AutismKB 2.0

Annotation Detail for EHMT1


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Basic Information Top
Gene Symbol:EHMT1 ( DEL9q34,DKFZp667M072,EUHMTASE1,Eu-HMTase1,FLJ12879,FP13812,GLP,KIAA1876,KMT1D,bA188C12.1 )
Gene Full Name: euchromatic histone-lysine N-methyltransferase 1
Band: 9q34.3
Quick LinksEntrez ID:79813; OMIM: 607001; Uniprot ID:EHMT1_HUMAN; ENSEMBL ID: ENSG00000181090; HGNC ID: 24650
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
No data
Desease Name
CANCER
overall effect
No data
Desease Name
Kleefstra syndrome
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of EHMT1 mRNAdecreases expression 18648102
C035207 4-amino-2,6-dinitrotoluene 4-amino-2,6-dinitrotoluene affects the expression of EHMT1 mRNAaffects expression 21346803
D000638 Amiodarone Amiodarone results in increased expression of EHMT1 mRNAincreases expression 19774075
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of EHMT1 mRNAdecreases expression 20106945
20064835
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of EHMT1 mRNAdecreases expression 19150397
D007657 Ketone Bodies Ketone Bodies results in decreased expression of EHMT1 mRNAdecreases expression 16807920
C006253 pirinixic acid pirinixic acid results in increased expression of EHMT1 mRNAincreases expression 18301758
C025643 vinclozolin vinclozolin results in decreased expression of EHMT1 mRNAdecreases expression 18042343
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced 4-amino-2,6-dinitrotoluene 4.287525203
MESH:D055371 Acute Lung Injury pirinixic acid 3.3818653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 2.0320127859 20464547
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 7.023712494
MESH:D000236 Adenoma Benzo(a)pyrene 7.026695378
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.8216434500
MESH:D001008 Anxiety Disorders vinclozolin 3.8319015723
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.3819183758
MESH:D001145 Arrhythmias, Cardiac Amiodarone 4.0318057881 18218290 20041841
MESH:D001281 Atrial Fibrillation Amiodarone 4.0819698954 18651412
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.401440618 11289319
MESH:D001778 Blood Coagulation Disorders Amiodarone 9.9019483382
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.9019483382
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.0120146248 17474063
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 1.773581430 7296757
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.777296757
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.1020419170
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 2.9619225199 15710769
MESH:D002341 Carotid Artery Thrombosis Amiodarone 5.4218974383
MESH:D002386 Cataract 4-amino-2,6-dinitrotoluene 3.7614694615
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 7.187505956
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7.1820889678
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 8.4319486331 9022650
MESH:D002779 Cholestasis pirinixic acid 8.4319176532
MESH:D000013 Congenital Abnormalities 4-amino-2,6-dinitrotoluene 4.3715095906
MESH:D003456 Cryptorchidism vinclozolin 4.6214966744
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.102524372 18759878 14531868 12868966 11298694 8970840 8156756 11906362
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5218249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.752952479 3621924
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 6.739328219 18648102 1440618 9022650 9653073 8291058 18692083 11289319 18289764 6679447 16192314 6482804 7440962
MESH:D056486 Drug-Induced Liver Injury 4-amino-2,6-dinitrotoluene 6.7321346803
MESH:D056486 Drug-Induced Liver Injury Amiodarone 6.7315265979 18218290
MESH:D004487 Edema pirinixic acid 2.7212083418
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 7.493581430
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7.4920426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 7.4916530937
MESH:D005234 Fatty Liver Amiodarone 8.6214986274
MESH:D005234 Fatty Liver pirinixic acid 8.6219236843 20131406
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.406705139
MESH:D030342 Genetic Diseases, Inborn vinclozolin 5.2716973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.6816417039
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.307505956
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.7720471113
MESH:D006333 Heart Failure pirinixic acid 2.6720558911
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.796705139
MESH:D006529 Hepatomegaly Amiodarone 9.6215265979
MESH:D006529 Hepatomegaly pirinixic acid 9.6219176532 19772884 18467677 16221962
MESH:D006937 Hypercholesterolemia Amiodarone 4.129751232 8137927
MESH:D006943 Hyperglycemia pirinixic acid 3.4120558911
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.2515034207
MESH:D007037 Hypothyroidism Amiodarone 4.8217991464 18020914
MESH:D007248 Infertility, Male vinclozolin 3.1916467254
MESH:D007333 Insulin Resistance pirinixic acid 2.7816306350
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.408074119 9022650
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 3.176582329
OMIM:610253 KLEEFSTRA SYNDROME marker/mechanism
MESH:D007984 Leydig Cell Tumor vinclozolin 5.0716417039
MESH:D008064 Lipidoses Amiodarone 3.6815342952 17567588
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.3315034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 1.3515474484
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 4.6221137059 20195826
MESH:D008113 Liver Neoplasms pirinixic acid 4.6215890375 20007298 16377806
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 2.676587162 598648 3712494 1399818
MESH:D008133 Long QT Syndrome Amiodarone 3.7615350150 11989578 17391786
MESH:D008171 Lung Diseases Amiodarone 3.5312587719
MESH:D017563 Lung Diseases, Interstitial Amiodarone 4.8518516814
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 1.5618569708 20869020 18816296 20064080 18520028 20135361 6695378 17053015 20464547
MESH:D008527 Medulloblastoma marker/mechanism 19270706
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.3716381670
MESH:D009135 Muscular Diseases pirinixic acid 3.8116239165
MESH:D009181 Mycoses Amiodarone 5.2817974566 12754197
MESH:D009203 Myocardial Infarction pirinixic acid 2.2219151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1316411023
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.553581430
MESH:D009369 Neoplasms Benzo(a)pyrene 5.1711141357
MESH:D009369 Neoplasms pirinixic acid 5.1717405874
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 3.066679447
MESH:D009765 Obesity pirinixic acid 1.8620558911
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 9.904026338 6482804
MESH:D009784 Occupational Diseases 4-amino-2,6-dinitrotoluene 9.9014694615
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.403988306
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.797296757
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.856228378
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 4.2318042343 18220299 19015723
MESH:D011469 Prostatic Diseases vinclozolin 5.2718220299
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.9317292933
MESH:D011472 Prostatitis vinclozolin 5.2718629315
MESH:D011658 Pulmonary Fibrosis Amiodarone 2.9312490602 12832656 11597910
MESH:D015427 Reperfusion Injury pirinixic acid 2.4919058328
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.553692021
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 5.4218724381
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 2.4619755658 10029692
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.562093021 20155912
MESH:D013276 Stomach Ulcer Amiodarone 3.5518087811
MESH:D013610 Tachycardia Amiodarone 4.5711238279
MESH:D017180 Tachycardia, Ventricular Amiodarone 4.4719225199
MESH:D013959 Thyroid Diseases Amiodarone 5.1319731979
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 3.063712494 6582329 1399818 7505956 6587162
MESH:D013971 Thyrotoxicosis Amiodarone 5.1719584973 18020914
MESH:D016171 Torsades de Pointes Amiodarone 4.5317467628 11989578
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 5.248074119
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 5.2417053015
Pathway ID Pathway Name
KEGG:00310 Lysine degradation
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA134941393
    • No data
    Releated disease ID Related disease Name
    PA443560Breast Neoplasms
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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