AutismKB 2.0

Annotation Detail for SHCBP1


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Basic Information Top
Gene Symbol:SHCBP1 ( FLJ22009,MGC26900,PAL )
Gene Full Name: SHC SH2-domain binding protein 1
Band: 16q11.2
Quick LinksEntrez ID:79801; OMIM: 611027; Uniprot ID:SHCBP_HUMAN; ENSEMBL ID: ENSG00000171241; HGNC ID: 29547
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C010914 2,4-diaminotoluene 2,4-diaminotoluene results in increased expression of SHCBP1 mRNAincreases expression 20713471
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of SHCBP1 mRNAincreases expression 18648102
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of SHCBP1 proteinaffects expression 20106945
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of SHCBP1 mRNAdecreases expression 20064835
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of SHCBP1 mRNAincreases expression 20106945
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of SHCBP1 mRNAdecreases expression 20018196
20382639
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of SHCBP1 mRNAaffects expression 17484886
D016572 Cyclosporine Cyclosporine affects the expression of SHCBP1 mRNAaffects expression 20106945
D004958 Estradiol Estradiol results in increased expression of SHCBP1 mRNAincreases expression 20106945
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of SHCBP1 mRNAaffects expression 17555576
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of SHCBP1 mRNAincreases expression 17942748
C011890 kojic acid kojic acid results in increased expression of SHCBP1 mRNAincreases expression 16595896
D008748 Methylcholanthrene Methylcholanthrene results in increased expression of SHCBP1 mRNAincreases expression 20713471
D010126 Ozone TTPA protein affects the reaction [Ozone results in increased expression of SHCBP1 mRNA]affects reaction|increases expression 19555225
D010634 Phenobarbital NR1I3 protein affects the reaction [Phenobarbital results in increased expression of SHCBP1 mRNA]affects reaction|increases expression 19482888
D010634 Phenobarbital Phenobarbital results in increased expression of SHCBP1 mRNAincreases expression 19482888
C006253 pirinixic acid pirinixic acid results in increased expression of SHCBP1 mRNAincreases expression 18301758
D011374 Progesterone Progesterone results in increased expression of SHCBP1 mRNAincreases expression 18070364
C017947 sodium arsenite sodium arsenite results in decreased expression of SHCBP1 mRNAdecreases expression 17998272
D013629 Tamoxifen Tamoxifen affects the expression of SHCBP1 mRNAaffects expression 17555576
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of SHCBP1 mRNAdecreases expression 20106945
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of SHCBP1 mRNAincreases expression 19465110
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.5214745880
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 8.186195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 8.1814514962 11752688 15322242
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.9117505938
MESH:D055371 Acute Lung Injury pirinixic acid 3.0818653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 6.9420127859 20464547
MESH:D000230 Adenocarcinoma Estradiol 6.9411473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 6.9414692618
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 11.073712494
MESH:D000236 Adenoma Benzo(a)pyrene 11.076695378
MESH:D000236 Adenoma Methylcholanthrene 11.0710545420 6695378
MESH:D018248 Adenoma, Liver Cell Phenobarbital 17.0917620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 17.0916434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 17.0916835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.6715276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.8716712894 17306315
MESH:D000544 Alzheimer Disease Ozone 2.4315513908
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.9111748828
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.0319183758
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.4211256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.6415885639
MESH:D001172 Arthritis, Rheumatoid Ozone 2.5515570426
MESH:D001249 Asthma Ozone 2.6216373670 17854713
MESH:D050197 Atherosclerosis Methylcholanthrene 3.4311922910
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 4.991440618 11289319
MESH:D001778 Blood Coagulation Disorders pirinixic acid 8.6319483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.6312125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.7615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.7315746008
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.3117868700
MESH:D001930 Brain Injuries Progesterone 4.2215845082 15665606 15380490
MESH:D001943 Breast Neoplasms 2,4-diaminotoluene 3.7511921183
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 3.7517474063 20146248
MESH:D001943 Breast Neoplasms Estradiol 3.7517018787 12948864 14630087 16675129 18497071 17289903 17261762 19861407
MESH:D001943 Breast Neoplasms Methylcholanthrene 3.7517474063
MESH:D001943 Breast Neoplasms Progesterone 3.7516175315 15562024 17614352
MESH:D001943 Breast Neoplasms Tamoxifen 3.7519011961 18629630 19221464 19066611 17049068 18821012 19288272 16818667 17440819 19103187 17893378 18997820 18815881 19142967 19155303 17261762 19189210 21152245 19115204 18425577 11161223 19289846 15668708 20065188 15565566 18984771 19189212 19059307 20859285 17242785 16873071 20005174 20544844 19244106 18351453 16202921 20135344 20390343 21138602 16273361 18855134 19200415 19084267 19487384 19410462
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 3.7520435547
MESH:D016535 Bronchial Hyperreactivity Ozone 3.6415516495 16777450 18417511 14754758 18315731 17626835 19059883
MESH:D002100 Cachexia Ozone 4.7016183385
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.4316111702
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.7410355542 16192424 18705752 16050911 16097048 16227642 16124888 15673190 16011737 15700767 3786805 15721981
