AutismKB 2.0

Annotation Detail for CALB2


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:CALB2 ( CAB29,CAL2,CR )
Gene Full Name: calbindin 2
Band: 16q22.2
Quick LinksEntrez ID:794; OMIM: 114051; Uniprot ID:CALB2_HUMAN; ENSEMBL ID: ENSG00000172137; HGNC ID: 1435
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1877Multiple sclerosis
2053Colon cancer
1846Pleural effusion, Malignant
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000643 Ammonium Chloride Ammonium Chloride affects the expression of CALB2 mRNAaffects expression 16483693
C006780 bisphenol A bisphenol A results in decreased expression of CALB2 mRNAdecreases expression 15901920
D002330 Carmustine Carmustine results in decreased expression of CALB2 mRNAdecreases expression 15980968
D016572 Cyclosporine Cyclosporine results in increased expression of CALB2 mRNAincreases expression 20106945
D004958 Estradiol Estradiol affects the expression of CALB2 mRNAaffects expression 14699072
D004958 Estradiol Estradiol results in increased expression of CALB2 mRNAincreases expression 17962382
D005472 Fluorouracil CALB2 protein results in increased susceptibility to Fluorouracilincreases response to substance 16510598
D005472 Fluorouracil Fluorouracil results in increased expression of CALB2 mRNAincreases expression 16510598
C030110 oxaliplatin CALB2 protein results in increased susceptibility to oxaliplatinincreases response to substance 16510598
C030110 oxaliplatin oxaliplatin results in increased expression of CALB2 mRNAincreases expression 16510598
D010795 Phthalic Acids Phthalic Acids affects the expression of CALB2 mRNAaffects expression 15728792
D010852 Picrotoxin Picrotoxin results in decreased expression of CALB2 proteindecreases expression 15382257
D020849 Raloxifene Raloxifene results in increased expression of CALB2 mRNAincreases expression 17962382
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.8018287403
MESH:D000230 Adenocarcinoma Estradiol 4.5711473722
MESH:D000230 Adenocarcinoma Fluorouracil 4.5717638652
MESH:D000419 Albuminuria Raloxifene 4.7917308373 17451421
MESH:D000544 Alzheimer Disease Raloxifene 2.5715800139
MESH:D000740 Anemia Fluorouracil 3.8716511603 15504547 17963324
MESH:D001289 Attention Deficit Disorder with Hyperactivity Phthalic Acids 4.4720106747
MESH:D001862 Bone Resorption bisphenol A 4.0311985600
MESH:D001930 Brain Injuries Raloxifene 4.6916580743
MESH:D001932 Brain Neoplasms Carmustine 4.5516187019
MESH:D001943 Breast Neoplasms bisphenol A 2.0217123778
MESH:D001943 Breast Neoplasms Estradiol 2.0219861407 17289903 17018787 16675129 17261762 12948864 18497071 14630087
MESH:D001943 Breast Neoplasms Fluorouracil 2.0218608205 18357371 16557594 16595493 19217205 16110121 15136595
MESH:D001943 Breast Neoplasms Raloxifene 2.0217261762 17893378 16837676 15572757 17049068 16912660 15775269 15758505 17595753 17242785 17440819 17952589
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.7016111702
MESH:D002276 Carcinoid Tumor Fluorouracil 4.9316051944
MESH:D002277 Carcinoma Fluorouracil 3.7017121937
MESH:D006528 Carcinoma, Hepatocellular Estradiol 3.1516924424
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 3.1517088986 16332177 18930000 17045692 17971768 16799960
MESH:D002278 Carcinoma in Situ bisphenol A 5.2317123778
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 3.0918695887
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 2.5317066447 16757204 16280240 18986760
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 4.2317572228
MESH:D002318 Cardiovascular Diseases Raloxifene 3.5615775269
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 6.9612371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 6.9618566989
MESH:D002779 Cholestasis Cyclosporine 3.0419486331
MESH:D003072 Cognition Disorders Raloxifene 4.8315800139
MESH:D003110 Colonic Neoplasms Fluorouracil 4.2715001691 17016597 16340194 17287894 17725105 17172411 16510598 17018589 17169374 18772588
MESH:D003110 Colonic Neoplasms oxaliplatin 4.2716004971 16510598 16024531
MESH:D015179 Colorectal Neoplasms Fluorouracil 2.9818288408 17094418 15289873 17594712 16391804 17255274 16282729 14970324 17016601 16331619 18448328 18509181 18949393 17401013 17454858 16524972 20501625 17695437 18383874 16303861 15148649 18802399
MESH:D015179 Colorectal Neoplasms oxaliplatin 2.9817594712 18448328 17401013 17255274 18509181 17695437
MESH:D007644 Darier Disease Fluorouracil 5.0316733453
MESH:D003865 Depressive Disorder, Major Raloxifene 4.3117474826
MESH:D003928 Diabetic Nephropathies Estradiol 9.5219279558
MESH:D003928 Diabetic Nephropathies Raloxifene 9.5215920148 17308373 17451421
MESH:D004487 Edema Raloxifene 3.5115860553
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 4.1915845917
MESH:D016889 Endometrial Neoplasms Estradiol 3.0919148513 11473722 18566989
