AutismKB 2.0

Annotation Detail for NUDT18


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Basic Information Top
Gene Symbol:NUDT18 ( FLJ22494 )
Gene Full Name: nudix (nucleoside diphosphate linked moiety X)-type motif 18
Band: 8p21.3
Quick LinksEntrez ID:79873; OMIM: NA; Uniprot ID:NUD18_HUMAN; ENSEMBL ID: ENSG00000173566; HGNC ID: 26194
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of NUDT18 mRNAaffects expression 17562736
C006632 arsenic trioxide arsenic trioxide results in increased expression of NUDT18 mRNAincreases expression 15761015
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of NUDT18 mRNAaffects expression 17484886
D004041 Dietary Fats Dietary Fats results in decreased expression of NUDT18 mRNAdecreases expression 18042831
C041786 palm oil palm oil results in decreased expression of NUDT18 mRNAdecreases expression 18042831
D010634 Phenobarbital NR1I3 protein affects the reaction [Phenobarbital results in increased expression of NUDT18 mRNA]affects reaction|increases expression 19482888
D010634 Phenobarbital Phenobarbital results in increased expression of NUDT18 mRNAincreases expression 19482888
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of NUDT18 mRNAaffects binding|decreases expression|increases activity 19710929
C006253 pirinixic acid pirinixic acid results in increased expression of NUDT18 mRNAincreases expression 18301758
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of NUDT18 mRNAincreases expression 20106945
D014810 Vitamin E Vitamin E results in increased expression of NUDT18 mRNAincreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 9.266195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 9.2614514962 11752688 15322242
MESH:D055371 Acute Lung Injury pirinixic acid 3.3418653653
MESH:D000230 Adenocarcinoma arsenic trioxide 2.3311798837 19825857
MESH:D018248 Adenoma, Liver Cell Phenobarbital 19.0417620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 19.0416434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 19.0416835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1411748828
MESH:D000799 Angioedema Acetaminophen 4.1610982225
MESH:D001161 Arteriosclerosis Dietary Fats 4.1515238619
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 16.5216206674
MESH:D001778 Blood Coagulation Disorders pirinixic acid 16.5219483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 16.5212125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.1115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8915746008
MESH:D001943 Breast Neoplasms Dietary Fats 1.9720435547
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9720435547
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.5511589617
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 10.8116227642 18705752 15673190 3786805 15700767 10355542 15721981 16192424 16097048 16011737 16124888 16050911
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 10.8116050911
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9616835633
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 6.793084413
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 6.7915073043 11135700 15553829 16217749 14691202
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 6.7918788625
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 6.796705139 17173139 1701930 20935162 20007298
MESH:D002291 Carcinoma, Papillary arsenic trioxide 5.1919014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.3112490120
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4718670907 18850075 16120746
MESH:D002386 Cataract Acetaminophen 2.6910977129
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.514080065
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3416835633
MESH:D002779 Cholestasis pirinixic acid 2.9719176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.188697196 16354765 15668235 12621046 15340226
MESH:D015179 Colorectal Neoplasms arsenic trioxide 1.8620501625
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2417141729 14669216
MESH:D023903 Coronary Restenosis arsenic trioxide 4.4212609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 3.8710525206
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.8720055451 10048152 15322242
MESH:D019465 Craniofacial Abnormalities Vitamin E 3.8719769572
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.3215213294
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5118249437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7117107852
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.4310915739 10663392 12958197 17522070 15968718 2444490 19085960 14550746 19416960 11421492 17906064 12392966 11739529 16485898 14986274 16393943 12705907 17562736 11461765 10774834 18071297 15619225 11743745 12153990 18713872 19923254 16081117 11529661 16109766 12540782 16227642 19164858 11834606 19370779 14725611 19420014 11287661 12594235 19739265 16177239 16781746
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 6.4310092053 16227642 6884620 17522070 3732212 16177239 7179309 15968718 7120509 7440962 21278145 4309450 15998439 9327722 15027814 10915739 2869522 19085960 6623471 19336974 3786805 11566570
