AutismKB 2.0

Annotation Detail for C7orf23


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Basic Information Top
Gene Symbol:C7orf23 ( MGC4175,MM-TRAG )
Gene Full Name: chromosome 7 open reading frame 23
Band: 7q21.1-q21.2
Quick LinksEntrez ID:79161; OMIM: NA; Uniprot ID:CG023_HUMAN; ENSEMBL ID: ENSG00000135185; HGNC ID:
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of C7ORF23 proteinaffects expression 20106945
D016572 Cyclosporine Cyclosporine results in increased expression of C7ORF23 mRNAincreases expression 20106945
D004317 Doxorubicin C7ORF23 mRNA results in decreased susceptibility to Doxorubicindecreases response to substance 15556294
D004317 Doxorubicin Doxorubicin results in increased expression of C7ORF23 mRNAincreases expression 15556294
18510171
D017239 Paclitaxel C7ORF23 mRNA results in decreased susceptibility to Paclitaxeldecreases response to substance 15556294
D017239 Paclitaxel Paclitaxel results in increased expression of C7ORF23 mRNAincreases expression 15556294
D012643 Selenium Selenium results in decreased expression of C7ORF23 mRNAdecreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000230 Adenocarcinoma Doxorubicin 2.6317418594
MESH:D000419 Albuminuria Doxorubicin 4.9821441931
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 5.3114601052
MESH:D001859 Bone Neoplasms Paclitaxel 4.9715867366
MESH:D001932 Brain Neoplasms Doxorubicin 4.1617150277
MESH:D001943 Breast Neoplasms Doxorubicin 2.5218382427 17426702 15692762 16595493 18628466 17369602 15939500 18234424 15993339 15634643 15136595 16935488 15994142 15668708 18695136 17983394 16264153 15567936 16826403 16322301 11325840 16115903 16096432 19526202
MESH:D001943 Breast Neoplasms Paclitaxel 2.5218323546 16115903 15136595 11325840 18234424 16273361 18223236 16244791
MESH:D002276 Carcinoid Tumor Doxorubicin 5.4216051944
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 5.0012907637 12619106 21507988
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 5.0017876044 16023760 18059187 16234567
MESH:D006528 Carcinoma, Hepatocellular Paclitaxel 5.0016313753
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 3.301485588 16201981
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 2.716189445
MESH:D009202 Cardiomyopathies Doxorubicin 3.7417924179 16952015 15792986 17007740 16731534 16242529 17382496 17928571 16109756 16455267 16269455 16612575 17974986 16278810 15505089 15811867 18627295 16364871 15476868 17131338 17519947 16651473 17308081 17329180 17351982
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 3.0417334414 16243910
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 2.7612371664
MESH:D002779 Cholestasis Cyclosporine 3.1719486331
MESH:D003092 Colitis Selenium 4.2617936198
MESH:D015179 Colorectal Neoplasms Doxorubicin 2.8818259882 18802399
MESH:D015179 Colorectal Neoplasms Paclitaxel 2.8818802399
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 4.3817416283
MESH:D056486 Drug-Induced Liver Injury Selenium 4.3815131321
MESH:D004362 Drug Toxicity Doxorubicin 3.9318602426
MESH:D016889 Endometrial Neoplasms Doxorubicin 3.6717359293
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 5.7718037988
MESH:D004938 Esophageal Neoplasms Paclitaxel 2.9616481741
MESH:D005234 Fatty Liver Cyclosporine 3.2319224547
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 5.1319069698
MESH:D005355 Fibrosis Cyclosporine 3.6212168785 12639820
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.768708960
MESH:D005909 Glioblastoma Doxorubicin 3.5617150277
MESH:D006258 Head and Neck Neoplasms Doxorubicin 3.7515692506
MESH:D006331 Heart Diseases Doxorubicin 3.7217875725 16144979 16495754 14766674 16244372 16244371 18006777 18674790 16707910 16330681 16879835 12587719 17888722
MESH:D006333 Heart Failure Doxorubicin 7.9217481944
MESH:D006333 Heart Failure Selenium 7.9217162251
MESH:D006394 Hemangiosarcoma Doxorubicin 4.2715692506
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.9615720958
