AutismKB 2.0

Annotation Detail for HSPBAP1


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Basic Information Top
Gene Symbol:HSPBAP1 ( FLJ22623,FLJ39386,PASS1 )
Gene Full Name: HSPB (heat shock 27kDa) associated protein 1
Band: 3q21.1
Quick LinksEntrez ID:79663; OMIM: 608263; Uniprot ID:HBAP1_HUMAN; ENSEMBL ID: ENSG00000169087; HGNC ID: 16389
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1777Intractable epilepsy
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of HSPBAP1 mRNAaffects expression 21346803
D000643 Ammonium Chloride Ammonium Chloride affects the expression of HSPBAP1 mRNAaffects expression 16483693
D002995 Clofibric Acid [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of HSPBAP1 mRNAaffects cotreatment|affects expression 17602206
D016572 Cyclosporine Cyclosporine results in increased expression of HSPBAP1 mRNAincreases expression 20106945
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of HSPBAP1 mRNAaffects cotreatment|affects expression 17602206
D012643 Selenium Selenium results in decreased expression of HSPBAP1 mRNAdecreases expression 19244175
D043343 Testosterone Propionate Testosterone Propionate results in decreased expression of HSPBAP1 mRNAdecreases expression 15601916
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.9518287403
MESH:D000236 Adenoma Diethylnitrosamine 2.996695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 4.3016434500 17620307 18056438 19052882 17162532 19061943
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.2017474063
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 3.1016705839
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 3.1019208518 20101231 20214788 20512989 10672840 18978308 16935385 11831363 17055752 20524982 16569478 10737359 3084413 18785209 16502159 19519916 18506893 18971187 16328049 20084675 19919837 19383236 17761372 20007298 18393292 16698587 18788625 16779866 20514400 18494052 19701751 16807293 16878318 17428255 17173139 18056438 16288022 19107877 20727157 19418558 19171122 19822196 17138121 17162532 18210153 18665156 19052882 19394651 19539802 3581430 17978847 20432363 20935162 16830150 16681979 21159647 19335982 16540662 18691550
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 12.246135515
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 12.2412371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 12.2417174075 21159647 7505956 2727394
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 3.9319052882
MESH:D002779 Cholestasis Cyclosporine 3.1219486331
MESH:D003092 Colitis Selenium 4.1417936198
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.3818551238
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 2.2420387270
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 6.6718551238 21346803
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 6.6719107877
MESH:D056486 Drug-Induced Liver Injury Selenium 6.6715131321
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.5616302075
MESH:D005234 Fatty Liver Cyclosporine 8.6719224547
MESH:D005234 Fatty Liver Diethylnitrosamine 8.6721071580 20387270
MESH:D005355 Fibrosis Cyclosporine 3.5012639820 12168785
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.628708960
MESH:D006333 Heart Failure Selenium 3.2317162251
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.8215720958
MESH:D006973 Hypertension Cyclosporine 2.1810903974
MESH:D007249 Inflammation Diethylnitrosamine 2.5018785209
MESH:D007251 Influenza, Human Selenium 4.6416624496
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.8815604871
MESH:D007674 Kidney Diseases Cyclosporine 2.4818776723 10903974 8314463
MESH:D007676 Kidney Failure, Chronic Selenium 4.1716518626
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 8.0616705839
MESH:D007680 Kidney Neoplasms Cyclosporine 8.0612371664
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.9619638242 20032147 18407596 18665156 18522880
MESH:D008107 Liver Diseases Diethylnitrosamine 2.1517034775
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 8.047678174
MESH:D008113 Liver Neoplasms Clofibric Acid 8.0417602206
MESH:D008113 Liver Neoplasms Diethylnitrosamine 8.0418754104 19833225 12112319 19427195 21278145 19256749 19426721 15885732 19294768 20501860 19499222 2862719 19638242 21071580 18644402 9163691 19812893 19090486 20137499 19551842 12771043 16942905 20452335 19255062 19690152 20492335 20101389 21167192 18977376 19850985 19254457 19642983 15175105 10737359 18648771 2422723 20434301 19073162 21047994 20583210 19996281 20405173 20118626 18978307
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 6.462876786 2876784 6135515
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 6.4618253720 18775883 18308698 19009564 18164116 19539802 16842330 18079962 2563599 16267830 17942915 18544905 18093689 18282651 3124819 19004024 9362446 17174075 17854601 19126423 21159647 19519916
MESH:D008175 Lung Neoplasms Diethylnitrosamine 1.766695378 20970405 20512841 21163286
MESH:D008325 Mammary Neoplasms, Experimental Selenium 2.9215318939
MESH:D008654 Mesothelioma Selenium 2.8815107826
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.2316801185
MESH:D009336 Necrosis 2,6-dinitrotoluene 4.2618551238 7678174
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.669029167 3581430
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.8817954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.5319348381 18481113
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 3.5720387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.5620387270
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.7016049721
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 2.5016540662
MESH:D010954 Plasmacytoma Selenium 5.3315087411
MESH:D011230 Precancerous Conditions Cyclosporine 9.7912371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 9.792563599
MESH:D011565 Psoriasis Cyclosporine 2.3016882103
MESH:D012640 Seizures 2,6-dinitrotoluene 2.7118551238
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 1.7618456281
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 3.197505956
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 2.3816049721
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.7110091137
MESH:D014605 Uveitis Cyclosporine 4.431336536
MESH:D014985 Xerophthalmia Cyclosporine 4.8817120751
No data
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Syndromic Genes

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AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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