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.4320420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.4219426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9111462148
MESH:D050171 Dyslipidemias Dietary Fats 3.6018367378
MESH:D004421 Dystonia Phenobarbital 4.221851702
MESH:C538011 Eales disease Vitamin E 5.029068938
MESH:D004487 Edema pirinixic acid 7.2312083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 7.2311000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.2218230668 15322242 16714409
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.2110568697 9294722
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.373659116
MESH:D004828 Epilepsies, Partial Phenobarbital 4.193922381 11558140
MESH:D004827 Epilepsy Phenobarbital 2.9820417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.726401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.517750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 4.303659116
MESH:D004938 Esophageal Neoplasms arsenic trioxide 2.3512903497
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1611564622
MESH:D005234 Fatty Liver arsenic trioxide 20.5615073043
MESH:D005234 Fatty Liver Carbon Tetrachloride 20.5616239168 19224547 12631006 17595544 15959796 61145 16045604 12795759
MESH:D005234 Fatty Liver Dietary Fats 20.5618296743 17967931 19004024 19551842
MESH:D005234 Fatty Liver pirinixic acid 20.5620131406 19236843
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.7111858732
MESH:D005355 Fibrosis Carbon Tetrachloride 16.3418705752
MESH:D005355 Fibrosis Dietary Fats 16.3418296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 16.3420067830
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.5016904648
MESH:D005756 Gastritis Acetaminophen 3.9916983495
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.9110696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.9011294989 10048152
MESH:D006330 Heart Defects, Congenital Vitamin E 6.9016080930
MESH:D006333 Heart Failure pirinixic acid 2.6520558911
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5411000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.8319900420 19110552
MESH:D006529 Hepatomegaly Phenobarbital 15.9616109766
MESH:D006529 Hepatomegaly pirinixic acid 15.9618467677 16221962 19176532 19772884
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 15.9615340226 12621046 16120746
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.7616490937 16863852
MESH:D019584 Hot Flashes Vitamin E 4.2914716179
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.3616959395 15340226 18606429 8697196 16354765
MESH:D006930 Hyperalgesia Acetaminophen 2.8616870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.8216899240
MESH:D006937 Hypercholesterolemia Dietary Fats 3.8021332399
MESH:D006943 Hyperglycemia pirinixic acid 3.3820558911
MESH:D006949 Hyperlipidemias Dietary Fats 3.8321332399
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9718850075 18670907
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.3515338365
MESH:D007249 Inflammation Dietary Fats 5.2420412841
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.2412878042 12200463
MESH:D007251 Influenza, Human Vitamin E 4.5316624496
MESH:D007333 Insulin Resistance Dietary Fats 7.6711836018 18457598
MESH:D007333 Insulin Resistance pirinixic acid 7.6716306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5416580747
MESH:D007674 Kidney Diseases Acetaminophen 6.3312587719 15629191
MESH:D007674 Kidney Diseases Vitamin E 6.3312488133
MESH:D007938 Leukemia arsenic trioxide 2.9215070760
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 4.0012560223 17077332
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.5916972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.5814633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 3.9719077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 2.1617050201 20471514 19850784 16467208 16968895
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.3416891316 12018890 16823087 17869043 11468182 15622746 12679006 12712474 16112521 19642359 19075265 16331271 17649720 19225113 9834237 11161223 19035177 16966277 15213294 16330433 15336539 17712046 17217047 17107899 15748426
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.5916882451
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 11.6417157831 17334410 11903743 17174718 16221502 11408273 16239168 21278145 16943688
MESH:D008103 Liver Cirrhosis Dietary Fats 11.6418296743
MESH:D008103 Liver Cirrhosis Phenobarbital 11.6421047994
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 5.1016248980 18395914 17640975 12649538 15876570 18412020 16033810 15370692 12632514 17922224 12741479 14620537 10355542 17805973 15996030 17708605 12958196 15052691 18279442 17869086 16027843 18251166 13678700 17823541 14716833 14748882 14724832 15925388 12898905 15931870 18205269 17565644 12586293 18472094 18418968 12389079 15730626 14512876 17721639 18006644 17525996 18277467 12445421 15818738 18481824 14716496 20821823 17714472 12546737 18317297 11481614 12445418 15673190 15893842 18210741 18376398 17766677 16116963 18166357 16136751 15123356 17481882 18395095 16015684 15057751 17976157 18705752 15338365 12609069 18263696 17900296 18472332 18187930 17698563 18339082 16638106 17944888 16011737 15362042 18054572 12667390 12666154 18420326 15959796 17557913 17761835 18429990 17631135 16097048 12632512 16192424 18156304 15650968
