AutismKB 2.0

Annotation Detail for CRELD2


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Basic Information Top
Gene Symbol:CRELD2 ( DKFZp667O055,MGC11256 )
Gene Full Name: cysteine-rich with EGF-like domains 2
Band: 22q13.33
Quick LinksEntrez ID:79174; OMIM: 607171; Uniprot ID:CREL2_HUMAN; ENSEMBL ID: ENSG00000184164; HGNC ID: 28150
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C049325 1,2-dithiol-3-thione 1,2-dithiol-3-thione results in increased expression of CRELD2 mRNAincreases expression 15302862
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of CRELD2 mRNAaffects expression 21346803
C035207 4-amino-2,6-dinitrotoluene 4-amino-2,6-dinitrotoluene affects the expression of CRELD2 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of CRELD2 mRNAaffects expression 17562736
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of CRELD2 mRNAaffects expression 17484886
D002995 Clofibric Acid [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of CRELD2 mRNAaffects cotreatment|affects expression 17602206
C030123 coumarin coumarin results in increased expression of CRELD2 mRNAincreases expression 18480146
D016572 Cyclosporine Cyclosporine results in increased expression of CRELD2 mRNAincreases expression 20106945
D003687 Dehydroepiandrosterone Dehydroepiandrosterone results in increased expression of CRELD2 mRNAincreases expression 18709148
D004041 Dietary Fats Dietary Fats results in increased expression of CRELD2 mRNAincreases expression 18042831
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of CRELD2 mRNAaffects cotreatment|affects expression 17602206
D004958 Estradiol Estradiol results in increased expression of CRELD2 mRNAincreases expression 18709148
17823450
C041786 palm oil palm oil results in increased expression of CRELD2 mRNAincreases expression 18042831
C023036 perfluorooctanoic acid perfluorooctanoic acid results in decreased expression of CRELD2 mRNAdecreases expression 18709148
C006253 pirinixic acid pirinixic acid results in decreased expression of CRELD2 mRNAdecreases expression 17426115
C006253 pirinixic acid pirinixic acid results in increased expression of CRELD2 mRNAincreases expression 18301758
D011374 Progesterone Progesterone affects the expression of CRELD2 mRNAaffects expression 17251523
C423915 TO-901317 TO-901317 results in decreased expression of CRELD2 mRNAdecreases expression 15302862
D014303 Trinitrotoluene Trinitrotoluene affects the expression of CRELD2 mRNAaffects expression 21346803
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced 4-amino-2,6-dinitrotoluene 8.867525203
MESH:D000014 Abnormalities, Drug-Induced Trinitrotoluene 8.867525203
MESH:D055371 Acute Lung Injury pirinixic acid 3.0818653653
MESH:D000230 Adenocarcinoma Estradiol 2.0911473722
MESH:D000236 Adenoma Diethylnitrosamine 2.8210737359 6695378
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 9.9816434500 19061943 17162532 19052882 18056438 17620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 9.9816434500
MESH:D000309 Adrenal Insufficiency Dehydroepiandrosterone 5.7217302879
MESH:D000799 Angioedema Acetaminophen 3.8110982225
MESH:D001161 Arteriosclerosis Dietary Fats 3.8515238619
MESH:D001321 Autistic Disorder Acetaminophen 1.4218445737
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.1119483382
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.3117868700
MESH:D001930 Brain Injuries Progesterone 4.2215845082 15665606 15380490
MESH:D001943 Breast Neoplasms Dietary Fats 1.9620435547
MESH:D001943 Breast Neoplasms Diethylnitrosamine 1.9617474063
MESH:D001943 Breast Neoplasms Estradiol 1.9617289903 14630087 12948864 17261762 16675129 18497071 17018787 19861407
MESH:D001943 Breast Neoplasms Progesterone 1.9616175315 15562024 17614352
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.4316111702
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.743786805 16227642 10355542 15700767 16011737 16050911 16097048 16192424 16124888 15673190 18705752 15721981
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 8.7916705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 8.793084413
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 8.7918788625
