AutismKB 2.0

Annotation Detail for MYH14


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Basic Information Top
Gene Symbol:MYH14 ( DFNA4,DKFZp667A1311,FLJ13881,FLJ43092,KIAA2034,MHC16,MYH17,NMHC-II-C,myosin )
Gene Full Name: myosin, heavy chain 14, non-muscle
Band: 19q13.33
Quick LinksEntrez ID:79784; OMIM: 608568; Uniprot ID:MYH14_HUMAN; ENSEMBL ID: ENSG00000105357; HGNC ID: 23212
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa05416Viral myocarditis
hsa04530Tight junction
hsa04810Regulation of actin cytoskeleton
Pathway IDPathway Name
Axon guidance
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Related Diseases/Disorders Top
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Desease Name
Deafness, autosomal dominant 4
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of MYH14 mRNAaffects expression 17562736
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of MYH14 proteinaffects expression 20106945
D004041 Dietary Fats Dietary Fats results in increased expression of MYH14 mRNAincreases expression 18042831
D004054 Diethylstilbestrol Diethylstilbestrol results in increased expression of MYH14 mRNAincreases expression 15289156
D004958 Estradiol Estradiol results in increased expression of MYH14 mRNAincreases expression 15289156
D019833 Genistein Genistein results in increased expression of MYH14 mRNAincreases expression 15289156
C041786 palm oil palm oil results in increased expression of MYH14 mRNAincreases expression 18042831
D010656 Phenylephrine Phenylephrine results in decreased expression of MYH14 mRNAdecreases expression 18158353
C006253 pirinixic acid pirinixic acid results in increased expression of MYH14 mRNAincreases expression 18301758
C025643 vinclozolin vinclozolin affects the expression of MYH14 mRNAaffects expression 19015723
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D055371 Acute Lung Injury pirinixic acid 3.3018653653
MESH:D000230 Adenocarcinoma Estradiol 4.5911473722
MESH:D000230 Adenocarcinoma Genistein 4.5911473722
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.7216434500
MESH:D000686 Amyloidosis Diethylstilbestrol 4.6815469931
MESH:D000799 Angioedema Acetaminophen 4.1110982225
MESH:D001008 Anxiety Disorders vinclozolin 3.7819015723
MESH:D001145 Arrhythmias, Cardiac Phenylephrine 4.2717460149
MESH:D001161 Arteriosclerosis Dietary Fats 4.1015238619
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.3219483382
MESH:D001919 Bradycardia Phenylephrine 4.7815306635
MESH:D001943 Breast Neoplasms Dietary Fats 2.0120435547
MESH:D001943 Breast Neoplasms Diethylstilbestrol 2.0115324884 17129689
MESH:D001943 Breast Neoplasms Estradiol 2.0119861407 12948864 16675129 17261762 17289903 17018787 14630087 18497071
MESH:D001943 Breast Neoplasms Genistein 2.0116873071 16541309 17200150
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.7016111702
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 9.143084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 9.1421507988 12619106 12907637
MESH:D006528 Carcinoma, Hepatocellular Diethylstilbestrol 9.1416924424 15948411
MESH:D006528 Carcinoma, Hepatocellular Estradiol 9.1416924424
MESH:D006528 Carcinoma, Hepatocellular Genistein 9.1416924424
MESH:D006332 Cardiomegaly Phenylephrine 3.6217287366 15728586 11754973 17124262 16170337 11179087
MESH:D002318 Cardiovascular Diseases Genistein 3.4216332659
MESH:D002386 Cataract Acetaminophen 2.6710977129
MESH:D002471 Cell Transformation, Neoplastic Estradiol 2.8818566989
MESH:D002779 Cholestasis pirinixic acid 2.9519176532
MESH:D003110 Colonic Neoplasms Genistein 2.3117182828
MESH:D003456 Cryptorchidism Diethylstilbestrol 12.0416002989 12952375
MESH:D003456 Cryptorchidism vinclozolin 12.0414966744
OMIM:600652 DEAFNESS, AUTOSOMAL DOMINANT 4 marker/mechanism
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4918249437
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 2.5216647724
MESH:D003928 Diabetic Nephropathies Estradiol 3.5619279558
