AutismKB 2.0

Annotation Detail for ASB13


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Basic Information Top
Gene Symbol:ASB13 ( FLJ13134,MGC19879 )
Gene Full Name: ankyrin repeat and SOCS box-containing 13
Band: 10p15.1
Quick LinksEntrez ID:79754; OMIM: NA; Uniprot ID:ASB13_HUMAN; ENSEMBL ID: ENSG00000196372; HGNC ID: 19765
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of ASB13 mRNAincreases expression 18648102
D000082 Acetaminophen Acetaminophen affects the expression of ASB13 mRNAaffects expression 17562736
D002251 Carbon Tetrachloride Carbon Tetrachloride results in decreased expression of ASB13 mRNAdecreases expression 17484886
D016572 Cyclosporine Cyclosporine results in decreased expression of ASB13 mRNAdecreases expression 20106945
C006253 pirinixic acid pirinixic acid results in decreased expression of ASB13 mRNAdecreases expression 18445702
C006253 pirinixic acid pirinixic acid results in increased expression of ASB13 mRNAincreases expression 18301758
D020849 Raloxifene [Raloxifene co-treated with ESR2 protein] results in decreased expression of ASB13 mRNAaffects cotreatment|decreases expression 19059307
D013629 Tamoxifen [Tamoxifen co-treated with ESR2 protein] results in decreased expression of ASB13 mRNAaffects cotreatment|decreases expression 19059307
C004648 testosterone enanthate testosterone enanthate affects the expression of ASB13 mRNAaffects expression 17440010
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of ASB13 mRNAincreases expression 19465110
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.8714745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.1311752688 14514962 15322242
MESH:D055371 Acute Lung Injury pirinixic acid 3.3418653653
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.863712494
MESH:D018248 Adenoma, Liver Cell pirinixic acid 10.8716434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 10.8716835633
MESH:D000419 Albuminuria Raloxifene 4.8317451421 17308373
MESH:D000544 Alzheimer Disease Raloxifene 2.5815800139
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1411748828
MESH:D000799 Angioedema Acetaminophen 4.1610982225
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.3411289319 1440618
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.4619483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.4612125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.1115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8915746008
MESH:D001930 Brain Injuries Raloxifene 4.7316580743
MESH:D001943 Breast Neoplasms Raloxifene 1.8817242785 17440819 16837676 15775269 17595753 17261762 17893378 15758505 16912660 17952589 15572757 17049068
MESH:D001943 Breast Neoplasms Tamoxifen 1.8816873071 19189212 19059307 19200415 17242785 17440819 20390343 18815881 16273361 17893378 19410462 15668708 21138602 19084267 18821012 21152245 18997820 19221464 17049068 20544844 19487384 20859285 17261762 19011961 20065188 15565566 19066611 19189210 19244106 18629630 16818667 18855134 19288272 20135344 19155303 19115204 19289846 19103187 18984771 18425577 11161223 19142967 18351453 20005174 16202921
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.8820435547
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 4.0416050911 16097048 18705752 16011737 16192424 16124888 10355542 15700767 15673190 16227642 15721981 3786805
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9616835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.7619066611
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 6.783581430 7296757
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 6.783084413
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 6.7818788625
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 6.7816924424
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.767296757
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 10.1517572228
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 10.1517572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4718850075 16120746 18670907
MESH:D002318 Cardiovascular Diseases Raloxifene 3.5815775269
MESH:D002386 Cataract Acetaminophen 2.6910977129
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 7.037505956
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 7.0312371664
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3416835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 14.2719486331 9022650
MESH:D002779 Cholestasis Cyclosporine 14.2719486331
MESH:D002779 Cholestasis pirinixic acid 14.2719176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.188697196 15340226 16354765 12621046 15668235
MESH:D003072 Cognition Disorders Raloxifene 4.8815800139
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2417141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2610048152 15322242 20055451
MESH:D003711 Demyelinating Diseases Tamoxifen 4.6219031437
MESH:D003865 Depressive Disorder, Major Raloxifene 4.3417474826
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.0618759878 11298694 8156756 14531868 11906362 2524372 12868966 8970840
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5118249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.713621924 2952479
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7117107852
MESH:D003928 Diabetic Nephropathies Raloxifene 9.6517451421 17308373 15920148
MESH:D003928 Diabetic Nephropathies Tamoxifen 9.6519279558
