AutismKB 2.0

Annotation Detail for DCAKD


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Basic Information Top
Gene Symbol:DCAKD ( FLJ22955 )
Gene Full Name: dephospho-CoA kinase domain containing
Band: 17q21.31
Quick LinksEntrez ID:79877; OMIM: NA; Uniprot ID:DCAKD_HUMAN; ENSEMBL ID: ENSG00000172992; HGNC ID: 26238
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
P02736Coenzyme A biosynthesis
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of DCAKD mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of DCAKD mRNAaffects expression 21346803
C035207 4-amino-2,6-dinitrotoluene 4-amino-2,6-dinitrotoluene affects the expression of DCAKD mRNAaffects expression 21346803
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of DCAKD mRNAdecreases expression 20106945
D002995 Clofibric Acid [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of DCAKD mRNAaffects cotreatment|affects expression 17602206
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of DCAKD mRNAaffects cotreatment|affects expression 17602206
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of DCAKD mRNAdecreases expression 17557909
C006253 pirinixic acid pirinixic acid results in increased expression of DCAKD mRNAincreases expression 18301758
17426115
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced 4-amino-2,6-dinitrotoluene 4.287525203
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.3217505938
MESH:D055371 Acute Lung Injury pirinixic acid 3.3818653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.3520127859 20464547
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.3514692618
MESH:D000236 Adenoma Benzo(a)pyrene 7.066695378
MESH:D000236 Adenoma Diethylnitrosamine 7.0610737359 6695378
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 11.2419061943 16434500 19052882 18056438 17620307 17162532
MESH:D018248 Adenoma, Liver Cell pirinixic acid 11.2416434500
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.3819183758
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.7711256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.8015885639
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.3919483382
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.0620146248 17474063
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.0617474063
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 4.7516705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 4.7516705839
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 4.7517428255 20432363 3084413 10737359 19539802 16681979 18393292 11831363 16807293 18691550 20935162 19335982 19052882 19208518 18210153 16328049 18785209 16540662 18506893 16779866 17055752 20101231 20727157 19383236 20214788 16502159 16569478 20084675 16878318 19822196 19919837 18665156 18788625 20524982 16935385 16698587 16288022 19107877 17173139 18971187 17761372 17162532 19701751 20007298 20514400 21159647 17978847 20512989 17138121 19394651 19171122 19519916 10672840 3581430 18056438 19418558 16830150 18494052 18978308
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.1020419170
MESH:D002386 Cataract 4-amino-2,6-dinitrotoluene 3.7614694615
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 7.236135515
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 7.2321159647 17174075 2727394 7505956
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 3.9019052882
MESH:D002779 Cholestasis Ethinyl Estradiol 8.3316919318 17110522 17681005 15861022 16105132 17333356 11677210
MESH:D002779 Cholestasis pirinixic acid 8.3319176532
MESH:D000013 Congenital Abnormalities 4-amino-2,6-dinitrotoluene 4.3715095906
MESH:D003490 Cyanosis 2,4-dinitrotoluene 11.9418551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 11.9418551238
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5218249437
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 2.2320387270
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 9.5321346803 18551238
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 9.5318551238 21346803
MESH:D056486 Drug-Induced Liver Injury 4-amino-2,6-dinitrotoluene 9.5321346803
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 9.5319107877
MESH:D004487 Edema pirinixic acid 2.7212083418
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.4712538720
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.4916302075
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 2.0616530937
MESH:D005234 Fatty Liver Diethylnitrosamine 14.5021071580 20387270
MESH:D005234 Fatty Liver Ethinyl Estradiol 14.5015345470
MESH:D005234 Fatty Liver pirinixic acid 14.5020131406 19236843
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.7720471113
MESH:D006333 Heart Failure pirinixic acid 2.6720558911
MESH:D006529 Hepatomegaly pirinixic acid 3.3019176532 16221962 18467677 19772884
MESH:D006943 Hyperglycemia pirinixic acid 3.4120558911
MESH:D007021 Hypospadias Ethinyl Estradiol 4.1216569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.7212013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.6417937319
MESH:D007249 Inflammation Diethylnitrosamine 2.4818785209
MESH:D007333 Insulin Resistance pirinixic acid 2.7816306350
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 8.0416705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 8.0416705839
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.9420032147 18407596 18665156 19638242 18522880
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 1.3515474484
MESH:D008107 Liver Diseases Diethylnitrosamine 2.1517034775
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 15.107678174
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 15.1020195826 21137059
MESH:D008113 Liver Neoplasms Clofibric Acid 15.1017602206
MESH:D008113 Liver Neoplasms Diethylnitrosamine 15.1021071580 19256749 2422723 18754104 20434301 19833225 19551842 9163691 20492335 19690152 20501860 21047994 18648771 18644402 20118626 19294768 20101389 18977376 18978307 20452335 20583210 19638242 19255062 19812893 19090486 19499222 15175105 12771043 19996281 20137499 10737359 12112319 15885732 19426721 19254457 21278145 19850985 20405173 19427195 19642983 21167192 19073162 16942905 2862719
MESH:D008113 Liver Neoplasms pirinixic acid 15.1020007298 15890375 16377806
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 6.392876786 2876784 6135515
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 6.3918093689 19009564 3124819 18079962 16842330 19539802 18282651 16267830 17942915 18544905 19126423 18775883 18308698 17174075 18164116 21159647 18253720 19519916 17854601 2563599 9362446 19004024
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 2.4320064080 20869020 17053015 18816296 20135361 18569708 6695378 20464547 18520028
MESH:D008175 Lung Neoplasms Diethylnitrosamine 2.436695378 20970405 20512841 21163286
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.3716381670
MESH:D009135 Muscular Diseases pirinixic acid 3.8116239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2219151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1316411023
MESH:D009336 Necrosis 2,4-dinitrotoluene 11.5018551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 11.507678174 18551238
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.653581430 9029167
MESH:D009369 Neoplasms Benzo(a)pyrene 5.1711141357
MESH:D009369 Neoplasms pirinixic acid 5.1717405874
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 3.5420387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.4920387270
MESH:D009765 Obesity pirinixic acid 1.8620558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 16.5316049721 12819281
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 16.5316049721
MESH:D009784 Occupational Diseases 4-amino-2,6-dinitrotoluene 16.5314694615
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 2.4916540662
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.9511578682
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.772563599
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.9317292933
MESH:D011537 Pruritus Ethinyl Estradiol 3.6516919318 15861022
MESH:D015427 Reperfusion Injury pirinixic acid 2.4919058328
MESH:D012640 Seizures 2,4-dinitrotoluene 6.3918551238
MESH:D012640 Seizures 2,6-dinitrotoluene 6.3918551238
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 2.4619755658 10029692
MESH:D013088 Spermatocele Ethinyl Estradiol 4.3216709447
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.382093021 20155912
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 2.3818456281
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.8811994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.3715669648
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 3.167505956
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 8.7416049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 8.7416049721
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 8.7417053015
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 13.1410091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 13.1410091137
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.5814692618
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.7814671159 15869587
No data
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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