESH:D015179 Colorectal Neoplasms Folic Acid 2.7017245555 16963246 17087956 16985020 17116713
MESH:D003711 Demyelinating Diseases Tamoxifen 4.3219031437
MESH:D003866 Depressive Disorder Amitriptyline 29.6118083778 15014590
MESH:D003866 Depressive Disorder Citalopram 29.6115014590
MESH:D003866 Depressive Disorder Doxepin 29.6115014590
MESH:D003866 Depressive Disorder Fluoxetine 29.6115014590
MESH:D003866 Depressive Disorder Imipramine 29.6120305041
MESH:D003866 Depressive Disorder Sertraline 29.6120305041 15014590 18822694
MESH:D003865 Depressive Disorder, Major Sertraline 5.3216968574
MESH:D003924 Diabetes Mellitus, Type 2 Clozapine 5.0116402076
MESH:D003924 Diabetes Mellitus, Type 2 Folic Acid 5.0116886840
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.4419279558
MESH:D006970 Disorders of Excessive Somnolence Clozapine 5.5315331141
MESH:D056486 Drug-Induced Liver Injury Amiodarone 6.6315265979 18218290
MESH:D056486 Drug-Induced Liver Injury Chlorpromazine 6.6311461765
MESH:D056486 Drug-Induced Liver Injury Ketoconazole 6.6318289764
MESH:D050171 Dyslipidemias Clozapine 4.1516402076
MESH:D004487 Edema Amitriptyline 11.9212798668
MESH:D004487 Edema Fluoxetine 11.9212798668
MESH:D004487 Edema Imipramine 11.9212798668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 3.5019031437
MESH:D016889 Endometrial Neoplasms Folic Acid 7.6717301261
MESH:D016889 Endometrial Neoplasms Tamoxifen 7.6720544844 19155303 16202921 17893378
MESH:D017889 Exfoliation Syndrome Folic Acid 5.4616504073
MESH:D005234 Fatty Liver Amiodarone 7.8214986274
MESH:D005234 Fatty Liver Tamoxifen 7.8214986274 19224547
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.2116709447
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.4914745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.1519069698
MESH:D005355 Fibrosis Trinitrobenzenesulfonic Acid 4.3117994277
MESH:D005756 Gastritis Folic Acid 5.0617171786
MESH:D005901 Glaucoma Folic Acid 5.0416504073
MESH:D006330 Heart Defects, Congenital Folic Acid 3.7716524890 17286298
MESH:D006529 Hepatomegaly Amiodarone 3.7115265979
MESH:D006561 Herpes Simplex Chlorpromazine 5.251682908
MESH:D006679 HIV Seropositivity Folic Acid 5.4617209195
MESH:D019584 Hot Flashes Fluoxetine 5.2814716179
MESH:D006816 Huntington Disease Sertraline 5.9818403212
MESH:D006937 Hypercholesterolemia Amiodarone 3.839751232 8137927
MESH:D020138 Hyperhomocysteinemia Folic Acid 4.4616755160 16395265 16397167 16865747 16433478
MESH:D006948 Hyperkinesis Clozapine 4.8716046005
MESH:D007021 Hypospadias Loratadine 6.0716407038
MESH:D007037 Hypothyroidism Amiodarone 4.4718020914 17991464
MESH:D007249 Inflammation Amitriptyline 12.0212798668
MESH:D007249 Inflammation Fluoxetine 12.0212798668
MESH:D007249 Inflammation Imipramine 12.0212798668
MESH:D007249 Inflammation Tamoxifen 12.0219457130
MESH:D015212 Inflammatory Bowel Diseases Trinitrobenzenesulfonic Acid 3.5618200517
MESH:D007410 Intestinal Diseases Trinitrobenzenesulfonic Acid 4.5717994277
MESH:D007680 Kidney Neoplasms Tamoxifen 3.0118625569
MESH:D016773 Leishmaniasis, Cutaneous Ketoconazole 4.662166429 19744259 1311351 8889330
MESH:D007898 Leishmaniasis, Visceral Ketoconazole 4.5111332679
MESH:D008064 Lipidoses marker/mechanism 15342952 16919414
MESH:D008064 Lipidoses Amiodarone 85.0715342952 17567588
MESH:D008064 Lipidoses Amitriptyline 85.0717567588 15342952
MESH:D008064 Lipidoses chlorcyclizine 85.0715342952
MESH:D008064 Lipidoses Chlorpromazine 85.0715342952 17567588
MESH:D008064 Lipidoses Citalopram 85.0717567588
MESH:D008064 Lipidoses Clozapine 85.0717567588
MESH:D008064 Lipidoses Fluoxetine 85.0717567588 15342952
MESH:D008064 Lipidoses Imipramine 85.0717567588 15342952
MESH:D008064 Lipidoses Ketoconazole 85.0717567588
MESH:D008064 Lipidoses Loratadine 85.0717567588
MESH:D008064 Lipidoses Perhexiline 85.0715342952 17567588
MESH:D008064 Lipidoses Sertraline 85.0717567588
MESH:D008064 Lipidoses Tamoxifen 85.0715342952 17567588
MESH:D008064 Lipidoses trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride 85.0715342952
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 1.7418564211
MESH:D008107 Liver Diseases Chlorpromazine 4.9714986274
MESH:D008107 Liver Diseases Folic Acid 4.9716877991