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 9.3918692083 7440962 9022650 9328219 1440618 6679447 6482804 18648102 18289764 16192314 8291058 9653073 11289319
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 9.3911287661 16485898 11461765 14986274 10663392 19085960 19739265 16781746 17906064 16393943 12153990 11421492 18071297 10774834 19416960 11834606 10915739 12705907 18713872 12958197 19923254 14725611 2444490 12392966 12540782 16177239 14550746 15968718 11529661 16109766 15619225 19370779 12594235 17562736 19164858 16227642 11743745 16081117 11739529 17522070 19420014
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 9.3916177239 3786805 2869522 6884620 19085960 7120509 15968718 10092053 21278145 19336974 10915739 3732212 11566570 15027814 9327722 7179309 7440962 4309450 17522070 6623471 15998439 16227642
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 9.3920420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.4219426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9111462148
MESH:D004487 Edema pirinixic acid 12.6612083418
MESH:D004487 Edema Raloxifene 12.6615860553
MESH:D004487 Edema Tetrachlorodibenzodioxin 12.6611000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.2215322242 18230668 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 10.0515845917
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 10.0519031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 3.1719155303 16202921 20544844 17893378
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.219294722 10568697
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 2.153581430
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1611564622
MESH:D005234 Fatty Liver Carbon Tetrachloride 27.0216045604 61145 12795759 19224547 12631006 17595544 15959796 16239168
MESH:D005234 Fatty Liver Cyclosporine 27.0219224547
MESH:D005234 Fatty Liver pirinixic acid 27.0220131406 19236843
MESH:D005234 Fatty Liver Raloxifene 27.0217473493
MESH:D005234 Fatty Liver Tamoxifen 27.0214986274 19224547
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.3516709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.7111858732
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.346705139
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.8114745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.4719069698
MESH:D005355 Fibrosis Carbon Tetrachloride 16.2918705752
MESH:D005355 Fibrosis Cyclosporine 16.2912168785 12639820
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 16.2920067830
MESH:D005756 Gastritis Acetaminophen 3.9916983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.508708960
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.267505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.9110696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4311294989 10048152
MESH:D006331 Heart Diseases Raloxifene 3.6711110106
MESH:D006333 Heart Failure pirinixic acid 2.6520558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.7115720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5411000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 10.036705139
MESH:D006505 Hepatitis Carbon Tetrachloride 10.0319110552 19900420
MESH:D006529 Hepatomegaly pirinixic acid 9.1418467677 19176532 19772884 16221962
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 9.1416120746 15340226 12621046
MESH:D019247 HIV Wasting Syndrome testosterone enanthate 6.0617440010
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.3615340226 18606429 16959395 16354765 8697196
MESH:D006930 Hyperalgesia Acetaminophen 2.8616870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.8216899240
MESH:D006943 Hyperglycemia pirinixic acid 3.3820558911
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.2015034207
MESH:D006973 Hypertension Cyclosporine 8.9810903974
MESH:D006973 Hypertension Raloxifene 8.9817577099 15787275
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 8.9818670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.3515338365
MESH:D007249 Inflammation Tamoxifen 5.2119457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.2112878042 12200463
MESH:D007333 Insulin Resistance pirinixic acid 2.7616306350
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.348074119 9022650
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5416580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.7615604871
MESH:D007674 Kidney Diseases Acetaminophen 6.1612587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 6.168314463 10903974 18776723
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 13.406582329
MESH:D007680 Kidney Neoplasms Cyclosporine 13.4012371664
MESH:D007680 Kidney Neoplasms Tamoxifen 13.4018625569
MESH:D007889 Leiomyoma Raloxifene 4.7216973256
MESH:D008064 Lipidoses Tamoxifen 3.3015342952 17567588
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.9117174718 16943688 16221502 17157831 11903743 21278145 17334410 16239168 11408273
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.319327722 15034207
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 5.0912649538 17565644 18395914 17721639 15931870 12667390 15338365 14716833 18412020 17525996 16638106 12445418 18251166 17823541 17805973 10355542 17922224 16116963 17557913 15650968 12898905 13678700 15818738 17944888 18376398 18263696 17481882 15057751 12546737 18418968 17869086 14716496 18472332 15925388 16136751 15893842 17714472 20821823 14748882 15052691 18472094 12389079 18210741 17698563 18277467 16015684 16248980 18705752 18339082 18205269 15123356 18420326 12632512 18054572 12958196 18006644 12586293 16097048 15876570 14620537 17761835 12609069 15362042 14724832 17640975 18166357 17708605 16011737 15730626 15959796 15673190 18481824 12445421 18395095 12632514 17900296 18156304 14512876 16192424 12666154 16027843 18279442 12741479 18317297 17766677 16033810 15996030 11481614 17631135 17976157 18187930 15370692 18429990