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 8.7910672840 16569478 19335982 18393292 19418558 17138121 18494052 20727157 18978308 17978847 10737359 16328049 20084675 18506893 18665156 16502159 18785209 19208518 16878318 17761372 18691550 19171122 3581430 20214788 19919837 16935385 20512989 17055752 18971187 16288022 19383236 17173139 20432363 20007298 18056438 16779866 16540662 18210153 19107877 21159647 16681979 20524982 17428255 19052882 20935162 19822196 18788625 19701751 16807293 19539802 20514400 11831363 19394651 3084413 19519916 20101231 17162532 16698587 16830150
MESH:D006528 Carcinoma, Hepatocellular Estradiol 8.7916924424
MESH:D002386 Cataract 4-amino-2,6-dinitrotoluene 12.3314694615
MESH:D002386 Cataract Acetaminophen 12.3310977129
MESH:D002386 Cataract Trinitrotoluene 12.3314694615 15817613
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 10.9812371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 10.987505956 2727394 17174075 21159647
MESH:D002471 Cell Transformation, Neoplastic Estradiol 10.9818566989
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 3.6519052882
MESH:D002779 Cholestasis Cyclosporine 7.6519486331
MESH:D002779 Cholestasis pirinixic acid 7.6519176532
MESH:D000013 Congenital Abnormalities 4-amino-2,6-dinitrotoluene 9.5515095906
MESH:D000013 Congenital Abnormalities Trinitrotoluene 9.5515095906
MESH:D003490 Cyanosis 2,4-dinitrotoluene 11.1018551238
MESH:D003490 Cyanosis Trinitrotoluene 11.1018551238
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4018249437
MESH:D003922 Diabetes Mellitus, Type 1 Dehydroepiandrosterone 3.6816616286
MESH:D003924 Diabetes Mellitus, Type 2 coumarin 4.7519647726
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 4.7520387270
MESH:D003928 Diabetic Nephropathies Estradiol 3.3719279558
MESH:D003929 Diabetic Neuropathies Progesterone 4.4517187935
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 15.1118551238 21346803
MESH:D056486 Drug-Induced Liver Injury 4-amino-2,6-dinitrotoluene 15.1121346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 15.1114550746 15968718 17562736 19085960 11529661 16109766 10663392 16177239 19370779 11287661 15619225 19416960 16393943 11743745 12392966 18071297 18713872 14725611 10774834 11461765 12540782 11739529 12153990 17906064 19420014 10915739 12958197 12705907 11421492 19739265 12594235 16081117 19923254 16781746 2444490 17522070 16485898 11834606 16227642 14986274 19164858
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 15.119327722 10915739 7440962 6884620 2869522 21278145 15968718 7179309 16177239 7120509 4309450 3732212 17522070 19336974 16227642 11566570 19085960 15027814 15998439 3786805 6623471 10092053
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 15.1119107877
MESH:D056486 Drug-Induced Liver Injury Trinitrotoluene 15.1121346803 18551238
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.0719426721
MESH:D050171 Dyslipidemias Dietary Fats 3.4218367378
MESH:D004487 Edema perfluorooctanoic acid 6.8512083418 17259670
MESH:D004487 Edema pirinixic acid 6.8512083418
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 3.7417692515
MESH:D016889 Endometrial Neoplasms Estradiol 2.9518566989 11473722 19148513
MESH:D004715 Endometriosis Progesterone 3.7316134523
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.0916302075
MESH:D005234 Fatty Liver Carbon Tetrachloride 24.2212795759 16239168 19224547 15959796 16045604 12631006 61145 17595544
MESH:D005234 Fatty Liver Cyclosporine 24.2219224547
MESH:D005234 Fatty Liver Dietary Fats 24.2217967931 18296743 19551842 19004024
MESH:D005234 Fatty Liver Diethylnitrosamine 24.2221071580 20387270
MESH:D005234 Fatty Liver pirinixic acid 24.2219236843 20131406
MESH:D005355 Fibrosis Carbon Tetrachloride 14.5718705752
MESH:D005355 Fibrosis Cyclosporine 14.5712168785 12639820
MESH:D005355 Fibrosis Dietary Fats 14.5718296743
MESH:D005756 Gastritis Acetaminophen 3.6516983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.188708960
MESH:D006333 Heart Failure pirinixic acid 2.5120558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.3915720958
MESH:D006505 Hepatitis Carbon Tetrachloride 3.5519900420 19110552
MESH:D006529 Hepatomegaly perfluorooctanoic acid 14.423609246
