AutismKB 2.0

Annotation Detail for NANOG


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Basic Information Top
Gene Symbol:NANOG ( - )
Gene Full Name: Nanog homeobox
Band: 12p13.31
Quick LinksEntrez ID:79923; OMIM: 607937; Uniprot ID:NANOG_HUMAN; ENSEMBL ID: ENSG00000111704; HGNC ID: 20857
Relate to Another Database: SFARIGene; denovo-db
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Related Diseases/Disorders Top
No data
Desease IDDesease Name
1739Oral cancer
1850Herpes
1976Squamous cell cancer
1979Testicular dysfunction
1986Eating disorder
2229Germ cell tumor
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D002087 Butyrates Butyrates results in increased expression of NANOG proteinincreases expression 20201064
D018021 Lithium Chloride Lithium Chloride results in increased expression of NANOG mRNAincreases expression 20069066
D018021 Lithium Chloride SFRP2 protein affects the reaction [Lithium Chloride results in increased expression of NANOG mRNA]affects reaction|increases expression 20069066
C091888 monoisoamyl-2,3-dimercaptosuccinate monoisoamyl-2,3-dimercaptosuccinate inhibits the reaction [sodium arsenite results in decreased expression of NANOG mRNA]decreases expression|decreases reaction 19615344
C091888 monoisoamyl-2,3-dimercaptosuccinate monoisoamyl-2,3-dimercaptosuccinate results in increased expression of NANOG mRNAincreases expression 19615344
D012643 Selenium Selenium results in increased expression of NANOG proteinincreases expression 18583539
C017947 sodium arsenite monoisoamyl-2,3-dimercaptosuccinate inhibits the reaction [sodium arsenite results in decreased expression of NANOG mRNA]decreases expression|decreases reaction 19615344
C017947 sodium arsenite sodium arsenite results in decreased expression of NANOG mRNAdecreases expression 19615344
D018038 Sodium Selenite Sodium Selenite results in decreased expression of NANOG mRNAdecreases expression 18175754
D014212 Tretinoin Tretinoin results in decreased expression of NANOG mRNAdecreases expression 16168501
17138961
D014212 Tretinoin NR6A1 protein affects the reaction [Tretinoin results in decreased expression of NANOG mRNA]affects reaction|decreases expression 16166633
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 5.1415276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 5.3516712894 17306315
MESH:D000505 Alopecia Tretinoin 3.8415955085
MESH:D001169 Arthritis, Experimental Tretinoin 3.2316412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.3116292516
MESH:D001249 Asthma Tretinoin 2.4116456186
MESH:D001471 Barrett Esophagus Tretinoin 4.7316935849
MESH:D001778 Blood Coagulation Disorders Tretinoin 3.8916197459 16206674
MESH:D001943 Breast Neoplasms Tretinoin 2.2416873071 16443354 16166294
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.9916813970
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.6016168501
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 3.1916507464 15276417 17306315
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 3.191917145
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 4.9118572023
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 4.9116096774 16051514
MESH:D002386 Cataract Tretinoin 3.2417460283
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 3.1719524636 20056578
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.9916129372
MESH:D002822 Choriocarcinoma Tretinoin 5.6016461808
MESH:D019457 Chromosome Breakage Sodium Selenite 5.1115894690
MESH:D002972 Cleft Palate Tretinoin 2.769407595
MESH:D003092 Colitis Selenium 10.7217936198
MESH:D003092 Colitis Tretinoin 10.7217035595
MESH:D003110 Colonic Neoplasms Butyrates 3.1115936596
MESH:D019465 Craniofacial Abnormalities Tretinoin 1.839211117 16925845 9664655 17551590 14991402 10589399 9224671 8800419 9125849 9142499
MESH:D003920 Diabetes Mellitus Sodium Selenite 4.0316285004
MESH:D056486 Drug-Induced Liver Injury Selenium 4.2715131321
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 4.2715131321
MESH:D004489 Edema, Cardiac Tretinoin 4.9118230668
MESH:D016889 Endometrial Neoplasms Tretinoin 3.2816569247
MESH:D005124 Eye Abnormalities Tretinoin 3.7816938888 9664655
MESH:D005355 Fibrosis Tretinoin 3.8717994277
MESH:D005833 Genital Neoplasms, Female sodium arsenite 5.0816452187