MESH:D002277 Carcinoma Methylcholanthrene 8.2110545420
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 8.2116835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.4719066611
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 14.003581430 7296757
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 14.0021507988 12619106 12907637
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 14.0018788625
MESH:D006528 Carcinoma, Hepatocellular Estradiol 14.0016924424
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 14.0017173139 20935162 6705139 20007298 1701930
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 14.0015276417 17306315 16507464
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 14.0016924424
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.657296757
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.5620419170
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 4.5618572023
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.5717572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3418850075 18670907 16120746
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 25.987505956
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 25.9820889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 25.9812371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 25.9818566989
MESH:D002471 Cell Transformation, Neoplastic Methylcholanthrene 25.9816192471
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 25.9819524636 20056578
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.214080065
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.1216835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 18.9419486331 9022650
MESH:D002779 Cholestasis Cyclosporine 18.9419486331
MESH:D002779 Cholestasis Ethinyl Estradiol 18.9416919318 11677210 16105132 17333356 17681005 17110522 15861022
MESH:D002779 Cholestasis pirinixic acid 18.9419176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.088697196 15340226 16354765 15668235 12621046
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.0214669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2515322242 20055451 10048152
MESH:D003711 Demyelinating Diseases Tamoxifen 4.3219031437
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.7714531868 11298694 8156756 12868966 11906362 18759878 2524372 8970840
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4018249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.453621924 2952479
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6617107852
MESH:D003928 Diabetic Nephropathies Estradiol 8.7119279558
MESH:D003928 Diabetic Nephropathies Tamoxifen 8.7119279558
MESH:D003929 Diabetic Neuropathies Progesterone 4.4517187935
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 6.1018289764 9653073 18692083 6679447 18648102 6482804 8291058 16192314 7440962 11289319 1440618 9022650 9328219
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 6.107120509 4309450 3732212 16227642 21278145 16177239 7179309 15968718 10092053 17522070 2869522 6623471 15027814 15998439 6884620 7440962 11566570 19085960 3786805 19336974 10915739 9327722
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.1020420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.7311462148
MESH:D004421 Dystonia Phenobarbital 3.961851702
MESH:D004487 Edema pirinixic acid 6.4012083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.4011000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.8718230668 16714409 15322242
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 15.0912538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 15.0917692515
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 15.0919031437
MESH:D016889 Endometrial Neoplasms Estradiol 7.2919148513 18566989 11473722
MESH:D016889 Endometrial Neoplasms Tamoxifen 7.2916202921 17893378 19155303 20544844
MESH:D004715 Endometriosis Progesterone 8.8016134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 8.8010568697 9294722
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.073659116
MESH:D004828 Epilepsies, Partial Phenobarbital 3.843922381 11558140
MESH:D004827 Epilepsy Phenobarbital 2.8720417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.506401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.217750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 3.983659116
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 7.123581430
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7.1220426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 7.1216530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.9811564622
MESH:D005234 Fatty Liver Carbon Tetrachloride 24.2117595544 19224547 15959796 16045604 16239168 12795759 12631006 61145
MESH:D005234 Fatty Liver Cyclosporine 24.2119224547
MESH:D005234 Fatty Liver Ethinyl Estradiol 24.2115345470
MESH:D005234 Fatty Liver pirinixic acid 24.2119236843 20131406
MESH:D005234 Fatty Liver Tamoxifen 24.2119224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.2116709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.4211858732
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 4.996705139
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.4914745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.1519069698
MESH:D005354 Fibrosarcoma Methylcholanthrene 4.9014633661 10962813
MESH:D005355 Fibrosis Carbon Tetrachloride 14.4918705752
MESH:D005355 Fibrosis Cyclosporine 14.4912168785 12639820
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 14.4920067830
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.6416452187
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.188708960
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.007505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.5710696789
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.3720471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.3710048152 11294989
