AutismKB 2.0

Annotation Detail for IPO4


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Basic Information Top
Gene Symbol:IPO4 ( FLJ23338,Imp4,MGC131665 )
Gene Full Name: importin 4
Band: 14q12
Quick LinksEntrez ID:79711; OMIM: NA; Uniprot ID:IPO4_HUMAN; ENSEMBL ID: ENSG00000196497; HGNC ID: 19426
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of IPO4 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of IPO4 mRNAaffects expression 21346803
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of IPO4 mRNAdecreases expression 18648102
C035207 4-amino-2,6-dinitrotoluene 4-amino-2,6-dinitrotoluene affects the expression of IPO4 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of IPO4 mRNAaffects expression 17562736
D000082 Acetaminophen Acetaminophen results in increased expression of IPO4 mRNAincreases expression 19420014
C006780 bisphenol A bisphenol A results in increased expression of IPO4 mRNAincreases expression 17989879
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in increased expression of IPO4 mRNAincreases expression 15336504
D016572 Cyclosporine Cyclosporine results in increased expression of IPO4 mRNAincreases expression 20106945
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of IPO4 mRNAaffects expression 17555576
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of IPO4 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of IPO4 mRNAaffects cotreatment|increases expression 17942748
D009532 Nickel MT1 affects the reaction [Nickel affects the expression of IPO4 mRNA]affects expression|affects reaction 16166738
D009532 Nickel MT2 affects the reaction [Nickel affects the expression of IPO4 mRNA]affects expression|affects reaction 16166738
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of IPO4 mRNAaffects binding|increases activity|increases expression 19710929
D011374 Progesterone Progesterone results in decreased expression of IPO4 mRNAdecreases expression 18037150
D013629 Tamoxifen Tamoxifen affects the expression of IPO4 mRNAaffects expression 17555576
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of IPO4 mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of IPO4 mRNAincreases expression 18796159
17942748
D014635 Valproic Acid Valproic Acid results in decreased expression of IPO4 mRNAdecreases expression 19101580
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.6114745880
MESH:D000014 Abnormalities, Drug-Induced 4-amino-2,6-dinitrotoluene 14.587525203
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 14.5811752688 15322242 14514962
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 14.588875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 3.9619490988
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.0017505938
MESH:D055371 Acute Lung Injury Nickel 9.3516166738
MESH:D055371 Acute Lung Injury pirinixic acid 9.3518653653
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8214692618
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.773712494
MESH:D018248 Adenoma, Liver Cell pirinixic acid 10.0716434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 10.0716835633
MESH:D000550 Amblyopia Valproic Acid 5.3017688650
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.9711748828
MESH:D000799 Angioedema Acetaminophen 3.9110982225
MESH:D001008 Anxiety Disorders Valproic Acid 3.5917497229
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.5111256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.6815885639
MESH:D001321 Autistic Disorder Acetaminophen 1.8518445737
MESH:D001321 Autistic Disorder Valproic Acid 1.8518316065 17157402 17507914 18396377 18558336 19232924 20603192 18177632 18985861 16609825 15238991 18775368 18940202 17688650 19460635
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.0811289319 1440618
MESH:D001714 Bipolar Disorder Valproic Acid 3.0920046352 17594078
MESH:D001778 Blood Coagulation Disorders pirinixic acid 8.8619483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.8612125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.8515340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 8.0815746008
MESH:D001848 Bone Diseases, Developmental Valproic Acid 8.088888407
MESH:D001862 Bone Resorption bisphenol A 3.8911985600
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.4017868700
MESH:D001930 Brain Injuries Progesterone 4.3015845082 15665606 15380490
MESH:D001943 Breast Neoplasms bisphenol A 2.3617123778
MESH:D001943 Breast Neoplasms Nickel 2.3615986119
MESH:D001943 Breast Neoplasms Progesterone 2.3615562024 17614352 16175315
MESH:D001943 Breast Neoplasms Tamoxifen 2.3617893378 19066611 18815881 21152245 19189210 19244106 20135344 19410462 19189212 21138602 15668708 17261762 19142967 20005174 19115204 16273361 19084267 18425577 20544844 16873071 16202921 17440819 11161223 20859285 19155303 18997820 19011961 17049068 18351453 19487384 19221464 19288272 15565566 20065188 18855134 17242785 19289846 18984771 18821012 19200415 18629630 16818667 19103187 20390343 19059307
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.3620435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8216835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.5519066611
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 8.9116705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 8.9116705839
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 8.913581430 7296757
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 8.913084413
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 8.9116924424
MESH:D002278 Carcinoma in Situ bisphenol A 5.0417123778
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.697296757
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.6417572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3818850075 18670907 16120746
MESH:D002386 Cataract 4-amino-2,6-dinitrotoluene 7.4714694615
MESH:D002386 Cataract Acetaminophen 7.4710977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 11.256135515
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 11.257505956
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 11.2512371664
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.7220734317
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.1916835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 19.399022650 19486331
MESH:D002779 Cholestasis Cyclosporine 19.3919486331
MESH:D002779 Cholestasis Ethinyl Estradiol 19.3916105132 11677210 16919318 17333356 17681005 15861022 17110522
MESH:D002779 Cholestasis pirinixic acid 19.3919176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1115340226 16354765 8697196 15668235 12621046
MESH:D000013 Congenital Abnormalities 4-amino-2,6-dinitrotoluene 9.2715095906
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 9.2714669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.4810048152 20055451 15322242
