AutismKB 2.0

Annotation Detail for THOC6


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Basic Information Top
Gene Symbol:THOC6 ( MGC2655,WDR58,fSAP35 )
Gene Full Name: THO complex 6 homolog (Drosophila)
Band: 16p13.3
Quick LinksEntrez ID:79228; OMIM: NA; Uniprot ID:THOC6_HUMAN; ENSEMBL ID: ENSG00000131652; HGNC ID: 28369
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of THOC6 mRNAaffects expression 21346803
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of THOC6 mRNAdecreases expression 20106945
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of THOC6 mRNAdecreases expression 15336504
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 2.0620464547 20127859
MESH:D000236 Adenoma Benzo(a)pyrene 2.886695378
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.7319183758
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.9917474063 20146248
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 1.7916705839
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.1420419170
MESH:D003490 Cyanosis 2,4-dinitrotoluene 4.6718551238
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 2.0618551238 21346803
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 2.0916530937
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.8520471113
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 3.3616705839
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 2.1721137059 20195826
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 1.5718520028 18816296 20464547 18569708 20064080 17053015 6695378 20135361 20869020
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.5316381670
MESH:D009336 Necrosis 2,4-dinitrotoluene 4.6018551238
MESH:D009369 Neoplasms Benzo(a)pyrene 2.3511141357
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 3.8812819281 16049721
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.9017292933
MESH:D012640 Seizures 2,4-dinitrotoluene 2.8118551238
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 6.2919755658 10029692
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 6.298532709
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.562093021 20155912
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 5.4316049721
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 5.4317053015
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 5.0610091137
Pathway ID Pathway Name
KEGG:03013 RNA transport
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA142670592
    • No data
    No data
    Releated drug ID Related drug Name
    PA449014cisplatin
    Drug Bank Top

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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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