AutismKB 2.0

Annotation Detail for MICALL2


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Basic Information Top
Gene Symbol:MICALL2 ( FLJ23471,FLJ41996,FLJ44858,FLJ45410,JRAB,MGC46023,MICAL-L2 )
Gene Full Name: MICAL-like 2
Band: 7p22.3
Quick LinksEntrez ID:79778; OMIM: NA; Uniprot ID:MILK2_HUMAN; ENSEMBL ID: ENSG00000164877; HGNC ID: 29672
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C472791 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in increased expression of MICALL2 mRNAincreases expression 16788091
D000082 Acetaminophen Acetaminophen affects the expression of MICALL2 mRNAaffects expression 17562736
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of MICALL2 proteinaffects expression 20106945
D000638 Amiodarone Amiodarone results in increased expression of MICALL2 mRNAincreases expression 19774075
D016572 Cyclosporine Cyclosporine results in increased expression of MICALL2 mRNAincreases expression 20106945
D004958 Estradiol Estradiol results in increased expression of MICALL2 mRNAincreases expression 20106945
D014212 Tretinoin Tretinoin results in increased expression of MICALL2 mRNAincreases expression 16788091
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000230 Adenocarcinoma Estradiol 2.1511473722
MESH:D000505 Alopecia Tretinoin 3.8415955085
MESH:D000799 Angioedema Acetaminophen 4.2910982225
MESH:D001145 Arrhythmias, Cardiac Amiodarone 4.0718057881 18218290 20041841
MESH:D001169 Arthritis, Experimental Tretinoin 3.2316412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.3116292516
MESH:D001249 Asthma Tretinoin 2.4116456186
MESH:D001281 Atrial Fibrillation Amiodarone 4.1118651412 19698954
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001471 Barrett Esophagus Tretinoin 4.7316935849
MESH:D001778 Blood Coagulation Disorders Amiodarone 10.2119483382
MESH:D001778 Blood Coagulation Disorders Tretinoin 10.2116197459 16206674
MESH:D001943 Breast Neoplasms Estradiol 2.1212948864 14630087 17289903 19861407 17261762 17018787 18497071 16675129
MESH:D001943 Breast Neoplasms Tretinoin 2.1216166294 16873071 16443354
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.9916813970
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.8616111702
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.6016168501
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 6.863084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 6.8621507988 12907637 12619106
MESH:D006528 Carcinoma, Hepatocellular Estradiol 6.8616924424
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 6.861917145
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 2.3516096774 16051514
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 2.9719225199 15710769
MESH:D002341 Carotid Artery Thrombosis Amiodarone 5.4818974383
MESH:D002386 Cataract Acetaminophen 7.7210977129
MESH:D002386 Cataract Tretinoin 7.7217460283
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 7.1912371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 7.1918566989
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.9916129372
MESH:D002779 Cholestasis Cyclosporine 3.1219486331
MESH:D002822 Choriocarcinoma Tretinoin 5.6016461808
MESH:D002972 Cleft Palate Tretinoin 2.769407595
MESH:D003092 Colitis Tretinoin 4.0617035595
MESH:D019465 Craniofacial Abnormalities Tretinoin 1.8317551590 9125849 9664655 8800419 14991402 9224671 16925845 9211117 10589399 9142499
MESH:D003928 Diabetic Nephropathies Estradiol 3.6619279558
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 4.0916781746 15619225 12958197 19420014 16109766 11529661 16081117 12392966 19923254 12153990 11287661 19370779 11421492 14550746 11461765 18713872 2444490 11743745 14986274 17562736 10915739 12705907 16177239 16485898 19739265 12594235 19085960 10663392 15968718 11739529 19416960 16393943 16227642 18071297 11834606 19164858 14725611 12540782 17522070 10774834 17906064
MESH:D056486 Drug-Induced Liver Injury Amiodarone 4.0915265979 18218290
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.5419426721
MESH:D004489 Edema, Cardiac Tretinoin 4.9118230668
MESH:D016889 Endometrial Neoplasms Estradiol 7.9819148513 18566989 11473722
MESH:D016889 Endometrial Neoplasms Tretinoin 7.9816569247
MESH:D005124 Eye Abnormalities Tretinoin 3.789664655 16938888
MESH:D005234 Fatty Liver Amiodarone 8.7914986274
MESH:D005234 Fatty Liver Cyclosporine 8.7919224547
MESH:D005355 Fibrosis Cyclosporine 9.9112168785 12639820
MESH:D005355 Fibrosis Tretinoin 9.9117994277
MESH:D005756 Gastritis Acetaminophen 4.1216983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.628708960
MESH:D005909 Glioblastoma Tretinoin 3.1717312396
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.3616096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.6016084493
MESH:D006330 Heart Defects, Congenital Tretinoin 3.029664655 14991402
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.8215720958
MESH:D006529 Hepatomegaly Amiodarone 4.1115265979
MESH:D006558 Herpes Genitalis Estradiol 5.4815709030
MESH:D019584 Hot Flashes Estradiol 4.1917088409
MESH:D006930 Hyperalgesia Acetaminophen 8.3716870215
MESH:D006930 Hyperalgesia Tretinoin 8.3716870215