MESH:D006689 Hodgkin Disease Doxorubicin 3.7318501091 15147373 17606976
MESH:D006973 Hypertension Cyclosporine 2.2010903974
MESH:D007251 Influenza, Human Selenium 4.8116624496
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 5.0515604871
MESH:D007674 Kidney Diseases Cyclosporine 6.728314463 18776723 10903974
MESH:D007674 Kidney Diseases Doxorubicin 6.7215369732 16775033 15699352
MESH:D007676 Kidney Failure, Chronic Doxorubicin 11.2516707910
MESH:D007676 Kidney Failure, Chronic Selenium 11.2516518626
MESH:D007680 Kidney Neoplasms Cyclosporine 3.0412371664
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 5.7716085563
MESH:D008080 Liposarcoma Paclitaxel 5.2317353645
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 2.1516595196 16439617
MESH:D008113 Liver Neoplasms Aflatoxin B1 2.4518177683 15890375 2125692 9163691
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 6.838603461
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 6.8317085340 16842330
MESH:D008175 Lung Neoplasms Aflatoxin B1 2.7114755239
MESH:D008175 Lung Neoplasms Doxorubicin 2.7117418594 6189445
MESH:D008223 Lymphoma Doxorubicin 3.7016098063
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 10.0017654614
MESH:D008228 Lymphoma, Non-Hodgkin Paclitaxel 10.0014749477
MESH:D016399 Lymphoma, T-Cell Doxorubicin 5.0515621674
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 6.9115458769
MESH:D008325 Mammary Neoplasms, Experimental Selenium 6.9115318939
MESH:D008545 Melanoma Doxorubicin 3.8316827129
MESH:D008545 Melanoma Paclitaxel 3.8316342250 12025231 12040289
MESH:D008654 Mesothelioma Doxorubicin 6.6717638057
MESH:D008654 Mesothelioma Selenium 6.6715107826
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.4016801185
MESH:D028361 Mitochondrial Diseases Doxorubicin 4.8715792986
MESH:D052016 Mucositis Doxorubicin 5.3317415656
MESH:D009101 Multiple Myeloma Paclitaxel 3.9314749477
MESH:D009203 Myocardial Infarction Doxorubicin 3.0715857846 19429709
MESH:D009362 Neoplasm Metastasis Doxorubicin 6.5218259882
MESH:D009362 Neoplasm Metastasis Paclitaxel 6.5215867366
MESH:D009401 Nephrosis Doxorubicin 5.2516899518 16636307
MESH:D009402 Nephrosis, Lipoid Cyclosporine 5.0517954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 10.4019348381 18481113
MESH:D009404 Nephrotic Syndrome Doxorubicin 10.4015640375 16889571
MESH:D009447 Neuroblastoma Doxorubicin 3.4215555623
MESH:D010014 Osteolysis Paclitaxel 5.5215867366
MESH:D012516 Osteosarcoma Doxorubicin 4.4015930896
MESH:D010051 Ovarian Neoplasms Paclitaxel 3.0711161223
MESH:D003557 Phyllodes Tumor Doxorubicin 5.7717983394
MESH:D010954 Plasmacytoma Selenium 5.5015087411
MESH:D010997 Pleural Neoplasms Doxorubicin 5.7717638057
MESH:D011230 Precancerous Conditions Cyclosporine 3.5512371664
MESH:D011471 Prostatic Neoplasms Doxorubicin 3.5315897917 16888761 18437689 16868541 16729912 15749863
MESH:D011471 Prostatic Neoplasms Paclitaxel 3.5317172428 16729912 16356831 17136230
MESH:D011565 Psoriasis Cyclosporine 2.3216882103
MESH:D051437 Renal Insufficiency Doxorubicin 4.7017922066
MESH:D012509 Sarcoma Doxorubicin 4.3418313854 16767912 15675481 17710206 17203757 15625365
MESH:D012512 Sarcoma, Ewing's Doxorubicin 4.6816326096 14601052
MESH:D012514 Sarcoma, Kaposi Doxorubicin 5.3317846226
MESH:D012878 Skin Neoplasms Doxorubicin 3.0915692506
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 5.0515625365 16767912 17203757
MESH:D013274 Stomach Neoplasms Paclitaxel 2.4518506536 18396642
MESH:D024801 Tauopathies Paclitaxel 5.3516930453
MESH:D013964 Thyroid Neoplasms Doxorubicin 3.6417909728 16010429
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 2.8717653716
MESH:D014605 Uveitis Cyclosporine 4.591336536
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 4.7017334414 17638931 17678736 16364871
MESH:D014985 Xerophthalmia Cyclosporine 5.0517120751
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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