AutismKB 2.0

Annotation Detail for ARHGAP10


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Basic Information Top
Gene Symbol:ARHGAP10 ( FLJ20896,FLJ41791,GRAF2,PS-GAP,PSGAP )
Gene Full Name: Rho GTPase activating protein 10
Band: 4q31.23
Quick LinksEntrez ID:79658; OMIM: 609746; Uniprot ID:RHG10_HUMAN; ENSEMBL ID: ENSG00000071205; HGNC ID: 26099
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa05100Bacterial invasion of epithelial cells
Pathway IDPathway Name
Apoptosis
Signaling by Rho GTPases
Pathway IDPathway Name
200167Arf1 pathway
Pathway IDPathway Name
P00047PDGF signaling pathway
P00034Integrin signalling pathway
Pathway IDPathway Name
500279Regulation of PAK-2p34 activity by PS-GAP/RHG10
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1818Systemic scleroderma
Desease Name
CARDIOVASCULAR
QT interval
Desease Name
QT interval
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of ARHGAP10 mRNAincreases expression 19933214
D003907 Dexamethasone Dexamethasone results in increased expression of ARHGAP10 mRNAincreases expression 17998272
D002117 Calcitriol Calcitriol results in increased expression of ARHGAP10 mRNAincreases expression 16002434
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of ARHGAP10 mRNAincreases expression 19933214
C047426 venlafaxine venlafaxine results in increased expression of ARHGAP10 mRNAincreases expression 16341940
D014810 Vitamin E Vitamin E results in increased expression of ARHGAP10 mRNAincreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.3111752688 14514962 15322242
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.8416835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.2511748828
MESH:D001169 Arthritis, Experimental Dexamethasone 3.7217659584
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.3712125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.3115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9515746008
MESH:D001943 Breast Neoplasms Calcitriol 2.0811237771
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.0820435547
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 4.3516050911
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 3.0516835633
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 2.6911237771
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.5216120746 18850075 18670907
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.4516835633
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.2116354765 15340226 8697196 12621046 15668235
MESH:D003110 Colonic Neoplasms Dexamethasone 2.5315824018
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.3414669216 17141729
MESH:D019465 Craniofacial Abnormalities Dexamethasone 3.9717728286
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.9710048152 20055451 15322242
MESH:D019465 Craniofacial Abnormalities Vitamin E 3.9719769572
MESH:D003866 Depressive Disorder venlafaxine 5.0420305041
MESH:D017449 Dermatitis, Allergic Contact Dexamethasone 3.8112438553
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7217107852
MESH:D003967 Diarrhea Dexamethasone 4.077237001
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 1.6020420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9911462148
MESH:C538011 Eales disease Vitamin E 5.229068938
MESH:D004485 Eczema Dexamethasone 4.8412438553
MESH:D004487 Edema Dexamethasone 7.9719703484
MESH:D004487 Edema Tetrachlorodibenzodioxin 7.9712711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.4218230668 15322242 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 4.3115138306
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.3310568697 9294722
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.2411564622
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.8711858732
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.3620067830
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 5.1210696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 7.0611294989 10048152
MESH:D006330 Heart Defects, Congenital Vitamin E 7.0616080930
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.6611000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.3115340226 16120746 12621046
MESH:D006548 Hernia, Diaphragmatic Dexamethasone 6.277520565
MESH:D006548 Hernia, Diaphragmatic Vitamin E 6.2716863852 16490937
MESH:D019584 Hot Flashes venlafaxine 12.5014716179
MESH:D019584 Hot Flashes Vitamin E 12.5014716179
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.5715340226 16959395 16354765 8697196 18606429
MESH:D006973 Hypertension Dexamethasone 5.5817042910
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.5818670907 18850075
MESH:D007249 Inflammation Dexamethasone 5.5711099482 8960868
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.5712200463 12878042
MESH:D007251 Influenza, Human Vitamin E 4.7316624496
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.6616580747
MESH:D007674 Kidney Diseases Vitamin E 2.9612488133
MESH:D008106 Liver Cirrhosis, Experimental Dexamethasone 3.6916718785
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.6912878042
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 3.6916169303
MESH:D017114 Liver Failure, Acute venlafaxine 5.7119857765
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 1.8116984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.2812151625
MESH:D008171 Lung Diseases Vitamin E 3.3716863852
MESH:D008175 Lung Neoplasms Dexamethasone 3.6115824018 11195469
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.6119555203 11884234
MESH:D008175 Lung Neoplasms Vitamin E 3.6111062179
MESH:D001523 Mental Disorders venlafaxine 5.3116856516
MESH:D008881 Migraine Disorders venlafaxine 4.9918803445
MESH:D009101 Multiple Myeloma Dexamethasone 3.7215744524 16118317 15867202
MESH:D009190 Myelodysplastic Syndromes Dexamethasone 3.709809623
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.2712213967
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.5914600291
MESH:D009771 Obsessive-Compulsive Disorder venlafaxine 5.9917503984
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.7712520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.9418163543
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Dexamethasone 3.7021297632
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.6511399792 11896295 11222880 11118676
MESH:D011470 Prostatic Hyperplasia Calcitriol 5.2415572423
MESH:D011471 Prostatic Neoplasms Calcitriol 3.3312479363 15754350 16644109 18247401 16289102
MESH:D011471 Prostatic Neoplasms Vitamin E 3.3315084515
MESH:D012128 Respiratory Distress Syndrome, Adult Dexamethasone 4.3711700416 18379247
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.2218990726
MESH:D012871 Skin Diseases Vitamin E 2.5018709164
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1716192470
MESH:D013272 Stomach Diseases Dexamethasone 4.7815472012
MESH:D013276 Stomach Ulcer Dexamethasone 3.8115138204
MESH:D020521 Stroke Vitamin E 3.7716517955
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.4212697716
MESH:D014605 Uveitis Dexamethasone 5.341336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 5.1212125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.7715886252
Pathway ID Pathway Name
REACT:578 Apoptosis
KEGG:05100 Bacterial invasion of epithelial cells
REACT:13714 Regulation of PAK-2p34 activity by PS-GAP
REACT:11044 Signaling by Rho GTPases
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA134904544
    • No data
    No data
    Releated drug ID Related drug Name
    PA448976choline
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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