Annotation Detail for PARP8
Basic Information Top
| Gene Symbol: | PARP8 ( FLJ21308,MGC42864,pART16 ) |
|---|---|
| Gene Full Name: | poly (ADP-ribose) polymerase family, member 8 |
| Band: | 5q11.1 |
| Quick Links | Entrez ID:79668; OMIM: NA; Uniprot ID:PARP8_HUMAN; ENSEMBL ID: ENSG00000151883; HGNC ID: 26124 |
| Relate to Another Database: | SFARIGene; denovo-db |
Related Pathway Information| Chemical ID | Chemical Name | Interaction | Interaction Action | Publication |
|---|---|---|---|---|
| D002251 | Carbon Tetrachloride | Carbon Tetrachloride affects the expression of PARP8 mRNA | affects expression | 17484886 |
| D016572 | Cyclosporine | Cyclosporine results in increased expression of PARP8 mRNA | increases expression | 20106945 |
| D004041 | Dietary Fats | Dietary Fats results in increased expression of PARP8 mRNA | increases expression | 18042831 |
| C041786 | palm oil | palm oil results in increased expression of PARP8 mRNA | increases expression | 18042831 |
| Disease ID | Disease Name | Direct Evidence | Inference Chemical Name | Inference Score | Publication |
|---|---|---|---|---|---|
| MESH:D001161 | Arteriosclerosis | Dietary Fats | 4.45 | 15238619 | |
| MESH:D001943 | Breast Neoplasms | Dietary Fats | 2.24 | 20435547 | |
| MESH:D002252 | Carbon Tetrachloride Poisoning | Carbon Tetrachloride | 4.34 | 16227642 16011737 16050911 15673190 10355542 16097048 3786805 15721981 18705752 15700767 16124888 16192424 | |
| MESH:D006528 | Carcinoma, Hepatocellular | Carbon Tetrachloride | 1.86 | 18788625 | |
| MESH:D002471 | Cell Transformation, Neoplastic | Cyclosporine | 2.79 | 12371664 | |
| MESH:D002779 | Cholestasis | Cyclosporine | 3.21 | 19486331 | |
| MESH:D056486 | Drug-Induced Liver Injury | Carbon Tetrachloride | 2.12 | 10915739 3786805 21278145 15027814 19085960 19336974 16227642 10092053 16177239 7120509 7440962 3732212 2869522 6623471 6884620 15968718 11566570 4309450 7179309 17522070 15998439 9327722 | |
| MESH:D050171 | Dyslipidemias | Dietary Fats | 3.73 | 18367378 | |
| MESH:D005234 | Fatty Liver | Carbon Tetrachloride | 15.71 | 61145 12795759 16239168 12631006 19224547 16045604 15959796 17595544 | |
| MESH:D005234 | Fatty Liver | Cyclosporine | 15.71 | 19224547 | |
| MESH:D005234 | Fatty Liver | Dietary Fats | 15.71 | 17967931 19551842 18296743 19004024 | |
| MESH:D005355 | Fibrosis | Carbon Tetrachloride | 18.33 | 18705752 | |
| MESH:D005355 | Fibrosis | Cyclosporine | 18.33 | 12639820 12168785 | |
| MESH:D005355 | Fibrosis | Dietary Fats | 18.33 | 18296743 | |
| MESH:D005885 | Gingival Hyperplasia | Cyclosporine | 4.85 | 8708960 | |
| MESH:D006457 | Hemoglobinuria, Paroxysmal | Cyclosporine | 5.05 | 15720958 | |
| MESH:D006505 | Hepatitis | Carbon Tetrachloride | 4.10 | 19900420 19110552 | |
| MESH:D006932 | Hyperbilirubinemia | Carbon Tetrachloride | 5.16 | 16899240 | |
| MESH:D006937 | Hypercholesterolemia | Dietary Fats | 4.02 | 21332399 | |
