AutismKB 2.0

Annotation Detail for CDC73


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Basic Information Top
Gene Symbol:CDC73 ( C1orf28,FLJ23316,HPTJT,HRPT2,HYX )
Gene Full Name: cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)
Band: 1q31.2
Quick LinksEntrez ID:79577; OMIM: 607393; Uniprot ID:CDC73_HUMAN; ENSEMBL ID: ENSG00000134371; HGNC ID: 16783
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1934Cancer
1920Hyperparathyroidism
No data
No data
Desease Name
Parathyroid adenoma with cystic changes
Hyperparathyroidism-jaw tumor syndrome
Parathyroid carcinoma
Hyperparathyroidism, familial primary
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of CDC73 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of CDC73 mRNAaffects expression 21346803
C006632 arsenic trioxide arsenic trioxide results in increased expression of CDC73 mRNAincreases expression 15761015
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of CDC73 mRNAdecreases expression 19150397
D005472 Fluorouracil Fluorouracil results in decreased expression of CDC73 mRNAdecreases expression 16510598
D012643 Selenium Selenium results in decreased expression of CDC73 mRNAdecreases expression 19244175
C017947 sodium arsenite sodium arsenite results in decreased expression of CDC73 mRNAdecreases expression 19072884
C025643 vinclozolin vinclozolin affects the expression of CDC73 mRNAaffects expression 19015723
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000230 Adenocarcinoma arsenic trioxide 4.6819825857 11798837
MESH:D000230 Adenocarcinoma Fluorouracil 4.6817638652
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 5.0815276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 5.2816712894 17306315
MESH:D000740 Anemia Fluorouracil 3.9416511603 15504547 17963324
MESH:D001008 Anxiety Disorders vinclozolin 3.8319015723
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 3.9116206674
MESH:D001943 Breast Neoplasms Fluorouracil 2.4515136595 19217205 18608205 16110121 16595493 16557594 18357371
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.5911589617
MESH:D002276 Carcinoid Tumor Fluorouracil 5.0416051944
MESH:D002277 Carcinoma Fluorouracil 3.7617121937
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 9.2316705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 9.2316705839
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 9.2315073043 16217749 11135700 14691202 15553829
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 9.2317088986 16332177 17045692 17971768 16799960 18930000
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 9.2317306315 16507464 15276417
MESH:D002291 Carcinoma, Papillary arsenic trioxide 5.2519014326
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 3.1118695887
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.3512490120
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 4.9616757204 18986760 17066447 16280240
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 4.9618572023
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 12.146135515
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 12.1420889678
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 12.1419524636 20056578
MESH:D003092 Colitis Selenium 4.0917936198
MESH:D003110 Colonic Neoplasms Fluorouracil 2.2617725105 17172411 16510598 17018589 15001691 17169374 18772588 17287894 16340194 17016597
MESH:D015179 Colorectal Neoplasms arsenic trioxide 2.5920501625
MESH:D015179 Colorectal Neoplasms Fluorouracil 2.5918509181 18288408 16524972 18949393 16303861 18448328 17454858 16391804 16282729 17594712 18383874 17094418 18802399 17255274 17695437 17016601 20501625 14970324 15289873 17401013 15148649 16331619
MESH:D023903 Coronary Restenosis arsenic trioxide 4.4712609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 1.8910525206
MESH:D003456 Cryptorchidism vinclozolin 4.6214966744
MESH:D003490 Cyanosis 2,4-dinitrotoluene 11.9418551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 11.9418551238
MESH:D007644 Darier Disease Fluorouracil 5.1316733453
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.3615213294
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 6.6121346803 18551238
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 6.6118551238 21346803
MESH:D056486 Drug-Induced Liver Injury Selenium 6.6115131321
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7.5820426865
MESH:D004938 Esophageal Neoplasms arsenic trioxide 7.5812903497
MESH:D004938 Esophageal Neoplasms Fluorouracil 7.5816481741 16337965 16785472 17638652 15173087
MESH:D005234 Fatty Liver arsenic trioxide 3.5315073043
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.5416904648
MESH:D030342 Genetic Diseases, Inborn vinclozolin 5.2716973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.6816417039
MESH:D005833 Genital Neoplasms, Female sodium arsenite 5.0216452187
MESH:D005910 Glioma Fluorouracil 2.9516145905
MESH:D006258 Head and Neck Neoplasms Fluorouracil 3.5415162350 18337622 15102660
MESH:D006333 Heart Failure Selenium 3.2117162251
MESH:D006689 Hodgkin Disease sodium arsenite 3.3612676792
MESH:D006961 Hyperparathyroidism marker/mechanism
MESH:D007248 Infertility, Male sodium arsenite 7.3612646999 15346721
MESH:D007248 Infertility, Male vinclozolin 7.3616467254
MESH:D007251 Influenza, Human Selenium 4.5716624496
MESH:D007674 Kidney Diseases sodium arsenite 2.9220008137
MESH:D007676 Kidney Failure, Chronic Selenium 4.1316518626
