AutismKB 2.0

Annotation Detail for DENND2D


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Basic Information Top
Gene Symbol:DENND2D ( FLJ22457,RP5-1180E21.2 )
Gene Full Name: DENN/MADD domain containing 2D
Band: 1p13.3-p13.2
Quick LinksEntrez ID:79961; OMIM: NA; Uniprot ID:DEN2D_HUMAN; ENSEMBL ID: ENSG00000162777; HGNC ID: 26192
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of DENND2D mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of DENND2D mRNAaffects expression 17562736
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of DENND2D proteinaffects expression 20106945
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of DENND2D mRNAincreases expression 17557909
D010634 Phenobarbital NR1I3 protein affects the reaction [Phenobarbital results in increased expression of DENND2D mRNA]affects reaction|increases expression 19482888
D010634 Phenobarbital Phenobarbital results in increased expression of DENND2D mRNAincreases expression 19482888
D014810 Vitamin E Vitamin E results in decreased expression of DENND2D mRNAdecreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 3.906195326
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.4617505938
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8714692618
MESH:D018248 Adenoma, Liver Cell Phenobarbital 4.4317620307
MESH:D000799 Angioedema Acetaminophen 4.3610982225
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.8811256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.8415885639
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 4.3516050911
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 6.8916705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 6.893084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 6.8921507988 12907637 12619106
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 6.8920007298 17173139 20935162 1701930 6705139
MESH:D002386 Cataract Acetaminophen 2.7510977129
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.674080065
MESH:D002779 Cholestasis Ethinyl Estradiol 3.1015861022 17681005 11677210 17333356 16919318 17110522 16105132
MESH:D019465 Craniofacial Abnormalities Vitamin E 1.9219769572
MESH:D003490 Cyanosis 2,4-dinitrotoluene 4.4318551238
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 3.9721346803 18551238
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 3.9711529661 19416960 11739529 16227642 12540782 16393943 14550746 12392966 17906064 17522070 11287661 18071297 19739265 16485898 11743745 16781746 10915739 17562736 19420014 16081117 2444490 15968718 19923254 16109766 10774834 12705907 15619225 16177239 10663392 11461765 19164858 14725611 18713872 19370779 12594235 14986274 12153990 12958197 11421492 19085960 11834606
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.6219426721
MESH:D004421 Dystonia Phenobarbital 4.361851702
MESH:C538011 Eales disease Vitamin E 5.229068938
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.5712538720
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.533659116
MESH:D004828 Epilepsies, Partial Phenobarbital 4.3911558140 3922381
MESH:D004827 Epilepsy Phenobarbital 3.0320417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.836401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.677750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 4.483659116
MESH:D005234 Fatty Liver Ethinyl Estradiol 3.1415345470
MESH:D005756 Gastritis Acetaminophen 4.1916983495
MESH:D006330 Heart Defects, Congenital Vitamin E 3.1316080930
MESH:D006529 Hepatomegaly Phenobarbital 3.9016109766
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.7916863852 16490937
MESH:D019584 Hot Flashes Vitamin E 4.4914716179
MESH:D006930 Hyperalgesia Acetaminophen 2.9516870215
MESH:D007021 Hypospadias Ethinyl Estradiol 4.2316569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.8112013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.6817937319
MESH:D007251 Influenza, Human Vitamin E 4.7316624496
MESH:D007674 Kidney Diseases Acetaminophen 6.5112587719 15629191
MESH:D007674 Kidney Diseases Vitamin E 6.5112488133
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 3.2416705839
MESH:D008103 Liver Cirrhosis Phenobarbital 3.0521047994
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 1.9016169303
MESH:D008107 Liver Diseases Acetaminophen 4.1512969438 16611625 19014921 11587558 19460945 16610002 19784758 12587719
MESH:D008107 Liver Diseases Phenobarbital 4.1519363144
MESH:D017114 Liver Failure, Acute Acetaminophen 3.5416871587 17185352
MESH:D008113 Liver Neoplasms Aflatoxin B1 4.9918177683 9163691 2125692 15890375
MESH:D008113 Liver Neoplasms Phenobarbital 4.9919812893 8742319 19482888 21047994 15975961 19073162
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 6.648603461
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 6.646150874 17172636 18308698 2563599 1399818
MESH:D008171 Lung Diseases Vitamin E 3.3716863852
MESH:D008175 Lung Neoplasms Aflatoxin B1 2.6114755239
MESH:D008175 Lung Neoplasms Vitamin E 2.6111062179
MESH:D008546 Melanoma, Experimental Acetaminophen 3.9819513568
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.9417484760
MESH:D009336 Necrosis 2,4-dinitrotoluene 4.3218551238
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.1418514411
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 3.7316049721 12819281
MESH:D010018 Osteomalacia Phenobarbital 4.8317016548
MESH:D010146 Pain Acetaminophen 2.6516870215
MESH:D010190 Pancreatic Neoplasms Phenobarbital 2.5816965848
MESH:D016584 Panic Disorder Ethinyl Estradiol 4.0411578682
MESH:D011230 Precancerous Conditions Phenobarbital 3.912563599
MESH:D011471 Prostatic Neoplasms Vitamin E 3.2515084515
MESH:D011537 Pruritus Ethinyl Estradiol 3.7716919318 15861022
MESH:D019310 Pseudolymphoma Phenobarbital 5.0212752131
MESH:D012640 Seizures 2,4-dinitrotoluene 6.6218551238
MESH:D012640 Seizures Phenobarbital 6.623137016 16876388 11442880 4039156
MESH:D003294 Seizures, Febrile Phenobarbital 5.286407741
MESH:D012871 Skin Diseases Vitamin E 2.5018709164
MESH:D013088 Spermatocele Ethinyl Estradiol 4.4616709447
MESH:D020521 Stroke Vitamin E 3.7716517955
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.9711994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.4415669648
MESH:D013964 Thyroid Neoplasms Phenobarbital 3.291399818
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 2.3816049721
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.7810091137
MESH:D014581 Urticaria Acetaminophen 3.3310982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.6814692618
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.8714671159 15869587
No data
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AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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