AutismKB 2.0

Annotation Detail for TMEM204


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Basic Information Top
Gene Symbol:TMEM204 ( C16orf30,CLP24,FLJ20898,MGC111564 )
Gene Full Name: transmembrane protein 204
Band: 16p13.3
Quick LinksEntrez ID:79652; OMIM: 611002; Uniprot ID:TM204_HUMAN; ENSEMBL ID: ENSG00000131634; HGNC ID: 14158
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D002251 Carbon Tetrachloride Carbon Tetrachloride results in decreased expression of TMEM204 mRNAdecreases expression 17484886
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of TMEM204 mRNAdecreases expression 17557909
D010634 Phenobarbital NR1I3 protein affects the reaction [Phenobarbital results in decreased expression of TMEM204 mRNA]affects reaction|decreases expression 19482888
D010634 Phenobarbital Phenobarbital results in decreased expression of TMEM204 mRNAdecreases expression 19482888
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of TMEM204 mRNAaffects binding|decreases expression|increases activity 19710929
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 4.076195326
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.6617505938
MESH:D055371 Acute Lung Injury pirinixic acid 3.5818653653
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8814692618
MESH:D018248 Adenoma, Liver Cell Phenobarbital 12.3217620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 12.3216434500
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 4.0211256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.8915885639
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.5719483382
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 4.3416097048 16011737 15721981 16124888 16050911 15700767 10355542 18705752 16192424 15673190 16227642 3786805
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 3.1918788625
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 3.1920007298 6705139 20935162 17173139 1701930
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.814080065
MESH:D002779 Cholestasis Ethinyl Estradiol 8.7317110522 17681005 17333356 16919318 15861022 16105132 11677210
MESH:D002779 Cholestasis pirinixic acid 8.7319176532
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5718249437
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 2.1210915739 3786805 15027814 19085960 2869522 10092053 21278145 17522070 16227642 15968718 7440962 9327722 11566570 7179309 16177239 3732212 15998439 6623471 4309450 19336974 6884620 7120509
MESH:D004421 Dystonia Phenobarbital 4.471851702
MESH:D004487 Edema pirinixic acid 2.9012083418
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.6912538720
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.673659116
MESH:D004828 Epilepsies, Partial Phenobarbital 4.5911558140 3922381
MESH:D004827 Epilepsy Phenobarbital 3.0620417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.916401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.817750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 4.653659116
MESH:D005234 Fatty Liver Carbon Tetrachloride 15.6412631006 61145 12795759 16239168 19224547 17595544 15959796 16045604
MESH:D005234 Fatty Liver Ethinyl Estradiol 15.6415345470
MESH:D005234 Fatty Liver pirinixic acid 15.6419236843 20131406
MESH:D005355 Fibrosis Carbon Tetrachloride 4.0118705752
MESH:D006333 Heart Failure pirinixic acid 2.7620558911
MESH:D006505 Hepatitis Carbon Tetrachloride 4.1019900420 19110552
MESH:D006529 Hepatomegaly Phenobarbital 10.4116109766
MESH:D006529 Hepatomegaly pirinixic acid 10.4118467677 16221962 19772884 19176532
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 5.1616899240
MESH:D006943 Hyperglycemia pirinixic acid 3.5820558911
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.6515338365
MESH:D007021 Hypospadias Ethinyl Estradiol 4.3716945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.9212013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.7317937319
MESH:D007333 Insulin Resistance pirinixic acid 2.8716306350
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 7.2817334410 17157831 17174718 16943688 16221502 11903743 11408273 21278145 16239168
MESH:D008103 Liver Cirrhosis Phenobarbital 7.2821047994
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 2.4116192424 12445418 17708605 14512876 14716496 17944888 18205269 18705752 16248980 15057751 18429990 18156304 18210741 18395095 12666154 15925388 17823541 18166357 12586293 20821823 17640975 16097048 17631135 12389079 18395914 18006644 15931870 18054572 12632512 15052691 18376398 18263696 15338365 16033810 18412020 14620537 12667390 18317297 17805973 15370692 12445421 11481614 17525996 12609069 18251166 14724832 16015684 14716833 17922224 17565644 18279442 16136751 15818738 15650968 14748882 18420326 13678700 17698563 18418968 17976157 16638106 15893842 18472332 16011737 18277467 17900296 17557913 18472094 17766677 17869086 18339082 12649538 17761835 17481882 12741479 16116963 12898905 15959796 12632514 18481824 15876570 17714472 15123356 18187930 10355542 15730626 17721639 15362042 15996030 12546737 12958196 16027843 15673190
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.4115474484
MESH:D008107 Liver Diseases Carbon Tetrachloride 4.3615720792 16964402 17285989 16246199 15830285
MESH:D008107 Liver Diseases Phenobarbital 4.3619363144
MESH:D017093 Liver Failure Carbon Tetrachloride 4.7315123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 4.0816899240 14706259
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 8.1419294768
MESH:D008113 Liver Neoplasms Phenobarbital 8.1419073162 8742319 21047994 19812893 19482888 15975961
MESH:D008113 Liver Neoplasms pirinixic acid 8.1415890375 20007298 16377806
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 6.7412014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 6.741399818 2563599 18308698 17172636 6150874
MESH:D009135 Muscular Diseases pirinixic acid 4.0716239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2719151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.2516411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 5.1117484760
MESH:D009369 Neoplasms pirinixic acid 2.1117405874
MESH:D009765 Obesity pirinixic acid 1.8820558911
MESH:D010018 Osteomalacia Phenobarbital 5.0017016548
MESH:D010190 Pancreatic Neoplasms Phenobarbital 2.6016965848
MESH:D016584 Panic Disorder Ethinyl Estradiol 4.1511578682
MESH:D011230 Precancerous Conditions Phenobarbital 3.992563599
MESH:D011537 Pruritus Ethinyl Estradiol 3.9416919318 15861022
MESH:D019310 Pseudolymphoma Phenobarbital 5.2212752131
MESH:D015427 Reperfusion Injury pirinixic acid 2.5519058328
MESH:D012640 Seizures Phenobarbital 2.9511442880 3137016 4039156 16876388
MESH:D003294 Seizures, Febrile Phenobarbital 5.456407741
MESH:D013088 Spermatocele Ethinyl Estradiol 4.6616709447
MESH:D019851 Thrombophilia Ethinyl Estradiol 4.0811994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.5215669648
MESH:D013964 Thyroid Neoplasms Phenobarbital 3.361399818
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.8014692618
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.9715869587 14671159
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA162406384
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    No data
    Drug Bank Top

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    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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