AutismKB 2.0

Annotation Detail for FZD3


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Basic Information Top
Gene Symbol:FZD3 ( Fz-3,hFz3 )
Gene Full Name: frizzled homolog 3 (Drosophila)
Band: 8p21.1
Quick LinksEntrez ID:7976; OMIM: 606143; Uniprot ID:FZD3_HUMAN; ENSEMBL ID: ENSG00000104290; HGNC ID: 4041
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04916Melanogenesis
hsa04310Wnt signaling pathway
hsa05217Basal cell carcinoma
hsa05200Pathways in cancer
Pathway IDPathway Name
Signaling by GPCR
No data
Pathway IDPathway Name
P00005Angiogenesis
P00004Alzheimer disease-presenilin pathway
P00012Cadherin signaling pathway
P00057Wnt signaling pathway
No data
Related Diseases/Disorders Top
No data
No data
Desease Name
methamphetamine psychosis
CHEMDEPENDENCY
PSYCH
schizophrenia
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene results in increased expression of FZD3 mRNAincreases expression 20406850
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of FZD3 proteinaffects expression 20106945
D004390 Chlorpyrifos Chlorpyrifos results in decreased expression of FZD3 mRNAdecreases expression 18502319
D003010 Clorgyline Clorgyline results in increased expression of FZD3 mRNAincreases expression 19691856
D003976 Diazinon Diazinon results in increased expression of FZD3 mRNAincreases expression 19130878
D004026 Dieldrin Dieldrin results in decreased expression of FZD3 mRNAdecreases expression 19130878
D019833 Genistein Genistein results in increased expression of FZD3 mRNAincreases expression 18847459
D018021 Lithium Chloride Lithium Chloride results in increased expression of FZD3 mRNAincreases expression 20069066
C025299 polyphenols polyphenols results in decreased expression of FZD3 mRNAdecreases expression 16293270
C009166 retinol acetate retinol acetate results in increased expression of FZD3 mRNAincreases expression 16772331
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000230 Adenocarcinoma Genistein 2.5111473722
MESH:D000382 Agricultural Workers' Diseases Chlorpyrifos 9.9817119214 16611668 11874814
MESH:D000382 Agricultural Workers' Diseases Diazinon 9.9816487989
MESH:D001943 Breast Neoplasms Dieldrin 2.6615770527 11859874
MESH:D001943 Breast Neoplasms Genistein 2.6616873071 17200150 16541309
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 4.7716705839
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 4.7712907637 21507988 12619106
MESH:D006528 Carcinoma, Hepatocellular Genistein 4.7716924424
MESH:D002318 Cardiovascular Diseases Genistein 3.4216332659
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 2.886135515
MESH:D003110 Colonic Neoplasms Genistein 4.1017182828
MESH:D003110 Colonic Neoplasms polyphenols 4.1016293270
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.2318551238
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 2.5216647724
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 4.2918551238 21346803
MESH:D056486 Drug-Induced Liver Injury polyphenols 4.2919370779
MESH:D004417 Dyspnea Diazinon 5.0616487989
MESH:D004714 Endometrial Hyperplasia Genistein 4.8316402032
MESH:D016889 Endometrial Neoplasms Genistein 3.4711473722
MESH:D005909 Glioblastoma Genistein 3.3616598420
MESH:D006505 Hepatitis Diazinon 4.7716487989
MESH:D006869 Hydronephrosis Lithium Chloride 6.2819797860
MESH:D007247 Infertility, Female Dieldrin 5.1210630421
MESH:D007248 Infertility, Male Diazinon 3.9312948887 16466525
MESH:D007249 Inflammation polyphenols 3.1416366677
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 3.1216705839
MESH:D007938 Leukemia Genistein 3.1017468513 18980019
MESH:D008106 Liver Cirrhosis, Experimental Genistein 2.0617823541
MESH:D008107 Liver Diseases Chlorpyrifos 4.8115991261
MESH:D008107 Liver Diseases polyphenols 4.8116698588
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 7.967678174
MESH:D008113 Liver Neoplasms Aflatoxin B1 7.969163691 15890375 18177683 2125692
MESH:D008113 Liver Neoplasms Dieldrin 7.968742319 9539021
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 6.312876784 2876786 6135515
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 6.318603461
MESH:D008175 Lung Neoplasms Aflatoxin B1 1.8714755239
MESH:D008325 Mammary Neoplasms, Experimental Genistein 3.0412929590 14578162
MESH:D009203 Myocardial Infarction Genistein 2.9217141266
MESH:D015428 Myocardial Reperfusion Injury Genistein 3.7917141266
MESH:D009336 Necrosis 2,6-dinitrotoluene 4.1018551238 7678174
MESH:D009369 Neoplasms Dieldrin 3.548820588
MESH:D009421 Nervous System Malformations Genistein 4.2316427766
MESH:D020258 Neurotoxicity Syndromes Chlorpyrifos 4.2815081274
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.5916049721
MESH:D010024 Osteoporosis Genistein 3.3519401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 4.2716169203
MESH:D010051 Ovarian Neoplasms Genistein 2.6419005980
MESH:D010300 Parkinson Disease Dieldrin 3.5811181820 16112328 17291500 16809432 11445065
MESH:D011041 Poisoning Diazinon 4.5317603234
MESH:D011141 Polyuria Lithium Chloride 6.2419692487
MESH:D011471 Prostatic Neoplasms Clorgyline 3.6919691856
MESH:D011471 Prostatic Neoplasms Genistein 3.6916925846 15256057 15378649
MESH:D012135 Respiratory Sounds Chlorpyrifos 4.8511874814 16611668 17119214
MESH:D012140 Respiratory Tract Diseases Chlorpyrifos 5.1617119214 16611668
MESH:D012640 Seizures 2,6-dinitrotoluene 2.6418551238
MESH:D012729 Sex Chromosome Aberrations Chlorpyrifos 6.356418539
MESH:D013705 Temporomandibular Joint Disorders polyphenols 5.5217997062
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 2.3416049721
MESH:D014570 Urologic Diseases Diazinon 5.5416487989
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.5610091137
Pathway ID Pathway Name
KEGG:05217 Basal cell carcinoma
KEGG:04916 Melanogenesis
KEGG:05200 Pathways in cancer
REACT:14797 Signaling by GPCR
KEGG:04310 Wnt signaling pathway
Pharmacogenomics Knowledge Base Top
Drug Bank Top

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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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