MESH:D006333 Heart Failure pirinixic acid 2.5120558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.3915720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.2911000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 9.096705139
MESH:D006505 Hepatitis Carbon Tetrachloride 9.0919900420 19110552
MESH:D006529 Hepatomegaly Phenobarbital 14.1616109766
MESH:D006529 Hepatomegaly pirinixic acid 14.1619772884 16221962 18467677 19176532
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 14.1616120746 15340226 12621046
MESH:D006558 Herpes Genitalis Estradiol 5.0015709030
MESH:D006689 Hodgkin Disease sodium arsenite 3.1112676792
MESH:D019584 Hot Flashes Estradiol 3.7217088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.0215340226 16354765 8697196 18606429 16959395
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.5016899240
MESH:D006943 Hyperglycemia pirinixic acid 3.1420558911
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 3.9015034207
MESH:D006973 Hypertension Cyclosporine 4.8910903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.8918670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.0515338365
MESH:D007021 Hypospadias Ethinyl Estradiol 3.7716945680 16569931
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.3615869954
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.4212013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 6.5417937319
MESH:D007248 Infertility, Male sodium arsenite 6.5412646999 15346721
MESH:D007249 Inflammation Progesterone 8.1615869954
MESH:D007249 Inflammation Tamoxifen 8.1619457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 8.1612200463 12878042
MESH:D007333 Insulin Resistance Estradiol 7.1016627594 16393666
MESH:D007333 Insulin Resistance pirinixic acid 7.1016306350
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 4.998074119 9022650
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.2916580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.4115604871
MESH:D007674 Kidney Diseases Cyclosporine 9.918314463 10903974 18776723
MESH:D007674 Kidney Diseases Estradiol 9.9115618244
MESH:D007674 Kidney Diseases sodium arsenite 9.9120008137
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 17.446582329
MESH:D007680 Kidney Neoplasms Cyclosporine 17.4412371664
MESH:D007680 Kidney Neoplasms Estradiol 17.4415610895
MESH:D007680 Kidney Neoplasms Tamoxifen 17.4418625569
MESH:D008064 Lipidoses Tamoxifen 3.1215342952 17567588
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 6.5511903743 11408273 17157831 21278145 16239168 16221502 17334410 16943688 17174718
MESH:D008103 Liver Cirrhosis Phenobarbital 6.5521047994
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.1715034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 6.6612741479 17823541 16033810 15893842 12667390 14620537 15338365 16116963 18279442 12389079 17721639 17708605 12632514 18263696 12958196 18006644 15996030 15931870 14724832 15052691 14716833 18054572 15673190 18277467 16027843 18472094 17714472 17698563 18205269 18472332 18156304 18317297 10355542 12666154 12586293 16015684 20821823 14716496 18481824 16011737 18418968 15959796 15876570 16136751 11481614 14748882 17805973 17565644 12898905 12649538 12445421 17761835 17766677 17922224 18395914 15925388 15730626 15818738 12546737 17976157 17525996 17869086 18705752 16638106 15057751 12445418 18412020 15370692 17900296 17481882 15123356 14512876 12609069 17640975 18395095 17944888 18339082 18166357 18187930 16248980 16097048 18376398 15362042 17557913 18251166 12632512 18420326 16192424 17631135 18429990 15650968 13678700 18210741
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 6.6614716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 6.6615474484
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 6.6618564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 6.6612878042
MESH:D008107 Liver Diseases Carbon Tetrachloride 4.0616964402 15720792 17285989 15830285 16246199
MESH:D008107 Liver Diseases Phenobarbital 4.0619363144
MESH:D017093 Liver Failure Carbon Tetrachloride 4.1215123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.6514706259 16899240
MESH:D008113 Liver Neoplasms Aflatoxin B1 25.7215890375 2125692 9163691 18177683
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 25.7221137059 20195826
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 25.7219294768
MESH:D008113 Liver Neoplasms Phenobarbital 25.728742319 19482888 21047994 19812893 15975961 19073162
MESH:D008113 Liver Neoplasms pirinixic acid 25.7220007298 15890375 16377806
MESH:D008113 Liver Neoplasms sodium arsenite 25.7215276417 16712894
MESH:D008113 Liver Neoplasms Tamoxifen 25.7216684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 25.7216984957
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 27.886587162 1399818 3712494 598648
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 27.888603461
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 27.8815583823 12014681
MESH:D008114 Liver Neoplasms, Experimental kojic acid 27.8818544905
MESH:D008114 Liver Neoplasms, Experimental Methylcholanthrene 27.881399818 598648
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 27.8818308698 17172636 6150874 1399818 2563599
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 27.8812151625
MESH:D008171 Lung Diseases Ozone 7.428266340 19066396
MESH:D008171 Lung Diseases sodium arsenite 7.4219095001
MESH:D055370 Lung Injury Ozone 3.8120417186
MESH:D008175 Lung Neoplasms Aflatoxin B1 10.6414755239
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 10.6418816296 18520028 20869020 17053015 6695378 20064080 20135361 18569708 20464547
MESH:D008175 Lung Neoplasms Methylcholanthrene 10.6420970405 15390079 7750092 11893704 17909032 20512841 16337739 9230183 16271038 10545420 1399818 6695378 21163286
MESH:D008175 Lung Neoplasms Ozone 10.647614698 8597069
MESH:D008175 Lung Neoplasms sodium arsenite 10.6416712894 19931552 17306315 15276417 17077188
MESH:D008175 Lung Neoplasms Tamoxifen 10.6418625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 10.6419555203 11884234
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.7219428831