| MESH:D006949 | Hyperlipidemias | Dietary Fats | 4.08 | 21332399 | |
| MESH:D006973 | Hypertension | Cyclosporine | 2.21 | 10903974 | |
| MESH:D006975 | Hypertension, Portal | Carbon Tetrachloride | 4.65 | 15338365 | |
| MESH:D007249 | Inflammation | Dietary Fats | 2.60 | 20412841 | |
| MESH:D007333 | Insulin Resistance | Dietary Fats | 3.34 | 11836018 18457598 | |
| MESH:D007638 | Keratoconjunctivitis Sicca | Cyclosporine | 5.16 | 15604871 | |
| MESH:D007674 | Kidney Diseases | Cyclosporine | 2.54 | 8314463 10903974 18776723 | |
| MESH:D007680 | Kidney Neoplasms | Cyclosporine | 3.08 | 12371664 | |
| MESH:D008103 | Liver Cirrhosis | Carbon Tetrachloride | 7.27 | 17334410 16943688 16239168 17157831 21278145 11408273 17174718 11903743 16221502 | |
| MESH:D008103 | Liver Cirrhosis | Dietary Fats | 7.27 | 18296743 | |
| MESH:D008106 | Liver Cirrhosis, Experimental | Carbon Tetrachloride | 1.75 | 17900296 17714472 18339082 13678700 16097048 12958196 18166357 17805973 15876570 12389079 18395095 15673190 12609069 12546737 18420326 17631135 20821823 15931870 18418968 12632514 17565644 18210741 16015684 14748882 18317297 18277467 15123356 17481882 16011737 17823541 12667390 16638106 15925388 12445421 15650968 15338365 12586293 12649538 17976157 17640975 17525996 15818738 18156304 18251166 18429990 15370692 18263696 17557913 15959796 18472332 12445418 17869086 18705752 12632512 16027843 18395914 17944888 17922224 18279442 16192424 14716833 16248980 16116963 17761835 11481614 18472094 10355542 18376398 15362042 18412020 18054572 14716496 15893842 12666154 15052691 16136751 14620537 17708605 18205269 14512876 18481824 18187930 14724832 17766677 17721639 15730626 18006644 12898905 15996030 16033810 17698563 15057751 12741479 | |
| MESH:D008107 | Liver Diseases | Carbon Tetrachloride | 2.15 | 16246199 15720792 17285989 15830285 16964402 | |
| MESH:D017093 | Liver Failure | Carbon Tetrachloride | 4.73 | 15123358 | |
| MESH:D017114 | Liver Failure, Acute | Carbon Tetrachloride | 4.08 | 16899240 14706259 | |
| MESH:D008113 | Liver Neoplasms | Carbon Tetrachloride | 2.34 | 19294768 | |
| MESH:D008114 | Liver Neoplasms, Experimental | Carbon Tetrachloride | 2.84 | 15583823 12014681 | |
| MESH:D008664 | Metal Metabolism, Inborn Errors | Cyclosporine | 5.51 | 16801185 | |
| MESH:D009402 | Nephrosis, Lipoid | Cyclosporine | 5.16 | 17954296 | |
| MESH:D009404 | Nephrotic Syndrome | Cyclosporine | 3.65 | 19348381 18481113 | |
| MESH:D009765 | Obesity | Dietary Fats | 2.36 | 21332399 20132043 17217161 16723640 18674790 20518802 18457598 19632207 11836018 | |
| MESH:D011230 | Precancerous Conditions | Cyclosporine | 3.59 | 12371664 | |
| MESH:D011565 | Psoriasis | Cyclosporine | 2.33 | 16882103 | |
| MESH:D014605 | Uveitis | Cyclosporine | 4.71 | 1336536 | |
| MESH:D015430 | Weight Gain | Dietary Fats | 4.11 | 16723640 | |
| MESH:D014985 | Xerophthalmia | Cyclosporine | 5.16 | 17120751 |
| No data |