AutismKB 2.0

Annotation Detail for CSPP1


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Basic Information Top
Gene Symbol:CSPP1 ( CSPP,FLJ22490,FLJ38886 )
Gene Full Name: centrosome and spindle pole associated protein 1
Band: 8q13.1-q13.2
Quick LinksEntrez ID:79848; OMIM: 611654; Uniprot ID:CSPP1_HUMAN; ENSEMBL ID: ENSG00000104218; HGNC ID: 26193
Relate to Another Database: SFARIGene; denovo-db
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Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C006632 arsenic trioxide arsenic trioxide results in decreased expression of CSPP1 mRNAdecreases expression 15761015
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of CSPP1 mRNAdecreases expression 19150397
D007213 Indomethacin Indomethacin results in decreased expression of CSPP1 mRNAdecreases expression 16984733
D010634 Phenobarbital Phenobarbital results in increased expression of CSPP1 mRNAincreases expression 12832660
D012643 Selenium [Selenium co-treated with Vitamin E] results in increased expression of CSPP1 mRNAaffects cotreatment|increases expression 19244175
D012643 Selenium Selenium results in decreased expression of CSPP1 mRNAdecreases expression 19244175
D013619 Tacrine Tacrine results in increased expression of CSPP1 mRNAincreases expression 12832660
D014810 Vitamin E [Selenium co-treated with Vitamin E] results in increased expression of CSPP1 mRNAaffects cotreatment|increases expression 19244175
D014810 Vitamin E Vitamin E results in decreased expression of CSPP1 mRNAdecreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 3.836195326
MESH:D000230 Adenocarcinoma arsenic trioxide 4.8411798837 19825857
MESH:D000230 Adenocarcinoma Indomethacin 4.8416537180
MESH:D000236 Adenoma Indomethacin 3.5911497255
MESH:D018248 Adenoma, Liver Cell Phenobarbital 4.3717620307
MESH:D016301 Alveolar Bone Loss Indomethacin 5.8117225004
MESH:D000544 Alzheimer Disease Indomethacin 5.1617627676 15579461
MESH:D000544 Alzheimer Disease Tacrine 5.1612725862
MESH:D001014 Aortic Aneurysm Indomethacin 5.1810231640
MESH:D017544 Aortic Aneurysm, Abdominal Indomethacin 5.2310388637
MESH:D018771 Arthralgia Indomethacin 5.612160914
MESH:D001172 Arthritis, Rheumatoid Indomethacin 2.8711248219
MESH:D001477 Bartter Syndrome Indomethacin 5.3410684365
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 3.9516206674
MESH:D001929 Brain Edema Indomethacin 5.4711481608
MESH:D002545 Brain Ischemia Indomethacin 4.8112524144
MESH:D001943 Breast Neoplasms Indomethacin 2.8017401462
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.6311589617
MESH:D002056 Burns Indomethacin 5.0610459503
MESH:D002100 Cachexia Indomethacin 5.4015141370 11239499 16537180 15625704
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 4.2916050911
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 4.9015073043 16217749 11135700 14691202 15553829
MESH:D006528 Carcinoma, Hepatocellular Indomethacin 4.9016391822
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 4.9020007298 20935162 17173139 6705139 1701930
MESH:D018827 Carcinoma, Lewis Lung Indomethacin 5.1211053908
MESH:D018276 Carcinoma, Medullary Indomethacin 5.7518791128 11352223 14736730
MESH:D002291 Carcinoma, Papillary arsenic trioxide 5.3219014326
MESH:D002292 Carcinoma, Renal Cell Indomethacin 3.4817341418
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.3812490120
MESH:D002294 Carcinoma, Squamous Cell Indomethacin 2.9112636206 15482327
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.9020889678
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.614080065
MESH:D002764 Cholecystitis Indomethacin 5.6111181007
MESH:D003092 Colitis Selenium 4.1417936198
MESH:D003110 Colonic Neoplasms Indomethacin 2.6311260862 15625704 15936596 15963497 15637740 15786552
MESH:D015179 Colorectal Neoplasms arsenic trioxide 2.7320501625
MESH:D015179 Colorectal Neoplasms Indomethacin 2.7317054584 12606626 18059344 11197048
MESH:D023903 Coronary Restenosis arsenic trioxide 4.5112609071
MESH:D018352 Coronavirus Infections Indomethacin 6.1617302372
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 2.7810525206
MESH:D019465 Craniofacial Abnormalities Vitamin E 2.7819769572
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.4015213294
MESH:D003967 Diarrhea Indomethacin 4.127237001 7907874
MESH:D056486 Drug-Induced Liver Injury Selenium 2.2315131321
MESH:D004374 Ductus Arteriosus, Patent Indomethacin 5.5518446180 18043480 12774134 16326151 17190690 16133044
