AutismKB 2.0

Annotation Detail for BCL2L14


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:BCL2L14 ( BCLG )
Gene Full Name: BCL2-like 14 (apoptosis facilitator)
Band: 12p13.2
Quick LinksEntrez ID:79370; OMIM: 606126; Uniprot ID:B2L14_HUMAN; ENSEMBL ID: ENSG00000121380; HGNC ID: 16657
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
No data
Pathway IDPathway Name
200101Direct p53 effectors
No data
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1976Squamous cell cancer
2125Bladder cancer
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of BCL2L14 mRNAaffects expression 17562736
D000082 Acetaminophen MAP3K5 protein affects the reaction [Acetaminophen results in increased expression of BCL2L14 mRNA]affects reaction|increases expression 18700144
C006632 arsenic trioxide arsenic trioxide results in increased expression of BCL2L14 mRNAincreases expression 20458559
D001205 Ascorbic Acid [Quercetin co-treated with Ascorbic Acid] results in decreased expression of BCL2L14 mRNAaffects cotreatment|decreases expression 17639512
D003513 Cycloheximide [Tetrachlorodibenzodioxin co-treated with Cycloheximide] results in increased expression of BCL2L14 mRNAaffects cotreatment|increases expression 19684285
D017313 Fenretinide Fenretinide results in increased expression of BCL2L14 mRNAincreases expression 16570282
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of BCL2L14 mRNAaffects binding|decreases expression|increases activity 19710929
D011794 Quercetin [Quercetin co-treated with Ascorbic Acid] results in decreased expression of BCL2L14 mRNAaffects cotreatment|decreases expression 17639512
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Cycloheximide] results in increased expression of BCL2L14 mRNAaffects cotreatment|increases expression 19684285
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of BCL2L14 mRNAincreases expression 19684285
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.1815322242 14514962 11752688
MESH:D055371 Acute Lung Injury pirinixic acid 3.3818653653
MESH:D000230 Adenocarcinoma arsenic trioxide 4.9311798837 19825857
MESH:D000230 Adenocarcinoma Fenretinide 4.9310697514
MESH:D018248 Adenoma, Liver Cell pirinixic acid 11.0516434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 11.0516835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1711748828
MESH:D000743 Anemia, Hemolytic Quercetin 4.4817084956
MESH:D000799 Angioedema Acetaminophen 4.2210982225
MESH:D001260 Ataxia Telangiectasia Quercetin 5.3115336622
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001327 Autoimmune Diseases Quercetin 4.7119761891
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 16.7416206674
MESH:D001778 Blood Coagulation Disorders pirinixic acid 16.7419483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 16.7412125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.1715340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9115746008
MESH:D001932 Brain Neoplasms Fenretinide 4.5816187019
MESH:D001943 Breast Neoplasms Ascorbic Acid 2.0716443354
MESH:D001943 Breast Neoplasms Fenretinide 2.0716601279
MESH:D001943 Breast Neoplasms Quercetin 2.0718628248
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.0720435547
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.5911589617
MESH:D002105 Cadmium Poisoning Quercetin 5.9216962696
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9916835633
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 6.893084413
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 6.8915553829 15073043 16217749 11135700 14691202
MESH:D006528 Carcinoma, Hepatocellular Fenretinide 6.8916270382 17159502
MESH:D006528 Carcinoma, Hepatocellular Quercetin 6.8919519916 12508355
MESH:D021441 Carcinoma, Pancreatic Ductal Quercetin 5.2617234771
MESH:D002291 Carcinoma, Papillary arsenic trioxide 5.2519014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.3512490120
MESH:D002294 Carcinoma, Squamous Cell Fenretinide 3.2316274795
MESH:D006332 Cardiomegaly Quercetin 7.2019794523
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 7.2018670907 16120746 18850075
MESH:D002386 Cataract Acetaminophen 2.7110977129
MESH:D018290 Cervical Intraepithelial Neoplasia Fenretinide 5.8116154183
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3816835633
MESH:D002779 Cholestasis pirinixic acid 3.0019176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1916354765 15668235 15340226 12621046 8697196
MESH:D003110 Colonic Neoplasms Quercetin 2.4517148506 16640504 15741050 11134977 17191121 19056647 19440933
MESH:D015179 Colorectal Neoplasms arsenic trioxide 3.6820501625
MESH:D015179 Colorectal Neoplasms Fenretinide 3.6817273769
MESH:D015179 Colorectal Neoplasms Quercetin 3.6818852136 18095365
MESH:D003139 Common Cold Ascorbic Acid 5.8517323712
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2717141729 14669216
