Chemical ID |
Chemical Name |
Interaction |
Interaction Action |
Publication |
---|
D001564 |
Benzo(a)pyrene |
Benzo(a)pyrene results in decreased expression of GNPTAB mRNA | decreases expression | 20064835
|
D015123 |
7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide |
7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of GNPTAB mRNA | decreases expression | 19150397
|
D016572 |
Cyclosporine |
Cyclosporine results in decreased expression of GNPTAB mRNA | decreases expression | 20106945
|
D004317 |
Doxorubicin |
GNPTAB protein affects the susceptibility to Doxorubicin | affects response to substance | 16217747
|
D014747 |
Vinblastine |
GNPTAB protein affects the susceptibility to Vinblastine | affects response to substance | 16217747
|
Disease ID |
Disease Name |
Direct Evidence |
Inference Chemical Name |
Inference Score |
Publication |
---|
MESH:D000230 |
Adenocarcinoma |
|
Benzo(a)pyrene |
4.69 | 20464547 20127859 |
MESH:D000230 |
Adenocarcinoma |
|
Doxorubicin |
4.69 | 17418594 |
MESH:D000236 |
Adenoma |
|
Benzo(a)pyrene |
2.84 | 6695378 |
MESH:D000419 |
Albuminuria |
|
Doxorubicin |
4.98 | 21441931 |
MESH:D017544 |
Aortic Aneurysm, Abdominal |
|
Benzo(a)pyrene |
4.56 | 19183758 |
MESH:D019046 |
Bone Marrow Neoplasms |
|
Doxorubicin |
5.31 | 14601052 |
MESH:D001932 |
Brain Neoplasms |
|
Doxorubicin |
4.16 | 17150277 |
MESH:D001943 |
Breast Neoplasms |
|
Benzo(a)pyrene |
2.20 | 20146248 17474063 |
MESH:D001943 |
Breast Neoplasms |
|
Doxorubicin |
2.20 | 16935488 16322301 18695136 15994142 16264153 18382427 18628466 15668708 15136595 17426702 15634643 15567936 19526202 16595493 15939500 15993339 17983394 18234424 16115903 16826403 16096432 15692762 17369602 11325840 |
MESH:D002276 |
Carcinoid Tumor |
|
Doxorubicin |
5.42 | 16051944 |
MESH:D006528 |
Carcinoma, Hepatocellular |
|
Doxorubicin |
2.26 | 18059187 17876044 16023760 16234567 |
MESH:D002292 |
Carcinoma, Renal Cell |
|
Doxorubicin |
7.43 | 1485588 16201981 |
MESH:D002292 |
Carcinoma, Renal Cell |
|
Vinblastine |
7.43 | 1485588 |
MESH:D002294 |
Carcinoma, Squamous Cell |
|
Benzo(a)pyrene |
4.97 | 20419170 |
MESH:D002294 |
Carcinoma, Squamous Cell |
|
Doxorubicin |
4.97 | 6189445 |
MESH:D009202 |
Cardiomyopathies |
|
Doxorubicin |
3.74 | 16269455 17928571 16651473 17308081 17351982 15811867 17519947 17007740 15476868 17974986 18627295 16952015 17131338 16278810 17329180 16455267 16364871 16612575 15792986 16242529 15505089 17924179 16109756 17382496 16731534 |
MESH:D002311 |
Cardiomyopathy, Dilated |
|
Doxorubicin |
3.04 | 16243910 17334414 |
MESH:D002471 |
Cell Transformation, Neoplastic |
|
7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide |
7.35 | 20889678 |
MESH:D002471 |
Cell Transformation, Neoplastic |
|
Cyclosporine |
7.35 | 12371664 |
MESH:D002779 |
Cholestasis |
|
Cyclosporine |
3.17 | 19486331 |
MESH:D015179 |
Colorectal Neoplasms |
|
Doxorubicin |
2.99 | 18259882 18802399 |
MESH:D015179 |
Colorectal Neoplasms |
|
Vinblastine |
2.99 | 18802399 |
MESH:D056486 |
Drug-Induced Liver Injury |
|
Doxorubicin |
2.52 | 17416283 |
MESH:D004362 |
Drug Toxicity |
|
Doxorubicin |
3.93 | 18602426 |
MESH:D016889 |
Endometrial Neoplasms |
|
Doxorubicin |
3.67 | 17359293 |
MESH:D004719 |
Endomyocardial Fibrosis |
|
Doxorubicin |
5.77 | 18037988 |
MESH:D004938 |
Esophageal Neoplasms |
|
7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide |
4.59 | 20426865 |
MESH:D004938 |
Esophageal Neoplasms |
|
Benzo(a)pyrene |
4.59 | 16530937 |
MESH:D005234 |
Fatty Liver |
|
Cyclosporine |
3.23 | 19224547 |
MESH:D018222 |
Fibromatosis, Aggressive |
|
Doxorubicin |
5.13 | 19069698 |
MESH:D005355 |
Fibrosis |
|
Cyclosporine |
3.62 | 12168785 12639820 |
MESH:D005885 |
Gingival Hyperplasia |
|
Cyclosporine |
4.76 | 8708960 |
MESH:D005909 |
Glioblastoma |
|
Doxorubicin |
3.56 | 17150277 |
MESH:D006258 |
Head and Neck Neoplasms |
|
Doxorubicin |
3.75 | 15692506 |
MESH:D006330 |
Heart Defects, Congenital |
|
Benzo(a)pyrene |
2.82 | 20471113 |
MESH:D006331 |
Heart Diseases |
|
Doxorubicin |
3.72 | 18006777 16244371 16879835 12587719 14766674 18674790 16495754 16144979 16244372 16330681 17875725 16707910 17888722 |
MESH:D006333 |
Heart Failure |
|
Doxorubicin |
3.54 | 17481944 |
MESH:D006394 |
Hemangiosarcoma |
|
Doxorubicin |
4.27 | 15692506 |
MESH:D006457 |
Hemoglobinuria, Paroxysmal |
|
Cyclosporine |
4.96 | 15720958 |
MESH:D006689 |
Hodgkin Disease |
|
Doxorubicin |
8.89 | 18501091 17606976 15147373 |
MESH:D006689 |
Hodgkin Disease |
|
Vinblastine |
8.89 | 18501091 18180244 |
MESH:D006973 |
Hypertension |
|
Cyclosporine |
2.20 | 10903974 |
MESH:D007638 |
Keratoconjunctivitis Sicca |
|
Cyclosporine |
5.05 | 15604871 |
MESH:D007674 |
Kidney Diseases |
|
Cyclosporine |
6.72 | 18776723 10903974 8314463 |
MESH:D007674 |
Kidney Diseases |
|
Doxorubicin |
6.72 | 15369732 15699352 16775033 |
MESH:D007676 |
Kidney Failure, Chronic |
|
Doxorubicin |
4.53 | 16707910 |
MESH:D007680 |
Kidney Neoplasms |
|
Cyclosporine |
3.04 | 12371664 |
MESH:D004915 |
Leukemia, Erythroblastic, Acute |
|
Doxorubicin |
5.77 | 16085563 |
MESH:D008106 |
Liver Cirrhosis, Experimental |
|
Doxorubicin |
2.15 | 16439617 16595196 |
MESH:D008113 |
Liver Neoplasms |
|
Benzo(a)pyrene |
2.14 | 21137059 20195826 |
MESH:D008114 |
Liver Neoplasms, Experimental |
|
Doxorubicin |
3.21 | 17085340 16842330 |
MESH:D008175 |
Lung Neoplasms |
|
Benzo(a)pyrene |
2.60 | 20464547 18520028 18569708 20135361 20869020 17053015 18816296 6695378 20064080 |
MESH:D008175 |
Lung Neoplasms |
|
Doxorubicin |
2.60 | 17418594 6189445 |
MESH:D008223 |
Lymphoma |
|
Doxorubicin |
3.70 | 16098063 |
MESH:D008228 |
Lymphoma, Non-Hodgkin |
|
Doxorubicin |
4.09 | 17654614 |
MESH:D016399 |
Lymphoma, T-Cell |
|
Doxorubicin |
5.05 | 15621674 |
MESH:D008325 |
Mammary Neoplasms, Experimental |
|
Doxorubicin |
3.24 | 15458769 |
MESH:D008545 |
Melanoma |
|
Doxorubicin |
3.94 | 16827129 |
MESH:D008545 |
Melanoma |
