AutismKB 2.0

Annotation Detail for FBXO31


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Basic Information Top
Gene Symbol:FBXO31 ( DKFZp434B027,DKFZp434J1815,FBX14,FBXO14,FLJ22477,Fbx31,MGC15419,MGC9527,pp2386 )
Gene Full Name: F-box protein 31
Band: 16q24.2
Quick LinksEntrez ID:79791; OMIM: 609102; Uniprot ID:FBX31_HUMAN; ENSEMBL ID: ENSG00000103264; HGNC ID: 16510
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1944Breast cancer
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of FBXO31 mRNAaffects expression 17562736
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of FBXO31 mRNAdecreases expression 20106945
D004041 Dietary Fats Dietary Fats results in decreased expression of FBXO31 mRNAdecreases expression 18042831
C041786 palm oil palm oil results in decreased expression of FBXO31 mRNAdecreases expression 18042831
D010634 Phenobarbital NR1I3 protein affects the reaction [Phenobarbital results in decreased expression of FBXO31 mRNA]affects reaction|decreases expression 19482888
D010634 Phenobarbital Phenobarbital results in decreased expression of FBXO31 mRNAdecreases expression 19482888
D010634 Phenobarbital Phenobarbital results in increased expression of FBXO31 mRNAincreases expression 19270015
C006253 pirinixic acid pirinixic acid results in increased expression of FBXO31 mRNAincreases expression 18445702
18301758
D014810 Vitamin E Vitamin E results in increased expression of FBXO31 mRNAincreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 3.836195326
MESH:D055371 Acute Lung Injury pirinixic acid 3.4218653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 2.0420127859 20464547
MESH:D000236 Adenoma Benzo(a)pyrene 2.806695378
MESH:D018248 Adenoma, Liver Cell Phenobarbital 11.4817620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 11.4816434500
MESH:D000799 Angioedema Acetaminophen 4.2910982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.4319183758
MESH:D001161 Arteriosclerosis Dietary Fats 4.2515238619
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.4319483382
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.0820146248 17474063
MESH:D001943 Breast Neoplasms Dietary Fats 2.0820435547
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 4.2916050911
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 2.983084413
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 2.9820935162 17173139 6705139 1701930 20007298
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.1120419170
MESH:D002386 Cataract Acetaminophen 2.7310977129
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.614080065
MESH:D002779 Cholestasis pirinixic acid 3.0319176532
MESH:D019465 Craniofacial Abnormalities Vitamin E 1.9219769572
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5318249437
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 1.6511834606 12153990 12958197 10663392 11421492 17906064 15968718 18713872 19085960 19420014 16485898 10774834 14986274 19923254 16393943 2444490 16227642 12540782 12392966 15619225 19370779 17562736 14725611 11739529 18071297 19164858 19739265 11743745 16177239 12594235 16109766 11529661 11461765 14550746 12705907 10915739 16781746 16081117 19416960 11287661 17522070
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.5419426721
MESH:D050171 Dyslipidemias Dietary Fats 3.6518367378
MESH:D004421 Dystonia Phenobarbital 4.311851702
MESH:C538011 Eales disease Vitamin E 5.159068938
MESH:D004487 Edema pirinixic acid 2.7612083418
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.473659116
MESH:D004828 Epilepsies, Partial Phenobarbital 4.313922381 11558140
MESH:D004827 Epilepsy Phenobarbital 3.0120417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.796401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.617750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 4.413659116
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 2.0616530937
MESH:D005234 Fatty Liver Dietary Fats 8.6517967931 19004024 19551842 18296743
MESH:D005234 Fatty Liver pirinixic acid 8.6520131406 19236843
