Annotation Detail for HMBOX1
Basic Information Top
| Gene Symbol: | HMBOX1 ( FLJ21616,HNF1LA,PBHNF ) |
|---|---|
| Gene Full Name: | homeobox containing 1 |
| Band: | 8p21.1-p12 |
| Quick Links | Entrez ID:79618; OMIM: NA; Uniprot ID:HMBX1_HUMAN; ENSEMBL ID: ENSG00000147421; HGNC ID: 26137 |
| Relate to Another Database: | SFARIGene; denovo-db |
Related Pathway Information| Chemical ID | Chemical Name | Interaction | Interaction Action | Publication |
|---|---|---|---|---|
| D002251 | Carbon Tetrachloride | Carbon Tetrachloride results in decreased expression of HMBOX1 mRNA | decreases expression | 17484886 |
| D016572 | Cyclosporine | Cyclosporine results in increased expression of HMBOX1 mRNA | increases expression | 20106945 |
| Disease ID | Disease Name | Direct Evidence | Inference Chemical Name | Inference Score | Publication |
|---|---|---|---|---|---|
| MESH:D002252 | Carbon Tetrachloride Poisoning | Carbon Tetrachloride | 4.54 | 18705752 15700767 16050911 15673190 16011737 16227642 16124888 15721981 16097048 16192424 3786805 10355542 | |
| MESH:D006528 | Carcinoma, Hepatocellular | Carbon Tetrachloride | 1.86 | 18788625 | |
| MESH:D002471 | Cell Transformation, Neoplastic | Cyclosporine | 2.85 | 12371664 | |
| MESH:D002779 | Cholestasis | Cyclosporine | 3.28 | 19486331 | |
| MESH:D056486 | Drug-Induced Liver Injury | Carbon Tetrachloride | 2.14 | 4309450 7179309 17522070 10092053 15968718 15027814 19085960 19336974 16227642 6623471 16177239 11566570 7440962 7120509 9327722 3786805 10915739 3732212 2869522 15998439 21278145 6884620 | |
| MESH:D005234 | Fatty Liver | Carbon Tetrachloride | 9.59 | 16239168 12795759 17595544 12631006 61145 15959796 19224547 16045604 | |
| MESH:D005234 | Fatty Liver | Cyclosporine | 9.59 | 19224547 | |
| MESH:D005355 | Fibrosis | Carbon Tetrachloride | 11.35 | 18705752 | |
| MESH:D005355 | Fibrosis | Cyclosporine | 11.35 | 12168785 12639820 | |
| MESH:D005885 | Gingival Hyperplasia | Cyclosporine | 5.11 | 8708960 | |
| MESH:D006457 | Hemoglobinuria, Paroxysmal | Cyclosporine | 5.31 | 15720958 | |
| MESH:D006505 | Hepatitis | Carbon Tetrachloride | 4.27 | 19900420 19110552 | |
| MESH:D006932 | Hyperbilirubinemia | Carbon Tetrachloride | 5.42 | 16899240 | |
| MESH:D006973 | Hypertension | Cyclosporine | 2.24 | 10903974 | |
| MESH:D006975 | Hypertension, Portal | Carbon Tetrachloride | 4.85 | 15338365 | |
| MESH:D007638 | Keratoconjunctivitis Sicca | Cyclosporine | 5.51 | 15604871 | |
| MESH:D007674 | Kidney Diseases | Cyclosporine | 2.58 | 18776723 10903974 8314463 | |
| MESH:D007680 | Kidney Neoplasms | Cyclosporine | 3.17 | 12371664 | |
| MESH:D008103 | Liver Cirrhosis | Carbon Tetrachloride | 3.04 | 11903743 11408273 16221502 16943688 17174718 16239168 17334410 17157831 21278145 | |
| MESH:D008106 | Liver Cirrhosis, Experimental | Carbon Tetrachloride | 1.76 | 17766677 17481882 18395095 18277467 12609069 17823541 15876570 18395914 17640975 15338365 12741479 17557913 12586293 15730626 18279442 18054572 16033810 18472332 13678700 12546737 18429990 16248980 14724832 18472094 16027843 12632514 15996030 17714472 12958196 17708605 17900296 16638106 14716833 14620537 18156304 17698563 10355542 18251166 17944888 14716496 15893842 14748882 15650968 15370692 12445421 15925388 18705752 18418968 15057751 18210741 18166357 12649538 18481824 12898905 17631135 18006644 16192424 17525996 12632512 15673190 16097048 15931870 11481614 18376398 18187930 16015684 18205269 12445418 17721639 12389079 18339082 17805973 18420326 17869086 15362042 15818738 15123356 16136751 20821823 14512876 15052691 12667390 15959796 17922224 18317297 17761835 16011737 18412020 17976157 12666154 16116963 18263696 17565644 | |
| MESH:D008107 | Liver Diseases | Carbon Tetrachloride | 2.17 | 16246199 16964402 15830285 15720792 17285989 | |
| MESH:D017093 | Liver Failure | Carbon Tetrachloride | 4.93 | 15123358 | |
| MESH:D017114 | Liver Failure, Acute | Carbon Tetrachloride | 4.20 | 16899240 14706259 | |
| MESH:D008113 | Liver Neoplasms | Carbon Tetrachloride | 2.36 | 19294768 | |
| MESH:D008114 | Liver Neoplasms, Experimental | Carbon Tetrachloride | 2.89 | 12014681 15583823 | |
| MESH:D008664 | Metal Metabolism, Inborn Errors | Cyclosporine | 5.86 | 16801185 | |
| MESH:D009402 | Nephrosis, Lipoid | Cyclosporine | 5.51 | 17954296 | |
| MESH:D009404 | Nephrotic Syndrome | Cyclosporine | 3.75 | 19348381 18481113 | |
| MESH:D011230 | Precancerous Conditions | Cyclosporine | 3.69 | 12371664 | |
| MESH:D011565 | Psoriasis | Cyclosporine | 2.35 | 16882103 | |
| MESH:D014605 | Uveitis | Cyclosporine | 5.05 | 1336536 | |
| MESH:D014985 | Xerophthalmia | Cyclosporine | 5.51 | 17120751 |
| No data |