AutismKB 2.0

Annotation Detail for PLA2G7


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:PLA2G7 ( LDL-PLA2,LP-PLA2,PAFAH )
Gene Full Name: phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
Band: 6p12.3
Quick LinksEntrez ID:7941; OMIM: 601690; Uniprot ID:PAFA_HUMAN; ENSEMBL ID: ENSG00000146070; HGNC ID: 9040
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa00565Ether lipid metabolism
hsa01100Metabolic pathways
Pathway IDPathway Name
Diabetes pathways
Pathway IDPathway Name
200114Lissencephaly gene (LIS1) in neuronal migration and development
No data
Pathway IDPathway Name
500141Synthesis, Secretion, and Deacylation of Ghrelin
Related Diseases/Disorders Top
No data
No data
Desease Name
cholesterol
cardiovascular disease
atherosclerosis, coronary
CARDIOVASCULAR
myocardial infarct
cardiomyopathy, nonfamilial hypertrophic
coronary artery spasm
body mass
aneurysm, abdominal aortic
METABOLIC
carotid atherosclerosis
Desease Name
Lipoprotein-associated phospholipase A2 activity and mass
Desease Name
Asthma, susceptibility to
Atopy, susceptibility to
Platelet-activating factor acetylhydrolase deficiency
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C036535 1,6-bis(cyclohexyloximinocarbonyl)hexane 1,6-bis(cyclohexyloximinocarbonyl)hexane results in decreased activity of PLA2G7 proteindecreases activity 18657971
D000082 Acetaminophen Acetaminophen affects the expression of PLA2G7 mRNAaffects expression 17562736
C109238 acyline acyline results in increased expression of PLA2G7 mRNAincreases expression 17510436
D019324 beta-Naphthoflavone [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of PLA2G7 mRNAaffects cotreatment|increases expression 18164116
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of PLA2G7 mRNAincreases expression 20713471
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in increased expression of PLA2G7 mRNAincreases expression 15336504
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in increased expression of PLA2G7 mRNAincreases expression 15336504
14729362
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of PLA2G7 mRNAaffects cotreatment|increases expression 18164116
D004958 Estradiol Estradiol results in decreased expression of PLA2G7 mRNAdecreases expression 19429434
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of PLA2G7 mRNAaffects expression 17555576
C108606 ezetimibe [orlistat co-treated with ezetimibe] results in decreased activity of PLA2G7 proteinaffects cotreatment|decreases activity 18513463
D011345 Fenofibrate Fenofibrate results in decreased activity of PLA2G7 proteindecreases activity 16911813
D011345 Fenofibrate [orlistat co-treated with Fenofibrate] results in decreased activity of PLA2G7 proteinaffects cotreatment|decreases activity 16911813
D006861 Hydrogen Peroxide Hydrogen Peroxide results in increased expression of PLA2G7 mRNAincreases expression 14729362
D008070 Lipopolysaccharides Lipopolysaccharides results in increased activity of PLA2G7 mRNAincreases activity 10409262
D008070 Lipopolysaccharides Lipopolysaccharides results in increased activity of PLA2G7 proteinincreases activity 10409262
D008070 Lipopolysaccharides Lipopolysaccharides results in increased activity of PLA2G7 proteinincreases activity 10409262
D008070 Lipopolysaccharides Lipopolysaccharides results in increased activity of PLA2G7 proteinincreases activity 10409262
D008070 Lipopolysaccharides Lipopolysaccharides results in increased expression of PLA2G7 mRNAincreases expression 10409262
D008748 Methylcholanthrene Methylcholanthrene results in increased expression of PLA2G7 mRNAincreases expression 20713471
C055122 orlistat [orlistat co-treated with ezetimibe] results in decreased activity of PLA2G7 proteinaffects cotreatment|decreases activity 18513463
C055122 orlistat [orlistat co-treated with Fenofibrate] results in decreased activity of PLA2G7 proteinaffects cotreatment|decreases activity 16911813
C055122 orlistat orlistat results in decreased activity of PLA2G7 proteindecreases activity 18513463