MESH:D005355 Fibrosis Dietary Fats 3.8818296743
MESH:D005756 Gastritis Acetaminophen 4.1216983495
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 7.1220471113
MESH:D006330 Heart Defects, Congenital Vitamin E 7.1216080930
MESH:D006333 Heart Failure pirinixic acid 2.6920558911
MESH:D006529 Hepatomegaly Phenobarbital 9.7016109766
MESH:D006529 Hepatomegaly pirinixic acid 9.7019772884 19176532 18467677 16221962
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.7816863852 16490937
MESH:D019584 Hot Flashes Vitamin E 4.4114716179
MESH:D006930 Hyperalgesia Acetaminophen 2.9216870215
MESH:D006937 Hypercholesterolemia Dietary Fats 3.8721332399
MESH:D006943 Hyperglycemia pirinixic acid 3.4520558911
MESH:D006949 Hyperlipidemias Dietary Fats 3.9221332399
MESH:D007249 Inflammation Dietary Fats 2.5520412841
MESH:D007251 Influenza, Human Vitamin E 4.6616624496
MESH:D007333 Insulin Resistance Dietary Fats 7.8218457598 11836018
MESH:D007333 Insulin Resistance pirinixic acid 7.8216306350
MESH:D007674 Kidney Diseases Acetaminophen 6.4512587719 15629191
MESH:D007674 Kidney Diseases Vitamin E 6.4512488133
MESH:D008103 Liver Cirrhosis Dietary Fats 7.1218296743
MESH:D008103 Liver Cirrhosis Phenobarbital 7.1221047994
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.4515474484
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 2.4516169303
MESH:D008107 Liver Diseases Acetaminophen 4.1319460945 16611625 19014921 11587558 12969438 12587719 16610002 19784758
MESH:D008107 Liver Diseases Phenobarbital 4.1319363144
MESH:D017114 Liver Failure, Acute Acetaminophen 3.5016871587 17185352
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 7.9120195826 21137059
MESH:D008113 Liver Neoplasms Phenobarbital 7.9119812893 8742319 19482888 21047994 19073162 15975961
MESH:D008113 Liver Neoplasms pirinixic acid 7.9120007298 15890375 16377806
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 2.866150874 1399818 18308698 17172636 2563599
MESH:D008171 Lung Diseases Vitamin E 3.3516863852
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 2.4917053015 18569708 18520028 18816296 20869020 20464547 6695378 20135361 20064080
MESH:D008175 Lung Neoplasms Vitamin E 2.4911062179
MESH:D008546 Melanoma, Experimental Acetaminophen 3.9319513568
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.4016381670
MESH:D009135 Muscular Diseases pirinixic acid 3.8616239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2419151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1616411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.8717484760
MESH:D009369 Neoplasms Benzo(a)pyrene 5.2211141357
MESH:D009369 Neoplasms pirinixic acid 5.2217405874
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.1018514411
MESH:D009765 Obesity Dietary Fats 4.6220132043 17217161 21332399 11836018 20518802 16723640 18457598 18674790 19632207
MESH:D009765 Obesity pirinixic acid 4.6220558911
MESH:D010018 Osteomalacia Phenobarbital 4.7617016548
MESH:D010146 Pain Acetaminophen 2.6216870215
MESH:D010190 Pancreatic Neoplasms Phenobarbital 2.5716965848
MESH:D011230 Precancerous Conditions Phenobarbital 3.872563599
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.1317292933
MESH:D011471 Prostatic Neoplasms Vitamin E 3.1315084515
MESH:D019310 Pseudolymphoma Phenobarbital 4.9412752131
MESH:D015427 Reperfusion Injury pirinixic acid 2.5019058328
MESH:D012640 Seizures Phenobarbital 2.8711442880 3137016 16876388 4039156
MESH:D003294 Seizures, Febrile Phenobarbital 5.226407741
MESH:D012871 Skin Diseases Vitamin E 2.5018709164
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 2.4819755658 10029692
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.562093021 20155912
MESH:D020521 Stroke Vitamin E 3.7416517955
MESH:D013964 Thyroid Neoplasms Phenobarbital 3.261399818
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 2.2617053015
MESH:D014581 Urticaria Acetaminophen 3.2810982225
MESH:D015430 Weight Gain Dietary Fats 3.9916723640
No data
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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