AutismKB 2.0

Annotation Detail for PPP1R3B


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Basic Information Top
Gene Symbol:PPP1R3B ( FLJ14005,FLJ34675,GL,PPP1R4 )
Gene Full Name: protein phosphatase 1, regulatory (inhibitor) subunit 3B
Band: 8p23.1
Quick LinksEntrez ID:79660; OMIM: 610541; Uniprot ID:PPR3B_HUMAN; ENSEMBL ID: ENSG00000173281; HGNC ID: 14942
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04910Insulin signaling pathway
No data
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No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of PPP1R3B mRNAdecreases expression 19933214
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of PPP1R3B mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of PPP1R3B mRNAaffects expression 17562736
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of PPP1R3B proteinaffects expression 20106945
D000643 Ammonium Chloride Ammonium Chloride affects the expression of PPP1R3B mRNAaffects expression 16483693
D017638 Asbestos, Crocidolite Asbestos, Crocidolite results in increased expression of PPP1R3B mRNAincreases expression 18687144
D016572 Cyclosporine Cyclosporine results in decreased expression of PPP1R3B mRNAdecreases expression 20106945
D004041 Dietary Fats Dietary Fats results in decreased expression of PPP1R3B mRNAdecreases expression 18042831
D004052 Diethylnitrosamine Diethylnitrosamine results in decreased expression of PPP1R3B mRNAdecreases expression 19638242
D002117 Calcitriol Calcitriol results in increased expression of PPP1R3B mRNAincreases expression 16002434
D004958 Estradiol Estradiol results in decreased expression of PPP1R3B mRNAdecreases expression 20106945
C119620 kenpaullone kenpaullone results in decreased expression of PPP1R3B mRNAdecreases expression 17993264
C041786 palm oil palm oil results in decreased expression of PPP1R3B mRNAdecreases expression 18042831
D010634 Phenobarbital Phenobarbital results in decreased expression of PPP1R3B mRNAdecreases expression 19270015
C009250 sevoflurane sevoflurane affects the expression of PPP1R3B mRNAaffects expression 15967596
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of PPP1R3B mRNAdecreases expression 20106945
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of PPP1R3B mRNAdecreases expression 19933214
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 8.366195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 8.3615322242 11752688 14514962
MESH:D000138 Acidosis Ammonium Chloride 3.5818287403
MESH:D000230 Adenocarcinoma Estradiol 2.1011473722
MESH:D000236 Adenoma Diethylnitrosamine 2.856695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 17.4816434500 19061943 17162532 17620307 18056438 19052882
MESH:D018248 Adenoma, Liver Cell Phenobarbital 17.4817620307
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 17.4816835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.9511748828
MESH:D000799 Angioedema Acetaminophen 3.8710982225
MESH:D001161 Arteriosclerosis Dietary Fats 3.9015238619
MESH:D001321 Autistic Disorder Acetaminophen 1.4218445737
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.0512125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.8215340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.7615746008
MESH:D001943 Breast Neoplasms Calcitriol 2.3311237771
MESH:D001943 Breast Neoplasms Dietary Fats 2.3320435547
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.3317474063
MESH:D001943 Breast Neoplasms Estradiol 2.3317018787 12948864 18497071 14630087 19861407 16675129 17261762 17289903
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.3320435547
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.4816111702
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8016835633
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 11.4116705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 11.413084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 11.4112907637 12619106 21507988
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 11.4111831363 17055752 19335982 16807293 19822196 18506893 20524982 19171122 16328049 18785209 18056438 17138121 19394651 19052882 18691550 19539802 3581430 17978847 18788625 17761372 20727157 16569478 16681979 16288022 16830150 20514400 20101231 17173139 16878318 20084675 20512989 17428255 19107877 18393292 16502159 10672840 18494052 3084413 18665156 19208518 10737359 20935162 20432363 19701751 17162532 18210153 20007298 19919837 18978308 19519916 19418558 16935385 19383236 20214788 18971187 21159647 16698587 16540662 16779866
MESH:D006528 Carcinoma, Hepatocellular Estradiol 11.4116924424
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 11.4120935162 20007298 6705139 1701930 17173139
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 2.6211237771
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3718850075 18670907 16120746
MESH:D002386 Cataract Acetaminophen 2.5810977129
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 11.1712371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 11.1717174075 7505956 21159647 2727394
MESH:D002471 Cell Transformation, Neoplastic Estradiol 11.1718566989
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.264080065
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 9.3319052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 9.3316835633