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 5.1015474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 5.1012878042
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 5.1016169303
MESH:D008107 Liver Diseases Acetaminophen 6.7512969438 11587558 16610002 12587719 19460945 16611625 19014921 19784758
MESH:D008107 Liver Diseases Carbon Tetrachloride 6.7516246199 16964402 17285989 15830285 15720792
MESH:D008107 Liver Diseases Phenobarbital 6.7519363144
MESH:D017093 Liver Failure Carbon Tetrachloride 4.4215123358
MESH:D017114 Liver Failure, Acute Acetaminophen 10.0616871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 10.0614706259 16899240
MESH:D008113 Liver Neoplasms arsenic trioxide 14.9814682389
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 14.9819294768
MESH:D008113 Liver Neoplasms Phenobarbital 14.9819073162 19812893 21047994 19482888 8742319 15975961
MESH:D008113 Liver Neoplasms pirinixic acid 14.9820007298 16377806 15890375
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 14.9816984957
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 15.1420377131
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 15.1415583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 15.1418308698 17172636 2563599 1399818 6150874
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 15.1412151625
MESH:D008133 Long QT Syndrome arsenic trioxide 3.5115213294
MESH:D008171 Lung Diseases Vitamin E 3.3116863852
MESH:D008175 Lung Neoplasms arsenic trioxide 3.5119825857 11798837
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.5119555203 11884234
MESH:D008175 Lung Neoplasms Vitamin E 3.5111062179
MESH:D008546 Melanoma, Experimental Acetaminophen 3.8319513568
MESH:D009101 Multiple Myeloma arsenic trioxide 3.2515949261 11468182 19417148 19549372 14977855
MESH:D009135 Muscular Diseases pirinixic acid 3.7616239165
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.9918349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 3.2516105982 16882451
MESH:D009203 Myocardial Infarction pirinixic acid 2.2119151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1812213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1016411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.7617484760
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.2016624393
MESH:D009369 Neoplasms pirinixic acid 2.0317405874
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.4514600291
MESH:D009436 Neural Tube Defects arsenic trioxide 3.2410525206
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.0418514411
MESH:D009765 Obesity Dietary Fats 4.5820518802 17217161 16723640 19632207 11836018 21332399 18457598 20132043 18674790
MESH:D009765 Obesity pirinixic acid 4.5820558911
MESH:D010018 Osteomalacia Phenobarbital 4.6517016548
MESH:D010051 Ovarian Neoplasms arsenic trioxide 2.4616624393 12452020 19769630
MESH:D010146 Pain Acetaminophen 2.5616870215
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 5.5115580305
MESH:D010190 Pancreatic Neoplasms Phenobarbital 5.5116965848
MESH:D010235 Paraganglioma arsenic trioxide 4.3819927285
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.5712520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8018163543
MESH:D011230 Precancerous Conditions Phenobarbital 3.802563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.4811118676 11222880 11399792 11896295
MESH:D011471 Prostatic Neoplasms arsenic trioxide 3.2519131511
MESH:D011471 Prostatic Neoplasms Vitamin E 3.2515084515
MESH:D019310 Pseudolymphoma Phenobarbital 4.8112752131
MESH:D015427 Reperfusion Injury pirinixic acid 2.4719058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0818990726
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 4.2016646077
MESH:D012640 Seizures Phenobarbital 2.8211442880 3137016 16876388 4039156
MESH:D003294 Seizures, Febrile Phenobarbital 5.116407741
MESH:D012871 Skin Diseases Vitamin E 2.4818709164
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1316192470
MESH:D013274 Stomach Neoplasms arsenic trioxide 1.8617007042
MESH:D020521 Stroke Vitamin E 3.6816517955
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.2212697716
MESH:D013964 Thyroid Neoplasms arsenic trioxide 7.7419014326
MESH:D013964 Thyroid Neoplasms Phenobarbital 7.741399818
MESH:D016171 Torsades de Pointes arsenic trioxide 4.2415213294
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 2.5512845720 20435036 12973940 11780464
MESH:D014581 Urticaria Acetaminophen 3.2010982225
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.9112125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.5715886252
MESH:D015430 Weight Gain Dietary Fats 3.9216723640
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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