MESH:D006529 Hepatomegaly pirinixic acid 14.4216221962 19176532 19772884 18467677
MESH:D006529 Hepatomegaly Trinitrotoluene 14.4215817613
MESH:D006558 Herpes Genitalis Estradiol 5.0015709030
MESH:D019584 Hot Flashes Estradiol 3.7217088409
MESH:D006930 Hyperalgesia Acetaminophen 7.7416870215
MESH:D006930 Hyperalgesia perfluorooctanoic acid 7.7412083418
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.5016899240
MESH:D006937 Hypercholesterolemia Dietary Fats 3.5521332399
MESH:D006943 Hyperglycemia pirinixic acid 3.1420558911
MESH:D006949 Hyperlipidemias Dietary Fats 3.5721332399
MESH:D006973 Hypertension Cyclosporine 2.0810903974
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.0515338365
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.3615869954
MESH:D007248 Infertility, Male Trinitrotoluene 3.6512150543
MESH:D007249 Inflammation Dietary Fats 11.8320412841
MESH:D007249 Inflammation Diethylnitrosamine 11.8318785209
MESH:D007249 Inflammation perfluorooctanoic acid 11.8312083418
MESH:D007249 Inflammation Progesterone 11.8315869954
MESH:D007333 Insulin Resistance Dietary Fats 12.1218457598 11836018
MESH:D007333 Insulin Resistance Estradiol 12.1216393666 16627594
MESH:D007333 Insulin Resistance pirinixic acid 12.1216306350
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.4115604871
MESH:D007674 Kidney Diseases Acetaminophen 9.8312587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 9.8318776723 8314463 10903974
MESH:D007674 Kidney Diseases Estradiol 9.8315618244
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 12.1516705839
MESH:D007680 Kidney Neoplasms Cyclosporine 12.1512371664
MESH:D007680 Kidney Neoplasms Estradiol 12.1515610895
MESH:D007984 Leydig Cell Tumor perfluorooctanoic acid 5.198812269
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 10.8811408273 16239168 17174718 21278145 17334410 16221502 11903743 17157831 16943688
MESH:D008103 Liver Cirrhosis Dietary Fats 10.8818296743
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 10.8819638242 18665156 18407596 20032147 18522880
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 3.4212898905 12586293 17761835 18481824 18006644 16027843 15818738 18339082 12649538 18187930 14620537 18418968 15925388 12632512 17922224 15893842 16638106 18166357 16136751 18156304 12445418 16116963 17708605 12741479 14716496 15057751 17557913 18429990 14512876 15362042 15370692 11481614 12666154 12445421 17823541 18210741 18376398 20821823 17481882 15650968 18251166 18395914 18054572 18412020 15931870 15730626 12632514 16248980 17714472 10355542 17698563 17805973 18472094 16192424 17869086 12667390 12389079 13678700 18277467 15996030 15959796 17631135 18472332 17525996 16097048 14724832 18420326 15052691 18263696 17944888 16015684 17640975 18395095 17766677 16011737 18205269 14716833 18317297 14748882 12546737 12609069 17721639 16033810 15876570 17900296 17565644 17976157 15338365 15123356 18279442 15673190 18705752 12958196
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 3.4214716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.4215474484
MESH:D008107 Liver Diseases Acetaminophen 6.4116610002 19014921 12969438 19784758 16611625 19460945 11587558 12587719
MESH:D008107 Liver Diseases Carbon Tetrachloride 6.4115720792 15830285 17285989 16246199 16964402
MESH:D008107 Liver Diseases Diethylnitrosamine 6.4117034775
MESH:D017093 Liver Failure Carbon Tetrachloride 4.1215123358
MESH:D017114 Liver Failure, Acute Acetaminophen 9.2816871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 9.2814706259 16899240
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 17.7919294768
MESH:D008113 Liver Neoplasms Clofibric Acid 17.7917602206
MESH:D008113 Liver Neoplasms Dehydroepiandrosterone 17.7918709148
MESH:D008113 Liver Neoplasms Diethylnitrosamine 17.7919090486 18648771 18978307 20101389 20583210 19254457 15885732 21278145 20492335 15175105 21047994 19499222 10737359 19812893 19642983 20137499 20405173 19294768 19427195 12771043 19255062 12112319 2862719 19638242 19850985 18977376 20501860 20452335 21071580 19073162 19551842 19690152 2422723 18754104 19256749 16942905 19996281 18644402 9163691 19426721 21167192 19833225 20434301 20118626
