AutismKB 2.0

Annotation Detail for MTERF


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Basic Information Top
Gene Symbol:MTERF ( MGC131634 )
Gene Full Name: mitochondrial transcription termination factor
Band: 7q21-q22
Quick LinksEntrez ID:7978; OMIM: 602318; Uniprot ID:MTERF_HUMAN; ENSEMBL ID: ENSG00000127989; HGNC ID:
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
Transcription
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Pathway IDPathway Name
500589Mitochondrial transcription termination
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of MTERF mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of MTERF mRNAaffects expression 21346803
D000643 Ammonium Chloride Ammonium Chloride affects the expression of MTERF mRNAaffects expression 16483693
C055494 caffeic acid phenethyl ester [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of MTERF mRNAaffects cotreatment|decreases expression 20360939
D016572 Cyclosporine Cyclosporine results in decreased expression of MTERF mRNAdecreases expression 20106945
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of MTERF mRNAaffects cotreatment|decreases expression 20360939
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 4.0218287403
MESH:D000236 Adenoma Diethylnitrosamine 3.0110737359 6695378
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 4.3616434500 19061943 17162532 19052882 18056438 17620307
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.2017474063
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 4.8016705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 4.8016705839
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 4.8016878318 18393292 3084413 19335982 17055752 17428255 18788625 18691550 17173139 16830150 10737359 16681979 20214788 18056438 16569478 20007298 19052882 20524982 19171122 20084675 17978847 18978308 19701751 17162532 18506893 16698587 20514400 20101231 17761372 19519916 19539802 19383236 19919837 19107877 16288022 20512989 20727157 19394651 10672840 18785209 18210153 19822196 19208518 16807293 17138121 16540662 16502159 3581430 18665156 21159647 16935385 18494052 16328049 20432363 18971187 11831363 19418558 20935162 16779866
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 12.396135515
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 12.3912371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 12.3917174075 2727394 7505956 21159647
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 3.9719052882
MESH:D002779 Cholestasis Cyclosporine 3.1419486331
MESH:D003490 Cyanosis 2,4-dinitrotoluene 12.3218551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 12.3218551238
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 2.2520387270
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 6.6918551238 21346803
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 6.6918551238 21346803
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 6.6919107877
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.6416302075
MESH:D005234 Fatty Liver Cyclosporine 8.8219224547
MESH:D005234 Fatty Liver Diethylnitrosamine 8.8220387270 21071580
MESH:D005355 Fibrosis Cyclosporine 3.5612168785 12639820
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.688708960
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.8815720958
MESH:D006973 Hypertension Cyclosporine 2.1910903974
MESH:D007249 Inflammation Diethylnitrosamine 2.5218785209
MESH:D007414 Intestinal Neoplasms caffeic acid phenethyl ester 4.8910783313
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.9615604871
MESH:D007674 Kidney Diseases caffeic acid phenethyl ester 6.8415369732
MESH:D007674 Kidney Diseases Cyclosporine 6.848314463 10903974 18776723
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 13.9716705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 13.9716705839
MESH:D007680 Kidney Neoplasms Cyclosporine 13.9712371664
MESH:D015473 Leukemia, Promyelocytic, Acute caffeic acid phenethyl ester 4.1816766008
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.9820032147 19638242 18665156 18407596 18522880
MESH:D008107 Liver Diseases Diethylnitrosamine 2.1617034775
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 4.897678174
MESH:D008113 Liver Neoplasms Diethylnitrosamine 4.8916942905 18977376 20501860 2862719 20452335 12112319 19427195 12771043 20492335 20137499 19256749 15175105 19996281 18644402 20434301 21071580 15885732 21278145 19255062 20101389 19812893 19690152 19833225 19254457 9163691 19294768 20118626 18648771 18978307 19499222 20583210 18754104 19850985 19642983 21167192 19426721 10737359 19638242 21047994 19090486 20405173 2422723 19073162 19551842
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 6.542876784 6135515 2876786
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 6.5418079962 18775883 18544905 2563599 18164116 19539802 18093689 16267830 18253720 19519916 19004024 9362446 16842330 19009564 18282651 17174075 19126423 18308698 17854601 21159647 17942915 3124819
MESH:D008175 Lung Neoplasms Diethylnitrosamine 1.766695378 20970405 21163286 20512841
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.3116801185
MESH:D009336 Necrosis 2,4-dinitrotoluene 11.9418551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 11.9418551238 7678174
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.679029167 3581430
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.9617954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.5718481113 19348381
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 3.6120387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.6420387270
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 9.9212819281 16049721
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 9.9216049721
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 2.5116540662
MESH:D011230 Precancerous Conditions Cyclosporine 9.9112371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 9.912563599
MESH:D011565 Psoriasis Cyclosporine 2.3116882103
MESH:D012640 Seizures 2,4-dinitrotoluene 6.5618551238
MESH:D012640 Seizures 2,6-dinitrotoluene 6.5618551238
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 1.7618456281
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 3.227505956
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 5.3616049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 5.3616049721
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 13.5810091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 13.5810091137
MESH:D014605 Uveitis Cyclosporine 4.501336536
MESH:D014985 Xerophthalmia Cyclosporine 4.9617120751
Pathway ID Pathway Name
REACT:1788 Transcription
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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