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 1.6319164858 17522070 12392966 14725611 12153990 10915739 18713872 12540782 16109766 19416960 16081117 12705907 10663392 14986274 15619225 19085960 16393943 11287661 19923254 11529661 2444490 19739265 16485898 11739529 19420014 16177239 19370779 11421492 10774834 14550746 12594235 18071297 17562736 11461765 11743745 17906064 12958197 16781746 15968718 11834606 16227642
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.3619426721
MESH:D050171 Dyslipidemias Dietary Fats 3.5718367378
MESH:D004487 Edema pirinixic acid 2.6512083418
MESH:D004714 Endometrial Hyperplasia Diethylstilbestrol 12.7016402032
MESH:D004714 Endometrial Hyperplasia Genistein 12.7016402032
MESH:D016889 Endometrial Neoplasms Diethylstilbestrol 13.1516804899 15700306
MESH:D016889 Endometrial Neoplasms Estradiol 13.1519148513 11473722 18566989
MESH:D016889 Endometrial Neoplasms Genistein 13.1511473722
MESH:D005234 Fatty Liver Dietary Fats 8.2817967931 18296743 19004024 19551842
MESH:D005234 Fatty Liver pirinixic acid 8.2819236843 20131406
MESH:D052776 Female Urogenital Diseases Diethylstilbestrol 3.7516611131 16534752 16002989 15751030 16513791
MESH:D005355 Fibrosis Dietary Fats 3.7418296743
MESH:D005756 Gastritis Acetaminophen 3.9416983495
MESH:D030342 Genetic Diseases, Inborn vinclozolin 5.1716973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.5716417039
MESH:D005833 Genital Neoplasms, Female Diethylstilbestrol 5.1816452187
MESH:D005909 Glioblastoma Genistein 3.3616598420
MESH:D006333 Heart Failure pirinixic acid 2.6320558911
MESH:D006529 Hepatomegaly pirinixic acid 3.2119176532 16221962 18467677 19772884
MESH:D006558 Herpes Genitalis Estradiol 5.3015709030
MESH:D019584 Hot Flashes Estradiol 4.0217088409
MESH:D006930 Hyperalgesia Acetaminophen 2.8416870215
MESH:D006937 Hypercholesterolemia Dietary Fats 3.7621332399
MESH:D006943 Hyperglycemia pirinixic acid 3.3420558911
MESH:D006949 Hyperlipidemias Dietary Fats 3.8021332399
MESH:D006965 Hyperplasia Diethylstilbestrol 4.6514722030 12960047
MESH:D006973 Hypertension Phenylephrine 3.1312717712 8949925
MESH:D006984 Hypertrophy Phenylephrine 4.7312791704 18502941
MESH:D007021 Hypospadias Diethylstilbestrol 4.7916002989
MESH:D007246 Infertility Diethylstilbestrol 4.5515036965
MESH:D007248 Infertility, Male vinclozolin 3.1516467254
MESH:D007249 Inflammation Dietary Fats 2.5120412841
MESH:D007333 Insulin Resistance Dietary Fats 12.9218457598 11836018
MESH:D007333 Insulin Resistance Estradiol 12.9216627594 16393666
MESH:D007333 Insulin Resistance pirinixic acid 12.9216306350
MESH:D007674 Kidney Diseases Acetaminophen 6.1912587719 15629191
MESH:D007674 Kidney Diseases Estradiol 6.1915618244
MESH:D007680 Kidney Neoplasms Diethylstilbestrol 8.0314681315 15003126 16762066
MESH:D007680 Kidney Neoplasms Estradiol 8.0315610895
MESH:D007859 Learning Disorders Diethylstilbestrol 4.2817184923
MESH:D007938 Leukemia Genistein 3.1017468513 18980019
MESH:D007984 Leydig Cell Tumor vinclozolin 4.9716417039
MESH:D008103 Liver Cirrhosis Dietary Fats 2.9618296743
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 3.5814716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Genistein 3.5817823541
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.5815474484
MESH:D008107 Liver Diseases Acetaminophen 1.6611587558 19460945 16611625 19784758 16610002 19014921 12587719 12969438
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4017185352 16871587
MESH:D008113 Liver Neoplasms Aflatoxin B1 7.829163691 15890375 2125692 18177683
MESH:D008113 Liver Neoplasms Diethylstilbestrol 7.8215890375 16712894
MESH:D008113 Liver Neoplasms pirinixic acid 7.8215890375 20007298 16377806
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 2.848603461
MESH:D008175 Lung Neoplasms Aflatoxin B1 1.8714755239
MESH:D008181 Lupus Nephritis Diethylstilbestrol 5.3915166399
MESH:D008223 Lymphoma Diethylstilbestrol 3.5915700306