|
Vinblastine |
3.94 | 16248763 18176117 16809738 12374674 15577323 15577320 17761969 18332650 16432458 18505091 |
MESH:D008654 |
Mesothelioma |
|
Doxorubicin |
3.17 | 17638057 |
MESH:D008664 |
Metal Metabolism, Inborn Errors |
|
Cyclosporine |
5.40 | 16801185 |
MESH:D028361 |
Mitochondrial Diseases |
|
Doxorubicin |
4.87 | 15792986 |
MESH:D009062 |
Mouth Neoplasms |
|
Benzo(a)pyrene |
3.46 | 16381670 |
OMIM:252500 |
MUCOLIPIDOSIS II ALPHA/BETA |
marker/mechanism |
|
| |
OMIM:252600 |
MUCOLIPIDOSIS III ALPHA/BETA |
marker/mechanism |
|
| |
MESH:D052016 |
Mucositis |
|
Doxorubicin |
5.33 | 17415656 |
MESH:D009203 |
Myocardial Infarction |
|
Doxorubicin |
3.07 | 19429709 15857846 |
MESH:D009362 |
Neoplasm Metastasis |
|
Doxorubicin |
3.07 | 18259882 |
MESH:D009369 |
Neoplasms |
|
Benzo(a)pyrene |
2.31 | 11141357 |
MESH:D009401 |
Nephrosis |
|
Doxorubicin |
5.25 | 16636307 16899518 |
MESH:D009402 |
Nephrosis, Lipoid |
|
Cyclosporine |
5.05 | 17954296 |
MESH:D009404 |
Nephrotic Syndrome |
|
Cyclosporine |
10.40 | 18481113 19348381 |
MESH:D009404 |
Nephrotic Syndrome |
|
Doxorubicin |
10.40 | 16889571 15640375 |
MESH:D009447 |
Neuroblastoma |
|
Doxorubicin |
3.42 | 15555623 |
MESH:D009503 |
Neutropenia |
|
Vinblastine |
4.97 | 17378895 |
MESH:D012516 |
Osteosarcoma |
|
Doxorubicin |
4.40 | 15930896 |
MESH:D003557 |
Phyllodes Tumor |
|
Doxorubicin |
5.77 | 17983394 |
MESH:D010997 |
Pleural Neoplasms |
|
Doxorubicin |
5.77 | 17638057 |
MESH:D011230 |
Precancerous Conditions |
|
Cyclosporine |
3.55 | 12371664 |
MESH:D011471 |
Prostatic Neoplasms |
|
Benzo(a)pyrene |
3.21 | 17292933 |
MESH:D011471 |
Prostatic Neoplasms |
|
Doxorubicin |
3.21 | 16868541 16729912 16888761 18437689 15749863 15897917 |
MESH:D011565 |
Psoriasis |
|
Cyclosporine |
2.32 | 16882103 |
MESH:D051437 |
Renal Insufficiency |
|
Doxorubicin |
4.70 | 17922066 |
MESH:D012509 |
Sarcoma |
|
Doxorubicin |
4.34 | 17203757 16767912 17710206 15625365 15675481 18313854 |
MESH:D012512 |
Sarcoma, Ewing's |
|
Doxorubicin |
4.68 | 14601052 16326096 |
MESH:D012514 |
Sarcoma, Kaposi |
|
Doxorubicin |
5.33 | 17846226 |
MESH:D012878 |
Skin Neoplasms |
|
Benzo(a)pyrene |
6.28 | 10029692 19755658 |
MESH:D012878 |
Skin Neoplasms |
|
Doxorubicin |
6.28 | 15692506 |
MESH:D012983 |
Soft Tissue Neoplasms |
|
Doxorubicin |
5.05 | 17203757 15625365 16767912 |
MESH:D013274 |
Stomach Neoplasms |
|
Benzo(a)pyrene |
1.56 | 20155912 2093021 |
MESH:D013964 |
Thyroid Neoplasms |
|
Doxorubicin |
3.64 | 17909728 16010429 |
MESH:D001749 |
Urinary Bladder Neoplasms |
|
Benzo(a)pyrene |
5.53 | 17053015 |
MESH:D001749 |
Urinary Bladder Neoplasms |
|
Doxorubicin |
5.53 | 17653716 |
MESH:D014605 |
Uveitis |
|
Cyclosporine |
4.59 | 1336536 |
MESH:D014625 |
Vaginal Neoplasms |
|
Vinblastine |
5.53 | 15577323 |
MESH:D018487 |
Ventricular Dysfunction, Left |
|
Doxorubicin |
4.70 | 17638931 17678736 16364871 17334414 |
MESH:D014985 |
Xerophthalmia |
|
Cyclosporine |
5.05 | 17120751 |