Annotation Detail for TMC5
Basic Information
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| Chemical ID |
Chemical Name |
Interaction |
Interaction Action |
Publication |
|---|
| D015123 |
7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide |
7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of TMC5 mRNA | decreases expression | 20018196
|
| D010634 |
Phenobarbital |
NR1I3 protein affects the reaction [Phenobarbital results in increased expression of TMC5 mRNA] | affects reaction|increases expression | 19482888
|
| D010634 |
Phenobarbital |
Phenobarbital results in increased expression of TMC5 mRNA | increases expression | 19482888
|
| D012643 |
Selenium |
[Selenium co-treated with Vitamin E] results in decreased expression of TMC5 mRNA | affects cotreatment|decreases expression | 19244175
|
| D014810 |
Vitamin E |
[Selenium co-treated with Vitamin E] results in decreased expression of TMC5 mRNA | affects cotreatment|decreases expression | 19244175
|
| D014810 |
Vitamin E |
Vitamin E results in decreased expression of TMC5 mRNA | decreases expression | 19244175
|
| Disease ID |
Disease Name |
Direct Evidence |
Inference Chemical Name |
Inference Score |
Publication |
|---|
| MESH:D000014 |
Abnormalities, Drug-Induced |
|
Phenobarbital |
4.07 | 6195326 |
| MESH:D018248 |
Adenoma, Liver Cell |
|
Phenobarbital |
4.60 | 17620307 |
| MESH:D002252 |
Carbon Tetrachloride Poisoning |
|
Vitamin E |
4.49 | 16050911 |
| MESH:D006528 |
Carcinoma, Hepatocellular |
|
Phenobarbital |
1.95 | 6705139 1701930 20935162 17173139 20007298 |
| MESH:D002471 |
Cell Transformation, Neoplastic |
|
7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide |
2.98 | 20889678 |
| MESH:D002493 |
Central Nervous System Diseases |
|
Phenobarbital |
4.81 | 4080065 |
| MESH:D003092 |
Colitis |
|
Selenium |
4.34 | 17936198 |
| MESH:D019465 |
Craniofacial Abnormalities |
|
Vitamin E |
1.93 | 19769572 |
| MESH:D056486 |
Drug-Induced Liver Injury |
|
Selenium |
2.26 | 15131321 |
| MESH:D004421 |
Dystonia |
|
Phenobarbital |
4.47 | 1851702 |
| MESH:C538011 |
Eales disease |
|
Vitamin E |
5.43 | 9068938 |
| MESH:D004831 |
Epilepsies, Myoclonic |
|
Phenobarbital |
4.67 | 3659116 |
| MESH:D004828 |
Epilepsies, Partial |
|
Phenobarbital |
4.59 | 11558140 3922381 |
| MESH:D004827 |
Epilepsy |
|
Phenobarbital |
3.06 | 20417680 |
| MESH:D004832 |
Epilepsy, Absence |
|
Phenobarbital |
3.91 | 6401628 |
| MESH:D017029 |
Epilepsy, Complex Partial |
|
Phenobarbital |
4.81 | 7750514 |
| MESH:D004830 |
Epilepsy, Tonic-Clonic |
|
Phenobarbital |
4.65 | 3659116 |
| MESH:D004938 |
Esophageal Neoplasms |
|
7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide |
2.15 | 20426865 |
| MESH:D006330 |
Heart Defects, Congenital |
|
Vitamin E |
3.17 | 16080930 |
| MESH:D006333 |
Heart Failure |
|
Selenium |
3.29 | 17162251 |
| MESH:D006529 |
Hepatomegaly |
|
Phenobarbital |
4.04 | 16109766 |
| MESH:D006548 |
Hernia, Diaphragmatic |
|
Vitamin E |
2.81 | 16863852 16490937 |
| MESH:D019584 |
Hot Flashes |
|
Vitamin E |
4.69 | 14716179 |
| MESH:D007251 |
Influenza, Human |
|
Selenium |
13.50 | 16624496 |
| MESH:D007251 |
Influenza, Human |
|
Vitamin E |
13.50 | 16624496 |
| MESH:D007674 |
Kidney Diseases |
|
Vitamin E |
3.00 | 12488133 |
| MESH:D007676 |
Kidney Failure, Chronic |
|
Selenium |
4.31 | 16518626 |
| MESH:D008103 |
Liver Cirrhosis |
|
Phenobarbital |
3.08 | 21047994 |
| MESH:D008106 |
Liver Cirrhosis, Experimental |
|
Vitamin E |
1.91 | 16169303 |
| MESH:D008107 |
Liver Diseases |
|
Phenobarbital |
2.24 | 19363144 |
| MESH:D008113 |
Liver Neoplasms |
|
Phenobarbital |
2.42 | 19812893 21047994 8742319 19073162 19482888 15975961 |
| MESH:D008114 |
Liver Neoplasms, Experimental |
|
Phenobarbital |
2.92 | 6150874 17172636 1399818 18308698 2563599 |
| MESH:D008171 |
Lung Diseases |
|
Vitamin E |
3.43 | 16863852 |
| MESH:D008175 |
Lung Neoplasms |
|
Vitamin E |
1.90 | 11062179 |
| MESH:D008325 |
Mammary Neoplasms, Experimental |
|
Selenium |
2.99 | 15318939 |
| MESH:D008654 |
Mesothelioma |
|
Selenium |
2.92 | 15107826 |
| MESH:D020191 |
Myoclonic Epilepsies, Progressive |
|
Phenobarbital |
5.11 | 17484760 |
| MESH:D010018 |
Osteomalacia |
|
Phenobarbital |
5.00 | 17016548 |
| MESH:D010190 |
Pancreatic Neoplasms |
|
Phenobarbital |
2.60 | 16965848 |
| MESH:D010954 |
Plasmacytoma |
|
Selenium |
5.61 | 15087411 |
| MESH:D011230 |
Precancerous Conditions |
|
Phenobarbital |
3.99 | 2563599 |
| MESH:D011471 |
Prostatic Neoplasms |
|
Vitamin E |
3.24 | 15084515 |
| MESH:D019310 |
Pseudolymphoma |
|
Phenobarbital |
5.22 | 12752131 |
| MESH:D012640 |
Seizures |
|
Phenobarbital |
2.95 | 11442880 3137016 4039156 16876388 |
| MESH:D003294 |
Seizures, Febrile |
|
Phenobarbital |
5.45 | 6407741 |
| MESH:D012871 |
Skin Diseases |
|
Vitamin E |
2.52 | 18709164 |
| MESH:D020521 |
Stroke |
|
Vitamin E |
3.84 | 16517955 |
| MESH:D013964 |
Thyroid Neoplasms |
|
Phenobarbital |
3.36 | 1399818 |
Related Pathway Information