MESH:D005909 Glioblastoma Tretinoin 3.1717312396
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.3616096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.6016084493
MESH:D006330 Heart Defects, Congenital Tretinoin 3.029664655 14991402
MESH:D006333 Heart Failure Selenium 3.2317162251
MESH:D006689 Hodgkin Disease sodium arsenite 3.4012676792
MESH:D006869 Hydronephrosis Lithium Chloride 6.4619797860
MESH:D006930 Hyperalgesia Tretinoin 3.4316870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.9316778211
MESH:D007248 Infertility, Male sodium arsenite 3.1615346721 12646999
MESH:D007251 Influenza, Human Selenium 4.6416624496
MESH:D007333 Insulin Resistance Sodium Selenite 3.4514714311
MESH:D007410 Intestinal Diseases Tretinoin 4.1217994277
MESH:D007569 Jaw Abnormalities Tretinoin 4.1817551590 15992940
MESH:D007674 Kidney Diseases sodium arsenite 2.9420008137
MESH:D007676 Kidney Failure, Chronic Selenium 4.1716518626
MESH:D007938 Leukemia Tretinoin 2.8917143497
MESH:D007951 Leukemia, Myeloid Tretinoin 3.9816482212 16932348 19285840
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.1117596541 19850784 16294345
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.3217301526 17712046 17361223 16766008 16891316 12679006 17294898 17339181 19029980 16331271 16935935 16140955 19035177 17368321 16823087 17506722 9834237 15748426 19075265 17217047 17649720 17107899 19225113 19642359 16788101
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.509224671
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 1.8118397230 16248980
MESH:D008113 Liver Neoplasms sodium arsenite 2.4515276417 16712894
MESH:D008171 Lung Diseases sodium arsenite 3.3519095001
MESH:D008175 Lung Neoplasms sodium arsenite 1.8917077188 15276417 16712894 19931552 17306315
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 4.3614737004
MESH:D008325 Mammary Neoplasms, Experimental Selenium 2.9215318939
MESH:D008527 Medulloblastoma Tretinoin 2.8717453147
MESH:D008545 Melanoma sodium arsenite 3.4719082730 16487513
MESH:D008545 Melanoma Tretinoin 3.4716752155
MESH:D008591 Meningomyelocele Tretinoin 4.7816940565
MESH:D008654 Mesothelioma Selenium 2.8815107826
MESH:D009190 Myelodysplastic Syndromes Tretinoin 3.2217596541
MESH:D009369 Neoplasms sodium arsenite 5.5111559025
MESH:D009369 Neoplasms Tretinoin 5.5116946489 16594593
MESH:D009374 Neoplasms, Experimental sodium arsenite 4.0220056578
MESH:D009373 Neoplasms, Germ Cell and Embryonal marker/mechanism 16168501
MESH:D009421 Nervous System Malformations Tretinoin 4.119125849
MESH:D009436 Neural Tube Defects sodium arsenite 7.8812854658
MESH:D009436 Neural Tube Defects Tretinoin 7.889142499
MESH:D010051 Ovarian Neoplasms sodium arsenite 5.1215276417 17306315
MESH:D010051 Ovarian Neoplasms Tretinoin 5.1216936753
MESH:D010146 Pain Tretinoin 3.1316870215
MESH:D010190 Pancreatic Neoplasms Tretinoin 2.5415976015
MESH:D010954 Plasmacytoma Selenium 5.3315087411
MESH:D011141 Polyuria Lithium Chloride 6.3919692487
MESH:D011471 Prostatic Neoplasms sodium arsenite 3.2816039940
MESH:D011471 Prostatic Neoplasms Sodium Selenite 3.2818760546
MESH:D011507 Proteinuria Tretinoin 3.9116636307
MESH:D011625 Pterygium Tretinoin 5.1916723453
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.4016116481 16283617
MESH:D012878 Skin Neoplasms sodium arsenite 6.1819524636 18572023
MESH:D012878 Skin Neoplasms Tretinoin 6.1816467112
MESH:D016135 Spinal Dysraphism sodium arsenite 4.0112854658
MESH:D013274 Stomach Neoplasms Tretinoin 1.8017261132
MESH:D013964 Thyroid Neoplasms Butyrates 8.2817967635
MESH:D013964 Thyroid Neoplasms Tretinoin 8.2817045167 16026305
MESH:D014062 Tongue Neoplasms Tretinoin 4.0516051514
MESH:D014376 Tuberculosis Tretinoin 3.3816040207
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 2.5911723127 16712894 16452187 17306315
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 10.3111813266
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 10.3116129372
MESH:D014604 Uveal Neoplasms Tretinoin 5.0516752155
MESH:D014652 Vascular Diseases sodium arsenite 4.8217056641
MESH:D014820 Vitiligo Tretinoin 4.3916761959
MESH:D009396 Wilms Tumor Tretinoin 4.2216287080
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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