MESH:D008113 Liver Neoplasms perfluorooctanoic acid 17.7914757943 18709148
MESH:D008113 Liver Neoplasms pirinixic acid 17.7916377806 20007298 15890375
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 9.8715583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Dehydroepiandrosterone 9.878603461
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 9.8719519916 18079962 17942915 18775883 16267830 18544905 9362446 19126423 18282651 18164116 19004024 17854601 18093689 3124819 19539802 21159647 18253720 19009564 16842330 17174075 2563599 18308698
MESH:D008175 Lung Neoplasms Diethylnitrosamine 1.7621163286 20512841 20970405 6695378
MESH:D008325 Mammary Neoplasms, Experimental Dehydroepiandrosterone 9.9816457693
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 9.9811807958 17203775 16891317 11408345
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 9.9811408345 17203775
MESH:D020149 Manganese Poisoning Estradiol 4.4519453300
MESH:D008546 Melanoma, Experimental Acetaminophen 3.5319513568
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.7616801185
MESH:D009135 Muscular Diseases pirinixic acid 3.4716239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.1219151258
MESH:D015428 Myocardial Reperfusion Injury Estradiol 8.1316810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 8.1316411023
MESH:D009336 Necrosis 2,4-dinitrotoluene 10.5618551238
MESH:D009336 Necrosis Trinitrotoluene 10.5618551238
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.553581430 9029167
MESH:D009369 Neoplasms pirinixic acid 1.9317405874
MESH:D009389 Neovascularization, Pathologic Estradiol 3.7017289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.4117954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.2418481113 19348381
MESH:D009421 Nervous System Malformations Estradiol 3.6116427766 11399458
MESH:D019636 Neurodegenerative Diseases Acetaminophen 8.0618514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 8.0620387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.0920387270
MESH:D052556 Niemann-Pick Disease, Type C perfluorooctanoic acid 4.919802331
MESH:D009765 Obesity Dietary Fats 4.4020518802 21332399 20132043 11836018 19632207 16723640 17217161 18457598 18674790
MESH:D009765 Obesity pirinixic acid 4.4020558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 15.0512819281 16049721
MESH:D009784 Occupational Diseases 4-amino-2,6-dinitrotoluene 15.0514694615
MESH:D009784 Occupational Diseases Trinitrotoluene 15.0512819281 17852074 14694615
MESH:D015663 Osteoporosis, Postmenopausal Dehydroepiandrosterone 4.9916397352
MESH:D010051 Ovarian Neoplasms Estradiol 4.8219401270
MESH:D010051 Ovarian Neoplasms Progesterone 4.8217393432 16525653
MESH:D010146 Pain Acetaminophen 2.3516870215
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 2.4116540662
MESH:D011230 Precancerous Conditions Cyclosporine 8.8212371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 8.822563599
MESH:D011297 Prenatal Exposure Delayed Effects perfluorooctanoic acid 4.3617132714
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.8420887781
MESH:D011471 Prostatic Neoplasms Estradiol 3.1016740699
MESH:D011565 Psoriasis Cyclosporine 2.2116882103
MESH:D015427 Reperfusion Injury pirinixic acid 2.3619058328
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.8418045962
MESH:D012640 Seizures 2,4-dinitrotoluene 6.1018551238
MESH:D012640 Seizures Trinitrotoluene 6.1018551238
MESH:D013119 Spinal Cord Injuries Progesterone 4.2416503802 15862959
MESH:D013163 Splenomegaly Trinitrotoluene 5.1615817613
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 1.7518456281
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 2.957505956
MESH:D013978 Tibial Fractures Estradiol 4.6619048282
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 2.2716049721
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.2810091137
MESH:D014581 Urticaria Acetaminophen 2.9410982225
MESH:D014605 Uveitis Cyclosporine 3.961336536
MESH:D014689 Venous Insufficiency coumarin 5.7512708602
MESH:D015430 Weight Gain Dietary Fats 3.7016723640
MESH:D014985 Xerophthalmia Cyclosporine 4.4117120751
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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