MESH:D019465 Craniofacial Abnormalities Valproic Acid 2.4817688650 16575769 8888407
MESH:D003490 Cyanosis 2,4-dinitrotoluene 11.0418551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 11.0418551238
MESH:D003711 Demyelinating Diseases Tamoxifen 4.4019031437
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 7.3818759878 11906362 12868966 2524372 11298694 14531868 8970840 8156756
MESH:D017449 Dermatitis, Allergic Contact Nickel 7.3819470301 17244072 17100760
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4418249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 9.652952479 3621924
MESH:D003877 Dermatitis, Contact Nickel 9.652952479
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6717107852
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.5019279558
MESH:D003929 Diabetic Neuropathies Progesterone 4.5317187935
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 18.8418551238 21346803
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 18.8421346803 18551238
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 18.8418289764 6482804 18692083 9328219 9653073 1440618 8291058 16192314 18648102 7440962 9022650 6679447 11289319
MESH:D056486 Drug-Induced Liver Injury 4-amino-2,6-dinitrotoluene 18.8421346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 18.8415968718 16109766 17522070 16227642 11421492 17906064 11529661 11461765 10663392 16177239 11739529 16781746 10774834 10915739 16393943 16081117 11743745 11287661 19164858 19739265 19923254 18071297 18713872 12705907 12153990 19085960 12594235 19416960 12540782 14725611 15619225 11834606 2444490 12958197 12392966 14986274 19370779 19420014 16485898 17562736 14550746
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 18.8420420201
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 18.841733752 19641884
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.1619426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.7811462148
MESH:D004421 Dystonia Valproic Acid 4.081851702
MESH:D004487 Edema pirinixic acid 6.6312083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.6311000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.9618230668 15322242 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 15.5512538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 15.5517692515
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 15.5519031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 3.0616202921 20544844 19155303 17893378
MESH:D004715 Endometriosis Progesterone 9.0216134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 9.029294722 10568697
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.193659116 17275665
MESH:D004828 Epilepsies, Partial Valproic Acid 3.9816628512 3922381
MESH:D004827 Epilepsy Valproic Acid 2.9518234410 20417680
MESH:D004832 Epilepsy, Absence Valproic Acid 3.617562514 6426943 6254150
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.347750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.113659116
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 2.113581430
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0311564622
MESH:D005234 Fatty Liver Cyclosporine 24.9819224547
MESH:D005234 Fatty Liver Ethinyl Estradiol 24.9815345470
MESH:D005234 Fatty Liver pirinixic acid 24.9820131406 19236843
MESH:D005234 Fatty Liver Tamoxifen 24.9814986274 19224547
MESH:D005234 Fatty Liver Valproic Acid 24.9814986274 19224547
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.2516709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5011858732
MESH:D005315 Fetal Diseases Valproic Acid 4.9516575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.178888407 18558336
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.086705139
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.5814745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.2319069698
MESH:D005355 Fibrosis Cyclosporine 8.6212639820 12168785
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 8.6220067830
MESH:D005756 Gastritis Acetaminophen 3.7416983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.278708960
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.077505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.6610696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.3410048152 11294989
MESH:D006333 Heart Failure pirinixic acid 2.5520558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.4715720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.3611000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.556705139
MESH:D006529 Hepatomegaly pirinixic acid 8.4016221962 19176532 18467677 19772884
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 8.4015340226 16120746 12621046
MESH:D015658 HIV Infections Nickel 3.8317263646
MESH:D006849 Hydrocephalus Valproic Acid 4.9217688650
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.118697196 18606429 15340226 16959395 16354765
MESH:D006930 Hyperalgesia Acetaminophen 2.7216870215
MESH:D006943 Hyperglycemia pirinixic acid 3.2120558911
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 3.9815034207
MESH:D006973 Hypertension Cyclosporine 4.9810903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.9818670907 18850075
MESH:D007021 Hypospadias Ethinyl Estradiol 3.8516569931 16945680
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.4415869954
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.4912013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.5017937319
MESH:D007249 Inflammation Nickel 12.1316166738
MESH:D007249 Inflammation Progesterone 12.1315869954
MESH:D007249 Inflammation Tamoxifen 12.1319457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 12.1312878042 12200463
MESH:D007333 Insulin Resistance bisphenol A 7.3716393666
MESH:D007333 Insulin Resistance pirinixic acid 7.3716306350
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.088074119 9022650
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.3616580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.5015604871
MESH:D007674 Kidney Diseases Acetaminophen 5.8512587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 5.8518776723 10903974 8314463
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 23.6016705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 23.6016705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 23.606582329
MESH:D007680 Kidney Neoplasms Cyclosporine 23.6012371664
MESH:D007680 Kidney Neoplasms Tamoxifen 23.6018625569
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 2.1516294345 17596541
MESH:D008064 Lipidoses Tamoxifen 3.1715342952 17567588
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.219327722 15034207
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.4015474484
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 3.4018564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.4012878042
MESH:D008107 Liver Diseases Acetaminophen 1.6319784758 16610002 19460945 12587719 19014921 11587558 12969438 16611625