18657971
16911813
D010126 Ozone Ozone results in decreased expression of PLA2G7 mRNAdecreases expression 12763052
C023036 perfluorooctanoic acid perfluorooctanoic acid results in increased expression of PLA2G7 mRNAincreases expression 17681415
C006253 pirinixic acid pirinixic acid results in increased expression of PLA2G7 mRNAincreases expression 20059764
17950772
18301758
C006253 pirinixic acid PPARA protein promotes the reaction [pirinixic acid results in increased expression of PLA2G7 mRNA]increases expression|increases reaction 20059764
17950772
D011794 Quercetin Quercetin affects the expression of PLA2G7 mRNAaffects expression 18178720
D020849 Raloxifene Raloxifene results in decreased expression of PLA2G7 mRNAdecreases expression 19429434
D013629 Tamoxifen Tamoxifen results in decreased expression of PLA2G7 mRNAdecreases expression 19429434
D013629 Tamoxifen Tamoxifen affects the expression of PLA2G7 mRNAaffects expression 17555576
D014302 Trinitrobenzenesulfonic Acid Trinitrobenzenesulfonic Acid results in increased expression of PLA2G7 mRNAincreases expression 17982090
D014303 Trinitrotoluene Trinitrotoluene affects the expression of PLA2G7 mRNAaffects expression 21346803
D014425 Turpentine Turpentine results in increased activity of PLA2G7 proteinincreases activity 10409262
D015054 Zymosan Zymosan results in increased activity of PLA2G7 proteinincreases activity 10409262
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.3514745880
MESH:D000014 Abnormalities, Drug-Induced Trinitrotoluene 4.007525203
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.7517505938
MESH:D055371 Acute Lung Injury Lipopolysaccharides 8.4511850527 18653653
MESH:D055371 Acute Lung Injury pirinixic acid 8.4518653653
MESH:D000210 Acute-Phase Reaction Turpentine 5.9816044259
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 6.7120464547 20127859
MESH:D000230 Adenocarcinoma Estradiol 6.7111473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 6.7114692618
MESH:D000236 Adenoma Benzo(a)pyrene 15.126695378
MESH:D000236 Adenoma beta-Naphthoflavone 15.1219389873
MESH:D000236 Adenoma Diethylnitrosamine 15.126695378 10737359
MESH:D000236 Adenoma Methylcholanthrene 15.126695378 10545420
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 9.4519061943 18056438 16434500 19052882 17162532 17620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 9.4516434500
MESH:D000419 Albuminuria Raloxifene 4.4117451421 17308373
MESH:D000544 Alzheimer Disease Ozone 4.2215513908
MESH:D000544 Alzheimer Disease Raloxifene 4.2215800139
MESH:D000740 Anemia Zymosan 4.3918664788
MESH:D000743 Anemia, Hemolytic Quercetin 4.0717084956
MESH:D000799 Angioedema Acetaminophen 3.6510982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.8819183758
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.2811256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 7.2015885639
MESH:D001169 Arthritis, Experimental Zymosan 7.2015944321 15142272 16872482 17659584 15188379
MESH:D001172 Arthritis, Rheumatoid Ozone 2.5115570426
MESH:D001249 Asthma marker/mechanism
MESH:D001249 Asthma Ozone 2.5817854713 16373670
MESH:D001260 Ataxia Telangiectasia Quercetin 4.7815336622
MESH:D050197 Atherosclerosis Methylcholanthrene 3.3411922910
MESH:D001321 Autistic Disorder Acetaminophen 1.4418445737
MESH:D001327 Autoimmune Diseases Quercetin 4.2219761891
MESH:D001778 Blood Coagulation Disorders pirinixic acid 2.9719483382
MESH:D001930 Brain Injuries Raloxifene 4.2916580743
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 3.6520146248 17474063
MESH:D001943 Breast Neoplasms Diethylnitrosamine 3.6517474063
MESH:D001943 Breast Neoplasms Estradiol 3.6517289903 16675129 17261762 12948864 18497071 19861407 14630087 17018787
MESH:D001943 Breast Neoplasms Methylcholanthrene 3.6517474063
MESH:D001943 Breast Neoplasms Quercetin 3.6518628248
MESH:D001943 Breast Neoplasms Raloxifene 3.6517595753 15572757 16912660 15775269 15758505 17242785 16837676 17261762 17893378 17952589 17440819 17049068