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 13.6516705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 13.6516705839
MESH:D007680 Kidney Neoplasms Fluorouracil 13.6516985049
MESH:D007938 Leukemia arsenic trioxide 2.9315070760
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 4.0417077332 12560223
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.6416972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.6014633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 4.0019077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 2.1719850784 17050201 16968895 20471514 16467208
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.3612679006 15213294 19075265 16891316 15336539 17712046 16330433 17107899 15748426 17649720 17869043 12712474 19225113 16823087 16331271 19642359 15622746 11468182 16966277 17217047 11161223 12018890 19035177 9834237 16112521
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.6316882451
MESH:D007984 Leydig Cell Tumor vinclozolin 5.0716417039
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 11.407678174
MESH:D008113 Liver Neoplasms arsenic trioxide 11.4014682389
MESH:D008113 Liver Neoplasms Fluorouracil 11.4015113037 17045692 18383874 16603448
MESH:D008113 Liver Neoplasms sodium arsenite 11.4015276417 16712894
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 6.432876784 2876786 6135515
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 6.4320377131
MESH:D008133 Long QT Syndrome arsenic trioxide 3.5315213294
MESH:D008171 Lung Diseases sodium arsenite 3.3219095001
MESH:D008175 Lung Neoplasms arsenic trioxide 3.6311798837 19825857
MESH:D008175 Lung Neoplasms Fluorouracil 3.6315246190
MESH:D008175 Lung Neoplasms sodium arsenite 3.6316712894 17077188 17306315 15276417 19931552
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 5.1315086387
MESH:D008325 Mammary Neoplasms, Experimental Selenium 2.9015318939
MESH:D008545 Melanoma sodium arsenite 2.0616487513 19082730
MESH:D008654 Mesothelioma Selenium 2.8715107826
MESH:D009062 Mouth Neoplasms Fluorouracil 3.8118986760 16757204
MESH:D009101 Multiple Myeloma arsenic trioxide 3.2711468182 14977855 19549372 15949261 19417148
MESH:D009182 Mycosis Fungoides arsenic trioxide 5.0518349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 3.2616882451 16105982
MESH:D009336 Necrosis 2,4-dinitrotoluene 11.5018551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 11.507678174 18551238
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.2416624393
MESH:D009369 Neoplasms Fluorouracil 5.5418600527 18239605 16928823
MESH:D009369 Neoplasms sodium arsenite 5.5411559025
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.9720056578
MESH:D009436 Neural Tube Defects arsenic trioxide 7.8310525206
MESH:D009436 Neural Tube Defects sodium arsenite 7.8312854658
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.5916436463
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 9.6612819281 16049721
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 9.6616049721
MESH:D010051 Ovarian Neoplasms arsenic trioxide 5.1212452020 19769630 16624393
MESH:D010051 Ovarian Neoplasms sodium arsenite 5.1217306315 15276417
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 5.6115580305
MESH:D010190 Pancreatic Neoplasms Fluorouracil 5.6119003803 16929163 16500647 15113037
MESH:D010235 Paraganglioma arsenic trioxide 4.4219927285
MESH:D010282 Parathyroid Neoplasms marker/mechanism
MESH:D010954 Plasmacytoma Selenium 5.2715087411
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 4.2318042343 19015723 18220299
MESH:D011469 Prostatic Diseases vinclozolin 5.2718220299
MESH:D011471 Prostatic Neoplasms arsenic trioxide 2.5719131511
MESH:D011471 Prostatic Neoplasms Fluorouracil 2.5719082440 18626508
MESH:D011471 Prostatic Neoplasms sodium arsenite 2.5716039940
MESH:D011472 Prostatitis vinclozolin 5.2718629315
MESH:D012004 Rectal Neoplasms Fluorouracil 4.2316160472 18722050 15538739 18286688
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 4.2416646077
MESH:D012640 Seizures 2,4-dinitrotoluene 6.3918551238
MESH:D012640 Seizures 2,6-dinitrotoluene 6.3918551238
MESH:D012878 Skin Neoplasms sodium arsenite 2.7918572023 19524636
MESH:D016135 Spinal Dysraphism sodium arsenite 3.9812854658
MESH:D013274 Stomach Neoplasms arsenic trioxide 2.5817007042
MESH:D013274 Stomach Neoplasms Fluorouracil 2.5817522103 16424979 18567086 19015929 18396642 17172411 15786421 16951190 19084572 17498489
MESH:D013964 Thyroid Neoplasms arsenic trioxide 3.2719014326
MESH:D014062 Tongue Neoplasms Fluorouracil 4.2216280240
MESH:D016171 Torsades de Pointes arsenic trioxide 4.3015213294
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 12.6116049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 12.6116049721
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 12.6112973940 20435036 12845720 11780464
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 12.6116712894 11723127 17306315 16452187
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 13.1410091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 13.1410091137
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 10.2516803524
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 10.2511813266
MESH:D014652 Vascular Diseases sodium arsenite 4.7617056641
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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