AutismKB 2.0

Annotation Detail for TUSC3


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Basic Information Top
Gene Symbol:TUSC3 ( D8S1992,M33,MGC13453,MRT7,N33,OST3A )
Gene Full Name: tumor suppressor candidate 3
Band: 8p22
Quick LinksEntrez ID:7991; OMIM: 601385; Uniprot ID:TUSC3_HUMAN; ENSEMBL ID: ENSG00000104723; HGNC ID: 30242
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04141Protein processing in endoplasmic reticulum
hsa00510N-Glycan biosynthesis
hsa01100Metabolic pathways
Pathway IDPathway Name
Metabolism of proteins
No data
No data
No data
Related Diseases/Disorders Top
No data
No data
No data
No data
Desease Name
Mental retardation, autosomal recessive 7
Mental retardation, autosomal recessive, 7
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of TUSC3 mRNAaffects expression 21346803
D000638 Amiodarone Amiodarone results in increased expression of TUSC3 mRNAincreases expression 19774075
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of TUSC3 mRNAincreases expression 20382639
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of TUSC3 mRNAdecreases expression 15336504
D016572 Cyclosporine Cyclosporine results in increased expression of TUSC3 mRNAincreases expression 20106945
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of TUSC3 mRNAaffects expression 17555576
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of TUSC3 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of TUSC3 mRNAaffects cotreatment|increases expression 17942748
D010634 Phenobarbital Phenobarbital affects the expression of TUSC3 mRNAaffects expression 19136022
D010634 Phenobarbital Phenobarbital results in increased expression of TUSC3 mRNAincreases expression 19270015
C006253 pirinixic acid pirinixic acid affects the expression of TUSC3 mRNAaffects expression 19136022
C006253 pirinixic acid pirinixic acid results in increased expression of TUSC3 mRNAincreases expression 18301758
D018038 Sodium Selenite Sodium Selenite results in increased expression of TUSC3 mRNAincreases expression 18175754
D013629 Tamoxifen Tamoxifen affects the expression of TUSC3 mRNAaffects expression 17555576
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of TUSC3 mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of TUSC3 mRNAincreases expression 17942748
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.7614745880
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 8.956195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 8.9511752688 14514962 15322242
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.1617505938
MESH:D055371 Acute Lung Injury pirinixic acid 3.2718653653
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8414692618
MESH:D018248 Adenoma, Liver Cell Phenobarbital 18.4717620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 18.4716434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 18.4716835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0811748828
MESH:D001145 Arrhythmias, Cardiac Amiodarone 3.9318218290 18057881 20041841
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.6411256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7415885639
MESH:D001281 Atrial Fibrillation Amiodarone 4.0118651412 19698954
MESH:D001778 Blood Coagulation Disorders Amiodarone 16.1519483382
MESH:D001778 Blood Coagulation Disorders pirinixic acid 16.1519483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 16.1512125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.0115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8515746008
MESH:D001943 Breast Neoplasms Tamoxifen 1.9519244106 20135344 19142967 17049068 19289846 15668708 18629630 19189210 18821012 19288272 19066611 19115204 18855134 19084267 16818667 19200415 19103187 16873071 20005174 19011961 17242785 21152245 16202921 16273361 19059307 18815881 18997820 19410462 18425577 17261762 18984771 19155303 20065188 19487384 21138602 20544844 17440819 18351453 20390343 11161223 19189212 20859285 19221464 15565566 17893378
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9520435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9116835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.6819066611
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 4.7016705839
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 4.7020935162 1701930 17173139 20007298 6705139
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 4.7016924424
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.7517572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4418670907 18850075 16120746
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 2.9315710769 19225199
MESH:D002341 Carotid Artery Thrombosis Amiodarone 5.2818974383
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 11.696135515
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 11.6920889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 11.6912371664
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.434080065
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2916835633
MESH:D002779 Cholestasis Cyclosporine 13.9519486331
MESH:D002779 Cholestasis Ethinyl Estradiol 13.9517333356 11677210 15861022 16105132 17110522 16919318 17681005
MESH:D002779 Cholestasis pirinixic acid 13.9519176532
MESH:D019457 Chromosome Breakage Sodium Selenite 4.9315894690