MESH:D004381 Duodenal Ulcer Indomethacin 4.4617045617 17351913 17151854 10671773 17329845 16699067 11535926 11595415 11991626 11595431 17202747
MESH:D004421 Dystonia Phenobarbital 4.311851702
MESH:C538011 Eales disease Vitamin E 5.159068938
MESH:D004487 Edema Indomethacin 3.787907874 8273558 16100529 7990266 19703484 8985016 10653021
MESH:D004715 Endometriosis Indomethacin 4.4115652904
MESH:D019446 Endotoxemia Indomethacin 4.9018509659
MESH:D004751 Enteritis Indomethacin 5.1910567023 16328016 17763956
MESH:D020345 Enterocolitis, Necrotizing Indomethacin 5.3417980183
MESH:D004802 Eosinophilia Indomethacin 4.4111298111
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.473659116
MESH:D004828 Epilepsies, Partial Phenobarbital 4.313922381 11558140
MESH:D004827 Epilepsy Phenobarbital 3.0120417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.796401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.617750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 4.413659116
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7.6720426865
MESH:D004938 Esophageal Neoplasms arsenic trioxide 7.6712903497
MESH:D004938 Esophageal Neoplasms Indomethacin 7.6711005569
MESH:D005234 Fatty Liver arsenic trioxide 3.5715073043
MESH:D005334 Fever Indomethacin 4.3810431976 11852909 17627676
MESH:D005354 Fibrosarcoma Indomethacin 5.2910962813
MESH:D005355 Fibrosis Indomethacin 4.4317994277
MESH:D005499 Folliculitis Indomethacin 5.6111298111
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.5916904648
MESH:D005756 Gastritis Indomethacin 5.1915046732
MESH:D005909 Glioblastoma Indomethacin 3.7312870263
MESH:D005910 Glioma Indomethacin 3.3116487511 18371953
MESH:D005923 Glomerulosclerosis, Focal Segmental Indomethacin 4.5111849393
MESH:D006073 Gout Indomethacin 5.7511248219
MESH:D006258 Head and Neck Neoplasms Indomethacin 3.9215482327
MESH:D006330 Heart Defects, Congenital Vitamin E 3.1216080930
MESH:D006333 Heart Failure Selenium 3.2317162251
MESH:D006501 Hepatic Encephalopathy Indomethacin 4.8515633222
MESH:D019698 Hepatitis C, Chronic Indomethacin 5.0115135802
MESH:D006529 Hepatomegaly Phenobarbital 3.8416109766
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.7816863852 16490937
MESH:D019584 Hot Flashes Vitamin E 4.4114716179
MESH:D006930 Hyperalgesia Indomethacin 3.9912727271
MESH:D034321 Hyperamylasemia Indomethacin 6.1617883296
MESH:D006940 Hyperemia Indomethacin 5.4012524144
MESH:D006949 Hyperlipidemias Indomethacin 4.4717546600
MESH:D007077 Ileal Diseases Indomethacin 5.4718306037 10574470
MESH:D007079 Ileitis Indomethacin 5.7510651667 16133968 10647630
MESH:D007235 Infant, Premature, Diseases Indomethacin 5.8116133044
MESH:D007249 Inflammation Indomethacin 3.103291741 12568917 7812673
MESH:D007251 Influenza, Human Selenium 12.4816624496
MESH:D007251 Influenza, Human Vitamin E 12.4816624496
MESH:D007410 Intestinal Diseases Indomethacin 4.6811855677 17994277 18236018 17329856 11686837 11713966 15610444 15831440 10210152
MESH:D019586 Intracranial Hypertension Indomethacin 5.8115241188
MESH:D007579 Jejunal Diseases Indomethacin 5.4718306037 16133968 10574470
MESH:D007674 Kidney Diseases Indomethacin 6.8417190690
MESH:D007674 Kidney Diseases Vitamin E 6.8412488133
MESH:D007676 Kidney Failure, Chronic Selenium 4.1716518626
MESH:D016773 Leishmaniasis, Cutaneous Indomethacin 4.1412228301 11703811 10320625
MESH:D007938 Leukemia arsenic trioxide 2.9515070760
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 4.0817077332 12560223
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.7016972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 9.2414633726
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Indomethacin 9.2410785260 15631656 16572323
MESH:D007951 Leukemia, Myeloid arsenic trioxide 4.0419077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 4.2217050201 19850784 16467208 20471514 16968895
MESH:D015470 Leukemia, Myeloid, Acute Indomethacin 4.2218360721
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.3815213294 16966277 12679006 15748426 17869043 19225113 15622746 17107899 19075265 15336539 9834237 19642359 17712046 16330433 12712474 11161223 19035177 16331271 17649720 12018890 16823087 17217047 16891316 11468182 16112521
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.6816882451
MESH:D007964 Leukocytosis Indomethacin 5.8116537180
MESH:D007969 Leukomalacia, Periventricular Indomethacin 6.1617980183
MESH:D008101 Liver Abscess, Amebic Indomethacin 6.1611479899
MESH:D008103 Liver Cirrhosis Phenobarbital 3.0321047994
MESH:D008106 Liver Cirrhosis, Experimental Indomethacin 2.8218194892
