AutismKB 2.0

Annotation Detail for DYNC2H1


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Basic Information Top
Gene Symbol:DYNC2H1 ( ATD3,DHC1b,DHC2,DNCH2,DYH1B,FLJ11756,hdhc11 )
Gene Full Name: dynein, cytoplasmic 2, heavy chain 1
Band: 11q22.3
Quick LinksEntrez ID:79659; OMIM: 603297; Uniprot ID:DYHC2_HUMAN; ENSEMBL ID: ENSG00000187240; HGNC ID: 2962
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04145Phagosome
hsa04962Vasopressin-regulated water reabsorption
No data
No data
Pathway IDPathway Name
P00029Huntington disease
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1934Cancer
No data
No data
Desease Name
Asphyxiating thoracic dystrophy 3
Short rib-polydactyly syndrome, type III
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D003010 Clorgyline Clorgyline results in increased expression of DYNC2H1 mRNAincreases expression 19691856
D005038 Ethylnitrosourea Ethylnitrosourea results in increased mutagenesis of DYNC2H1 geneincreases mutagenesis 15755804
C017947 sodium arsenite sodium arsenite results in increased expression of DYNC2H1 mRNAincreases expression 17879257
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000236 Adenoma Ethylnitrosourea 3.946695378
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 5.5715276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 5.7716712894 17306315
OMIM:613091 ASPHYXIATING THORACIC DYSTROPHY 3 marker/mechanism
MESH:D001927 Brain Diseases Ethylnitrosourea 5.3314991843
MESH:D001932 Brain Neoplasms Ethylnitrosourea 4.7416651633 16436596 16357521 18412241 15144691
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 2.0117306315 16507464 15276417
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 2.4718572023
MESH:D002471 Cell Transformation, Neoplastic Ethylnitrosourea 8.0816003739
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 8.0820056578 19524636
MESH:D016543 Central Nervous System Neoplasms Ethylnitrosourea 6.8517160924
MESH:D004476 Ectodermal Dysplasia Ethylnitrosourea 6.8518357618
MESH:D005833 Genital Neoplasms, Female sodium arsenite 5.4216452187
MESH:D005909 Glioblastoma Ethylnitrosourea 4.1016436596
MESH:D005910 Glioma Ethylnitrosourea 3.6316357521 18412241 16651633
MESH:D006689 Hodgkin Disease sodium arsenite 3.5612676792
MESH:D007248 Infertility, Male sodium arsenite 3.2612646999 15346721
MESH:D007674 Kidney Diseases sodium arsenite 3.0220008137
MESH:D007680 Kidney Neoplasms Ethylnitrosourea 4.3217379185
MESH:D008113 Liver Neoplasms sodium arsenite 2.4916712894 15276417
MESH:D008171 Lung Diseases sodium arsenite 3.4519095001
MESH:D008175 Lung Neoplasms Ethylnitrosourea 2.9117703301 16271038 6695378 16019985
MESH:D008175 Lung Neoplasms sodium arsenite 2.9116712894 19931552 17306315 17077188 15276417
MESH:D008223 Lymphoma Ethylnitrosourea 4.2515790496
MESH:D016399 Lymphoma, T-Cell Ethylnitrosourea 5.7015375218
MESH:D008325 Mammary Neoplasms, Experimental Ethylnitrosourea 3.7718041768 10838139 10767621
MESH:D008545 Melanoma sodium arsenite 2.0719082730 16487513
MESH:D008579 Meningioma Ethylnitrosourea 6.8517943659
MESH:D009369 Neoplasms sodium arsenite 2.6811559025
MESH:D009374 Neoplasms, Experimental Ethylnitrosourea 11.6416707424
MESH:D009374 Neoplasms, Experimental sodium arsenite 11.6420056578
MESH:D009436 Neural Tube Defects sodium arsenite 3.4112854658
MESH:D009442 Neurilemmoma Ethylnitrosourea 6.1616003739 17160924 16651423
MESH:D009837 Oligodendroglioma Ethylnitrosourea 6.8517160924
MESH:D010051 Ovarian Neoplasms sodium arsenite 2.5417306315 15276417
MESH:D011471 Prostatic Neoplasms Clorgyline 3.5819691856
MESH:D011471 Prostatic Neoplasms sodium arsenite 3.5816039940
MESH:C537602 Short rib-polydactyly syndrome, Verma-Naumoff type marker/mechanism
MESH:D012878 Skin Neoplasms sodium arsenite 2.8718572023 19524636
MESH:D016135 Spinal Dysraphism sodium arsenite 4.1412854658
MESH:D013953 Thymus Neoplasms Ethylnitrosourea 5.9015790496
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 2.6417306315 16712894 16452187 11723127
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 4.2111813266
MESH:D014652 Vascular Diseases sodium arsenite 5.1717056641
Pathway ID Pathway Name
KEGG:04145 Phagosome
KEGG:04962 Vasopressin-regulated water reabsorption
Pharmacogenomics Knowledge Base Top
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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