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1515668235 8697196 15340226 16354765 12621046
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1814669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2610048152 20055451 15322242
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.1918551238
MESH:D003711 Demyelinating Diseases Tamoxifen 4.5419031437
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4818249437
MESH:D003920 Diabetes Mellitus Sodium Selenite 3.9016285004
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6917107852
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.6019279558
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 9.3118551238 21346803
MESH:D056486 Drug-Induced Liver Injury Amiodarone 9.3115265979 18218290
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 9.3115131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 9.3120420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8611462148
MESH:D004421 Dystonia Phenobarbital 4.151851702
MESH:D004487 Edema pirinixic acid 7.0012083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 7.0011000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.1218230668 16714409 15322242
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 9.4912538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 9.4919031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 3.1317893378 20544844 16202921 19155303
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.159294722 10568697
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.283659116
MESH:D004828 Epilepsies, Partial Phenobarbital 4.093922381 11558140
MESH:D004827 Epilepsy Phenobarbital 2.9520417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.676401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.437750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 4.213659116
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.1020426865
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1211564622
MESH:D005234 Fatty Liver Amiodarone 26.2414986274
MESH:D005234 Fatty Liver Cyclosporine 26.2419224547
MESH:D005234 Fatty Liver Ethinyl Estradiol 26.2415345470
MESH:D005234 Fatty Liver pirinixic acid 26.2419236843 20131406
MESH:D005234 Fatty Liver Tamoxifen 26.2414986274 19224547
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.3116709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.6311858732
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.7214745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.3819069698
MESH:D005355 Fibrosis Cyclosporine 9.0712639820 12168785
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 9.0720067830
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.418708960
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.8110696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4010048152 11294989
MESH:D006333 Heart Failure pirinixic acid 2.6220558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.6215720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4811000095
MESH:D006529 Hepatomegaly Amiodarone 22.2315265979
MESH:D006529 Hepatomegaly Phenobarbital 22.2316109766
MESH:D006529 Hepatomegaly pirinixic acid 22.2318467677 19772884 16221962 19176532
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 22.2315340226 12621046 16120746
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.2616959395 15340226 16354765 8697196 18606429
MESH:D006937 Hypercholesterolemia Amiodarone 4.019751232 8137927
MESH:D006943 Hyperglycemia pirinixic acid 3.3120558911
MESH:D006973 Hypertension Cyclosporine 5.1010903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.1018670907 18850075
MESH:D007021 Hypospadias Ethinyl Estradiol 3.9816569931 16945680
MESH:D007037 Hypothyroidism Amiodarone 4.6918020914 17991464
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.6112013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.5717937319
MESH:D007249 Inflammation Tamoxifen 5.1119457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.1112878042 12200463
MESH:D007333 Insulin Resistance pirinixic acid 7.6016306350
MESH:D007333 Insulin Resistance Sodium Selenite 7.6014714311
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.4816580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.6615604871
MESH:D007674 Kidney Diseases Cyclosporine 2.418314463 10903974 18776723
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 13.0716705839
MESH:D007680 Kidney Neoplasms Cyclosporine 13.0712371664
MESH:D007680 Kidney Neoplasms Tamoxifen 13.0718625569
MESH:D008064 Lipidoses Amiodarone 8.2517567588 15342952
MESH:D008064 Lipidoses Tamoxifen 8.2515342952 17567588
MESH:D008103 Liver Cirrhosis Phenobarbital 2.9621047994
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.4615474484
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 3.4618564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.4612878042
MESH:D008107 Liver Diseases Phenobarbital 2.2019363144
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 14.757678174
MESH:D008113 Liver Neoplasms Phenobarbital 14.758742319 15975961 21047994 19812893 19482888 19073162
MESH:D008113 Liver Neoplasms pirinixic acid 14.7520007298 16377806 15890375
MESH:D008113 Liver Neoplasms Tamoxifen 14.7516684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 14.7516984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 10.292876784 2876786 6135515