MESH:D052801 Male Urogenital Diseases Diethylstilbestrol 5.7816002989
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 6.4417203775 11807958 11408345 16891317
MESH:D008325 Mammary Neoplasms, Experimental Genistein 6.4414578162 12929590
MESH:D020149 Manganese Poisoning Estradiol 4.7519453300
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7819513568
MESH:D009135 Muscular Diseases pirinixic acid 3.7216239165
MESH:D009203 Myocardial Infarction Genistein 5.8917141266
MESH:D009203 Myocardial Infarction pirinixic acid 5.8919151258
MESH:D015428 Myocardial Reperfusion Injury Estradiol 14.9516810080
MESH:D015428 Myocardial Reperfusion Injury Genistein 14.9517141266
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 14.9516411023
MESH:D009369 Neoplasms Diethylstilbestrol 5.3015313581
MESH:D009369 Neoplasms pirinixic acid 5.3017405874
MESH:D009389 Neovascularization, Pathologic Estradiol 3.9717289903
MESH:D009421 Nervous System Malformations Diethylstilbestrol 17.6911399458
MESH:D009421 Nervous System Malformations Estradiol 17.6911399458 16427766
MESH:D009421 Nervous System Malformations Genistein 17.6916427766
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.0118514411
MESH:D009765 Obesity Dietary Fats 4.5611836018 21332399 20132043 17217161 18674790 16723640 20518802 18457598 19632207
MESH:D009765 Obesity pirinixic acid 4.5620558911
MESH:D010024 Osteoporosis Genistein 3.3519401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 4.2716169203
MESH:D010051 Ovarian Neoplasms Estradiol 5.0519401270
MESH:D010051 Ovarian Neoplasms Genistein 5.0519005980
MESH:D010146 Pain Acetaminophen 2.5316870215
MESH:D010900 Pituitary Diseases Diethylstilbestrol 5.4314722030
MESH:D010911 Pituitary Neoplasms Diethylstilbestrol 4.8916977796 15687265
MESH:D011297 Prenatal Exposure Delayed Effects Diethylstilbestrol 10.6317184923
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 10.6318220299 19015723 18042343
MESH:D011469 Prostatic Diseases vinclozolin 5.1718220299
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 4.0620887781
MESH:D011471 Prostatic Neoplasms marker/mechanism 17013881
MESH:D011471 Prostatic Neoplasms Diethylstilbestrol 2.5915046698 17136230 15846301
MESH:D011471 Prostatic Neoplasms Estradiol 2.5916740699
MESH:D011471 Prostatic Neoplasms Genistein 2.5915256057 16925846 15378649
MESH:D011472 Prostatitis vinclozolin 5.1718629315
MESH:D015427 Reperfusion Injury pirinixic acid 2.4619058328
MESH:D012852 Sinusitis Phenylephrine 4.947327846
MESH:D013088 Spermatocele Diethylstilbestrol 4.9816709447 16002989
MESH:D013978 Tibial Fractures Estradiol 4.9519048282
MESH:D001749 Urinary Bladder Neoplasms Diethylstilbestrol 2.8317306315 16712894 16452187
MESH:D014581 Urticaria Acetaminophen 3.1610982225
MESH:D002583 Uterine Cervical Neoplasms Diethylstilbestrol 4.1916175088
MESH:D014591 Uterine Diseases Diethylstilbestrol 5.4314652134
MESH:D014594 Uterine Neoplasms Diethylstilbestrol 4.2715809267 16690809
MESH:D014625 Vaginal Neoplasms Diethylstilbestrol 4.6516002989 16513791
MESH:D015430 Weight Gain Dietary Fats 3.8916723640
Pathway ID Pathway Name
REACT:18266 Axon guidance
KEGG:04810 Regulation of actin cytoskeleton
KEGG:04530 Tight junction
KEGG:05416 Viral myocarditis
Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB01944 - (S)-blebbistatin
DB02212 - Pyrophosphate 2-
DB03126 - Mant-Adp
DB03431 - Adenosine-5'-Diphosphate
DB04444 - Tetrafluoroaluminate Ion
DB07468 - (3aS)-3a-hydroxy-5-methyl-1-phenyl-1,2,3,3a-tetrahydro-4H-pyrrolo[2,3-b]quinolin-4-one
DB07469 - (3aS)-3a-hydroxy-7-methyl-1-phenyl-1,2,3,3a-tetrahydro-4H-pyrrolo[2,3-b]quinolin-4-one
DB07470 - (3aS)-3a-hydroxy-1-phenyl-1,2,3,3a-tetrahydro-4H-pyrrolo[2,3-b]quinolin-4-one
DB08276 - N-METHYL O-NITROPHENYL AMINOETHYLDIPHOSPHATE BERYLLIUM TRIFLUORIDE
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Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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