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 5.0915474484
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 5.0918564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 5.0912878042
MESH:D008107 Liver Diseases Acetaminophen 4.0519460945 12587719 12969438 16611625 19784758 11587558 19014921 16610002
MESH:D008107 Liver Diseases Carbon Tetrachloride 4.0516964402 15830285 16246199 15720792 17285989
MESH:D017093 Liver Failure Carbon Tetrachloride 4.4215123358
MESH:D017114 Liver Failure, Acute Acetaminophen 10.0617185352 16871587
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 10.0616899240 14706259
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 11.2419294768
MESH:D008113 Liver Neoplasms pirinixic acid 11.2416377806 20007298 15890375
MESH:D008113 Liver Neoplasms Tamoxifen 11.2416684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 11.2416984957
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 10.49598648 1399818 6587162 3712494
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 10.4915583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 10.4912151625
MESH:D008175 Lung Neoplasms Tamoxifen 2.3018625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.3011884234 19555203
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 4.0419428831
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 2.7414580682 19196722 11731420 16827153 19196723
MESH:D020149 Manganese Poisoning Tamoxifen 4.8719453300
MESH:D008545 Melanoma Tamoxifen 1.9019393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.4715990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.8319513568
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.1116801185
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 5.8715863610
MESH:D009101 Multiple Myeloma Raloxifene 3.5816497877
MESH:D009135 Muscular Diseases pirinixic acid 3.7616239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2119151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1812213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1016411023
MESH:D009232 Myxoma Raloxifene 5.8716343187
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 5.933581430
MESH:D009362 Neoplasm Metastasis Tamoxifen 5.9319393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5719410462
MESH:D009369 Neoplasms pirinixic acid 2.0317405874
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.3219196722 19200415 19189210
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.7617954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.4718481113 19348381
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.4514600291
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 3.046679447
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.0418514411
MESH:D009765 Obesity pirinixic acid 1.8520558911
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.614026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.343988306
MESH:D010024 Osteoporosis Raloxifene 3.5115775268 17882678 19059307
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 4.4517823083 15579764 17893378 15758505
MESH:D010146 Pain Acetaminophen 2.5616870215
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.747296757
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.5712520081
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.796228378
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8018163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.4012371664
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.4811896295 11222880 11118676 11399792
MESH:D011471 Prostatic Neoplasms Raloxifene 3.3216220300 16536755 15731164
MESH:D011471 Prostatic Neoplasms Tamoxifen 3.3215067354
MESH:D011565 Psoriasis Cyclosporine 2.2916882103
MESH:D011693 Purpura Raloxifene 5.8715770314
MESH:D015427 Reperfusion Injury pirinixic acid 2.4719058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0818990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.523692021
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1316192470
MESH:D013088 Spermatocele Tamoxifen 4.6116709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.3219457130
MESH:D020521 Stroke Raloxifene 3.9816837676
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.2212697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 3.041399818 6587162 6582329 7505956 3712494
MESH:D013978 Tibial Fractures Raloxifene 5.5319048282
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 8.778074119
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 8.7717572228
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 8.778653321 17572228 16712894
MESH:D014581 Urticaria Acetaminophen 3.2010982225
MESH:D014605 Uveitis Cyclosporine 4.301336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.9112125929
MESH:D054556 Venous Thromboembolism Raloxifene 5.5316837676
MESH:D014846 Vulvar Neoplasms Raloxifene 5.8716343187
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.5715886252
MESH:D014985 Xerophthalmia Cyclosporine 4.7617120751
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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