MESH:D001943 Breast Neoplasms Tamoxifen 3.6518855134 20390343 19288272 21152245 19244106 11161223 16873071 19189212 18629630 19115204 16273361 19084267 18984771 17893378 19142967 20135344 18997820 19155303 19103187 15668708 18821012 17261762 16202921 15565566 21138602 18815881 17049068 18351453 19410462 20544844 20065188 20859285 19289846 19221464 19066611 19011961 20005174 19200415 18425577 19189210 17242785 19059307 19487384 17440819 16818667
MESH:D016535 Bronchial Hyperreactivity Ozone 3.5317626835 15516495 16777450 18315731 14754758 18417511 19059883
MESH:D019121 Burkholderia Infections orlistat 6.4517874328
MESH:D002100 Cachexia Ozone 4.5516183385
MESH:D002105 Cadmium Poisoning Quercetin 5.3516962696
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.2716111702
MESH:D002277 Carcinoma Methylcholanthrene 3.8210545420
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.3219066611
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 8.533084413
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 8.5320727157 18506893 16681979 18210153 18691550 19539802 3581430 17978847 19335982 16878318 20101231 3084413 16935385 17173139 18056438 16288022 16830150 17055752 20432363 19394651 18494052 16807293 19107877 20084675 19383236 20935162 20524982 10672840 16502159 19052882 17162532 18393292 20007298 19519916 16328049 17138121 19822196 16569478 19208518 17761372 20512989 19919837 16779866 11831363 19418558 20514400 10737359 19171122 18978308 18788625 21159647 17428255 16540662 18785209 18665156 19701751 16698587 20214788 18971187
MESH:D006528 Carcinoma, Hepatocellular Estradiol 8.5316924424
MESH:D006528 Carcinoma, Hepatocellular Quercetin 8.5319519916 12508355
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 8.5316924424
MESH:D021441 Carcinoma, Pancreatic Ductal Quercetin 4.7717234771
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.0020419170
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 8.9417572228
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 8.9417572228
MESH:D006332 Cardiomegaly Quercetin 3.2119794523
MESH:D002318 Cardiovascular Diseases Hydrogen Peroxide 7.1416936243
MESH:D002318 Cardiovascular Diseases Raloxifene 7.1415775269
MESH:D002386 Cataract Acetaminophen 7.1410977129
MESH:D002386 Cataract Trinitrotoluene 7.1414694615 15817613
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 10.537505956 21159647 17174075 2727394
MESH:D002471 Cell Transformation, Neoplastic Estradiol 10.5318566989
MESH:D002471 Cell Transformation, Neoplastic Methylcholanthrene 10.5316192471
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 3.5219052882
MESH:D002779 Cholestasis Ethinyl Estradiol 7.2811677210 15861022 17681005 17110522 16105132 17333356 16919318
MESH:D002779 Cholestasis pirinixic acid 7.2819176532
MESH:D002916 Chylothorax orlistat 6.4517003701
MESH:D003072 Cognition Disorders Raloxifene 4.4315800139
MESH:D003092 Colitis Trinitrobenzenesulfonic Acid 4.3611698051 17936198 16782535 16804969 18200517 16474422 17991707 18023891 16867261
MESH:D003093 Colitis, Ulcerative Trinitrobenzenesulfonic Acid 3.3817276891
MESH:D003110 Colonic Neoplasms Quercetin 2.3919056647 19440933 17148506 11134977 16640504 15741050 17191121
MESH:D015179 Colorectal Neoplasms Quercetin 2.1818095365 18852136
MESH:D000013 Congenital Abnormalities Trinitrotoluene 4.2415095906
MESH:D003490 Cyanosis Trinitrotoluene 4.7318551238
MESH:D003711 Demyelinating Diseases Tamoxifen 4.1719031437
MESH:D003865 Depressive Disorder, Major Raloxifene 4.0017474826
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3418249437
MESH:D048909 Diabetes Complications orlistat 5.6419207292
MESH:D003921 Diabetes Mellitus, Experimental Quercetin 3.5819496084
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 2.1520387270
MESH:D003928 Diabetic Nephropathies Estradiol 14.0919279558
MESH:D003928 Diabetic Nephropathies Raloxifene 14.0917308373 17451421 15920148
MESH:D003928 Diabetic Nephropathies Tamoxifen 14.0919279558