MESH:D008325 Mammary Neoplasms, Experimental 2,4-diaminotoluene 14.0811921183
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 14.0816891317 17203775 11807958 11408345
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 14.0817203775 11408345
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 14.0819196723 11731420 19196722 14580682 16827153
MESH:D020149 Manganese Poisoning Estradiol 12.5519453300
MESH:D020149 Manganese Poisoning Tamoxifen 12.5519453300
MESH:D008545 Melanoma sodium arsenite 3.2919082730 16487513
MESH:D008545 Melanoma Tamoxifen 3.2912393984 19393235
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.1515990972
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.7616801185
MESH:D008679 Metaplasia Ozone 5.0810496685
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.1516381670
MESH:D009135 Muscular Diseases pirinixic acid 3.4716239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.1219151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.9812213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 8.1316810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 8.1316411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.4417484760
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 5.643581430
MESH:D009362 Neoplasm Metastasis Tamoxifen 5.6419393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5019410462
MESH:D009369 Neoplasms Benzo(a)pyrene 8.0811141357
MESH:D009369 Neoplasms pirinixic acid 8.0817405874
MESH:D009369 Neoplasms sodium arsenite 8.0811559025
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.6320056578
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 3.9719189210 19200415 19196722
MESH:D009389 Neovascularization, Pathologic Estradiol 3.7017289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.4117954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.2419348381 18481113
MESH:D009421 Nervous System Malformations Estradiol 9.3316427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 9.3314600291
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 7.166679447
MESH:D009436 Neural Tube Defects sodium arsenite 7.1612854658
MESH:D009765 Obesity pirinixic acid 1.8020558911
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.384026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 4.993988306
MESH:D010018 Osteomalacia Phenobarbital 4.3317016548
MESH:D010051 Ovarian Neoplasms Estradiol 7.8219401270
MESH:D010051 Ovarian Neoplasms Progesterone 7.8217393432 16525653
MESH:D010051 Ovarian Neoplasms sodium arsenite 7.8217306315 15276417
MESH:D010190 Pancreatic Neoplasms Phenobarbital 2.4816965848
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.6511578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.447296757
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.2212520081
MESH:D010538 Peritonitis Ozone 4.0916369182
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.446228378
MESH:D011014 Pneumonia Ozone 4.3618007984 18381685 18929643
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.5218163543
MESH:D011230 Precancerous Conditions Cyclosporine 8.8412371664
MESH:D011230 Precancerous Conditions Phenobarbital 8.842563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.1611399792 11118676 11896295 11222880
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.8420887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.0617292933
MESH:D011471 Prostatic Neoplasms Estradiol 2.0616740699
MESH:D011471 Prostatic Neoplasms sodium arsenite 2.0616039940
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.0615067354
MESH:D011537 Pruritus Ethinyl Estradiol 3.2816919318 15861022
MESH:D019310 Pseudolymphoma Phenobarbital 4.4712752131
MESH:D011565 Psoriasis Cyclosporine 2.2116882103
MESH:D015427 Reperfusion Injury pirinixic acid 2.3619058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.8018990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.343692021
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.8418045962
MESH:D012640 Seizures Phenobarbital 2.664039156 11442880 3137016 16876388
MESH:D003294 Seizures, Febrile Phenobarbital 4.796407741
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 9.2819755658 10029692
MESH:D012878 Skin Neoplasms sodium arsenite 9.2819524636 18572023
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 9.2816192470
MESH:D013088 Spermatocele Ethinyl Estradiol 11.4716709447
MESH:D013088 Spermatocele Tamoxifen 11.4716709447
MESH:D013119 Spinal Cord Injuries Progesterone 10.7515862959 16503802
MESH:D013119 Spinal Cord Injuries Tamoxifen 10.7519457130
MESH:D016135 Spinal Dysraphism sodium arsenite 3.7612854658
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.562093021 20155912
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.5811994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.1115669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.8712697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 7.031399818 6587162 7505956 6582329 3712494
MESH:D013964 Thyroid Neoplasms Phenobarbital 7.031399818
MESH:D013978 Tibial Fractures Estradiol 4.6619048282
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 11.788074119
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 11.7817053015
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 11.7816452187 16712894 11723127 17306315
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 11.788653321 16712894 17572228
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 3.7311813266
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.2614692618
MESH:D014605 Uveitis Cyclosporine 3.961336536
MESH:D014652 Vascular Diseases sodium arsenite 4.3917056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.5712125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.5015869587 14671159
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.2215886252
MESH:D014985 Xerophthalmia Cyclosporine 4.4117120751
No data
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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