MESH:D004938 Esophageal Neoplasms Fluorouracil 2.4815173087 16481741 16785472 16337965 17638652
MESH:D005234 Fatty Liver Cyclosporine 8.4519224547
MESH:D005234 Fatty Liver Raloxifene 8.4517473493
MESH:D005355 Fibrosis Cyclosporine 3.3612639820 12168785
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.468708960
MESH:D005909 Glioblastoma Carmustine 4.0316187019
MESH:D005910 Glioma Fluorouracil 2.9316145905
MESH:D006258 Head and Neck Neoplasms Fluorouracil 3.5018337622 15102660 15162350
MESH:D006331 Heart Diseases Raloxifene 3.6511110106
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.6615720958
MESH:D006558 Herpes Genitalis Estradiol 5.3015709030
MESH:D019584 Hot Flashes Estradiol 4.0217088409
MESH:D006930 Hyperalgesia oxaliplatin 4.4917418472
MESH:D006973 Hypertension Cyclosporine 5.4910903974
MESH:D006973 Hypertension Raloxifene 5.4915787275 17577099
MESH:D007333 Insulin Resistance bisphenol A 7.8016393666
MESH:D007333 Insulin Resistance Estradiol 7.8016393666 16627594
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.7115604871
MESH:D007674 Kidney Diseases Cyclosporine 6.248314463 10903974 18776723
MESH:D007674 Kidney Diseases Estradiol 6.2415618244
MESH:D007680 Kidney Neoplasms Cyclosporine 13.2712371664
MESH:D007680 Kidney Neoplasms Estradiol 13.2715610895
MESH:D007680 Kidney Neoplasms Fluorouracil 13.2716985049
MESH:D007889 Leiomyoma Raloxifene 4.6816973256
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 1.6814659978 14716833
MESH:D008113 Liver Neoplasms Fluorouracil 2.5315113037 17045692 18383874 16603448
MESH:D008175 Lung Neoplasms Fluorouracil 2.0015246190
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 5.0315086387
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 2.6611408345 11807958 16891317 17203775
MESH:D020149 Manganese Poisoning Estradiol 4.7519453300
MESH:D008545 Melanoma Carmustine 2.8812393984
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.0516801185
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 5.8215863610
MESH:D009062 Mouth Neoplasms Fluorouracil 3.7616757204 18986760
MESH:D009101 Multiple Myeloma Raloxifene 3.5616497877
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.4116810080
MESH:D009232 Myxoma Raloxifene 5.8216343187
MESH:D009369 Neoplasms Fluorouracil 2.6818600527 18239605 16928823
MESH:D009389 Neovascularization, Pathologic Estradiol 3.9717289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.7117954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.4419348381 18481113
MESH:D009421 Nervous System Malformations bisphenol A 10.4111399458 16427766
MESH:D009421 Nervous System Malformations Estradiol 10.4116427766 11399458
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.5516436463
MESH:D010024 Osteoporosis Raloxifene 3.4915775268 17882678 19059307
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 4.4117893378 15579764 15758505 17823083
MESH:D010049 Ovarian Diseases bisphenol A 5.2311985600
MESH:D010051 Ovarian Neoplasms Estradiol 2.2619401270
MESH:D010190 Pancreatic Neoplasms Fluorouracil 2.7215113037 19003803 16929163 16500647
MESH:D011230 Precancerous Conditions Cyclosporine 3.3712371664
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 4.1910548101
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 11.1320887781
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 11.1320887781
MESH:D011471 Prostatic Neoplasms bisphenol A 2.0816740699
MESH:D011471 Prostatic Neoplasms Estradiol 2.0816740699
MESH:D011471 Prostatic Neoplasms Fluorouracil 2.0818626508 19082440
MESH:D011471 Prostatic Neoplasms Raloxifene 2.0815731164 16220300 16536755
MESH:D011565 Psoriasis Cyclosporine 2.2816882103
MESH:D011629 Puberty, Precocious bisphenol A 5.0210548101
MESH:D011693 Purpura Raloxifene 5.8215770314
MESH:D012004 Rectal Neoplasms Fluorouracil 4.1616160472 18286688 18722050 15538739
MESH:D012640 Seizures Picrotoxin 4.108954991 8635557
MESH:D013274 Stomach Neoplasms Fluorouracil 2.0018567086 17522103 19084572 16424979 18396642 15786421 16951190 17498489 19015929 17172411
MESH:D020521 Stroke Raloxifene 3.9616837676
MESH:D019966 Substance-Related Disorders bisphenol A 4.2216045194 16684133
MESH:D013978 Tibial Fractures Estradiol 14.6219048282
MESH:D013978 Tibial Fractures Raloxifene 14.6219048282
MESH:D014062 Tongue Neoplasms Fluorouracil 4.1516280240
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 2.8717572228
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 4.0416803524
MESH:D014591 Uterine Diseases bisphenol A 5.2714652134
MESH:D014605 Uveitis Cyclosporine 4.251336536
MESH:D054556 Venous Thromboembolism Raloxifene 5.4716837676
MESH:D014846 Vulvar Neoplasms Raloxifene 5.8216343187
MESH:D014985 Xerophthalmia Cyclosporine 4.7117120751
No data
Pharmacogenomics Knowledge Base Top
Drug Bank Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved