AutismKB 2.0

Annotation Detail for ST7


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Basic Information Top
Gene Symbol:ST7 ( DKFZp762O2113,ETS7q,FAM4A,FAM4A1,HELG,RAY1,SEN4,TSG7 )
Gene Full Name: suppression of tumorigenicity 7
Band: 7q31.2
Quick LinksEntrez ID:7982; OMIM: 600833; Uniprot ID:ST7_HUMAN; ENSEMBL ID: ENSG00000004866; HGNC ID: 11351
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of ST7 mRNAaffects expression 21346803
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of ST7 mRNAincreases expression 18648102
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of ST7 mRNAdecreases expression 20064835
20106945
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of ST7 mRNAdecreases expression 15336504
D004052 Diethylnitrosamine Diethylnitrosamine results in increased expression of ST7 mRNAincreases expression 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of ST7 mRNA]decreases reaction|increases expression 17942915
D004958 Estradiol [Progesterone co-treated with Estradiol] results in decreased expression of ST7 mRNAaffects cotreatment|decreases expression 17404688
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of ST7 mRNAincreases expression 17942748
D005047 Etoposide ST7 protein affects the susceptibility to Etoposideaffects response to substance 16217747
C071834 glycidamide glycidamide results in decreased expression of ST7 mRNAdecreases expression 17822822
C008493 methylselenic acid methylselenic acid affects the expression of ST7 mRNAaffects expression 14617803
C008493 methylselenic acid methylselenic acid results in decreased expression of ST7 mRNAdecreases expression 18548127
D016685 Mitomycin ST7 protein affects the susceptibility to Mitomycinaffects response to substance 16217747
D011374 Progesterone [Progesterone co-treated with Estradiol] results in decreased expression of ST7 mRNAaffects cotreatment|decreases expression 17404688
C004648 testosterone enanthate testosterone enanthate affects the expression of ST7 mRNAaffects expression 17440010
D019772 Topotecan ST7 protein affects the susceptibility to Topotecanaffects response to substance 16217747
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.0417505938
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 7.0820127859 20464547
MESH:D000230 Adenocarcinoma Estradiol 7.0811473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 7.0814692618
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 11.313712494
MESH:D000236 Adenoma Benzo(a)pyrene 11.316695378
MESH:D000236 Adenoma Diethylnitrosamine 11.3110737359 6695378
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 3.9817162532 17620307 16434500 19052882 18056438 19061943
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.1519183758
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.5411256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.6915885639
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.121440618 11289319
MESH:D019046 Bone Marrow Neoplasms Etoposide 5.2614601052
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.4317868700
MESH:D001930 Brain Injuries Progesterone 4.3315665606 15380490 15845082
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.3617474063 20146248
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.3617474063
MESH:D001943 Breast Neoplasms Estradiol 2.3617289903 16675129 17018787 12948864 19861407 14630087 18497071 17261762
MESH:D001943 Breast Neoplasms Etoposide 2.3616322251
MESH:D001943 Breast Neoplasms Progesterone 2.3617614352 15562024 16175315
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.5516111702
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 6.6316705839
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 6.633581430 7296757
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 6.6316681979 17162532 16328049 20935162 19052882 18393292 18056438 20101231 17055752 18785209 20727157 18506893 10672840 20084675 19208518 20524982 18971187 16807293 20214788 11831363 18210153 19701751 16569478 19383236 18691550 19519916 20514400 19107877 19418558 3084413 20432363 21159647 19919837 20512989 16935385 18978308 18665156 19335982 16502159 16698587 16878318 17173139 10737359 18494052 18788625 19171122 16540662 19822196 17978847 20007298 17761372 17138121 19394651 16830150 16288022 16779866 19539802 3581430 17428255
MESH:D006528 Carcinoma, Hepatocellular Estradiol 6.6316924424
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.707296757
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.0620419170
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 11.407505956
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 11.4021159647 2727394 17174075 7505956
MESH:D002471 Cell Transformation, Neoplastic Estradiol 11.4018566989
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 3.7319052882
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 7.999022650 19486331
MESH:D002779 Cholestasis Ethinyl Estradiol 7.9917681005 15861022 11677210 16919318 16105132 17333356 17110522
MESH:D003490 Cyanosis 2,4-dinitrotoluene 4.0918551238
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.878970840 2524372 11298694 12868966 14531868 8156756 18759878 11906362
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.553621924 2952479
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 2.2020387270
MESH:D003928 Diabetic Nephropathies Estradiol 3.4619279558
MESH:D003929 Diabetic Neuropathies Progesterone 4.5617187935
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 6.3218551238 21346803
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 6.3218648102 7440962 11289319 16192314 9328219 6679447 6482804 8291058 9022650 18692083 9653073 18289764 1440618
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 6.3219107877
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 9.2512538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 9.2517692515
MESH:D016889 Endometrial Neoplasms Estradiol 3.0119148513 18566989 11473722
MESH:D004715 Endometriosis Progesterone 3.8216134523
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.2116302075
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 4.403581430
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.4016530937
MESH:D005234 Fatty Liver Diethylnitrosamine 7.8821071580 20387270
MESH:D005234 Fatty Liver Ethinyl Estradiol 7.8815345470
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.126705139
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.107505956