MESH:D003967 Diarrhea orlistat 4.5420002075
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 5.9710663392 15968718 17522070 12594235 14725611 18713872 12540782 16485898 12705907 2444490 16081117 19370779 16227642 19420014 11287661 10774834 16177239 19923254 16781746 16393943 19739265 11743745 11834606 19164858 11529661 11739529 19085960 15619225 11461765 12392966 18071297 17562736 17906064 14986274 16109766 14550746 19416960 12153990 11421492 12958197 10915739
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 5.9719107877
MESH:D056486 Drug-Induced Liver Injury Trinitrotoluene 5.9718551238 21346803
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.9119426721
MESH:D050171 Dyslipidemias Fenofibrate 4.2916707586
MESH:D004487 Edema perfluorooctanoic acid 15.1217259670 12083418
MESH:D004487 Edema pirinixic acid 15.1212083418
MESH:D004487 Edema Raloxifene 15.1215860553
MESH:D004487 Edema Zymosan 15.127907874
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 14.2812538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 14.2815845917
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 14.2819031437
MESH:D016889 Endometrial Neoplasms Estradiol 11.8418566989 19148513 11473722
MESH:D016889 Endometrial Neoplasms Fenofibrate 11.8416569247
MESH:D016889 Endometrial Neoplasms Tamoxifen 11.8420544844 16202921 19155303 17893378
MESH:D019446 Endotoxemia Lipopolysaccharides 4.2015328337 17637181 15821434
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.9216302075
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 1.9616530937
MESH:D005234 Fatty Liver Diethylnitrosamine 22.8021071580 20387270
MESH:D005234 Fatty Liver Ethinyl Estradiol 22.8015345470
MESH:D005234 Fatty Liver pirinixic acid 22.8020131406 19236843
MESH:D005234 Fatty Liver Raloxifene 22.8017473493
MESH:D005234 Fatty Liver Tamoxifen 22.8014986274 19224547
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.1216709447
MESH:D005334 Fever Lipopolysaccharides 3.859205823 11852909
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.3414745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 3.9919069698
MESH:D005354 Fibrosarcoma Methylcholanthrene 4.7514633661 10962813
MESH:D005355 Fibrosis Quercetin 8.6519474275
MESH:D005355 Fibrosis Trinitrobenzenesulfonic Acid 8.6517994277
MESH:D005414 Flatulence orlistat 6.4520002075
MESH:D005756 Gastritis Acetaminophen 3.4816983495
MESH:D005909 Glioblastoma Quercetin 3.2719804834
MESH:D005910 Glioma Quercetin 2.9817643826
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.5620471113
MESH:D006331 Heart Diseases Raloxifene 3.4011110106
MESH:D006333 Heart Failure pirinixic acid 2.4220558911
MESH:D006463 Hemolytic-Uremic Syndrome Lipopolysaccharides 4.2216366002
MESH:D006505 Hepatitis Zymosan 4.5119110552
MESH:D006529 Hepatomegaly perfluorooctanoic acid 13.553609246
MESH:D006529 Hepatomegaly pirinixic acid 13.5519176532 18467677 19772884 16221962
MESH:D006529 Hepatomegaly Trinitrotoluene 13.5515817613
MESH:D006558 Herpes Genitalis Estradiol 4.8415709030
MESH:D019584 Hot Flashes Estradiol 3.5617088409
MESH:D006930 Hyperalgesia Acetaminophen 7.3616870215
MESH:D006930 Hyperalgesia perfluorooctanoic acid 7.3612083418
MESH:D006937 Hypercholesterolemia ezetimibe 5.5715374793 17076980
MESH:D006943 Hyperglycemia pirinixic acid 8.6920558911
MESH:D006943 Hyperglycemia Quercetin 8.6918262572 11834736
MESH:D006949 Hyperlipidemias orlistat 4.9121332399
MESH:D006967 Hypersensitivity marker/mechanism
MESH:D006973 Hypertension Quercetin 5.3418356687
MESH:D006973 Hypertension Raloxifene 5.3415787275 17577099
MESH:D007021 Hypospadias Ethinyl Estradiol 3.6216945680 16569931
OMIM:147050 IgE RESPONSIVENESS, ATOPIC marker/mechanism
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.2812013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 6.4817937319
MESH:D007248 Infertility, Male Trinitrotoluene 6.4812150543
MESH:D007249 Inflammation Diethylnitrosamine 14.8518785209
