AutismKB 2.0

Annotation Detail for ELMO3


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Basic Information Top
Gene Symbol:ELMO3 ( CED-12,CED12,ELMO-3,FLJ13824 )
Gene Full Name: engulfment and cell motility 3
Band: 16q22.1
Quick LinksEntrez ID:79767; OMIM: 606422; Uniprot ID:ELMO3_HUMAN; ENSEMBL ID: ENSG00000102890; HGNC ID: 17289
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000638 Amiodarone Amiodarone results in increased expression of ELMO3 mRNAincreases expression 19774075
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of ELMO3 mRNAdecreases expression 20106945
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of ELMO3 mRNAaffects expression 17555576
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of ELMO3 mRNAincreases expression 17557909
C017947 sodium arsenite sodium arsenite results in increased expression of ELMO3 mRNAincreases expression 16322246
D013629 Tamoxifen Tamoxifen affects the expression of ELMO3 mRNAaffects expression 17555576
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 5.1614745880
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.5517505938
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.4120127859 20464547
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.4114692618
MESH:D000236 Adenoma Benzo(a)pyrene 2.846695378
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 5.3115276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 5.5117306315 16712894
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.5619183758
MESH:D001145 Arrhythmias, Cardiac Amiodarone 4.1520041841 18218290 18057881
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.9511256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.8615885639
MESH:D001281 Atrial Fibrillation Amiodarone 4.1618651412 19698954
MESH:D001778 Blood Coagulation Disorders Amiodarone 4.2719483382
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.0517474063 20146248
MESH:D001943 Breast Neoplasms Tamoxifen 2.0515668708 18821012 21138602 19103187 19084267 20390343 19487384 18997820 19410462 16818667 16873071 17049068 19011961 17440819 20135344 19155303 18351453 20005174 17893378 19066611 11161223 19288272 18815881 17261762 18855134 18629630 19189212 18984771 19221464 19244106 19189210 20065188 15565566 18425577 19142967 17242785 19115204 21152245 20544844 20859285 16202921 19059307 19200415 16273361 19289846
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.9919066611
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 3.1916507464 15276417 17306315
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 3.1916924424
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.8820419170
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 4.8818572023
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.9617572228
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 2.9919225199 15710769
MESH:D002341 Carotid Artery Thrombosis Amiodarone 5.6218974383
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 3.2219524636 20056578
MESH:D002779 Cholestasis Ethinyl Estradiol 3.1317681005 17333356 16105132 15861022 16919318 11677210 17110522
MESH:D003711 Demyelinating Diseases Tamoxifen 4.8519031437
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.8019279558
MESH:D056486 Drug-Induced Liver Injury Amiodarone 2.4615265979 18218290
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 10.4512538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 10.4519031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 3.2617893378 19155303 20544844 16202921
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 2.0716530937
MESH:D005234 Fatty Liver Amiodarone 15.4114986274
MESH:D005234 Fatty Liver Ethinyl Estradiol 15.4115345470
MESH:D005234 Fatty Liver Tamoxifen 15.4119224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.4316709447
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 5.0714745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.7219069698
MESH:D005833 Genital Neoplasms, Female sodium arsenite 5.2216452187
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.8220471113
MESH:D006529 Hepatomegaly Amiodarone 4.2315265979
MESH:D006689 Hodgkin Disease sodium arsenite 3.4712676792
MESH:D006937 Hypercholesterolemia Amiodarone 4.259751232 8137927
MESH:D007021 Hypospadias Ethinyl Estradiol 4.2916945680 16569931
MESH:D007037 Hypothyroidism Amiodarone 5.0017991464 18020914
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.8712013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 7.4017937319
MESH:D007248 Infertility, Male sodium arsenite 7.4012646999 15346721
MESH:D007249 Inflammation Tamoxifen 2.5119457130
MESH:D007674 Kidney Diseases sodium arsenite 2.9820008137
MESH:D007680 Kidney Neoplasms Tamoxifen 3.3518625569
MESH:D008064 Lipidoses Amiodarone 8.7517567588 15342952
MESH:D008064 Lipidoses Tamoxifen 8.7517567588 15342952
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 1.7518564211
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 8.1121137059 20195826
MESH:D008113 Liver Neoplasms sodium arsenite 8.1116712894 15276417
MESH:D008113 Liver Neoplasms Tamoxifen 8.1116684651
MESH:D008133 Long QT Syndrome Amiodarone 3.8515350150 17391786 11989578
MESH:D008171 Lung Diseases Amiodarone 8.2712587719
MESH:D008171 Lung Diseases sodium arsenite 8.2719095001
MESH:D017563 Lung Diseases, Interstitial Amiodarone 5.0918516814
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 3.6018816296 17053015 18569708 18520028 20464547 20869020 20064080 6695378 20135361
MESH:D008175 Lung Neoplasms sodium arsenite 3.6016712894 19931552 17306315 15276417 17077188
MESH:D008175 Lung Neoplasms Tamoxifen 3.6018625569
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 4.3019428831
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 2.8311731420 19196722 14580682 19196723 16827153
MESH:D020149 Manganese Poisoning Tamoxifen 5.1619453300
MESH:D008545 Melanoma sodium arsenite 3.4719082730 16487513
MESH:D008545 Melanoma Tamoxifen 3.4712393984 19393235
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.7215990972
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.4616381670
MESH:D009181 Mycoses Amiodarone 5.5112754197 17974566
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.6619393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.6019410462
MESH:D009369 Neoplasms Benzo(a)pyrene 5.5311141357
MESH:D009369 Neoplasms sodium arsenite 5.5311559025
MESH:D009374 Neoplasms, Experimental sodium arsenite 4.1520056578
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.6119200415 19189210 19196722
MESH:D009436 Neural Tube Defects sodium arsenite 3.3612854658
MESH:D010051 Ovarian Neoplasms sodium arsenite 2.5217306315 15276417
MESH:D016584 Panic Disorder Ethinyl Estradiol 4.0911578682
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.4717292933
MESH:D011471 Prostatic Neoplasms sodium arsenite 2.4716039940
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.4715067354
MESH:D011537 Pruritus Ethinyl Estradiol 3.8515861022 16919318
MESH:D011658 Pulmonary Fibrosis Amiodarone 2.9612490602 12832656 11597910
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 5.6218724381
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 6.1910029692 19755658
MESH:D012878 Skin Neoplasms sodium arsenite 6.1919524636 18572023
MESH:D013088 Spermatocele Ethinyl Estradiol 13.6916709447
MESH:D013088 Spermatocele Tamoxifen 13.6916709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.5819457130
MESH:D016135 Spinal Dysraphism sodium arsenite 4.0712854658
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.5620155912 2093021
MESH:D013276 Stomach Ulcer Amiodarone 3.6818087811
MESH:D013610 Tachycardia Amiodarone 4.7311238279
MESH:D017180 Tachycardia, Ventricular Amiodarone 4.6319225199
MESH:D019851 Thrombophilia Ethinyl Estradiol 4.0211994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.4815669648
MESH:D013959 Thyroid Diseases Amiodarone 5.3719731979
MESH:D013971 Thyrotoxicosis Amiodarone 5.3418020914 19584973
MESH:D016171 Torsades de Pointes Amiodarone 4.7317467628 11989578
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 8.9817053015
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 8.9816712894 11723127 17306315 16452187
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 8.9816712894 8653321 17572228
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 4.1111813266
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.7414692618
MESH:D014652 Vascular Diseases sodium arsenite 4.9617056641
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.9114671159 15869587
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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