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.6820471113
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.586705139
MESH:D006558 Herpes Genitalis Estradiol 5.1315709030
MESH:D006561 Herpes Simplex Etoposide 4.6410809021
MESH:D019247 HIV Wasting Syndrome testosterone enanthate 5.8417440010
MESH:D006689 Hodgkin Disease Etoposide 3.9216135485 15147373 18180244 17606976 16200630
MESH:D019584 Hot Flashes Estradiol 3.8517088409
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.0115034207
MESH:D007021 Hypospadias Ethinyl Estradiol 3.8816569931 16945680
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.4715869954
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.5212013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.5217937319
MESH:D007249 Inflammation Diethylnitrosamine 5.2618785209
MESH:D007249 Inflammation Progesterone 5.2615869954
MESH:D007333 Insulin Resistance Estradiol 3.0016627594 16393666
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.128074119 9022650
MESH:D007674 Kidney Diseases Estradiol 2.6115618244
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 12.6716705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 12.676582329
MESH:D007680 Kidney Neoplasms Estradiol 12.6715610895
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.8519638242 20032147 18407596 18665156 18522880
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.2315034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 1.6814716833 14659978
MESH:D008107 Liver Diseases Diethylnitrosamine 2.1117034775
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 7.6921137059 20195826
MESH:D008113 Liver Neoplasms Diethylnitrosamine 7.6918978307 12112319 18977376 20583210 19090486 19256749 18644402 20452335 19294768 19499222 19254457 19073162 19551842 12771043 20118626 21047994 18754104 19426721 2422723 20137499 20101389 19850985 18648771 10737359 15175105 16942905 20501860 20434301 19638242 21278145 19812893 2862719 15885732 19690152 19427195 19255062 19996281 20492335 19833225 21167192 20405173 21071580 9163691 19642983
MESH:D008113 Liver Neoplasms Mitomycin 7.6915113037
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 6.031399818 3712494 598648 6587162
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 6.0319004024 18308698 2563599 3124819 19519916 21159647 17174075 18775883 19009564 18253720 19539802 18164116 16267830 18282651 17942915 19126423 9362446 16842330 17854601 18093689 18079962 18544905
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 2.3918816296 18520028 20135361 18569708 6695378 17053015 20064080 20464547 20869020
MESH:D008175 Lung Neoplasms Diethylnitrosamine 2.3920970405 6695378 21163286 20512841
MESH:D008223 Lymphoma Etoposide 3.9612556972 12854902
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 6.1711408345 17203775 11807958 16891317
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 6.1717203775 11408345
MESH:D020149 Manganese Poisoning Estradiol 4.5819453300
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.2316381670
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.3216810080
MESH:D009336 Necrosis 2,4-dinitrotoluene 3.9418551238
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 5.773581430
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 5.773581430 9029167
MESH:D009369 Neoplasms Benzo(a)pyrene 2.1911141357
MESH:D009389 Neovascularization, Pathologic Estradiol 3.8117289903
MESH:D009421 Nervous System Malformations Estradiol 3.7211399458 16427766
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 2.956679447
MESH:D009447 Neuroblastoma Topotecan 3.8715176712
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 3.3920387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.2120387270
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 9.0516049721 12819281
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 9.056482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.123988306
MESH:D010051 Ovarian Neoplasms Estradiol 4.9219401270
MESH:D010051 Ovarian Neoplasms Progesterone 4.9217393432 16525653
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 8.9516540662
MESH:D010190 Pancreatic Neoplasms Etoposide 8.9519003803
MESH:D010190 Pancreatic Neoplasms Mitomycin 8.9515113037
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.7511578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.557296757
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.576228378
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.602563599
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.9420887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.1217292933
MESH:D011471 Prostatic Neoplasms Estradiol 2.1216740699
MESH:D011471 Prostatic Neoplasms Etoposide 2.1217172428
MESH:D011471 Prostatic Neoplasms methylselenic acid 2.1216205645
MESH:D011537 Pruritus Ethinyl Estradiol 3.3915861022 16919318
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.413692021
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.8718045962
MESH:D012512 Sarcoma, Ewing's Etoposide 4.7714601052
MESH:D012640 Seizures 2,4-dinitrotoluene 2.5718551238
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 5.7910029692 19755658
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 5.798532709
MESH:D013088 Spermatocele Ethinyl Estradiol 4.0416709447
MESH:D013119 Spinal Cord Injuries Progesterone 4.3615862959 16503802
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.342093021 20155912
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 2.3418456281
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.6811994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.2015669648
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 7.261399818 7505956 6587162 3712494 6582329
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 7.267505956
MESH:D013978 Tibial Fractures Estradiol 4.7819048282
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 8.3816049721
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 8.388074119
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 8.3817053015
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.4010091137
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.3614692618
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.5914671159 15869587
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA36173
    • No data
    Releated disease ID Related disease Name
    PA153906318Autism Spectrum Disorder
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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