MESH:D007249 Inflammation Lipopolysaccharides 14.8517237260 12878042 17255318 9205823 17963957
MESH:D007249 Inflammation perfluorooctanoic acid 14.8512083418
MESH:D007249 Inflammation Tamoxifen 14.8519457130
MESH:D007249 Inflammation Zymosan 14.8511289658 8014878
MESH:D015212 Inflammatory Bowel Diseases Trinitrobenzenesulfonic Acid 3.5018200517
MESH:D007251 Influenza, Human Quercetin 4.3216624496
MESH:D007333 Insulin Resistance Estradiol 11.7716627594 16393666
MESH:D007333 Insulin Resistance orlistat 11.7717201808
MESH:D007333 Insulin Resistance pirinixic acid 11.7716306350
MESH:D007410 Intestinal Diseases Trinitrobenzenesulfonic Acid 4.4217994277
MESH:D019189 Iron Metabolism Disorders Lipopolysaccharides 4.4517255318
MESH:D043183 Irritable Bowel Syndrome Zymosan 5.6417553498
MESH:D007627 Keloid Quercetin 4.7717086741
MESH:D007674 Kidney Diseases Acetaminophen 9.4412587719 15629191
MESH:D007674 Kidney Diseases Estradiol 9.4415618244
MESH:D007674 Kidney Diseases Quercetin 9.4416962696
MESH:C531755 Kidney disorder involving deposition of calcium and oxalate or phosphate in the renal tubules orlistat 6.4517185156
MESH:D007676 Kidney Failure, Chronic Hydrogen Peroxide 4.1016518626
MESH:D007680 Kidney Neoplasms Estradiol 6.8715610895
MESH:D007680 Kidney Neoplasms Tamoxifen 6.8718625569
MESH:D007889 Leiomyoma Raloxifene 4.3216973256
MESH:D007938 Leukemia Quercetin 3.0617468513
MESH:D007970 Leukopenia Lipopolysaccharides 4.5115821434
MESH:D007984 Leydig Cell Tumor perfluorooctanoic acid 5.048812269
MESH:D008064 Lipidoses Tamoxifen 3.0217567588 15342952
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 6.8318665156 18407596 20032147 19638242 18522880
MESH:D008103 Liver Cirrhosis orlistat 6.8317404856
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 8.4314659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental Fenofibrate 8.4315474484
MESH:D008106 Liver Cirrhosis, Experimental Lipopolysaccharides 8.4312878042
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 8.4315474484
MESH:D008106 Liver Cirrhosis, Experimental Quercetin 8.4312741479
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 8.4318564211
MESH:D008107 Liver Diseases Acetaminophen 3.7411587558 19784758 12587719 19460945 16611625 12969438 16610002 19014921
MESH:D008107 Liver Diseases Diethylnitrosamine 3.7417034775
MESH:D017114 Liver Failure, Acute Acetaminophen 3.0717185352 16871587
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 24.7120195826 21137059
MESH:D008113 Liver Neoplasms beta-Naphthoflavone 24.7119389873 21295105
MESH:D008113 Liver Neoplasms Diethylnitrosamine 24.7119499222 19254457 20492335 19996281 20137499 19642983 18754104 19427195 19638242 15885732 18977376 19255062 12112319 20101389 19690152 19833225 18644402 18648771 20452335 18978307 10737359 15175105 21278145 16942905 12771043 20118626 19256749 21167192 9163691 19551842 20405173 2862719 19426721 19294768 19812893 19073162 21071580 21047994 19850985 20501860 20434301 19090486 2422723 20583210
MESH:D008113 Liver Neoplasms Fenofibrate 24.7118978307
MESH:D008113 Liver Neoplasms perfluorooctanoic acid 24.7118709148 14757943
MESH:D008113 Liver Neoplasms pirinixic acid 24.7120007298 16377806 15890375
MESH:D008113 Liver Neoplasms Quercetin 24.7118980244
MESH:D008113 Liver Neoplasms Tamoxifen 24.7116684651
MESH:D008114 Liver Neoplasms, Experimental beta-Naphthoflavone 17.4418164116
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 17.4418253720 17942915 19004024 18079962 18164116 19009564 19126423 18775883 21159647 18544905 16842330 19539802 18282651 16267830 17174075 2563599 3124819 9362446 17854601 18093689 19519916 18308698
MESH:D008114 Liver Neoplasms, Experimental Fenofibrate 17.4418775883 18253720
MESH:D008114 Liver Neoplasms, Experimental Methylcholanthrene 17.44598648 1399818
MESH:D008114 Liver Neoplasms, Experimental Quercetin 17.4419519916
MESH:D008171 Lung Diseases Ozone 3.2519066396 8266340
MESH:D055370 Lung Injury Lipopolysaccharides 8.6121114838
MESH:D055370 Lung Injury Ozone 8.6120417186