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 10.291399818 18308698 17172636 6150874 2563599
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 10.2912151625
MESH:D008133 Long QT Syndrome Amiodarone 3.6917391786 11989578 15350150
MESH:D008171 Lung Diseases Amiodarone 3.4612587719
MESH:D017563 Lung Diseases, Interstitial Amiodarone 4.7018516814
MESH:D008175 Lung Neoplasms Tamoxifen 2.2818625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.2819555203 11884234
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 4.2114737004
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.9519428831
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 2.7119196722 11731420 19196723 14580682 16827153
MESH:D020149 Manganese Poisoning Tamoxifen 4.7619453300
MESH:D008545 Melanoma Tamoxifen 1.9012393984 19393235
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.3815990972
OMIM:611093 MENTAL RETARDATION, AUTOSOMAL RECESSIVE 7 marker/mechanism
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.0116801185
MESH:D009135 Muscular Diseases pirinixic acid 3.6816239165
MESH:D009181 Mycoses Amiodarone 5.1212754197 17974566
MESH:D009203 Myocardial Infarction pirinixic acid 2.1919151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1312213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.0516411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.6717484760
MESH:D009336 Necrosis 2,6-dinitrotoluene 4.0518551238 7678174
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.5919393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5519410462
MESH:D009369 Neoplasms pirinixic acid 2.0117405874
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.2219196722 19189210 19200415
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.6617954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.4118481113 19348381
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.3714600291
MESH:D009765 Obesity pirinixic acid 1.8420558911
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.5616049721
MESH:D010018 Osteomalacia Phenobarbital 4.5617016548
MESH:D010190 Pancreatic Neoplasms Phenobarbital 2.5316965848
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.8411578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.4712520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.7218163543
MESH:D011230 Precancerous Conditions Cyclosporine 9.3912371664
MESH:D011230 Precancerous Conditions Phenobarbital 9.392563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.3811118676 11896295 11399792 11222880
MESH:D011471 Prostatic Neoplasms marker/mechanism
MESH:D011471 Prostatic Neoplasms Sodium Selenite 3.2518760546
MESH:D011471 Prostatic Neoplasms Tamoxifen 3.2515067354
MESH:D011537 Pruritus Ethinyl Estradiol 3.5116919318 15861022
MESH:D019310 Pseudolymphoma Phenobarbital 4.7112752131
MESH:D011565 Psoriasis Cyclosporine 2.2716882103
MESH:D011658 Pulmonary Fibrosis Amiodarone 2.9012490602 12832656 11597910
MESH:D015427 Reperfusion Injury pirinixic acid 2.4519058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0018990726
MESH:D012640 Seizures 2,6-dinitrotoluene 6.2418551238
MESH:D012640 Seizures Phenobarbital 6.2411442880 16876388 3137016 4039156
MESH:D003294 Seizures, Febrile Phenobarbital 5.026407741
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 5.2818724381
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 5.798532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.7916192470
MESH:D013088 Spermatocele Ethinyl Estradiol 12.3016709447
MESH:D013088 Spermatocele Tamoxifen 12.3016709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.2319457130
MESH:D013276 Stomach Ulcer Amiodarone 3.4518087811
MESH:D013610 Tachycardia Amiodarone 4.4511238279
MESH:D017180 Tachycardia, Ventricular Amiodarone 4.3519225199
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.7711994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.2815669648
MESH:D013959 Thyroid Diseases Amiodarone 12.7919731979
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 12.7912697716
MESH:D013964 Thyroid Neoplasms Phenobarbital 3.161399818
MESH:D013971 Thyrotoxicosis Amiodarone 5.0419584973 18020914
MESH:D016171 Torsades de Pointes Amiodarone 4.3817467628 11989578
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 5.2016049721
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 5.2017572228 16712894 8653321
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.5110091137
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.4614692618
MESH:D014605 Uveitis Cyclosporine 4.201336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.8112125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.6814671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.4715886252
MESH:D014985 Xerophthalmia Cyclosporine 4.6617120751
Pathway ID Pathway Name
KEGG:01100 Metabolic pathways
REACT:17015 Metabolism of proteins
KEGG:00510 N-Glycan biosynthesis
KEGG:04141 Protein processing in endoplasmic reticulum
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA128394537
    • No data
    Releated disease ID Related disease Name
    PA444929Mental Retardation
    PA161615744Mental Retardation, Autosomal Recessive
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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