MESH:D008113 Liver Neoplasms Tamoxifen 2.2016684651
MESH:D008133 Long QT Syndrome Amiodarone 3.5417391786 15350150 11989578
MESH:D008171 Lung Diseases Amiodarone 3.3412587719
MESH:D017563 Lung Diseases, Interstitial Amiodarone 4.4518516814
MESH:D008175 Lung Neoplasms Tamoxifen 1.7418625569
MESH:D008180 Lupus Erythematosus, Systemic Folic Acid 3.3217718048
MESH:D016778 Malaria, Falciparum Perhexiline 5.9316882315
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.7219428831
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 2.5911731420 16827153 19196723 19196722 14580682
MESH:D020149 Manganese Poisoning Tamoxifen 4.5219453300
MESH:D019767 Maxillofacial Abnormalities Folic Acid 5.6616832597
MESH:D008545 Melanoma Tamoxifen 1.8712393984 19393235
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.1515990972
MESH:D001523 Mental Disorders Amitriptyline 42.7316856516
MESH:D001523 Mental Disorders Chlorpromazine 42.7316856516
MESH:D001523 Mental Disorders Citalopram 42.7316856516
MESH:D001523 Mental Disorders Clozapine 42.7316856516
MESH:D001523 Mental Disorders Doxepin 42.7316856516
MESH:D001523 Mental Disorders Fluoxetine 42.7316856516
MESH:D001523 Mental Disorders Imipramine 42.7316856516
MESH:D001523 Mental Disorders Sertraline 42.7316856516
MESH:D024821 Metabolic Syndrome X Clozapine 4.3719142101
MESH:D008881 Migraine Disorders Amitriptyline 4.7618803445
MESH:D009175 Mycoplasma Infections Chlorpromazine 5.9710773494
MESH:D009181 Mycoses Amiodarone 4.8712754197 17974566
MESH:D009207 Myoclonus Fluoxetine 5.848041377
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.5319393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5019410462
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 3.9719196722 19200415 19189210
MESH:D009436 Neural Tube Defects Folic Acid 3.9217438019
MESH:D009503 Neutropenia Folic Acid 4.4616322990
MESH:D009765 Obesity Clozapine 3.0119142110 18515891
MESH:D009771 Obsessive-Compulsive Disorder Fluoxetine 5.4020418887
MESH:D010146 Pain Amitriptyline 11.6912798668
MESH:D010146 Pain Fluoxetine 11.6912798668
MESH:D010146 Pain Imipramine 11.6912798668
MESH:D010195 Pancreatitis Trinitrobenzenesulfonic Acid 4.1617698068
MESH:D020774 Pick Disease of the Brain Fluoxetine 5.968041377
MESH:D011471 Prostatic Neoplasms Ketoconazole 3.7317404083
MESH:D011471 Prostatic Neoplasms Tamoxifen 3.7315067354
MESH:D011618 Psychotic Disorders Clozapine 4.1515331141
MESH:D011658 Pulmonary Fibrosis Amiodarone 2.8411597910 12490602 12832656
MESH:D051437 Renal Insufficiency Folic Acid 4.7415728788
MESH:D012559 Schizophrenia Clozapine 4.1120521320 20107430 18806925 20452607 20168265 19369910 11151749 17726453 17667964 20580759 16141801 18855531 17123785 11763009 20521326
MESH:D012559 Schizophrenia Folic Acid 4.1116641680
MESH:D020230 Serotonin Syndrome Fluoxetine 5.878704074
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 5.0518724381
MESH:D012871 Skin Diseases Folic Acid 3.2418709164
MESH:D012892 Sleep Deprivation Imipramine 6.1619798453
MESH:D007319 Sleep Initiation and Maintenance Disorders Amitriptyline 10.9915341891
MESH:D007319 Sleep Initiation and Maintenance Disorders Doxepin 10.9915341891
MESH:D013088 Spermatocele Tamoxifen 4.2616709447
MESH:D013118 Spinal Cord Diseases Folic Acid 5.4616361298
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.0019457130
MESH:D013274 Stomach Neoplasms Folic Acid 2.7017171786
MESH:D013276 Stomach Ulcer Amiodarone 3.2818087811
MESH:D020521 Stroke Folic Acid 4.2916517955
MESH:D013610 Tachycardia Amiodarone 4.2511238279
MESH:D017180 Tachycardia, Ventricular Amiodarone 4.1519225199
MESH:D013959 Thyroid Diseases Amiodarone 4.7319731979
MESH:D013971 Thyrotoxicosis Amiodarone 4.8218020914 19584973
MESH:D016171 Torsades de Pointes Amiodarone 10.9111989578 17467628
MESH:D016171 Torsades de Pointes Flecainide 10.9117467628
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 2.3417572228 16712894 8653321
MESH:D014581 Urticaria Loratadine 5.332568013
MESH:D015430 Weight Gain Clozapine 4.4320521320 17502770 16402076 20107430 20564506 16141801
MESH:D015431 Weight Loss Clozapine 5.0417933447
No data
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018