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 8.256695378 20869020 20135361 20064080 18520028 20464547 17053015 18816296 18569708
MESH:D008175 Lung Neoplasms Diethylnitrosamine 8.2520512841 21163286 20970405 6695378
MESH:D008175 Lung Neoplasms Methylcholanthrene 8.257750092 20970405 16337739 10545420 16271038 6695378 15390079 21163286 1399818 17909032 9230183 11893704 20512841
MESH:D008175 Lung Neoplasms Ozone 8.257614698 8597069
MESH:D008175 Lung Neoplasms Quercetin 8.2516280456
MESH:D008175 Lung Neoplasms Tamoxifen 8.2518625569
MESH:D008207 Lymphatic Metastasis orlistat 5.7020805790 18770866
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.5719428831
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 5.5717203775 16891317 11408345 11807958
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 5.5711731420 16827153 14580682 19196722 19196723
MESH:D020149 Manganese Poisoning Estradiol 12.0019453300
MESH:D020149 Manganese Poisoning Tamoxifen 12.0019453300
MESH:D008545 Melanoma orlistat 3.7218770866 20805790
MESH:D008545 Melanoma Tamoxifen 3.7212393984 19393235
MESH:D018328 Melanoma, Amelanotic Tamoxifen 3.9915990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.3819513568
MESH:D008679 Metaplasia Ozone 4.9110496685
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 5.3615863610
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.0416381670
MESH:D009101 Multiple Myeloma Raloxifene 3.3016497877
MESH:D009102 Multiple Organ Failure Zymosan 5.0315834315 17724436 12130978 15213630 10479408 12879239 15241586 10890648 18160304 15259001
MESH:D009135 Muscular Diseases orlistat 10.1118430571
MESH:D009135 Muscular Diseases pirinixic acid 10.1116239165
MESH:D009164 Mycobacterium Infections orlistat 5.3021442799
MESH:D009203 Myocardial Infarction pirinixic acid 5.4619151258
MESH:D009203 Myocardial Infarction Quercetin 5.4619595682
MESH:D015428 Myocardial Reperfusion Injury Estradiol 13.3516810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 13.3516411023
MESH:D015428 Myocardial Reperfusion Injury Quercetin 13.3519207477
MESH:D009232 Myxoma Raloxifene 5.3616343187
MESH:D009336 Necrosis Trinitrotoluene 4.5718551238
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 5.489029167 3581430
MESH:D009362 Neoplasm Metastasis Tamoxifen 5.4819393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.4519410462
MESH:D009369 Neoplasms Benzo(a)pyrene 11.1511141357
MESH:D009369 Neoplasms orlistat 11.1518710210
MESH:D009369 Neoplasms pirinixic acid 11.1517405874
MESH:D009369 Neoplasms Quercetin 11.1515185748
MESH:D009374 Neoplasms, Experimental orlistat 4.8719381703
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 3.8119189210 19196722 19200415
MESH:D009389 Neovascularization, Pathologic Estradiol 9.8517289903
MESH:D009389 Neovascularization, Pathologic orlistat 9.8517012255
MESH:D009421 Nervous System Malformations Estradiol 3.4716427766 11399458
MESH:D019636 Neurodegenerative Diseases Acetaminophen 7.6618514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 7.6620387270
MESH:D020078 Neurogenic Inflammation Quercetin 4.1817929310
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.9220387270
MESH:D052556 Niemann-Pick Disease, Type C perfluorooctanoic acid 4.769802331
MESH:C541083 Non-alcoholic Fatty Liver Disease orlistat 5.3917404856
MESH:D009765 Obesity orlistat 4.8119207292 20002075 18773755 19046740 19461584 16938137 21442799 20599501 20065556 20540997 21438711 20518802
MESH:D009765 Obesity pirinixic acid 4.8120558911
MESH:D009784 Occupational Diseases Trinitrotoluene 4.1717852074 14694615 12819281
MESH:D010024 Osteoporosis Raloxifene 3.2815775268 17882678 19059307
MESH:D015663 Osteoporosis, Postmenopausal Quercetin 9.6019495926
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 9.6015579764 17893378 15758505 17823083
MESH:D010051 Ovarian Neoplasms Estradiol 4.7519401270
MESH:D010051 Ovarian Neoplasms Quercetin 4.7519005980
MESH:D010146 Pain Acetaminophen 2.2416870215
