AutismKB 2.0

Annotation Detail for FAT4


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:FAT4 ( CDHF14,CDHR11,FAT-J,FATJ,FLJ23056,FLJ77878,NBLA00548 )
Gene Full Name: FAT tumor suppressor homolog 4 (Drosophila)
Band: 4q28.1
Quick LinksEntrez ID:79633; OMIM: 612411; Uniprot ID:FAT4_HUMAN; ENSEMBL ID: ENSG00000196159; HGNC ID: 23109
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
No data
Desease Name
NEUROLOGICAL
Cognitive performance
Desease Name
Cognitive performance
Bipolar disorder and major depressive disorder (combined)
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of FAT4 mRNAdecreases expression 19933214
D012643 Selenium Selenium results in decreased expression of FAT4 mRNAdecreases expression 19244175
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of FAT4 mRNAdecreases expression 19933214
D014810 Vitamin E Vitamin E results in decreased expression of FAT4 mRNAdecreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.4711752688 15322242 14514962
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 4.0116835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.3411748828
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.4712125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.5115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 3.0015746008
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.6720435547
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 4.4916050911
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 3.1216835633
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.5618670907 18850075 16120746
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.5316835633
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.2412621046 15340226 16354765 8697196 15668235
MESH:D003092 Colitis Selenium 4.3417936198
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.4317141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.5720055451 10048152 15322242
MESH:D019465 Craniofacial Abnormalities Vitamin E 2.5719769572
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7417107852
MESH:D056486 Drug-Induced Liver Injury Selenium 4.0815131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 4.0820420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 3.0511462148
MESH:C538011 Eales disease Vitamin E 5.439068938
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.8012711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.6215322242 16714409 18230668
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.429294722 10568697
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.3111564622
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 4.0211858732
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.5120067830
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 5.3210696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 7.1710048152 11294989
MESH:D006330 Heart Defects, Congenital Vitamin E 7.1716080930
MESH:D006333 Heart Failure Selenium 3.2917162251
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.7611000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.4516120746 12621046 15340226
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.8116863852 16490937
MESH:D019584 Hot Flashes Vitamin E 4.6914716179
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.7716959395 8697196 16354765 15340226 18606429
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 2.0218670907 18850075
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 2.0312878042 12200463
MESH:D007251 Influenza, Human Selenium 13.5016624496
MESH:D007251 Influenza, Human Vitamin E 13.5016624496
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.7616580747
MESH:D007674 Kidney Diseases Vitamin E 3.0012488133
MESH:D052177 Kidney Diseases, Cystic marker/mechanism 18604206
MESH:D007676 Kidney Failure, Chronic Selenium 4.3116518626
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.4312878042
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 2.4316169303
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 1.8316984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.3312151625
MESH:D008171 Lung Diseases Vitamin E 3.4316863852
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.3919555203 11884234
MESH:D008175 Lung Neoplasms Vitamin E 2.3911062179
MESH:D008325 Mammary Neoplasms, Experimental Selenium 2.9915318939
MESH:D008654 Mesothelioma Selenium 2.9215107826
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.3412213967
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.7214600291
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.9712520081
MESH:D010954 Plasmacytoma Selenium 5.6115087411
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 4.0718163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.8211118676 11399792 11222880 11896295
MESH:D011471 Prostatic Neoplasms Vitamin E 3.2415084515
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.3518990726
MESH:D012871 Skin Diseases Vitamin E 2.5218709164
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.2016192470
MESH:D020521 Stroke Vitamin E 3.8416517955
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.6212697716
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 5.3212125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.9715886252
No data
Pharmacogenomics Knowledge Base Top
Drug Bank Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved