AutismKB 2.0

Annotation Detail for TBL1XR1


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Basic Information Top
Gene Symbol:TBL1XR1 ( C21,DC42,FLJ12894,IRA1,TBLR1 )
Gene Full Name: transducin (beta)-like 1 X-linked receptor 1
Band: 3q26.32
Quick LinksEntrez ID:79718; OMIM: 608628; Uniprot ID:TBL1R_HUMAN; ENSEMBL ID: ENSG00000177565; HGNC ID: 29529
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04310Wnt signaling pathway
Pathway IDPathway Name
Metabolism of lipids and lipoproteins
Pathway IDPathway Name
200106Regulation of Wnt-mediated beta catenin signaling and target gene transcription
Pathway IDPathway Name
P00057Wnt signaling pathway
Pathway IDPathway Name
500817Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of TBL1XR1 mRNAaffects expression 21346803
C472791 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in decreased expression of TBL1XR1 mRNAdecreases expression 12958071
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of TBL1XR1 mRNAdecreases expression 20018196
19150397
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of TBL1XR1 mRNAaffects expression 17484886
C099555 CD 437 CD 437 results in decreased expression of TBL1XR1 mRNAdecreases expression 12958071
D002995 Clofibric Acid [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of TBL1XR1 mRNAaffects cotreatment|affects expression 17602206
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of TBL1XR1 mRNAaffects cotreatment|affects expression 17602206
D004958 Estradiol Estradiol results in decreased expression of TBL1XR1 mRNAdecreases expression 20068009
C006253 pirinixic acid pirinixic acid results in increased expression of TBL1XR1 mRNAincreases expression 18445702
18301758
D018038 Sodium Selenite Sodium Selenite results in decreased expression of TBL1XR1 mRNAdecreases expression 18175754
C025643 vinclozolin vinclozolin affects the expression of TBL1XR1 mRNAaffects expression 19015723
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D055371 Acute Lung Injury pirinixic acid 3.2718653653
MESH:D000230 Adenocarcinoma Estradiol 2.1311473722
MESH:D000236 Adenoma Diethylnitrosamine 2.9310737359 6695378
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 10.7516434500 19052882 19061943 17620307 18056438 17162532
MESH:D018248 Adenoma, Liver Cell pirinixic acid 10.7516434500
MESH:D001008 Anxiety Disorders vinclozolin 3.7519015723
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.2919483382
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.1217474063
MESH:D001943 Breast Neoplasms Estradiol 2.1217261762 12948864 18497071 16675129 17018787 17289903 14630087 19861407
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.6616111702
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.9515721981 16124888 15673190 16011737 16227642 16097048 3786805 18705752 16192424 10355542 15700767 16050911
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 6.7316705839
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 6.7318788625
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 6.7319919837 19171122 17162532 17138121 16698587 19335982 10737359 20727157 18056438 16288022 19418558 19539802 16540662 17978847 16830150 16502159 16569478 3581430 19107877 10672840 18978308 19519916 20432363 20935162 18494052 18788625 20512989 16779866 16935385 16878318 18971187 18785209 19383236 20514400 20524982 19701751 16681979 20084675 18691550 17428255 18665156 3084413 20214788 18210153 20007298 19394651 17055752 17761372 20101231 16328049 19208518 17173139 16807293 11831363 19822196 18393292 21159647 18506893 19052882
MESH:D006528 Carcinoma, Hepatocellular Estradiol 6.7316924424
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 16.826135515
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 16.8220889678
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 16.827505956 17174075 21159647 2727394
MESH:D002471 Cell Transformation, Neoplastic Estradiol 16.8218566989
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 3.8119052882
MESH:D002779 Cholestasis pirinixic acid 2.9319176532
MESH:D019457 Chromosome Breakage Sodium Selenite 4.9315894690
MESH:D003456 Cryptorchidism vinclozolin 4.5014966744
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.1918551238
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4818249437
MESH:D003920 Diabetes Mellitus Sodium Selenite 3.9016285004
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 2.2220387270
MESH:D003928 Diabetic Nephropathies Estradiol 3.5419279558
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 9.3221346803 18551238
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 9.3210915739 16227642 7179309 11566570 19336974 16177239 2869522 15998439 15027814 17522070 7120509 4309450 6884620 7440962 10092053 9327722 21278145 19085960 3786805 15968718 3732212 6623471
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 9.3219107877
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 9.3215131321
MESH:D004487 Edema pirinixic acid 2.6212083418
MESH:D016889 Endometrial Neoplasms Estradiol 3.0718566989 11473722 19148513
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.3316302075
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.1020426865
MESH:D005234 Fatty Liver Carbon Tetrachloride 13.9316045604 15959796 12631006 16239168 61145 12795759 19224547 17595544
MESH:D005234 Fatty Liver Diethylnitrosamine 13.9321071580 20387270
MESH:D005234 Fatty Liver pirinixic acid 13.9319236843 20131406
MESH:D005355 Fibrosis Carbon Tetrachloride 3.6318705752
MESH:D030342 Genetic Diseases, Inborn vinclozolin 5.1316973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.5216417039
MESH:D006333 Heart Failure pirinixic acid 2.6220558911
MESH:D006505 Hepatitis Carbon Tetrachloride 3.7619110552 19900420
MESH:D006529 Hepatomegaly pirinixic acid 3.1718467677 16221962 19772884 19176532
MESH:D006558 Herpes Genitalis Estradiol 5.2515709030
MESH:D019584 Hot Flashes Estradiol 3.9717088409
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.7316899240
MESH:D006943 Hyperglycemia pirinixic acid 3.3120558911
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.2615338365
MESH:D007248 Infertility, Male vinclozolin 3.1316467254
MESH:D007249 Inflammation Diethylnitrosamine 2.4418785209
MESH:D007333 Insulin Resistance Estradiol 12.8316627594 16393666
MESH:D007333 Insulin Resistance pirinixic acid 12.8316306350
MESH:D007333 Insulin Resistance Sodium Selenite 12.8314714311
MESH:D007674 Kidney Diseases Estradiol 2.6615618244
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 7.7616705839
MESH:D007680 Kidney Neoplasms Estradiol 7.7615610895
MESH:D007984 Leydig Cell Tumor vinclozolin 4.9316417039
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 6.8521278145 17334410 11903743 16943688 17157831 16239168 17174718 11408273 16221502
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 6.8520032147 18665156 18522880 18407596 19638242
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 3.5212586293 12649538 17708605 18317297 17805973 18420326 17900296 16638106 16033810 17869086 17721639 18472332 16192424 12666154 12445421 16116963 12958196 17481882 12667390 15818738 15996030 18166357 12632512 14748882 10355542 12632514 15876570 12898905 17525996 12445418 18279442 18472094 16027843 12389079 17631135 17565644 18205269 18006644 18210741 17944888 18418968 16136751 18156304 17698563 17766677 18251166 18187930 15730626 15123356 14620537 15338365 18277467 18429990 18481824 18339082 15057751 16097048 16015684 17640975 15673190 17761835 17823541 13678700 18376398 16248980 14716496 12741479 16011737 15362042 20821823 17976157 14716833 14724832 11481614 18395914 18705752 14512876 12546737 15650968 18412020 18263696 12609069 15931870 17714472 15893842 18054572 15925388 15959796 18395095 17557913 15370692 17922224 15052691
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 3.5214716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.5215474484
MESH:D008107 Liver Diseases Carbon Tetrachloride 4.1816964402 16246199 17285989 15830285 15720792
MESH:D008107 Liver Diseases Diethylnitrosamine 4.1817034775
MESH:D017093 Liver Failure Carbon Tetrachloride 4.3415123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.8216899240 14706259
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 14.777678174
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 14.7719294768
MESH:D008113 Liver Neoplasms Clofibric Acid 14.7717602206
MESH:D008113 Liver Neoplasms Diethylnitrosamine 14.7719255062 21278145 20434301 19426721 19996281 18644402 15885732 19690152 19254457 19256749 2422723 20405173 20583210 19812893 16942905 12112319 18977376 19427195 20118626 12771043 20101389 20137499 18978307 18754104 19090486 20452335 19551842 19073162 21071580 19499222 20501860 21047994 19850985 19833225 19642983 19294768 21167192 9163691 18648771 19638242 2862719 20492335 15175105 10737359
MESH:D008113 Liver Neoplasms pirinixic acid 14.7716377806 15890375 20007298
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 10.356135515 2876784 2876786
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 10.3512014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 10.3516842330 18079962 19519916 18253720 17174075 18544905 9362446 18775883 21159647 17942915 19004024 18164116 19126423 19539802 18308698 16267830 17854601 3124819 2563599 19009564 18282651 18093689
MESH:D008175 Lung Neoplasms Diethylnitrosamine 1.766695378 20970405 20512841 21163286
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 4.2114737004
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 2.6417203775 11807958 11408345 16891317
MESH:D020149 Manganese Poisoning Estradiol 4.7019453300
MESH:D009135 Muscular Diseases pirinixic acid 3.6816239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.1919151258
MESH:D015428 Myocardial Reperfusion Injury Estradiol 8.6116810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 8.6116411023
MESH:D009336 Necrosis 2,6-dinitrotoluene 4.0518551238 7678174
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.613581430 9029167
MESH:D009369 Neoplasms pirinixic acid 2.0117405874
MESH:D009389 Neovascularization, Pathologic Estradiol 3.9317289903
MESH:D009421 Nervous System Malformations Estradiol 3.8111399458 16427766
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 3.4620387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.3320387270
MESH:D009765 Obesity pirinixic acid 1.8420558911
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.5616049721
MESH:D010051 Ovarian Neoplasms CD 437 5.2917474084
MESH:D010051 Ovarian Neoplasms Estradiol 5.2919401270
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 2.4616540662
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.682563599
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 4.0918220299 18042343 19015723
MESH:D011469 Prostatic Diseases vinclozolin 5.1318220299
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 4.0220887781
MESH:D011471 Prostatic Neoplasms Estradiol 3.2316740699
MESH:D011471 Prostatic Neoplasms Sodium Selenite 3.2318760546
MESH:D011472 Prostatitis vinclozolin 5.1318629315
MESH:D015427 Reperfusion Injury pirinixic acid 2.4519058328
MESH:D012640 Seizures 2,6-dinitrotoluene 2.6218551238
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 1.7618456281
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 3.097505956
MESH:D013978 Tibial Fractures Estradiol 4.9019048282
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 5.5816049721
MESH:D001749 Urinary Bladder Neoplasms CD 437 5.5816720286
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.5110091137
Pathway ID Pathway Name
REACT:22258 Metabolism of lipids and lipoproteins
KEGG:04310 Wnt signaling pathway
Pharmacogenomics Knowledge Base Top
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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