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 5.1616540662
MESH:D010190 Pancreatic Neoplasms Quercetin 5.1616965848
MESH:D010195 Pancreatitis orlistat 8.5816938137 20065556
MESH:D010195 Pancreatitis Trinitrobenzenesulfonic Acid 8.5817698068
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.5111578682
MESH:D010212 Papilloma Hydrogen Peroxide 3.9012065085
MESH:D010538 Peritonitis Ozone 9.7816369182
MESH:D010538 Peritonitis Zymosan 9.7819088179 18760300 19641140 14761945 18557954 11985352 17826846 18977430 15259001 17371808 15979727
MESH:D011014 Pneumonia Lipopolysaccharides 10.4612224865 11605937
MESH:D011014 Pneumonia Ozone 10.4618007984 18381685 18929643
MESH:D011085 Polycystic Ovary Syndrome orlistat 5.1217201808
MESH:D011230 Precancerous Conditions Diethylnitrosamine 8.692563599
MESH:D011230 Precancerous Conditions Quercetin 8.6919056647
MESH:D011297 Prenatal Exposure Delayed Effects perfluorooctanoic acid 4.2017132714
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.7120887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 1.8717292933
MESH:D011471 Prostatic Neoplasms Estradiol 1.8716740699
MESH:D011471 Prostatic Neoplasms Quercetin 1.8717292933 14715546
MESH:D011471 Prostatic Neoplasms Raloxifene 1.8716220300 15731164 16536755
MESH:D011471 Prostatic Neoplasms Tamoxifen 1.8715067354
MESH:D011537 Pruritus Ethinyl Estradiol 3.1216919318 15861022
MESH:D011693 Purpura Raloxifene 5.3615770314
MESH:D012035 Refsum Disease orlistat 5.8820871815
MESH:D015427 Reperfusion Injury pirinixic acid 2.2919058328
MESH:D012130 Respiratory Hypersensitivity Lipopolysaccharides 3.6110835634
MESH:D012554 Schistosomiasis japonica Quercetin 5.3516862918
MESH:D012640 Seizures Trinitrotoluene 3.3218551238
MESH:D018805 Sepsis Zymosan 4.4911441115
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 9.0219755658 10029692
MESH:D012878 Skin Neoplasms Hydrogen Peroxide 9.0212065085
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 9.028532709
MESH:D013088 Spermatocele Ethinyl Estradiol 10.9216709447
MESH:D013088 Spermatocele Tamoxifen 10.9216709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 3.8519457130
MESH:D013163 Splenomegaly Trinitrotoluene 5.0115817613
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 3.422093021 20155912
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 3.4218456281
MESH:D013274 Stomach Neoplasms orlistat 3.4219381703
MESH:D020521 Stroke Raloxifene 3.6716837676
MESH:D013921 Thrombocytopenia Lipopolysaccharides 4.0015821434
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.4411994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.9915669648
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 2.847505956
MESH:D013978 Tibial Fractures Estradiol 13.0719048282
MESH:D013978 Tibial Fractures Raloxifene 13.0719048282
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 11.3417053015
MESH:D001749 Urinary Bladder Neoplasms Quercetin 11.3416720314
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 11.3417572228
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 11.3416712894 8653321 17572228
MESH:D014581 Urticaria Acetaminophen 2.8010982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.1214692618
MESH:D014605 Uveitis Zymosan 5.2111006244
MESH:D054556 Venous Thromboembolism Raloxifene 5.0216837676
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.3714671159 15869587
MESH:D014846 Vulvar Neoplasms Raloxifene 5.3616343187
Pathway ID Pathway Name
REACT:15380 Diabetes pathways
KEGG:00565 Ether lipid metabolism
KEGG:01100 Metabolic pathways
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA33368
    • No data
    Releated disease ID Related disease Name
    PA443797Coronary Disease
    PA444368Heart Diseases
    Releated drug ID Related drug Name
    PA165884699darapladib
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB07821 - (1R)-1,2,2-TRIMETHYLPROPYL (R)-METHYLPHOSPHINATE
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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