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 2.8216169303
MESH:D008107 Liver Diseases Phenobarbital 2.2219363144
MESH:D008113 Liver Neoplasms arsenic trioxide 4.9514682389
MESH:D008113 Liver Neoplasms Phenobarbital 4.9521047994 19073162 19812893 15975961 19482888 8742319
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 6.5620377131
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 6.5618308698 1399818 6150874 17172636 2563599
MESH:D008133 Long QT Syndrome arsenic trioxide 3.5615213294
MESH:D008171 Lung Diseases Vitamin E 3.3516863852
MESH:D008175 Lung Neoplasms arsenic trioxide 3.6911798837 19825857
MESH:D008175 Lung Neoplasms Indomethacin 3.6911497255 11053908 16537180
MESH:D008175 Lung Neoplasms Vitamin E 3.6911062179
MESH:D008325 Mammary Neoplasms, Experimental Selenium 2.9215318939
MESH:D008654 Mesothelioma Selenium 2.8815107826
MESH:D008881 Migraine Disorders Indomethacin 3.8611903285
MESH:D009062 Mouth Neoplasms Indomethacin 4.2012636206
MESH:D009101 Multiple Myeloma arsenic trioxide 3.2919417148 19549372 15949261 11468182 14977855
MESH:D009182 Mycosis Fungoides arsenic trioxide 5.1218349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 3.2816882451 16105982
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.8717484760
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.2916624393
MESH:D009362 Neoplasm Metastasis Indomethacin 3.2611053908 16537180 11239499
MESH:D009374 Neoplasms, Experimental Indomethacin 4.4910663608 15625704
MESH:D009436 Neural Tube Defects arsenic trioxide 3.2810525206
MESH:D019636 Neurodegenerative Diseases Indomethacin 4.1712349958
MESH:D007752 Obstetric Labor, Premature Indomethacin 5.616374098
MESH:D010003 Osteoarthritis Indomethacin 3.827009135
MESH:D010018 Osteomalacia Phenobarbital 4.7617016548
MESH:D010051 Ovarian Neoplasms arsenic trioxide 2.4716624393 12452020 19769630
MESH:D010146 Pain Indomethacin 3.693291741 17440234 13679232 17627676
MESH:D010149 Pain, Postoperative Indomethacin 5.1218702446 12538197
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 5.5815580305
MESH:D010190 Pancreatic Neoplasms Phenobarbital 5.5816965848
MESH:D010195 Pancreatitis Indomethacin 4.2215028970 17883296
MESH:D010235 Paraganglioma arsenic trioxide 4.4719927285
MESH:D010257 Paraneoplastic Syndromes Indomethacin 6.1616537180
MESH:D020734 Parkinsonian Disorders Indomethacin 4.3812349958
MESH:D051302 Paroxysmal Hemicrania Indomethacin 6.1611903285
MESH:D010437 Peptic Ulcer Indomethacin 5.5511148446
MESH:D010518 Periodontitis Indomethacin 5.3617225004
MESH:D010954 Plasmacytoma Selenium 5.3315087411
MESH:D011230 Precancerous Conditions Phenobarbital 3.872563599
MESH:D047928 Premature Birth Indomethacin 5.4917000239
MESH:D011471 Prostatic Neoplasms arsenic trioxide 3.2419131511
MESH:D011471 Prostatic Neoplasms Vitamin E 3.2415084515
MESH:D011507 Proteinuria Indomethacin 4.4711849393
MESH:D019310 Pseudolymphoma Phenobarbital 4.9412752131
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 4.2916646077
MESH:D012640 Seizures Phenobarbital 2.874039156 3137016 11442880 16876388
MESH:D003294 Seizures, Febrile Phenobarbital 5.226407741
MESH:D012871 Skin Diseases Vitamin E 2.5018709164
MESH:D013272 Stomach Diseases Indomethacin 4.8116280098 17207306 18545984 10215738 10192188 10486359 16113693 15038085 15472012 17160473 16184426 18209964 17638125
MESH:D013274 Stomach Neoplasms arsenic trioxide 2.7217007042
MESH:D013274 Stomach Neoplasms Indomethacin 2.7215609394
MESH:D013276 Stomach Ulcer Indomethacin 3.8612077510 16252198 16150113 14567935 17977527 12467913 16631530 15255614 18087811 11523592 15138204 18237397 15104355 17657623 10750652 16934674 11729361 16169175 11906479 11595431 16755016 18193104 11595415 11145282 16397915 12500499 17895592 18726076 17918041 18181030 18299717 12787963 17627676 18209962 18431645 17654042 17135157 1323529 12498302 10878458 18543354 10423059
MESH:D020521 Stroke Vitamin E 3.7416517955
MESH:D013964 Thyroid Neoplasms arsenic trioxide 13.3219014326
MESH:D013964 Thyroid Neoplasms Indomethacin 13.3214736730 18791128 11352223
MESH:D013964 Thyroid Neoplasms Phenobarbital 13.321399818
MESH:D016171 Torsades de Pointes arsenic trioxide 4.3615213294
MESH:D014456 Ulcer Indomethacin 5.2917380554 10574470
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 2.5720435036 12845720 12973940 11780464
MESH:D014839 Vomiting Indomethacin 5.1911897121
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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