MESH:D002779 Cholestasis Cyclosporine 2.9219486331
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.108697196 12621046 15340226 16354765 15668235
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.0614669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2510048152 20055451 15322242
MESH:D003490 Cyanosis 2,4-dinitrotoluene 4.0318551238
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 4.2220387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.2217107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.4119279558
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 8.9521346803 18551238
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 8.9512594235 11834606 19164858 14725611 19420014 11461765 10774834 11421492 19370779 19739265 16485898 14986274 12392966 11529661 16177239 17522070 18713872 19416960 11743745 18071297 10663392 16781746 16393943 17906064 11739529 12540782 19923254 12958197 2444490 16227642 19085960 14550746 15968718 10915739 16081117 11287661 17562736 12705907 16109766 12153990 15619225
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 8.9519107877
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 8.9520420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.1319426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.7611462148
MESH:D050171 Dyslipidemias Dietary Fats 3.4518367378
MESH:D004421 Dystonia Phenobarbital 4.011851702
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.3811000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.9318230668 15322242 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 3.9415138306
MESH:D016889 Endometrial Neoplasms Estradiol 2.9818566989 11473722 19148513
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.0210568697 9294722
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.123659116
MESH:D004828 Epilepsies, Partial Phenobarbital 3.903922381 11558140
MESH:D004827 Epilepsy Phenobarbital 2.8920417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.546401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.267750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 4.043659116
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.1516302075
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0111564622
MESH:D005234 Fatty Liver Cyclosporine 13.1519224547
MESH:D005234 Fatty Liver Dietary Fats 13.1518296743 17967931 19551842 19004024
MESH:D005234 Fatty Liver Diethylnitrosamine 13.1521071580 20387270
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.4711858732
MESH:D005355 Fibrosis Cyclosporine 14.8112168785 12639820
MESH:D005355 Fibrosis Dietary Fats 14.8118296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 14.8120067830
MESH:D005756 Gastritis Acetaminophen 3.7116983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.248708960
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.6210696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.3310048152 11294989
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.4415720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.3411000095
MESH:D006529 Hepatomegaly Phenobarbital 8.4916109766
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 8.4912621046 16120746 15340226
MESH:D006558 Herpes Genitalis Estradiol 5.0615709030
MESH:D019584 Hot Flashes Estradiol 3.7817088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.0815340226 16959395 18606429 16354765 8697196
MESH:D006930 Hyperalgesia Acetaminophen 2.7016870215
MESH:D006937 Hypercholesterolemia Dietary Fats 3.6021332399
MESH:D006949 Hyperlipidemias Dietary Fats 3.6221332399
MESH:D006973 Hypertension Cyclosporine 4.9510903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.9518670907 18850075
MESH:D007249 Inflammation Dietary Fats 8.2920412841
MESH:D007249 Inflammation Diethylnitrosamine 8.2918785209
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 8.2912200463 12878042
MESH:D007333 Insulin Resistance Dietary Fats 7.3818457598 11836018
MESH:D007333 Insulin Resistance Estradiol 7.3816393666 16627594
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.3416580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.4715604871
MESH:D007674 Kidney Diseases Acetaminophen 9.9812587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 9.988314463 10903974 18776723
MESH:D007674 Kidney Diseases Estradiol 9.9815618244
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 12.3816705839
MESH:D007680 Kidney Neoplasms Cyclosporine 12.3812371664
MESH:D007680 Kidney Neoplasms Estradiol 12.3815610895
MESH:D007859 Learning Disorders sevoflurane 4.7819212262
MESH:D008103 Liver Cirrhosis Dietary Fats 11.0418296743
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 11.0418665156 19638242 20032147 18522880 18407596
MESH:D008103 Liver Cirrhosis Phenobarbital 11.0421047994
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 2.2614659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.2612878042
MESH:D008107 Liver Diseases Acetaminophen 6.4919014921 12587719 19460945 11587558 12969438 16611625 19784758 16610002
MESH:D008107 Liver Diseases Diethylnitrosamine 6.4917034775
MESH:D008107 Liver Diseases Phenobarbital 6.4919363144
MESH:D017114 Liver Failure, Acute Acetaminophen 3.2417185352 16871587
MESH:D008113 Liver Neoplasms Aflatoxin B1 10.719163691 18177683 2125692 15890375
