AutismKB 2.0

Annotation Detail for NUP85


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Basic Information Top
Gene Symbol:NUP85 ( FLJ12549,Nup75 )
Gene Full Name: nucleoporin 85kDa
Band: 17q25
Quick LinksEntrez ID:79902; OMIM: 170285; Uniprot ID:NUP85_HUMAN; ENSEMBL ID: ENSG00000125450; HGNC ID: 8734
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
Pathway IDPathway Name
Metabolism of carbohydrates
Cell Cycle, Mitotic
DNA Replication
Transmembrane transport of small molecules
HIV Infection
No data
No data
Pathway IDPathway Name
500347Regulation of Glucokinase by Glucokinase Regulatory Protein
500899Transport of the SLBP Dependant Mature mRNA
500748Vpr-mediated nuclear import of PICs
500734Late Phase of HIV Life Cycle
500858snRNP Assembly
500687Transport of Ribonucleoproteins into the Host Nucleus
500696NEP/NS2 Interacts with the Cellular Export Machinery
500928Transport of Mature mRNA derived from an Intron-Containing Transcript
500749Interactions of Rev with host cellular proteins
500744Rev-mediated nuclear export of HIV-1 RNA
500657Transport of Mature Transcript to Cytoplasm
500862Transport of Mature mRNA Derived from an Intronless Transcript
500879Transport of the SLBP independent Mature mRNA
500658Transport of Mature mRNAs Derived from Intronless Transcripts
500750Nuclear import of Rev protein
Related Diseases/Disorders Top
No data
Desease IDDesease Name
2075Heart failure
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of NUP85 mRNAaffects expression 17562736
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of NUP85 mRNAdecreases expression 20382639
19150397
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000799 Angioedema Acetaminophen 4.9110982225
MESH:D001321 Autistic Disorder Acetaminophen 1.3918445737
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 1.413084413
MESH:D002386 Cataract Acetaminophen 2.8310977129
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 3.0420889678
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 1.6811421492 14986274 17522070 14550746 19416960 16109766 16081117 11529661 19739265 16227642 12705907 11743745 11287661 11739529 11461765 2444490 15968718 12392966 14725611 19085960 16781746 18713872 10915739 12958197 18071297 19420014 17906064 11834606 19923254 12594235 17562736 12153990 16485898 19164858 19370779 10774834 15619225 16177239 12540782 10663392 16393943
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 5.1719426721
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.1620426865
MESH:D005756 Gastritis Acetaminophen 4.7416983495
MESH:D006930 Hyperalgesia Acetaminophen 3.1116870215
MESH:D007674 Kidney Diseases Acetaminophen 2.4412587719 15629191
MESH:D008107 Liver Diseases Acetaminophen 1.7119784758 16611625 19460945 12969438 12587719 16610002 11587558 19014921
MESH:D017114 Liver Failure, Acute Acetaminophen 3.7416871587 17185352
MESH:D008546 Melanoma, Experimental Acetaminophen 4.3319513568
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.3118514411
MESH:D010146 Pain Acetaminophen 2.8216870215
MESH:D014581 Urticaria Acetaminophen 3.5810982225
Pathway ID Pathway Name
REACT:152 Cell Cycle, Mitotic
REACT:383 DNA Replication
REACT:6185 HIV Infection
REACT:474 Metabolism of carbohydrates
KEGG:03013 RNA transport
REACT:15518 Transmembrane transport of small molecules
Pharmacogenomics Knowledge Base Top
Drug Bank Top

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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018