MESH:D017114 Liver Failure, Acute Acetaminophen 3.2617185352 16871587
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 10.757678174
MESH:D008113 Liver Neoplasms pirinixic acid 10.7516377806 20007298 15890375
MESH:D008113 Liver Neoplasms Tamoxifen 10.7516684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 10.7516984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 9.872876784 6135515 2876786
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 9.87598648 1399818 6587162 3712494
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 9.8712151625
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.3217228818
MESH:D008175 Lung Neoplasms Tamoxifen 2.2518625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.2519555203 11884234
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.8119428831
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 6.1411408345 17203775
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 6.1411731420 19196723 14580682 16827153 19196722
MESH:D020149 Manganese Poisoning Tamoxifen 4.6119453300
MESH:D008545 Melanoma Tamoxifen 1.8819393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.2315990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.6119513568
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.8516801185
MESH:D008881 Migraine Disorders Valproic Acid 3.2118765137 18803445
MESH:D009135 Muscular Diseases pirinixic acid 3.5516239165
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.068888407
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 3.1717596541
MESH:D009203 Myocardial Infarction pirinixic acid 2.1519151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0412213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.9716411023
MESH:D009336 Necrosis 2,4-dinitrotoluene 10.5218551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 10.527678174 18551238
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 5.733581430
MESH:D009362 Neoplasm Metastasis Tamoxifen 5.7319393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5219410462
MESH:D009369 Neoplasms pirinixic acid 1.9617405874
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.0619189210 19200415 19196722
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.5017954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.3118481113 19348381
MESH:D009421 Nervous System Malformations bisphenol A 9.7111399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 9.7114600291
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 7.316679447
MESH:D009436 Neural Tube Defects Valproic Acid 7.3116359493 8888407
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.8918514411
MESH:D009765 Obesity pirinixic acid 1.8220558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 21.8316049721 12819281
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 21.8316049721
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 21.834026338 6482804
MESH:D009784 Occupational Diseases 4-amino-2,6-dinitrotoluene 21.8314694615
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.083988306
MESH:D010049 Ovarian Diseases bisphenol A 5.0411985600
MESH:D010051 Ovarian Neoplasms Progesterone 2.5317393432 16525653
MESH:D010146 Pain Acetaminophen 2.4116870215
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.7211578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.527296757
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.3112520081
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.536228378
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.5918163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.2512371664
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 16.5610548101
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 16.5611399792 11896295 11222880 11118676
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 16.5620603192
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 4.2420887781
MESH:D011471 Prostatic Neoplasms bisphenol A 3.2916740699
MESH:D011471 Prostatic Neoplasms Tamoxifen 3.2915067354
MESH:D011537 Pruritus Ethinyl Estradiol 3.3615861022 16919318
MESH:D019310 Pseudolymphoma Valproic Acid 4.6012752131 11422049
MESH:D011565 Psoriasis Cyclosporine 2.2416882103
MESH:D011629 Puberty, Precocious bisphenol A 4.8410548101
MESH:D015427 Reperfusion Injury pirinixic acid 2.4019058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.8718990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.393692021
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.2119155313
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.8618045962
MESH:D012559 Schizophrenia Valproic Acid 2.0715737665 19110320
MESH:D012640 Seizures 2,4-dinitrotoluene 9.9318551238
MESH:D012640 Seizures 2,6-dinitrotoluene 9.9318551238
MESH:D012640 Seizures Valproic Acid 9.9311738929 14763951 16876388 3137016 17978042 11044598 15475178 1511512
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 5.638532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.6316192470
MESH:D013088 Spermatocele Ethinyl Estradiol 11.7716709447
MESH:D013088 Spermatocele Tamoxifen 11.7716709447
MESH:D013119 Spinal Cord Injuries Progesterone 11.0416503802 15862959
MESH:D013119 Spinal Cord Injuries Tamoxifen 11.0419457130
MESH:D016135 Spinal Dysraphism Valproic Acid 3.8019490988
MESH:D013226 Status Epilepticus Valproic Acid 4.6012833885
MESH:D019966 Substance-Related Disorders bisphenol A 4.0316684133 16045194
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.6511994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.1815669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.9612697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 2.903712494 6582329 7505956 6587162 1399818
MESH:D014178 Translocation, Genetic Valproic Acid 5.3017262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.573119515
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 12.0016049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 12.0016049721
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 12.008074119
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 12.0017572228 16712894 8653321
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.688888407
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 12.1610091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 12.1610091137
MESH:D014581 Urticaria Acetaminophen 3.0110982225
MESH:D014591 Uterine Diseases bisphenol A 5.0714652134
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.3314692618
MESH:D014605 Uveitis Cyclosporine 4.051336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.6612125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.5714671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.3115886252
MESH:D014985 Xerophthalmia Cyclosporine 4.5017120751
No data
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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