Annotation Detail for ATP8B4
Basic Information Top
| Gene Symbol: | ATP8B4 ( ATPIM,FLJ25418 ) |
|---|---|
| Gene Full Name: | ATPase, class I, type 8B, member 4 |
| Band: | 15q21.2 |
| Quick Links | Entrez ID:79895; OMIM: 609123; Uniprot ID:AT8B4_HUMAN; ENSEMBL ID: ENSG00000104043; HGNC ID: 13536 |
| Relate to Another Database: | SFARIGene; denovo-db |
Related Pathway Information| Chemical ID | Chemical Name | Interaction | Interaction Action | Publication |
|---|---|---|---|---|
| D004052 | Diethylnitrosamine | Diethylnitrosamine results in increased expression of ATP8B4 mRNA | increases expression | 17942915 |
| D004052 | Diethylnitrosamine | MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of ATP8B4 mRNA] | decreases reaction|increases expression | 17942915 |
| Disease ID | Disease Name | Direct Evidence | Inference Chemical Name | Inference Score | Publication |
|---|---|---|---|---|---|
| MESH:D000236 | Adenoma | Diethylnitrosamine | 3.12 | 6695378 10737359 | |
| MESH:D018248 | Adenoma, Liver Cell | Diethylnitrosamine | 4.99 | 19052882 19061943 16434500 18056438 17620307 17162532 | |
| MESH:D001943 | Breast Neoplasms | Diethylnitrosamine | 2.18 | 17474063 | |
| MESH:D006528 | Carcinoma, Hepatocellular | Diethylnitrosamine | 1.88 | 20512989 18210153 16540662 19052882 18978308 21159647 16830150 3084413 16502159 20524982 10737359 18691550 18665156 17761372 16698587 3581430 20727157 19394651 16328049 16807293 18971187 16681979 20514400 20084675 19418558 19335982 17978847 11831363 16935385 20101231 18506893 18785209 16569478 18056438 19919837 19822196 19701751 18494052 20214788 16779866 18788625 20935162 19208518 20007298 10672840 17428255 16878318 19107877 17173139 17162532 16288022 19519916 17055752 20432363 19171122 18393292 17138121 19383236 19539802 | |
| MESH:D002471 | Cell Transformation, Neoplastic | Diethylnitrosamine | 3.21 | 17174075 21159647 2727394 7505956 | |
| MESH:D018281 | Cholangiocarcinoma | Diethylnitrosamine | 4.21 | 19052882 | |
| MESH:D003924 | Diabetes Mellitus, Type 2 | Diethylnitrosamine | 2.28 | 20387270 | |
| MESH:D056486 | Drug-Induced Liver Injury | Diethylnitrosamine | 2.16 | 19107877 | |
| MESH:D004931 | Esophageal Achalasia | Diethylnitrosamine | 6.53 | 16302075 | |
| MESH:D005234 | Fatty Liver | Diethylnitrosamine | 3.81 | 21071580 20387270 | |
| MESH:D007249 | Inflammation | Diethylnitrosamine | 2.61 | 18785209 | |
| MESH:D008103 | Liver Cirrhosis | Diethylnitrosamine | 3.08 | 18665156 20032147 18522880 18407596 19638242 | |
| MESH:D008107 | Liver Diseases | Diethylnitrosamine | 2.19 | 17034775 | |
| MESH:D008113 | Liver Neoplasms | Diethylnitrosamine | 2.39 | 12112319 19427195 21278145 19812893 19426721 20118626 20101389 2422723 19499222 18978307 18977376 10737359 19638242 19256749 19254457 18644402 12771043 9163691 20137499 20492335 15175105 18754104 19690152 16942905 18648771 20405173 19642983 15885732 19996281 21047994 20583210 20501860 19551842 19073162 2862719 20452335 21167192 19833225 21071580 19294768 19850985 19255062 20434301 19090486 | |
| MESH:D008114 | Liver Neoplasms, Experimental | Diethylnitrosamine | 2.93 | 21159647 19519916 18775883 2563599 17942915 9362446 18164116 18282651 18079962 17854601 19004024 16842330 3124819 18308698 18544905 19009564 19126423 16267830 17174075 19539802 18253720 18093689 | |
| MESH:D008175 | Lung Neoplasms | Diethylnitrosamine | 1.77 | 6695378 20970405 21163286 20512841 | |
| MESH:D009362 | Neoplasm Metastasis | Diethylnitrosamine | 2.73 | 3581430 9029167 | |
| MESH:D019636 | Neurodegenerative Diseases | Diethylnitrosamine | 3.83 | 20387270 | |
| MESH:D009461 | Neurologic Manifestations | Diethylnitrosamine | 6.53 | 20387270 | |
| MESH:D010190 | Pancreatic Neoplasms | Diethylnitrosamine | 2.56 | 16540662 | |
| MESH:D011230 | Precancerous Conditions | Diethylnitrosamine | 4.08 | 2563599 | |
| MESH:D013274 | Stomach Neoplasms | Diethylnitrosamine | 1.76 | 18456281 | |
| MESH:D013964 | Thyroid Neoplasms | Diethylnitrosamine | 3.41 | 7505956 |
| Pathway ID | Pathway Name |
|---|---|
| REACT:15518 | Transmembrane transport of small molecules |