MESH:D006937 Hypercholesterolemia Amiodarone 4.159751232 8137927
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.9316778211
MESH:D006973 Hypertension Cyclosporine 2.1810903974
MESH:D007037 Hypothyroidism Amiodarone 4.8718020914 17991464
MESH:D007333 Insulin Resistance Estradiol 3.1316393666 16627594
MESH:D007410 Intestinal Diseases Tretinoin 4.1217994277
MESH:D007569 Jaw Abnormalities Tretinoin 4.1817551590 15992940
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.8815604871
MESH:D007674 Kidney Diseases Acetaminophen 10.8312587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 10.8318776723 10903974 8314463
MESH:D007674 Kidney Diseases Estradiol 10.8315618244
MESH:D007680 Kidney Neoplasms Cyclosporine 8.0612371664
MESH:D007680 Kidney Neoplasms Estradiol 8.0615610895
MESH:D007938 Leukemia Tretinoin 2.8917143497
MESH:D007951 Leukemia, Myeloid Tretinoin 3.9816482212 19285840 16932348
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.1119850784 16294345 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.3216140955 17368321 17649720 16891316 17301526 17361223 19225113 17339181 17294898 17107899 16935935 17712046 17217047 9834237 16766008 19075265 16331271 19642359 16823087 19035177 19029980 16788101 12679006 17506722 15748426
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.509224671
MESH:D008064 Lipidoses Amiodarone 3.7015342952 17567588
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 2.5314659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 2.5318397230 16248980
MESH:D008107 Liver Diseases Acetaminophen 1.6819014921 16611625 19460945 16610002 12969438 12587719 19784758 11587558
MESH:D017114 Liver Failure, Acute Acetaminophen 3.5017185352 16871587
MESH:D008113 Liver Neoplasms Aflatoxin B1 2.439163691 18177683 2125692 15890375
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 2.908603461
MESH:D008133 Long QT Syndrome Amiodarone 3.7915350150 11989578 17391786
MESH:D008171 Lung Diseases Amiodarone 3.5512587719
MESH:D017563 Lung Diseases, Interstitial Amiodarone 4.9218516814
MESH:D008175 Lung Neoplasms Aflatoxin B1 1.8714755239
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 2.7211807958 11408345 17203775 16891317
MESH:D020149 Manganese Poisoning Estradiol 4.9319453300
MESH:D008527 Medulloblastoma Tretinoin 2.8717453147
MESH:D008545 Melanoma Tretinoin 1.9716752155
MESH:D008546 Melanoma, Experimental Acetaminophen 3.9319513568
MESH:D008591 Meningomyelocele Tretinoin 4.7816940565
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.2316801185
MESH:D009181 Mycoses Amiodarone 5.3417974566 12754197
MESH:D009190 Myelodysplastic Syndromes Tretinoin 3.2217596541
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.4916810080
MESH:D009369 Neoplasms Tretinoin 2.5216594593 16946489
MESH:D009389 Neovascularization, Pathologic Estradiol 4.1317289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.8817954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.5319348381 18481113
MESH:D009421 Nervous System Malformations Estradiol 10.7916427766 11399458
MESH:D009421 Nervous System Malformations Tretinoin 10.799125849
MESH:D009436 Neural Tube Defects Tretinoin 3.229142499
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.1018514411
MESH:D010051 Ovarian Neoplasms Estradiol 5.0419401270
MESH:D010051 Ovarian Neoplasms Tretinoin 5.0416936753
MESH:D010146 Pain Acetaminophen 7.3716870215
MESH:D010146 Pain Tretinoin 7.3716870215
MESH:D010190 Pancreatic Neoplasms Tretinoin 2.5415976015
MESH:D011230 Precancerous Conditions Cyclosporine 3.4712371664
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 4.1720887781
MESH:D011471 Prostatic Neoplasms Estradiol 3.0416740699
MESH:D011507 Proteinuria Tretinoin 3.9116636307
MESH:D011565 Psoriasis Cyclosporine 2.3016882103
MESH:D011625 Pterygium Tretinoin 5.1916723453
MESH:D011658 Pulmonary Fibrosis Amiodarone 2.9412490602 12832656 11597910
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.4016283617 16116481
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 5.4818724381
MESH:D012878 Skin Neoplasms Tretinoin 2.7216467112
MESH:D013274 Stomach Neoplasms Tretinoin 1.8017261132
MESH:D013276 Stomach Ulcer Amiodarone 3.5918087811
MESH:D013610 Tachycardia Amiodarone 4.6211238279
MESH:D017180 Tachycardia, Ventricular Amiodarone 4.5219225199
MESH:D013959 Thyroid Diseases Amiodarone 5.2019731979
MESH:D013964 Thyroid Neoplasms Tretinoin 3.2316026305 17045167
MESH:D013971 Thyrotoxicosis Amiodarone 5.2219584973 18020914
MESH:D013978 Tibial Fractures Estradiol 5.1319048282
MESH:D014062 Tongue Neoplasms Tretinoin 4.0516051514
MESH:D016171 Torsades de Pointes Amiodarone 4.5917467628 11989578
MESH:D014376 Tuberculosis Tretinoin 3.3816040207
MESH:D014581 Urticaria Acetaminophen 3.2810982225
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.9416129372
MESH:D014604 Uveal Neoplasms Tretinoin 5.0516752155
MESH:D014605 Uveitis Cyclosporine 4.431336536
MESH:D014820 Vitiligo Tretinoin 4.3916761959
MESH:D009396 Wilms Tumor Tretinoin 4.2216287080
MESH:D014985 Xerophthalmia Cyclosporine 4.8817120751
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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