MESH:D023903 Coronary Restenosis arsenic trioxide 4.4712609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 2.5310525206
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.5320055451 10048152 15322242
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.3615213294
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5218249437
MESH:D003921 Diabetes Mellitus, Experimental Quercetin 3.9319496084
MESH:D003924 Diabetes Mellitus, Type 2 Ascorbic Acid 4.7216506275
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.7217107852
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 3.7515619225 17562736 12958197 12594235 16227642 10663392 19420014 16485898 16177239 11529661 17522070 12392966 14986274 16393943 10774834 12153990 11834606 2444490 11421492 19923254 17906064 12540782 19416960 14550746 18713872 19370779 16081117 19164858 12705907 15968718 11461765 19085960 16781746 14725611 18071297 19739265 16109766 10915739 11287661 11739529 11743745
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.7520420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.4719426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9311462148
MESH:C538011 Eales disease Ascorbic Acid 5.859068938
MESH:D004487 Edema pirinixic acid 7.3512083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 7.3511000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.2818230668 15322242 16714409
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.259294722 10568697
MESH:D004938 Esophageal Neoplasms arsenic trioxide 2.3612903497
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1911564622
MESH:D005234 Fatty Liver arsenic trioxide 8.5415073043
MESH:D005234 Fatty Liver pirinixic acid 8.5419236843 20131406
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.7611858732
MESH:D005355 Fibrosis Quercetin 9.8019474275
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 9.8020067830
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.5416904648
MESH:D005756 Gastritis Acetaminophen 4.0516983495
MESH:D005909 Glioblastoma Fenretinide 8.0816187019
MESH:D005909 Glioblastoma Quercetin 8.0819804834
MESH:D005910 Glioma Quercetin 3.1317643826
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.9710696789
MESH:D006330 Heart Defects, Congenital Ascorbic Acid 7.2316080930
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 7.2311294989 10048152
MESH:D006333 Heart Failure pirinixic acid 2.6720558911
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5811000095
MESH:D006529 Hepatomegaly pirinixic acid 9.3016221962 18467677 19772884 19176532
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 9.3015340226 12621046 16120746
MESH:D006548 Hernia, Diaphragmatic Ascorbic Acid 3.5416490937 16863852
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.4215340226 8697196 16354765 18606429 16959395
MESH:D006930 Hyperalgesia Acetaminophen 2.8916870215
MESH:D006943 Hyperglycemia pirinixic acid 10.0120558911
MESH:D006943 Hyperglycemia Quercetin 10.0111834736 18262572
MESH:D006973 Hypertension Quercetin 5.4818356687
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.4818850075 18670907
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9612200463 12878042
MESH:D007251 Influenza, Human Quercetin 4.8816624496
MESH:D007333 Insulin Resistance pirinixic acid 2.7816306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5816580747
MESH:D007627 Keloid Quercetin 5.2617086741
MESH:D007674 Kidney Diseases Acetaminophen 6.5012587719 15629191
MESH:D007674 Kidney Diseases Quercetin 6.5016962696
MESH:D007938 Leukemia arsenic trioxide 6.8415070760
MESH:D007938 Leukemia Quercetin 6.8417468513
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 4.0417077332 12560223
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.6416972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.6014633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 4.0019077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 2.1717050201 20471514 16968895 19850784 16467208
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.3617217047 19035177 11161223 17107899 15336539 16112521 16330433 19642359 15748426 11468182 16331271 17712046 19225113 17649720 12018890 9834237 16966277 15213294 12712474 16891316 19075265 16823087 12679006 15622746 17869043
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.6316882451
MESH:D007972 Leukoplakia, Oral Fenretinide 6.4216707609
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.5715474484
MESH:D008106 Liver Cirrhosis, Experimental Quercetin 3.5712741479
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.5712878042
MESH:D008107 Liver Diseases Acetaminophen 1.6711587558 12969438 19460945 16611625 19014921 16610002 12587719 19784758
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4616871587 17185352
MESH:D008113 Liver Neoplasms arsenic trioxide 11.3614682389