MESH:D008113 Liver Neoplasms Diethylnitrosamine 10.7119427195 15175105 19996281 18977376 20583210 19690152 18978307 20492335 15885732 12112319 21071580 12771043 19294768 9163691 20118626 19256749 20501860 20452335 19255062 10737359 16942905 20101389 2862719 18644402 20434301 19812893 19642983 19833225 19073162 20137499 19090486 19499222 2422723 18754104 19850985 21047994 21167192 19638242 19551842 19254457 20405173 18648771 21278145 19426721
MESH:D008113 Liver Neoplasms Phenobarbital 10.7121047994 19812893 19482888 15975961 8742319 19073162
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 10.7116984957
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 14.138603461
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 14.1318544905 17854601 3124819 9362446 18093689 19009564 18775883 16842330 18079962 16267830 21159647 18308698 17174075 19519916 18282651 17942915 18164116 19004024 19126423 18253720 19539802 2563599
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 14.1317172636 1399818 18308698 2563599 6150874
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 14.1312151625
MESH:D055370 Lung Injury Asbestos, Crocidolite 4.0417365036
MESH:D008175 Lung Neoplasms Aflatoxin B1 3.3914755239
MESH:D008175 Lung Neoplasms Diethylnitrosamine 3.3920512841 20970405 21163286 6695378
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.3911884234 19555203
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 2.5616891317 11408345 11807958 17203775
MESH:D020149 Manganese Poisoning Estradiol 4.5119453300
MESH:D008546 Melanoma, Experimental Acetaminophen 3.5819513568
MESH:D008569 Memory Disorders sevoflurane 4.7619212262
MESH:D008654 Mesothelioma Asbestos, Crocidolite 3.1816166281 16966607 18303189
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.8216801185
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0212213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.2816810080
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.5017484760
MESH:D009336 Necrosis 2,4-dinitrotoluene 3.8818551238
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.579029167 3581430
MESH:D009389 Neovascularization, Pathologic Estradiol 3.7517289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.4717954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.2918481113 19348381
MESH:D009421 Nervous System Malformations Estradiol 9.5016427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 9.5014600291
MESH:D019636 Neurodegenerative Diseases Acetaminophen 8.1918514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 8.1920387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.1520387270
MESH:D009765 Obesity Dietary Fats 2.2916723640 18674790 20518802 21332399 11836018 19632207 18457598 17217161 20132043
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 3.4312819281 16049721
MESH:D010018 Osteomalacia Phenobarbital 4.3817016548
MESH:D010051 Ovarian Neoplasms Estradiol 2.2219401270
MESH:D010146 Pain Acetaminophen 2.3916870215
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 5.2616540662
MESH:D010190 Pancreatic Neoplasms Phenobarbital 5.2616965848
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.2812520081
MESH:D010995 Pleural Diseases Asbestos, Crocidolite 4.9110923243
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.5718163543
MESH:D011230 Precancerous Conditions Cyclosporine 15.2912371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 15.292563599
MESH:D011230 Precancerous Conditions Phenobarbital 15.292563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.2111118676 11896295 11399792 11222880
MESH:D011470 Prostatic Hyperplasia Calcitriol 4.8015572423
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.8920887781
MESH:D011471 Prostatic Neoplasms Calcitriol 3.3212479363 16289102 18247401 15754350 16644109
MESH:D011471 Prostatic Neoplasms Estradiol 3.3216740699
MESH:D019310 Pseudolymphoma Phenobarbital 4.5312752131
MESH:D011565 Psoriasis Cyclosporine 2.2316882103
MESH:D011658 Pulmonary Fibrosis Asbestos, Crocidolite 3.0317322281 17365031 15814490 17975199
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.8518990726
MESH:D012640 Seizures 2,4-dinitrotoluene 5.9318551238
MESH:D012640 Seizures Phenobarbital 5.9316876388 4039156 3137016 11442880
MESH:D003294 Seizures, Febrile Phenobarbital 4.846407741
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.0416192470
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 1.7518456281
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.9312697716
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 7.197505956
MESH:D013964 Thyroid Neoplasms Phenobarbital 7.191399818
MESH:D013978 Tibial Fractures Estradiol 4.7219048282
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 2.2916049721
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.3310091137
MESH:D014581 Urticaria Acetaminophen 2.9810982225
MESH:D014605 Uveitis Cyclosporine 4.011336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.6212125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.2815886252
MESH:D015430 Weight Gain Dietary Fats 3.7416723640
MESH:D014985 Xerophthalmia Cyclosporine 4.4717120751
Pathway ID Pathway Name
KEGG:04910 Insulin signaling pathway
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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