MESH:D008113 Liver Neoplasms pirinixic acid 11.3615890375 16377806 20007298
MESH:D008113 Liver Neoplasms Quercetin 11.3618980244
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 11.3616984957
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 15.3720377131
MESH:D008114 Liver Neoplasms, Experimental Ascorbic Acid 15.3718544905
MESH:D008114 Liver Neoplasms, Experimental Quercetin 15.3719519916
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 15.3712151625
MESH:D008133 Long QT Syndrome arsenic trioxide 3.5315213294
MESH:D008171 Lung Diseases Ascorbic Acid 4.1016863852
MESH:D008175 Lung Neoplasms arsenic trioxide 5.0919825857 11798837
MESH:D008175 Lung Neoplasms Ascorbic Acid 5.0916401635
MESH:D008175 Lung Neoplasms Quercetin 5.0916280456
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 5.0919555203 11884234
MESH:D008325 Mammary Neoplasms, Experimental Fenretinide 3.7110697514
MESH:D008545 Melanoma Fenretinide 2.8516270382
MESH:D008546 Melanoma, Experimental Acetaminophen 3.8719513568
MESH:D009062 Mouth Neoplasms Fenretinide 4.5016274795
MESH:D009101 Multiple Myeloma arsenic trioxide 3.2714977855 15949261 19549372 19417148 11468182
MESH:D009135 Muscular Diseases pirinixic acid 3.8116239165
MESH:D009182 Mycosis Fungoides arsenic trioxide 5.0518349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 3.2616882451 16105982
MESH:D009203 Myocardial Infarction pirinixic acid 6.0119151258
MESH:D009203 Myocardial Infarction Quercetin 6.0119595682
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.2112213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 9.0616411023
MESH:D015428 Myocardial Reperfusion Injury Quercetin 9.0619207477
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.2416624393
MESH:D009369 Neoplasms Fenretinide 9.0215958647 17353921
MESH:D009369 Neoplasms pirinixic acid 9.0217405874
MESH:D009369 Neoplasms Quercetin 9.0215185748
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.4914600291
MESH:D009436 Neural Tube Defects arsenic trioxide 3.2610525206
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.0718514411
MESH:D020078 Neurogenic Inflammation Quercetin 4.6217929310
MESH:D009472 Neuronal Ceroid-Lipofuscinoses Fenretinide 6.0216303764
MESH:D009765 Obesity Ascorbic Acid 4.9117217161
MESH:D009765 Obesity pirinixic acid 4.9120558911
MESH:D015663 Osteoporosis, Postmenopausal Quercetin 4.4819495926
MESH:D010051 Ovarian Neoplasms arsenic trioxide 8.4419769630 16624393 12452020
MESH:D010051 Ovarian Neoplasms Fenretinide 8.4416133793
MESH:D010051 Ovarian Neoplasms Quercetin 8.4419005980
MESH:D010146 Pain Acetaminophen 2.5916870215
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 9.2215580305
MESH:D010190 Pancreatic Neoplasms Fenretinide 9.2215580305
MESH:D010190 Pancreatic Neoplasms Quercetin 9.2216965848
MESH:D010235 Paraganglioma arsenic trioxide 4.4219927285
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.6212520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8418163543
MESH:D011230 Precancerous Conditions Quercetin 4.1919056647
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.5311896295 11222880 11118676 11399792
MESH:D011471 Prostatic Neoplasms arsenic trioxide 2.7019131511
MESH:D011471 Prostatic Neoplasms Fenretinide 2.7017024972
MESH:D011471 Prostatic Neoplasms Quercetin 2.7014715546 17292933
MESH:D011657 Pulmonary Eosinophilia Ascorbic Acid 5.7114606601
MESH:D015427 Reperfusion Injury pirinixic acid 2.4919058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.1218990726
MESH:D012162 Retinal Degeneration Fenretinide 4.5816303925
MESH:D012174 Retinitis Pigmentosa Ascorbic Acid 3.3616849425
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 4.2416646077
MESH:D012554 Schistosomiasis japonica Quercetin 5.9216862918
MESH:D012871 Skin Diseases Ascorbic Acid 3.2618709164
MESH:D012878 Skin Neoplasms Fenretinide 6.2216467112
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 6.2216192470
MESH:D013274 Stomach Neoplasms arsenic trioxide 1.8617007042
MESH:D013276 Stomach Ulcer Ascorbic Acid 4.1318726076
MESH:D020521 Stroke Ascorbic Acid 4.4816517955 16403987
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.2812697716
MESH:D013964 Thyroid Neoplasms arsenic trioxide 3.2719014326
MESH:D016171 Torsades de Pointes arsenic trioxide 4.3015213294
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 8.9912973940 20435036 12845720 11780464
MESH:D001749 Urinary Bladder Neoplasms Fenretinide 8.9916720286
MESH:D001749 Urinary Bladder Neoplasms Quercetin 8.9916720314
MESH:D014581 Urticaria Acetaminophen 3.2410982225
MESH:D002583 Uterine Cervical Neoplasms Fenretinide 4.7916154183
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.9712125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.6215886252
No data
Pharmacogenomics Knowledge Base Top
Drug Bank Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved